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The map label for this gene is hisG [H]

Identifier: 93007017

GI number: 93007017

Start: 2697085

End: 2697780

Strand: Reverse

Name: hisG [H]

Synonym: Pcryo_2193

Alternate gene names: 93007017

Gene position: 2697780-2697085 (Counterclockwise)

Preceding gene: 93007018

Following gene: 93007016

Centisome position: 88.17

GC content: 44.4

Gene sequence:

>696_bases
ATGACTGAAGTAACCAACAGCTTACCAACCAGTGGTTTATTAAACGAAGTAAATGATGAGTTTTCAGGCTTAACACTGGC
GTTATCCAAGGGTCGTATCTTAGAAGAGACGATGCCACTTTTGCGTGCCGCTGGCGTTGAATTATTGGAAGATCCTGAAG
CCTCACGCAAGCTTATTTTTCCAACCTCAAATCCCAATGTCCGAGTATTAATTTTACGCGCAAGCGATGTGCCAACGTAT
GTTGAACACGGTGCAGCGGACTTTGGTGTGGCAGGTAAAGATGTGTTGCTTGAGCATGGCGCCAATCATGTTTATGAATT
ATTAGATCTGAAGATTGCTCAGTGTAAGCTCATGACCGCTGGTGTAAAAGATGCACCTTTGCCAAACCGTCGCCTACGTA
TTGCCACCAAATATGTGAATGTTGCTCGTGCTTATTTTGCAAGTCAAGGACAGCAAGTTGATGTGATCAAGCTGTACGGC
TCGATGGAACTTGCGCCCTTGGTTGGTTTAGGTGATTTGATAGTCGACGTGGTTGATACGGGCAATACCTTACGTGCCAA
TGGACTCGAAGCGCGCGATCATATCTGTGATGTCTCTTCCCGTCTTATCGTCAACCAAGTCAGTTATAAGCGCAAGTTTT
CACTGTTTGAGCCGATATTAGATAGTTTTAAAAACAGTATCAGCAGTACTCCATAA

Upstream 100 bases:

>100_bases
GGCGTTATAATCAAAATAAATTTTAAGCCTAGTGTAATATTAAAAATGCCCTTTGACGGCGACAACTTTCAGCACCATCA
GCACACGGACCAGCGTCACT

Downstream 100 bases:

>100_bases
ATCAGTACATGATAAAAGCGTATCGTAGATTGATAATATCAAGTATGGTTATACAAAATTCCAAACCAGTTTAGCGCTCT
AAGGAGAACATAGCGTGCTA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTEVTNSLPTSGLLNEVNDEFSGLTLALSKGRILEETMPLLRAAGVELLEDPEASRKLIFPTSNPNVRVLILRASDVPTY
VEHGAADFGVAGKDVLLEHGANHVYELLDLKIAQCKLMTAGVKDAPLPNRRLRIATKYVNVARAYFASQGQQVDVIKLYG
SMELAPLVGLGDLIVDVVDTGNTLRANGLEARDHICDVSSRLIVNQVSYKRKFSLFEPILDSFKNSISSTP

Sequences:

>Translated_231_residues
MTEVTNSLPTSGLLNEVNDEFSGLTLALSKGRILEETMPLLRAAGVELLEDPEASRKLIFPTSNPNVRVLILRASDVPTY
VEHGAADFGVAGKDVLLEHGANHVYELLDLKIAQCKLMTAGVKDAPLPNRRLRIATKYVNVARAYFASQGQQVDVIKLYG
SMELAPLVGLGDLIVDVVDTGNTLRANGLEARDHICDVSSRLIVNQVSYKRKFSLFEPILDSFKNSISSTP
>Mature_230_residues
TEVTNSLPTSGLLNEVNDEFSGLTLALSKGRILEETMPLLRAAGVELLEDPEASRKLIFPTSNPNVRVLILRASDVPTYV
EHGAADFGVAGKDVLLEHGANHVYELLDLKIAQCKLMTAGVKDAPLPNRRLRIATKYVNVARAYFASQGQQVDVIKLYGS
MELAPLVGLGDLIVDVVDTGNTLRANGLEARDHICDVSSRLIVNQVSYKRKFSLFEPILDSFKNSISSTP

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=179, Percent_Identity=32.9608938547486, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320896, Length=172, Percent_Identity=32.5581395348837, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25191; Mature: 25060

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVTNSLPTSGLLNEVNDEFSGLTLALSKGRILEETMPLLRAAGVELLEDPEASRKLIF
CCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEE
PTSNPNVRVLILRASDVPTYVEHGAADFGVAGKDVLLEHGANHVYELLDLKIAQCKLMTA
ECCCCCEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHEEEEC
GVKDAPLPNRRLRIATKYVNVARAYFASQGQQVDVIKLYGSMELAPLVGLGDLIVDVVDT
CCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCC
GNTLRANGLEARDHICDVSSRLIVNQVSYKRKFSLFEPILDSFKNSISSTP
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEVTNSLPTSGLLNEVNDEFSGLTLALSKGRILEETMPLLRAAGVELLEDPEASRKLIF
CCCCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEE
PTSNPNVRVLILRASDVPTYVEHGAADFGVAGKDVLLEHGANHVYELLDLKIAQCKLMTA
ECCCCCEEEEEEECCCCCHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHEEEEC
GVKDAPLPNRRLRIATKYVNVARAYFASQGQQVDVIKLYGSMELAPLVGLGDLIVDVVDT
CCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCC
GNTLRANGLEARDHICDVSSRLIVNQVSYKRKFSLFEPILDSFKNSISSTP
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA