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The map label for this gene is tpm [H]

Identifier: 93006905

GI number: 93006905

Start: 2547206

End: 2547811

Strand: Reverse

Name: tpm [H]

Synonym: Pcryo_2081

Alternate gene names: 93006905

Gene position: 2547811-2547206 (Counterclockwise)

Preceding gene: 93006906

Following gene: 93006902

Centisome position: 83.27

GC content: 45.71

Gene sequence:

>606_bases
ATGGAAAACGTCAATCAAGCGCAGTTTTGGCAGCAGCGTTATGAGCAAGACAGTATCGGTTGGGATATGGGACAGGTGTC
GCCGCCACTAAAAGCTTATATTGACCAGTTACCTGAAGCCGCTAAAAATCAGGCTGTTTTAGTGCCGGGTGCAGGTAATG
CTTACGAGGTGGGTTATCTACATGAGCAAGGGTTTACCAATGTCACCTTGGTTGATTTTGCCCCTGCGCCGATTGCAGCG
TTTGCTGAGCGTTATCCTAATTTTCCAGCTAAGCATCTAATCTGTGCCGACTTTTTTGAGTTATCGCCTGAGCAATATCA
GTTTGATTGGGTGCTTGAGCAGACGTTTTTTTGTGCGATAAATCCATCACGCCGTGACGAGTACGTGCAGCAGATGGCAT
CATTAGTGAAGCCGAATGGTAAACTGATTGGGTTGCTATTTGACAAAGATTTTGGGCGAGATGAGCCACCGTTTGGCGGT
ACAAAAGATGAATATCAGCAGCGTTTTGCGACTCATTTTGACATTGATATTATGGAGCCGAGTTACAATTCACACCCAGC
ACGGCAAGGCAGTGAGCTTTTTATTGAGATGCATGTAAAAGACTGA

Upstream 100 bases:

>100_bases
TACTTGGGTGGTTTCAGTCATGTCGATAAGCCTGATATGATAAGACATAACGGTACGAATCGTGTCGTTTAAATAATAGA
TTTATCTACAGGGATGTCAT

Downstream 100 bases:

>100_bases
TTTCACGCTTGATATTGTCTCGAGCTTGTACTTCGAAGTAGTTATGATAATACGCTGTCAAATAAAGTACTGGGTGTGAG
AGTAATTTCTGCAAGACTGT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MENVNQAQFWQQRYEQDSIGWDMGQVSPPLKAYIDQLPEAAKNQAVLVPGAGNAYEVGYLHEQGFTNVTLVDFAPAPIAA
FAERYPNFPAKHLICADFFELSPEQYQFDWVLEQTFFCAINPSRRDEYVQQMASLVKPNGKLIGLLFDKDFGRDEPPFGG
TKDEYQQRFATHFDIDIMEPSYNSHPARQGSELFIEMHVKD

Sequences:

>Translated_201_residues
MENVNQAQFWQQRYEQDSIGWDMGQVSPPLKAYIDQLPEAAKNQAVLVPGAGNAYEVGYLHEQGFTNVTLVDFAPAPIAA
FAERYPNFPAKHLICADFFELSPEQYQFDWVLEQTFFCAINPSRRDEYVQQMASLVKPNGKLIGLLFDKDFGRDEPPFGG
TKDEYQQRFATHFDIDIMEPSYNSHPARQGSELFIEMHVKD
>Mature_201_residues
MENVNQAQFWQQRYEQDSIGWDMGQVSPPLKAYIDQLPEAAKNQAVLVPGAGNAYEVGYLHEQGFTNVTLVDFAPAPIAA
FAERYPNFPAKHLICADFFELSPEQYQFDWVLEQTFFCAINPSRRDEYVQQMASLVKPNGKLIGLLFDKDFGRDEPPFGG
TKDEYQQRFATHFDIDIMEPSYNSHPARQGSELFIEMHVKD

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 23023; Mature: 23023

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVNQAQFWQQRYEQDSIGWDMGQVSPPLKAYIDQLPEAAKNQAVLVPGAGNAYEVGYL
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEE
HEQGFTNVTLVDFAPAPIAAFAERYPNFPAKHLICADFFELSPEQYQFDWVLEQTFFCAI
ECCCCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEHEEEECCEEEEEE
NPSRRDEYVQQMASLVKPNGKLIGLLFDKDFGRDEPPFGGTKDEYQQRFATHFDIDIMEP
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEECC
SYNSHPARQGSELFIEMHVKD
CCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MENVNQAQFWQQRYEQDSIGWDMGQVSPPLKAYIDQLPEAAKNQAVLVPGAGNAYEVGYL
CCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEE
HEQGFTNVTLVDFAPAPIAAFAERYPNFPAKHLICADFFELSPEQYQFDWVLEQTFFCAI
ECCCCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEHEEEECCEEEEEE
NPSRRDEYVQQMASLVKPNGKLIGLLFDKDFGRDEPPFGGTKDEYQQRFATHFDIDIMEP
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCEEEECC
SYNSHPARQGSELFIEMHVKD
CCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA