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The map label for this gene is hisD [H]

Identifier: 93007016

GI number: 93007016

Start: 2695547

End: 2696845

Strand: Reverse

Name: hisD [H]

Synonym: Pcryo_2192

Alternate gene names: 93007016

Gene position: 2696845-2695547 (Counterclockwise)

Preceding gene: 93007017

Following gene: 93007015

Centisome position: 88.14

GC content: 48.11

Gene sequence:

>1299_bases
ATGCGCCAATTAAGTACGCAAGACGCCGATTTTGACAGTCAGTTGACAGAACTGCTTGCTTTTGAAACCGTTAATGATGC
CGATTTACTCAAAACGGTAGATGACATTATTAGTAAAGTGCGTCATGGCGGGGATAGTGTGGTGCTAGAATTGACGCAGC
AGTTTGATCAACATCCAGCAACGACGATGAAGGCTTTAGAATTATCCAAAGAGGCACTTGCTGAAGCCTTTGCCAATCTT
GATGATGCCGTGAAAAGCGCTCTGACCACAGCAGCGACGCGCGTGCAGAGCTTTCATGAGCGCCAAGTACAAGAGTCATG
GCAGTATGAAGATGAATTCGGTAATCGTTTAGGTCAAAAGGTCACGCCGCTTGACCGTGTCGGCATTTATGTGCCGGGCG
GTCTGGCATCTTATCCTTCTTCAGTATTAATGAACGCTATCCCTGCCAAAGTTGCTGGTGTCAAAGAAGTTATCATGGTA
GTGCCAGCGCCAAAAGGTGTGCTCAATCCCTTGGTATTAGCGGCGGCGCATTTGGCACAAGTTGATCGCGTTTTTACTAT
TGGCGGTGCACAAGCGGTAGCGGCATTGGCATATGGTACTGAAACGATTTCGGCAGTAGATAAAATCACTGGACCGGGCA
ATAAATATGTTGCAGCCGCCAAACGCGCGGTATTCGGTCAAGTCGGTATAGATATGATTGCCGGACCTTCTGAGGTTCTG
GTTTATGCAGAAGGCGAAGCGCCAGACCGTGCTGATTGGTTAGCGATGGATTTATTATCACAGGCAGAGCATGACCGTAT
TGCCCAAGCGATTTTTTTGACCACAAGTGAAAAACAGCTTAAAGAAGTCGCCATTGAGATTGAAAAAGCCTTGGCTGAAT
TACCCAAGGCAGATATCGCTCGTGATTCGCTAAAAAATCGTGGCGCGCTTATCTTGGTTAAAGACCGTGCAGAAGGCATG
GCGGTGATCAATCGCGTTGCGCCTGAGCATTTGGAGCTGTCTGTTGATAATCCAGACGCGTTGCTTGGTAGTATTCGTCA
TGCAGGTGCTATCTTTATGGGACGTCATACGCCAGAGGCAATCGGTGACTACTGTGCAGGACCGAACCATGTGCTACCGA
CATCGGGTACAGCACGCTTTTCGTCACCGCTTGGCGTCTATGATTTTCAAAAGAAGTCATCCATTATTTATTGTAGTGAA
GCGGGCAGTAAGCCTTTGGCTGAGACGGCAGATATTTTAGCGCAGCATGAGGACTTAGAAGCCCATGCACGTTCAGCCCG
TTATCGTTACCAGTCCTAA

Upstream 100 bases:

>100_bases
ACCGTATAGTCTGAATGTGATTACTATAAATAAGCTGACATCTAAGCCCTCATATTATCCTTTTTACCGCCGTATTCATG
CTCAAATATAGGACAAAGCC

Downstream 100 bases:

>100_bases
TTTTTTCAAAGACAATTATTGGAATAACAGGTCTTTGGATAACAACTTTTAGAATAACAGTTTTAGAAATAACCATTTCT
GTGATTAATAGTAGGATAAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRQLSTQDADFDSQLTELLAFETVNDADLLKTVDDIISKVRHGGDSVVLELTQQFDQHPATTMKALELSKEALAEAFANL
DDAVKSALTTAATRVQSFHERQVQESWQYEDEFGNRLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMV
VPAPKGVLNPLVLAAAHLAQVDRVFTIGGAQAVAALAYGTETISAVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
VYAEGEAPDRADWLAMDLLSQAEHDRIAQAIFLTTSEKQLKEVAIEIEKALAELPKADIARDSLKNRGALILVKDRAEGM
AVINRVAPEHLELSVDNPDALLGSIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSE
AGSKPLAETADILAQHEDLEAHARSARYRYQS

Sequences:

>Translated_432_residues
MRQLSTQDADFDSQLTELLAFETVNDADLLKTVDDIISKVRHGGDSVVLELTQQFDQHPATTMKALELSKEALAEAFANL
DDAVKSALTTAATRVQSFHERQVQESWQYEDEFGNRLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMV
VPAPKGVLNPLVLAAAHLAQVDRVFTIGGAQAVAALAYGTETISAVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
VYAEGEAPDRADWLAMDLLSQAEHDRIAQAIFLTTSEKQLKEVAIEIEKALAELPKADIARDSLKNRGALILVKDRAEGM
AVINRVAPEHLELSVDNPDALLGSIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSE
AGSKPLAETADILAQHEDLEAHARSARYRYQS
>Mature_432_residues
MRQLSTQDADFDSQLTELLAFETVNDADLLKTVDDIISKVRHGGDSVVLELTQQFDQHPATTMKALELSKEALAEAFANL
DDAVKSALTTAATRVQSFHERQVQESWQYEDEFGNRLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMV
VPAPKGVLNPLVLAAAHLAQVDRVFTIGGAQAVAALAYGTETISAVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
VYAEGEAPDRADWLAMDLLSQAEHDRIAQAIFLTTSEKQLKEVAIEIEKALAELPKADIARDSLKNRGALILVKDRAEGM
AVINRVAPEHLELSVDNPDALLGSIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSE
AGSKPLAETADILAQHEDLEAHARSARYRYQS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=405, Percent_Identity=42.962962962963, Blast_Score=295, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=36.6906474820144, Blast_Score=244, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46466; Mature: 46466

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQLSTQDADFDSQLTELLAFETVNDADLLKTVDDIISKVRHGGDSVVLELTQQFDQHPA
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCH
TTMKALELSKEALAEAFANLDDAVKSALTTAATRVQSFHERQVQESWQYEDEFGNRLGQK
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
VTPLDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAQ
CCCHHHCCEEECCCHHHCCHHHHHHHHHHHHHCHHHEEEEECCCCHHHHHHHHHHHHHHH
VDRVFTIGGAQAVAALAYGTETISAVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
HHHHEEECCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHCCCCCEEE
VYAEGEAPDRADWLAMDLLSQAEHDRIAQAIFLTTSEKQLKEVAIEIEKALAELPKADIA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCHHHHH
RDSLKNRGALILVKDRAEGMAVINRVAPEHLELSVDNPDALLGSIRHAGAIFMGRHTPEA
HHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCEEEECCCCHHH
IGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSEAGSKPLAETADILAQHEDLE
HHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
AHARSARYRYQS
HHHHHHHCCCCC
>Mature Secondary Structure
MRQLSTQDADFDSQLTELLAFETVNDADLLKTVDDIISKVRHGGDSVVLELTQQFDQHPA
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCH
TTMKALELSKEALAEAFANLDDAVKSALTTAATRVQSFHERQVQESWQYEDEFGNRLGQK
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
VTPLDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAQ
CCCHHHCCEEECCCHHHCCHHHHHHHHHHHHHCHHHEEEEECCCCHHHHHHHHHHHHHHH
VDRVFTIGGAQAVAALAYGTETISAVDKITGPGNKYVAAAKRAVFGQVGIDMIAGPSEVL
HHHHEEECCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHCCCCCEEE
VYAEGEAPDRADWLAMDLLSQAEHDRIAQAIFLTTSEKQLKEVAIEIEKALAELPKADIA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCHHHHH
RDSLKNRGALILVKDRAEGMAVINRVAPEHLELSVDNPDALLGSIRHAGAIFMGRHTPEA
HHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCEEEECCCCHHH
IGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSEAGSKPLAETADILAQHEDLE
HHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
AHARSARYRYQS
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA