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The map label for this gene is tktA [H]

Identifier: 93006673

GI number: 93006673

Start: 2282158

End: 2284155

Strand: Reverse

Name: tktA [H]

Synonym: Pcryo_1849

Alternate gene names: 93006673

Gene position: 2284155-2282158 (Counterclockwise)

Preceding gene: 93006674

Following gene: 93006671

Centisome position: 74.65

GC content: 47.15

Gene sequence:

>1998_bases
ATGCCAGCTCCAATTAGCGAACGTAAATTAGCCAATGCCATCCGCGTACTGTCGTTTGACGCGGTTCAAAAAGCCAATTC
TGGGCACCCGGGTGCACCAATGGGCATGGCTGATATTGCCGAAGTTTTGTGGCGCAAGTTTTTAAAGCATAATCCTGCTG
ACCCAAGCTGGCACAACCGTGATCGTTTTGTCTTATCAAACGGTCATGGGTCGATGCTTATCTATTCATTGCTACATTTA
TCAGGCTATGACGTTAGCGTTGATGACCTAAAAGGTTTCCGTCAATTACATTCGAAAACGCCGGGTCATCCAGAGCTTGG
CTATACGCCAGGTGTTGAAACCACCACTGGTCCATTAGGACAGGGTATTGCCAATGCGGTTGGTTTTGCAATTGCAGAAA
AAACGTTGGCAGCGCAATTTAATCGTGATGGTCATAATATTGTCGATCATCATACTTATGCGTTTTTAGGCGATGGCTGC
TTGATGGAAGGTATTAGCCATGAAGTCTGCTCATTGGCTGGCACGTTAGAGCTTGGCAAATTGGTATTTTTCTATGATGA
CAATGGCATCTCTATCGATGGTAATGTCGAAGGTTGGTTCACTGATGATACGCAAGCGCGCTTTGAGTCTTATGGCTGGC
AAGTTATCAAGGTCGATGGTCATGATACTGATGAGATTACGCAAGCAACTGAGCAAGCGATTAAAGAAACGACTAAGCCA
AGCTTAATCATTTGCAAAACGACTATTGGCGCTGGTAGCCCAAATAAACAAGGCTTAGCAGCCAGTCATGGCGCGCCACT
TGGCGATGATGAAATCGTTTTAACCCGTGATGCATTATCTTGGACGCATGCGCCGTTTGAGCTAGATGATGAAATCTATC
AAGCGTGGGATGGTAAAGCGAAAGGCGACGTCTTACAGAAAAACTGGAACGCGAACTTTGACGCTTATAAGAAGGCTTAT
CCAGAGTTAGCAACTGAGTTGCTTCGTCGTTTAGAGGGTGACTTACCAGCTGATTTTGAGCAAAAAGCGCAAGAGTATAT
CCAGCAAACTCAAGAGCAGGGCGGTGATGTTGCCAGTCGTAAGGCCAGCCAAAATGCCATCAATACCTTACAGCCATTAC
TGCCAGAATTACTTGGTGGCTCAGCGGATTTAGCAGGCTCAAACCTCACGCTATTTAAAGACGCCAAAGGCATCCAAGAC
GATGACGCGGGCAACTATATCTATTATGGTGTGCGCGAATTCGGTATGACGGCCATTGCTAACGGTATCGCGTTACATGG
CGGCTTTGTTCCTTATGTTGCGACGTTCCTGATGTTTATGGAATACGCACGTAATGCGGTACGTATGGGCGCGCTCATGA
AGCAGCGTGTGATTCATGTCTATACTCATGACTCAATCGGTCTCGGTGAAGATGGTCCAACGCATCAGCCAGTTGAGCAA
TTGACCAGCTTACGTACCACGCCAAATCTACGTACATGGCGTCCTTGTGATGCGACTGAATCAGCAAGCGCTTGGGTTGA
GGCAATTAAATCAGAAAATAATCCATCTGCCTTGATTTTCAGTCGTCAAAGCTTGCCACACCAAGCGCGTGACCGCGAGC
AAGTAGCAAACATCACCAAAGGTGGTTATGTACTTGCAAAAGAGCAAGGCGAGCTACAAGCGATTATCATCGCAACTGGC
TCAGAAGTCGGTCTTGCTATGCAAGCTTACGCGACCTTGAGCGAAAATGGCGTCGGTGTACGTGTGGTCTCTATGCCGTG
TGCAGAAATCTTCGTTGAGCAAGATACTAGCTACCGTGAAGCGGTATTGCCTGCCAATACTCGCGCCCGCGTCGCAGTAG
AAGCAGCACACGTCGATTACTGGTATAAGTTCGTTGGTTTAGACGGTAAAGTGATTGGCATGACGACTTATGGTGAATCA
GCGCCTGCTGATGAGTTATATAAAGAGTTTGGTATCACCACTGAAGCCGTGGTTGATGCGGTGAATAGCTTGGTGTAA

Upstream 100 bases:

>100_bases
GATTATTCGTTAAGGGCGCCTATTGCGTCCTTATTTTATGACCCTCTGAGTAAACTCTCCTCTTATCCTCCATACTTCTA
TCCGAATATTAGGACACTCT

Downstream 100 bases:

>100_bases
GTATTTAAAACTGCTCAAACAAAAAAGAGTTGCTAGGATTTCTAGCAACTCTTTTTTTTATGTTCTTTTAAGTCTTTCAG
AGCTTAATTAGCAGCAATCA

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MPAPISERKLANAIRVLSFDAVQKANSGHPGAPMGMADIAEVLWRKFLKHNPADPSWHNRDRFVLSNGHGSMLIYSLLHL
SGYDVSVDDLKGFRQLHSKTPGHPELGYTPGVETTTGPLGQGIANAVGFAIAEKTLAAQFNRDGHNIVDHHTYAFLGDGC
LMEGISHEVCSLAGTLELGKLVFFYDDNGISIDGNVEGWFTDDTQARFESYGWQVIKVDGHDTDEITQATEQAIKETTKP
SLIICKTTIGAGSPNKQGLAASHGAPLGDDEIVLTRDALSWTHAPFELDDEIYQAWDGKAKGDVLQKNWNANFDAYKKAY
PELATELLRRLEGDLPADFEQKAQEYIQQTQEQGGDVASRKASQNAINTLQPLLPELLGGSADLAGSNLTLFKDAKGIQD
DDAGNYIYYGVREFGMTAIANGIALHGGFVPYVATFLMFMEYARNAVRMGALMKQRVIHVYTHDSIGLGEDGPTHQPVEQ
LTSLRTTPNLRTWRPCDATESASAWVEAIKSENNPSALIFSRQSLPHQARDREQVANITKGGYVLAKEQGELQAIIIATG
SEVGLAMQAYATLSENGVGVRVVSMPCAEIFVEQDTSYREAVLPANTRARVAVEAAHVDYWYKFVGLDGKVIGMTTYGES
APADELYKEFGITTEAVVDAVNSLV

Sequences:

>Translated_665_residues
MPAPISERKLANAIRVLSFDAVQKANSGHPGAPMGMADIAEVLWRKFLKHNPADPSWHNRDRFVLSNGHGSMLIYSLLHL
SGYDVSVDDLKGFRQLHSKTPGHPELGYTPGVETTTGPLGQGIANAVGFAIAEKTLAAQFNRDGHNIVDHHTYAFLGDGC
LMEGISHEVCSLAGTLELGKLVFFYDDNGISIDGNVEGWFTDDTQARFESYGWQVIKVDGHDTDEITQATEQAIKETTKP
SLIICKTTIGAGSPNKQGLAASHGAPLGDDEIVLTRDALSWTHAPFELDDEIYQAWDGKAKGDVLQKNWNANFDAYKKAY
PELATELLRRLEGDLPADFEQKAQEYIQQTQEQGGDVASRKASQNAINTLQPLLPELLGGSADLAGSNLTLFKDAKGIQD
DDAGNYIYYGVREFGMTAIANGIALHGGFVPYVATFLMFMEYARNAVRMGALMKQRVIHVYTHDSIGLGEDGPTHQPVEQ
LTSLRTTPNLRTWRPCDATESASAWVEAIKSENNPSALIFSRQSLPHQARDREQVANITKGGYVLAKEQGELQAIIIATG
SEVGLAMQAYATLSENGVGVRVVSMPCAEIFVEQDTSYREAVLPANTRARVAVEAAHVDYWYKFVGLDGKVIGMTTYGES
APADELYKEFGITTEAVVDAVNSLV
>Mature_664_residues
PAPISERKLANAIRVLSFDAVQKANSGHPGAPMGMADIAEVLWRKFLKHNPADPSWHNRDRFVLSNGHGSMLIYSLLHLS
GYDVSVDDLKGFRQLHSKTPGHPELGYTPGVETTTGPLGQGIANAVGFAIAEKTLAAQFNRDGHNIVDHHTYAFLGDGCL
MEGISHEVCSLAGTLELGKLVFFYDDNGISIDGNVEGWFTDDTQARFESYGWQVIKVDGHDTDEITQATEQAIKETTKPS
LIICKTTIGAGSPNKQGLAASHGAPLGDDEIVLTRDALSWTHAPFELDDEIYQAWDGKAKGDVLQKNWNANFDAYKKAYP
ELATELLRRLEGDLPADFEQKAQEYIQQTQEQGGDVASRKASQNAINTLQPLLPELLGGSADLAGSNLTLFKDAKGIQDD
DAGNYIYYGVREFGMTAIANGIALHGGFVPYVATFLMFMEYARNAVRMGALMKQRVIHVYTHDSIGLGEDGPTHQPVEQL
TSLRTTPNLRTWRPCDATESASAWVEAIKSENNPSALIFSRQSLPHQARDREQVANITKGGYVLAKEQGELQAIIIATGS
EVGLAMQAYATLSENGVGVRVVSMPCAEIFVEQDTSYREAVLPANTRARVAVEAAHVDYWYKFVGLDGKVIGMTTYGESA
PADELYKEFGITTEAVVDAVNSLV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=676, Percent_Identity=26.0355029585799, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4507521, Length=676, Percent_Identity=26.0355029585799, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI133778974, Length=578, Percent_Identity=25.9515570934256, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI225637459, Length=577, Percent_Identity=22.0103986135182, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI225637461, Length=549, Percent_Identity=21.6757741347905, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637463, Length=475, Percent_Identity=22.3157894736842, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=68.0786686838124, Blast_Score=954, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=64.8036253776435, Blast_Score=908, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=586, Percent_Identity=25.5972696245734, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=45.933734939759, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6319593, Length=665, Percent_Identity=44.2105263157895, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45551847, Length=706, Percent_Identity=26.2039660056657, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45550715, Length=706, Percent_Identity=26.2039660056657, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24645119, Length=669, Percent_Identity=26.3079222720478, Blast_Score=149, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24666278, Length=271, Percent_Identity=32.8413284132841, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72457; Mature: 72326

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPISERKLANAIRVLSFDAVQKANSGHPGAPMGMADIAEVLWRKFLKHNPADPSWHNR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DRFVLSNGHGSMLIYSLLHLSGYDVSVDDLKGFRQLHSKTPGHPELGYTPGVETTTGPLG
CEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
QGIANAVGFAIAEKTLAAQFNRDGHNIVDHHTYAFLGDGCLMEGISHEVCSLAGTLELGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEECCCHHHHHCHHHHHHHHCCEEECC
LVFFYDDNGISIDGNVEGWFTDDTQARFESYGWQVIKVDGHDTDEITQATEQAIKETTKP
EEEEECCCCEEECCCCCEEECCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
SLIICKTTIGAGSPNKQGLAASHGAPLGDDEIVLTRDALSWTHAPFELDDEIYQAWDGKA
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCC
KGDVLQKNWNANFDAYKKAYPELATELLRRLEGDLPADFEQKAQEYIQQTQEQGGDVASR
CCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
KASQNAINTLQPLLPELLGGSADLAGSNLTLFKDAKGIQDDDAGNYIYYGVREFGMTAIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHH
NGIALHGGFVPYVATFLMFMEYARNAVRMGALMKQRVIHVYTHDSIGLGEDGPTHQPVEQ
CCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHH
LTSLRTTPNLRTWRPCDATESASAWVEAIKSENNPSALIFSRQSLPHQARDREQVANITK
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCC
GGYVLAKEQGELQAIIIATGSEVGLAMQAYATLSENGVGVRVVSMPCAEIFVEQDTSYRE
CCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCHHH
AVLPANTRARVAVEAAHVDYWYKFVGLDGKVIGMTTYGESAPADELYKEFGITTEAVVDA
EECCCCCCCEEEEEEHHHHEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
VNSLV
HHHCC
>Mature Secondary Structure 
PAPISERKLANAIRVLSFDAVQKANSGHPGAPMGMADIAEVLWRKFLKHNPADPSWHNR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DRFVLSNGHGSMLIYSLLHLSGYDVSVDDLKGFRQLHSKTPGHPELGYTPGVETTTGPLG
CEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
QGIANAVGFAIAEKTLAAQFNRDGHNIVDHHTYAFLGDGCLMEGISHEVCSLAGTLELGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCEEEEECCCHHHHHCHHHHHHHHCCEEECC
LVFFYDDNGISIDGNVEGWFTDDTQARFESYGWQVIKVDGHDTDEITQATEQAIKETTKP
EEEEECCCCEEECCCCCEEECCCHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCC
SLIICKTTIGAGSPNKQGLAASHGAPLGDDEIVLTRDALSWTHAPFELDDEIYQAWDGKA
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCC
KGDVLQKNWNANFDAYKKAYPELATELLRRLEGDLPADFEQKAQEYIQQTQEQGGDVASR
CCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHH
KASQNAINTLQPLLPELLGGSADLAGSNLTLFKDAKGIQDDDAGNYIYYGVREFGMTAIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHH
NGIALHGGFVPYVATFLMFMEYARNAVRMGALMKQRVIHVYTHDSIGLGEDGPTHQPVEQ
CCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCHHHHH
LTSLRTTPNLRTWRPCDATESASAWVEAIKSENNPSALIFSRQSLPHQARDREQVANITK
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCC
GGYVLAKEQGELQAIIIATGSEVGLAMQAYATLSENGVGVRVVSMPCAEIFVEQDTSYRE
CCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCHHH
AVLPANTRARVAVEAAHVDYWYKFVGLDGKVIGMTTYGESAPADELYKEFGITTEAVVDA
EECCCCCCCEEEEEEHHHHEEEEEECCCCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
VNSLV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]