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The map label for this gene is hemN [H]

Identifier: 93007273

GI number: 93007273

Start: 3025714

End: 3027258

Strand: Direct

Name: hemN [H]

Synonym: Pcryo_2449

Alternate gene names: 93007273

Gene position: 3025714-3027258 (Clockwise)

Preceding gene: 93007272

Following gene: 93007278

Centisome position: 98.88

GC content: 42.07

Gene sequence:

>1545_bases
ATGTCAGAACAAGTTGATATCAATAGCACACCTGAACACGCCATCAATGCGAGCGATCAGCCCACTACAGTGCGTCCTGT
TATGCAACCGGACAATCCCTATGCCAGTACTCGTGGCAGCATCACCAGCAAACAGCTGCCAGCATTCGATCAAGATATCA
TTAATAAGTATAATCGTTCGGGACCACGCTATACCTCTTACCCAACTGCTTTAGAGTTTTCATCGATACCAGAAGGGCTT
GAGACAAAAATCCTGCAAGCGCGCGAAGCTCATGCGCCGCTATCACTTTACTTCCATATCCCGTTTTGTCGCCATCTTTG
CTATTACTGTGCTTGCAATAAAATCATCACCAAAAAGAATAGCGATGCAGGCGATTATTTAGCCTATCTAATTGCTGAAA
TTAAACACAAACGTGGGTTATTAACGCCACCAGAAGACGGTAAAAAACCACTGGTTAAACAGCTACATTTCGGTGGTGGT
ACGCCAACGTTTTTACAAGACAATGAGTTGATACAACTGTGGGAGTTTTTGCAGACCCAGTTTGAGTTTTTACCAGAAGA
TCAAGGTGATTACTCTATCGAAATTGACCCGCGCGAGCTCAGTAGCGAGACCTTAAAAGTATTGCGTACTCTTGGTTTTA
ACCGCGTCAGCTTAGGCGTACAGGATTTAGACGAAACCGTACAAATTGCGGTCAATCGTGTGCATTCAGCAGAGCTTATT
GAAAATGTATTAAATGAGGCGCGCGAATTAGGCTTTCATTCTATCAATGTCGATTTGATTTATGGCTTACCACATCAAAC
GCCTGAAACCTTTGATAAAACCATACGCCGTATTATCGAGATGTCGCCAGATCGCTTGTCGGTATTTAATTATGCTCATT
TGCCTGAACGCTTTAAGGCGCAGCGTCAAATCAAAGAGGACGATTTACCTACTCCATCTGATAAGTTCACGATGCTCGGT
AATACCATCAATACTTTAACTGAAGCCGGTTATCAATATATTGGCATTGACCATTTTGCCAAACCTGATGATGAGCTTGC
CGTCGCCCAGCGTGAGGGCAAGTTGCATCGTAATTTTCAGGGCTATACCATCATGGGCGATTGTGATTTATTGGGCTTTG
GCGTGTCTTCAATCAGTCAAATTGCCAATGCCAACAGCAGTTATATCCTACAAAACCATACTGATTTGCAAGTATATAAA
GACAATATCGATGCGGCACGTAATAATCCTACCATCATGCCAGCGGTCAATGTGATTAAAACCTCTATCAAAGATCGCTT
ACGTGAATACGTGATTATGAATTTACTGTGTCACGATTATATGGACTTTAGAGACATCAATCAGAAATTTGGCATCGATG
CTATTACCTATTTTATTCATGAGATTCAACAGCTTGGTGAAATGCAAGAAGACCGCTTGATTGATATGGATGCTGCTGGC
ATTCGCGTATTACCAAGAGGTCGCTTATTGGGTCGTAATGTAGCCATGGTATTCGATGAATATCTGGATAAAAAACATAA
AGACCGCTTCTCAAAAGTTATTTAA

Upstream 100 bases:

>100_bases
AATCGTTTTTTATTAGCTTTCGTAAGAAATACAGCTATTAGCAAAGCCATAAATGTCTTATTCAAAATAGCGATCGATAC
AGTCAAACGAGGAATCTCGC

Downstream 100 bases:

>100_bases
ATCCTTAGCCTCTAAAATATAAATAATAAAAAAGACCTCGATTGAGGTCTTTTTTTGGTTAGTGATAAATGTAATGTCTT
ATTATTAGAGACCGTTTTTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSEQVDINSTPEHAINASDQPTTVRPVMQPDNPYASTRGSITSKQLPAFDQDIINKYNRSGPRYTSYPTALEFSSIPEGL
ETKILQAREAHAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAGDYLAYLIAEIKHKRGLLTPPEDGKKPLVKQLHFGGG
TPTFLQDNELIQLWEFLQTQFEFLPEDQGDYSIEIDPRELSSETLKVLRTLGFNRVSLGVQDLDETVQIAVNRVHSAELI
ENVLNEARELGFHSINVDLIYGLPHQTPETFDKTIRRIIEMSPDRLSVFNYAHLPERFKAQRQIKEDDLPTPSDKFTMLG
NTINTLTEAGYQYIGIDHFAKPDDELAVAQREGKLHRNFQGYTIMGDCDLLGFGVSSISQIANANSSYILQNHTDLQVYK
DNIDAARNNPTIMPAVNVIKTSIKDRLREYVIMNLLCHDYMDFRDINQKFGIDAITYFIHEIQQLGEMQEDRLIDMDAAG
IRVLPRGRLLGRNVAMVFDEYLDKKHKDRFSKVI

Sequences:

>Translated_514_residues
MSEQVDINSTPEHAINASDQPTTVRPVMQPDNPYASTRGSITSKQLPAFDQDIINKYNRSGPRYTSYPTALEFSSIPEGL
ETKILQAREAHAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAGDYLAYLIAEIKHKRGLLTPPEDGKKPLVKQLHFGGG
TPTFLQDNELIQLWEFLQTQFEFLPEDQGDYSIEIDPRELSSETLKVLRTLGFNRVSLGVQDLDETVQIAVNRVHSAELI
ENVLNEARELGFHSINVDLIYGLPHQTPETFDKTIRRIIEMSPDRLSVFNYAHLPERFKAQRQIKEDDLPTPSDKFTMLG
NTINTLTEAGYQYIGIDHFAKPDDELAVAQREGKLHRNFQGYTIMGDCDLLGFGVSSISQIANANSSYILQNHTDLQVYK
DNIDAARNNPTIMPAVNVIKTSIKDRLREYVIMNLLCHDYMDFRDINQKFGIDAITYFIHEIQQLGEMQEDRLIDMDAAG
IRVLPRGRLLGRNVAMVFDEYLDKKHKDRFSKVI
>Mature_513_residues
SEQVDINSTPEHAINASDQPTTVRPVMQPDNPYASTRGSITSKQLPAFDQDIINKYNRSGPRYTSYPTALEFSSIPEGLE
TKILQAREAHAPLSLYFHIPFCRHLCYYCACNKIITKKNSDAGDYLAYLIAEIKHKRGLLTPPEDGKKPLVKQLHFGGGT
PTFLQDNELIQLWEFLQTQFEFLPEDQGDYSIEIDPRELSSETLKVLRTLGFNRVSLGVQDLDETVQIAVNRVHSAELIE
NVLNEARELGFHSINVDLIYGLPHQTPETFDKTIRRIIEMSPDRLSVFNYAHLPERFKAQRQIKEDDLPTPSDKFTMLGN
TINTLTEAGYQYIGIDHFAKPDDELAVAQREGKLHRNFQGYTIMGDCDLLGFGVSSISQIANANSSYILQNHTDLQVYKD
NIDAARNNPTIMPAVNVIKTSIKDRLREYVIMNLLCHDYMDFRDINQKFGIDAITYFIHEIQQLGEMQEDRLIDMDAAGI
RVLPRGRLLGRNVAMVFDEYLDKKHKDRFSKVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=250, Percent_Identity=29.2, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082341, Length=469, Percent_Identity=49.0405117270789, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI1789325, Length=250, Percent_Identity=28, Blast_Score=102, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 58651; Mature: 58520

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVDINSTPEHAINASDQPTTVRPVMQPDNPYASTRGSITSKQLPAFDQDIINKYNRS
CCCCCCCCCCCCHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
GPRYTSYPTALEFSSIPEGLETKILQAREAHAPLSLYFHIPFCRHLCYYCACNKIITKKN
CCCCCCCCCCEEHHCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
SDAGDYLAYLIAEIKHKRGLLTPPEDGKKPLVKQLHFGGGTPTFLQDNELIQLWEFLQTQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
FEFLPEDQGDYSIEIDPRELSSETLKVLRTLGFNRVSLGVQDLDETVQIAVNRVHSAELI
HHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHH
ENVLNEARELGFHSINVDLIYGLPHQTPETFDKTIRRIIEMSPDRLSVFNYAHLPERFKA
HHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHH
QRQIKEDDLPTPSDKFTMLGNTINTLTEAGYQYIGIDHFAKPDDELAVAQREGKLHRNFQ
HHHHHHCCCCCCCCCEEECCCHHHHHHHCCCEEECCCCCCCCCHHHHHHHHCCCHHCCCC
GYTIMGDCDLLGFGVSSISQIANANSSYILQNHTDLQVYKDNIDAARNNPTIMPAVNVIK
CEEEEECCCHHHCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHH
TSIKDRLREYVIMNLLCHDYMDFRDINQKFGIDAITYFIHEIQQLGEMQEDRLIDMDAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHCCEEECCCCC
IRVLPRGRLLGRNVAMVFDEYLDKKHKDRFSKVI
EEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQVDINSTPEHAINASDQPTTVRPVMQPDNPYASTRGSITSKQLPAFDQDIINKYNRS
CCCCCCCCCCCHHCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCC
GPRYTSYPTALEFSSIPEGLETKILQAREAHAPLSLYFHIPFCRHLCYYCACNKIITKKN
CCCCCCCCCCEEHHCCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
SDAGDYLAYLIAEIKHKRGLLTPPEDGKKPLVKQLHFGGGTPTFLQDNELIQLWEFLQTQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
FEFLPEDQGDYSIEIDPRELSSETLKVLRTLGFNRVSLGVQDLDETVQIAVNRVHSAELI
HHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHH
ENVLNEARELGFHSINVDLIYGLPHQTPETFDKTIRRIIEMSPDRLSVFNYAHLPERFKA
HHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHH
QRQIKEDDLPTPSDKFTMLGNTINTLTEAGYQYIGIDHFAKPDDELAVAQREGKLHRNFQ
HHHHHHCCCCCCCCCEEECCCHHHHHHHCCCEEECCCCCCCCCHHHHHHHHCCCHHCCCC
GYTIMGDCDLLGFGVSSISQIANANSSYILQNHTDLQVYKDNIDAARNNPTIMPAVNVIK
CEEEEECCCHHHCCHHHHHHHHCCCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHH
TSIKDRLREYVIMNLLCHDYMDFRDINQKFGIDAITYFIHEIQQLGEMQEDRLIDMDAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHCCEEECCCCC
IRVLPRGRLLGRNVAMVFDEYLDKKHKDRFSKVI
EEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767567; 10984043 [H]