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The map label for this gene is rppH [H]

Identifier: 93007134

GI number: 93007134

Start: 2837482

End: 2838003

Strand: Direct

Name: rppH [H]

Synonym: Pcryo_2310

Alternate gene names: 93007134

Gene position: 2837482-2838003 (Clockwise)

Preceding gene: 93007131

Following gene: 93007137

Centisome position: 92.73

GC content: 48.85

Gene sequence:

>522_bases
ATGATAGATGCAGACGGCTTTCGCGCCAATGTCGGCATCATCTTGGCAAATACACAAGGGCAAGTTCTGTGGGCAAAACG
TATTGGTCACAACGCTTGGCAGTTCCCTCAAGGCGGTATCGACCGTGGGGAGACGCCGATGGATGCGATGTATCGCGAGC
TCTGGGAAGAGGTCGGTCTACATCCGCGTCATGTCGATTTGCTAGCGGTTACGCAAGATTGGTTGCGTTATCGTCTGCCA
AAACGCTATGTGCGTCATGGGCAGTACCCTTTATGTATTGGGCAAAAACAGAAATGGTTTTTGCTACGCTTAGATGAGCC
AAATACCCAACACATCCGCTTTGATGAGGGAAAACCAGAGTTTGATAACTGGCAATGGGTCAGCTACTGGTATCCACTTG
GACAAGTGATTCACTTTAAACGCAGCGTATATCGTCGCGCCTTGCAAGAATTGGTGCCCGAGCTACCGCTTCAACAAGGG
CTTATTATTCCGGAACAAAACAACCATTTGTTGGTGGAATAA

Upstream 100 bases:

>100_bases
TTGCCAAAGTATCGATAGCAATCACCCTATAATAATTATGATTGCTGTCACTGTGCCTTGTTGAAATAAGCTATTTTTAA
ACATTTTAAAAGGTTACGTC

Downstream 100 bases:

>100_bases
AGTCACCAATTTTTAATGCAATTAGCACAATAACAAATACCGTTAGTGATATTTAATATTACTAACGGTATTTTTTTCAC
TGGATTTTTCTTAATAGCTA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGLHPRHVDLLAVTQDWLRYRLP
KRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKPEFDNWQWVSYWYPLGQVIHFKRSVYRRALQELVPELPLQQG
LIIPEQNNHLLVE

Sequences:

>Translated_173_residues
MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGLHPRHVDLLAVTQDWLRYRLP
KRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKPEFDNWQWVSYWYPLGQVIHFKRSVYRRALQELVPELPLQQG
LIIPEQNNHLLVE
>Mature_173_residues
MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGLHPRHVDLLAVTQDWLRYRLP
KRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKPEFDNWQWVSYWYPLGQVIHFKRSVYRRALQELVPELPLQQG
LIIPEQNNHLLVE

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=166, Percent_Identity=55.421686746988, Blast_Score=193, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20565; Mature: 20565

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGL
CCCCCCEEEEEEEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
HPRHVDLLAVTQDWLRYRLPKRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKPE
CCCCCHHHHHHHHHHHHHCCHHHHHCCCCCEEECCCCCEEEEEECCCCCCEEEECCCCCC
FDNWQWVSYWYPLGQVIHFKRSVYRRALQELVPELPLQQGLIIPEQNNHLLVE
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCEEEECCCCEEEEC
>Mature Secondary Structure
MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGL
CCCCCCEEEEEEEEEECCCCCEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
HPRHVDLLAVTQDWLRYRLPKRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKPE
CCCCCHHHHHHHHHHHHHCCHHHHHCCCCCEEECCCCCEEEEEECCCCCCEEEECCCCCC
FDNWQWVSYWYPLGQVIHFKRSVYRRALQELVPELPLQQGLIIPEQNNHLLVE
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA