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The map label for this gene is ftsI [H]

Identifier: 93007202

GI number: 93007202

Start: 2924018

End: 2926105

Strand: Reverse

Name: ftsI [H]

Synonym: Pcryo_2378

Alternate gene names: 93007202

Gene position: 2926105-2924018 (Counterclockwise)

Preceding gene: 93007203

Following gene: 93007201

Centisome position: 95.63

GC content: 46.31

Gene sequence:

>2088_bases
ATGAGCGATAAAAAACCCAGTGCTAAAGCGACCAGCAAAAAACCCGCCAGCGGCAAGGTTACTAAGCCACTACGCCGTGC
TAGTGCGGCCAAATCTGGGCAAACGAGTAGCAAGCCTGACCATAAATCAGATGATGGCCGTAAAGCCAAGCTATTTGGTC
GCTTAAAAAAGAATGAAGAACAGGGTGCTTATACCAGTGTCAAAAATCTAAAAAGCAAAAGATCAATTTTGGGAAAAGCA
TCTGGTGCTTCCTCTCGCGGCGGTGTCGAACAAGATAAGAACCGTTTCCGTTTGATTTGGGGTATAGCGCTGCTTATTTT
GGTGGCACTTATCGGTCGTGCTTACTATATTCAAATTGCCAATACTCAGTTTTATCAAGATAAAGGCAATGAGCTCATCA
CCAGTGTACGCACGCAAAAATCCTATCGTGGCATGATTACGGATCGCAACGATTTGCCATTGGCTGTCAGTGCACCACTT
GCGACAGTCTCTTTTAGCCCGCATGACTATGCCCGTGAATACTACGAGCTTAAGCGTATTATTATCACCAATCCTGAAAG
TCCGCAGCTTATCGCACGTATGCAAAAGCGCTTAGACAATATGGATTTGACGACGCTTGCGGCGGCTGCCAACATCTCAG
CCGATGAGCTAAAAAGAGTGACAGCTATCGACCCTACTATTGATGTAACGGATGAGGTGGCAGTCAAAGCAGCGCTGCCA
TCGGGTGCAGGCTCGCATTATTTGCCACTATTAAATAAAGTAACGCCGGAGATTGCAGAAAGCGTTAGCTCGCTTGATTT
TCCTGGTGTTAATGAGAAAAACTTTTTTCAGCGCTATTATCCGCAGCCACAGCCTAACTCGCAACTACTAGGTTTCATGG
GACAAAATGCCAACGATCCTGAAGGTGGTTATGAAGGACGTGCTGGTATCGAACGTCAGTATGAGAAAGATCTGGCGGGT
GATGATGGTAAGGTTTTGGTGCTCAAAGATGCCAAACAAAACAGTCTTAAAGAAATCAAACAGGTTGAACCAGAAGTACC
AGGTAAAGATGTGACATTGACCATTGATTCGCGTTTGCAATATTTGCTTTATAAAGAGCTAGAAAAAGCGGGGCGTTTGC
AAAAAGCGCGCTGGTCGACAGGTATGGTAGTCGATGTACAAACTGGTGAAGTACTTGCGCTATCGACATGGCCGTCATTT
AACTCTAATAATCTGAATGAGATGACGGGTGAAAATCAGCGTAACCGTGCGCTCCTTGATGTCTTTGAACCCGGTTCAGT
CATGAAGCCATTCACCGTTGCTGCGGCTTTAGATTCAGGGAAATACACTGCCACTACTTTAATCGATACCAATCCTGGCT
CTATCCGTGTCCGTGGTTATACGATTCGTGACCATAATAATCTAGGGCGGATCACGATGGCAACGCTACTACAGAAATCT
AGTAACGTCGCCTCGACCAAGATTGCTTTGTCTCTACCGGCTGACGGCATTACCAATATGCAAAGACAGTTTGGCTTTGG
GGCAAAAACACCACTGCAATTTCCAGGTGAAGGCAGTGGGCTTGTGGTGACACCAGAAGAAAAAGAAACTTCGAGACGGG
CAACGGTCAGTTATGGCTATGGTATACAGGTAACACTGGCACAGATAGCACAAGCTTATTCAGCGCTGGCGGCAGGTGGC
GTCATGCATCCGCTAACGTTGAATAAAAATGACAAAGCGCTACCAAGCAAACGTATTATGGCGCATGAACAAGCGATGGC
CATCGTACAGATGATGGAAAGTGTCACAGAAGACGGCGGTACGGCTAAAGGTGCGGCTATTGATGGTTACCGCGTTGCTG
GTAAAACAGGAACCTCGCGCCGTATCAATCCAAAAGGTGGCTACTATACTGACCAGTATCGTAATGTCTTTGCGGGTATG
GCACCAGCTTCTAATCCAAAACTGGTCGGTGTCATGTTAATCGAAGACCCGCGTGGTCAGATTTATGCTGGTTTAACCGT
GGCTCCTGTTTTCCATAATGTCATGAAAGAGGCACTACGTTTATATAATGTGCCTTTAGATAAGCCGCTCAAAACCGAAG
CTCAATAG

Upstream 100 bases:

>100_bases
CTTTAACGACGAATGATTCTGATGTTTTCGAAGCTGATGCTGTGAGCGATGCACCCGTTAAGGCTGCTGCTACCGATTCT
GACCTAGCGGAGGCAGGACA

Downstream 100 bases:

>100_bases
ATATAAAAGTAAATTTTTTAATATCCACCTCTTAACTATTTGATGTGTTTTAACCGTTTAGGATTTGCCAATGACCCTGT
CTACCTCGTCGCCAAGCAGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MSDKKPSAKATSKKPASGKVTKPLRRASAAKSGQTSSKPDHKSDDGRKAKLFGRLKKNEEQGAYTSVKNLKSKRSILGKA
SGASSRGGVEQDKNRFRLIWGIALLILVALIGRAYYIQIANTQFYQDKGNELITSVRTQKSYRGMITDRNDLPLAVSAPL
ATVSFSPHDYAREYYELKRIIITNPESPQLIARMQKRLDNMDLTTLAAAANISADELKRVTAIDPTIDVTDEVAVKAALP
SGAGSHYLPLLNKVTPEIAESVSSLDFPGVNEKNFFQRYYPQPQPNSQLLGFMGQNANDPEGGYEGRAGIERQYEKDLAG
DDGKVLVLKDAKQNSLKEIKQVEPEVPGKDVTLTIDSRLQYLLYKELEKAGRLQKARWSTGMVVDVQTGEVLALSTWPSF
NSNNLNEMTGENQRNRALLDVFEPGSVMKPFTVAAALDSGKYTATTLIDTNPGSIRVRGYTIRDHNNLGRITMATLLQKS
SNVASTKIALSLPADGITNMQRQFGFGAKTPLQFPGEGSGLVVTPEEKETSRRATVSYGYGIQVTLAQIAQAYSALAAGG
VMHPLTLNKNDKALPSKRIMAHEQAMAIVQMMESVTEDGGTAKGAAIDGYRVAGKTGTSRRINPKGGYYTDQYRNVFAGM
APASNPKLVGVMLIEDPRGQIYAGLTVAPVFHNVMKEALRLYNVPLDKPLKTEAQ

Sequences:

>Translated_695_residues
MSDKKPSAKATSKKPASGKVTKPLRRASAAKSGQTSSKPDHKSDDGRKAKLFGRLKKNEEQGAYTSVKNLKSKRSILGKA
SGASSRGGVEQDKNRFRLIWGIALLILVALIGRAYYIQIANTQFYQDKGNELITSVRTQKSYRGMITDRNDLPLAVSAPL
ATVSFSPHDYAREYYELKRIIITNPESPQLIARMQKRLDNMDLTTLAAAANISADELKRVTAIDPTIDVTDEVAVKAALP
SGAGSHYLPLLNKVTPEIAESVSSLDFPGVNEKNFFQRYYPQPQPNSQLLGFMGQNANDPEGGYEGRAGIERQYEKDLAG
DDGKVLVLKDAKQNSLKEIKQVEPEVPGKDVTLTIDSRLQYLLYKELEKAGRLQKARWSTGMVVDVQTGEVLALSTWPSF
NSNNLNEMTGENQRNRALLDVFEPGSVMKPFTVAAALDSGKYTATTLIDTNPGSIRVRGYTIRDHNNLGRITMATLLQKS
SNVASTKIALSLPADGITNMQRQFGFGAKTPLQFPGEGSGLVVTPEEKETSRRATVSYGYGIQVTLAQIAQAYSALAAGG
VMHPLTLNKNDKALPSKRIMAHEQAMAIVQMMESVTEDGGTAKGAAIDGYRVAGKTGTSRRINPKGGYYTDQYRNVFAGM
APASNPKLVGVMLIEDPRGQIYAGLTVAPVFHNVMKEALRLYNVPLDKPLKTEAQ
>Mature_694_residues
SDKKPSAKATSKKPASGKVTKPLRRASAAKSGQTSSKPDHKSDDGRKAKLFGRLKKNEEQGAYTSVKNLKSKRSILGKAS
GASSRGGVEQDKNRFRLIWGIALLILVALIGRAYYIQIANTQFYQDKGNELITSVRTQKSYRGMITDRNDLPLAVSAPLA
TVSFSPHDYAREYYELKRIIITNPESPQLIARMQKRLDNMDLTTLAAAANISADELKRVTAIDPTIDVTDEVAVKAALPS
GAGSHYLPLLNKVTPEIAESVSSLDFPGVNEKNFFQRYYPQPQPNSQLLGFMGQNANDPEGGYEGRAGIERQYEKDLAGD
DGKVLVLKDAKQNSLKEIKQVEPEVPGKDVTLTIDSRLQYLLYKELEKAGRLQKARWSTGMVVDVQTGEVLALSTWPSFN
SNNLNEMTGENQRNRALLDVFEPGSVMKPFTVAAALDSGKYTATTLIDTNPGSIRVRGYTIRDHNNLGRITMATLLQKSS
NVASTKIALSLPADGITNMQRQFGFGAKTPLQFPGEGSGLVVTPEEKETSRRATVSYGYGIQVTLAQIAQAYSALAAGGV
MHPLTLNKNDKALPSKRIMAHEQAMAIVQMMESVTEDGGTAKGAAIDGYRVAGKTGTSRRINPKGGYYTDQYRNVFAGMA
PASNPKLVGVMLIEDPRGQIYAGLTVAPVFHNVMKEALRLYNVPLDKPLKTEAQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=594, Percent_Identity=33.6700336700337, Blast_Score=328, Evalue=6e-91,
Organism=Escherichia coli, GI1786854, Length=622, Percent_Identity=25.5627009646302, Blast_Score=119, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 75784; Mature: 75653

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKKPSAKATSKKPASGKVTKPLRRASAAKSGQTSSKPDHKSDDGRKAKLFGRLKKNEE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
QGAYTSVKNLKSKRSILGKASGASSRGGVEQDKNRFRLIWGIALLILVALIGRAYYIQIA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCEEEEEEC
NTQFYQDKGNELITSVRTQKSYRGMITDRNDLPLAVSAPLATVSFSPHDYAREYYELKRI
CCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEECCCHHHHHHHHHHEEE
IITNPESPQLIARMQKRLDNMDLTTLAAAANISADELKRVTAIDPTIDVTDEVAVKAALP
EEECCCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHEECCCCCCCCCHHEEEEECC
SGAGSHYLPLLNKVTPEIAESVSSLDFPGVNEKNFFQRYYPQPQPNSQLLGFMGQNANDP
CCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHEECCCCCCC
EGGYEGRAGIERQYEKDLAGDDGKVLVLKDAKQNSLKEIKQVEPEVPGKDVTLTIDSRLQ
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEEHHHHHH
YLLYKELEKAGRLQKARWSTGMVVDVQTGEVLALSTWPSFNSNNLNEMTGENQRNRALLD
HHHHHHHHHHCCHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCEEEE
VFEPGSVMKPFTVAAALDSGKYTATTLIDTNPGSIRVRGYTIRDHNNLGRITMATLLQKS
EECCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEEEEEEEECCCCCCHHHHHHHHHHC
SNVASTKIALSLPADGITNMQRQFGFGAKTPLQFPGEGSGLVVTPEEKETSRRATVSYGY
CCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHCCCCCEEEEECC
GIQVTLAQIAQAYSALAAGGVMHPLTLNKNDKALPSKRIMAHEQAMAIVQMMESVTEDGG
CEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TAKGAAIDGYRVAGKTGTSRRINPKGGYYTDQYRNVFAGMAPASNPKLVGVMLIEDPRGQ
CCCCCEECCEEEECCCCCCCEECCCCCEECHHHHHHHHCCCCCCCCCEEEEEEEECCCCC
IYAGLTVAPVFHNVMKEALRLYNVPLDKPLKTEAQ
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDKKPSAKATSKKPASGKVTKPLRRASAAKSGQTSSKPDHKSDDGRKAKLFGRLKKNEE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
QGAYTSVKNLKSKRSILGKASGASSRGGVEQDKNRFRLIWGIALLILVALIGRAYYIQIA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCEEEEEEC
NTQFYQDKGNELITSVRTQKSYRGMITDRNDLPLAVSAPLATVSFSPHDYAREYYELKRI
CCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEECCCHHHHHHHHHHEEE
IITNPESPQLIARMQKRLDNMDLTTLAAAANISADELKRVTAIDPTIDVTDEVAVKAALP
EEECCCCHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHEECCCCCCCCCHHEEEEECC
SGAGSHYLPLLNKVTPEIAESVSSLDFPGVNEKNFFQRYYPQPQPNSQLLGFMGQNANDP
CCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHEECCCCCCC
EGGYEGRAGIERQYEKDLAGDDGKVLVLKDAKQNSLKEIKQVEPEVPGKDVTLTIDSRLQ
CCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEEHHHHHH
YLLYKELEKAGRLQKARWSTGMVVDVQTGEVLALSTWPSFNSNNLNEMTGENQRNRALLD
HHHHHHHHHHCCHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCHHHCCCCCCCCEEEE
VFEPGSVMKPFTVAAALDSGKYTATTLIDTNPGSIRVRGYTIRDHNNLGRITMATLLQKS
EECCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEEEEEEEECCCCCCHHHHHHHHHHC
SNVASTKIALSLPADGITNMQRQFGFGAKTPLQFPGEGSGLVVTPEEKETSRRATVSYGY
CCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHCCCCCEEEEECC
GIQVTLAQIAQAYSALAAGGVMHPLTLNKNDKALPSKRIMAHEQAMAIVQMMESVTEDGG
CEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
TAKGAAIDGYRVAGKTGTSRRINPKGGYYTDQYRNVFAGMAPASNPKLVGVMLIEDPRGQ
CCCCCEECCEEEECCCCCCCEECCCCCEECHHHHHHHHCCCCCCCCCEEEEEEEECCCCC
IYAGLTVAPVFHNVMKEALRLYNVPLDKPLKTEAQ
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]