Click here to switch to the map view.

The map label for this gene is serS

Identifier: 93006674

GI number: 93006674

Start: 2284468

End: 2285754

Strand: Reverse

Name: serS

Synonym: Pcryo_1850

Alternate gene names: 93006674

Gene position: 2285754-2284468 (Counterclockwise)

Preceding gene: 93006677

Following gene: 93006673

Centisome position: 74.7

GC content: 44.06

Gene sequence:

>1287_bases
ATGATAGACCCAAAACTCTTACGCGGCGATTTGACAGATTTACAGCAGCAATTGGCCACCCGTGGTTATACGCTTGATAT
AGCGTTCTGGCAAAATATTGAGAACGAACGTAAATCGCTACAAGTAAAGACCGAAGAGTTGCAGTCGCGCCGTAATACAG
GCGCAAAACAAGTTGGCGTGCTTAAAAAATCTGGCGAAGATGCTAGTGAGTTGCTTGCTGAGATGCAAAGTGTCAGTGGT
GAGATTAAGACAGCCGAAGACGAGCTACGTACCTTACAAGAGCGCATTAGCCAAGCAGCAATGCAAATTCCAAATATCCC
AGCAGCAGATGTGCCAGTTGGTACATCAGAAGACGATAACGTCGAAGTACGCAAATGGGGCACACCGCGTGAGTTTGATT
TTGAGATTAAAGATCATACGCATATTGGTGAGACACTTGGTATGCTCGATTTTGAAGCAGCAACCAAGCTTACAGGAAGT
CGCTTTAACGTCTTAAAAGGACAATTGGCGCAGATGCATCGTGCGTTGATTCAGTTTATGCTCAATACCCATACGATCAA
GTATGGCTATACTGAAACTTATGTACCGTATATTGTTAATTCTGAAAGTTTAAAAGGTACAGGTCAGCTGCCTAAGTTTG
AAGATGATTTGTTTAAATTGACCAATCATACCAATAATGATGACATGGATTTTTATCTCATTCCAACCGCTGAAGTGCCA
ATGACCAACTTGGTACGCGGCGAGCGCTTAGATATCAAAGAGCTACCGTTGAAATTTACCGCGCATACGCCGTGTTTCCG
TAGTGAAGCTGGCTCGCATGGTCGTGATACCCGTGGTCTGATTCGTCAGCATCAGTTTGAAAAAGTTGAGATGGTTAATA
TTGCCACAGCTGAGCAGTCAGATGAGTTGCTTGAAGCGATGACTGGACAAGCAGAATTTATTTTACAGCAGCTTAATTTG
CCATACCGCACCGTCAAATTGTGCACCGGCGATATGGGTTTTGCCGCCCAAAAAACTTATGATATCGAAGTCTGGTTACC
AAGCCAAGAGACCTATCGTGAAATCTCAAGCTGCTCAAACTGCGGCGATTTCCAAGCACGCCGTATGGGTACACGTGTTA
AGGACGGCAAACAAACCAGTTTAGCTCATACCTTAAACGGTTCGGGTTTAGCAGTAGGTCGTACATTATTGGCAGTGATG
GAAAACCATCAAAACGCTGATGGTAGTATTACGATTCCAGAAGTATTGCGTCCGTTTATGGGTGGTGCTGACATCATTTT
ATTATAG

Upstream 100 bases:

>100_bases
TAGCGGCTACCACCTAATTTTAAGCAAAATCAGGCTATAGAGCCCAGATTTTCATTATTTTCACACCTTTTATCCACTTT
TAGCGCGACAGGCACCTATT

Downstream 100 bases:

>100_bases
TTTTTTGATATGCGGGTTTTTGACATATAGTTATTTGATGATTGATGCAATTAGTGAGTTGGTATTCAGGCTCGCCGATT
GTGTTTTATTGCAGTAAGTA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIDPKLLRGDLTDLQQQLATRGYTLDIAFWQNIENERKSLQVKTEELQSRRNTGAKQVGVLKKSGEDASELLAEMQSVSG
EIKTAEDELRTLQERISQAAMQIPNIPAADVPVGTSEDDNVEVRKWGTPREFDFEIKDHTHIGETLGMLDFEAATKLTGS
RFNVLKGQLAQMHRALIQFMLNTHTIKYGYTETYVPYIVNSESLKGTGQLPKFEDDLFKLTNHTNNDDMDFYLIPTAEVP
MTNLVRGERLDIKELPLKFTAHTPCFRSEAGSHGRDTRGLIRQHQFEKVEMVNIATAEQSDELLEAMTGQAEFILQQLNL
PYRTVKLCTGDMGFAAQKTYDIEVWLPSQETYREISSCSNCGDFQARRMGTRVKDGKQTSLAHTLNGSGLAVGRTLLAVM
ENHQNADGSITIPEVLRPFMGGADIILL

Sequences:

>Translated_428_residues
MIDPKLLRGDLTDLQQQLATRGYTLDIAFWQNIENERKSLQVKTEELQSRRNTGAKQVGVLKKSGEDASELLAEMQSVSG
EIKTAEDELRTLQERISQAAMQIPNIPAADVPVGTSEDDNVEVRKWGTPREFDFEIKDHTHIGETLGMLDFEAATKLTGS
RFNVLKGQLAQMHRALIQFMLNTHTIKYGYTETYVPYIVNSESLKGTGQLPKFEDDLFKLTNHTNNDDMDFYLIPTAEVP
MTNLVRGERLDIKELPLKFTAHTPCFRSEAGSHGRDTRGLIRQHQFEKVEMVNIATAEQSDELLEAMTGQAEFILQQLNL
PYRTVKLCTGDMGFAAQKTYDIEVWLPSQETYREISSCSNCGDFQARRMGTRVKDGKQTSLAHTLNGSGLAVGRTLLAVM
ENHQNADGSITIPEVLRPFMGGADIILL
>Mature_428_residues
MIDPKLLRGDLTDLQQQLATRGYTLDIAFWQNIENERKSLQVKTEELQSRRNTGAKQVGVLKKSGEDASELLAEMQSVSG
EIKTAEDELRTLQERISQAAMQIPNIPAADVPVGTSEDDNVEVRKWGTPREFDFEIKDHTHIGETLGMLDFEAATKLTGS
RFNVLKGQLAQMHRALIQFMLNTHTIKYGYTETYVPYIVNSESLKGTGQLPKFEDDLFKLTNHTNNDDMDFYLIPTAEVP
MTNLVRGERLDIKELPLKFTAHTPCFRSEAGSHGRDTRGLIRQHQFEKVEMVNIATAEQSDELLEAMTGQAEFILQQLNL
PYRTVKLCTGDMGFAAQKTYDIEVWLPSQETYREISSCSNCGDFQARRMGTRVKDGKQTSLAHTLNGSGLAVGRTLLAVM
ENHQNADGSITIPEVLRPFMGGADIILL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=335, Percent_Identity=37.6119402985075, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI8923421, Length=333, Percent_Identity=30.9309309309309, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=30.9309309309309, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=60.2771362586605, Blast_Score=527, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17539260, Length=334, Percent_Identity=34.4311377245509, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=349, Percent_Identity=31.5186246418338, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=399, Percent_Identity=32.3308270676692, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=407, Percent_Identity=29.2383292383292, Blast_Score=182, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24581334, Length=325, Percent_Identity=35.6923076923077, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17737985, Length=349, Percent_Identity=33.2378223495702, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PSYCK (Q1Q9M6)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_581111.1
- ProteinModelPortal:   Q1Q9M6
- SMR:   Q1Q9M6
- STRING:   Q1Q9M6
- GeneID:   4035184
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_1850
- NMPDR:   fig|335284.3.peg.2236
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q1Q9M6
- ProtClustDB:   PRK05431
- BioCyc:   PCRY335284:PCRYO_1850-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48018; Mature: 48018

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 290-290 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPKLLRGDLTDLQQQLATRGYTLDIAFWQNIENERKSLQVKTEELQSRRNTGAKQVGV
CCCCHHHHCCHHHHHHHHHHCCCEEEEHHHHCHHHHHHHHEEHHHHHHHHHCCCHHHHHH
LKKSGEDASELLAEMQSVSGEIKTAEDELRTLQERISQAAMQIPNIPAADVPVGTSEDDN
HHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRKWGTPREFDFEIKDHTHIGETLGMLDFEAATKLTGSRFNVLKGQLAQMHRALIQFM
EEEEECCCCCCEEEEECCCCHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LNTHTIKYGYTETYVPYIVNSESLKGTGQLPKFEDDLFKLTNHTNNDDMDFYLIPTAEVP
HHCCEEEECCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCC
MTNLVRGERLDIKELPLKFTAHTPCFRSEAGSHGRDTRGLIRQHQFEKVEMVNIATAEQS
HHHHCCCCCCCHHHCCEEEECCCCCHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHH
DELLEAMTGQAEFILQQLNLPYRTVKLCTGDMGFAAQKTYDIEVWLPSQETYREISSCSN
HHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEEECCHHHHHHHHHCCC
CGDFQARRMGTRVKDGKQTSLAHTLNGSGLAVGRTLLAVMENHQNADGSITIPEVLRPFM
CCCHHHHHHCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHC
GGADIILL
CCCCEEEC
>Mature Secondary Structure
MIDPKLLRGDLTDLQQQLATRGYTLDIAFWQNIENERKSLQVKTEELQSRRNTGAKQVGV
CCCCHHHHCCHHHHHHHHHHCCCEEEEHHHHCHHHHHHHHEEHHHHHHHHHCCCHHHHHH
LKKSGEDASELLAEMQSVSGEIKTAEDELRTLQERISQAAMQIPNIPAADVPVGTSEDDN
HHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRKWGTPREFDFEIKDHTHIGETLGMLDFEAATKLTGSRFNVLKGQLAQMHRALIQFM
EEEEECCCCCCEEEEECCCCHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LNTHTIKYGYTETYVPYIVNSESLKGTGQLPKFEDDLFKLTNHTNNDDMDFYLIPTAEVP
HHCCEEEECCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCC
MTNLVRGERLDIKELPLKFTAHTPCFRSEAGSHGRDTRGLIRQHQFEKVEMVNIATAEQS
HHHHCCCCCCCHHHCCEEEECCCCCHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHH
DELLEAMTGQAEFILQQLNLPYRTVKLCTGDMGFAAQKTYDIEVWLPSQETYREISSCSN
HHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEEECCHHHHHHHHHCCC
CGDFQARRMGTRVKDGKQTSLAHTLNGSGLAVGRTLLAVMENHQNADGSITIPEVLRPFM
CCCHHHHHHCCCCCCCCCHHHHEECCCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHC
GGADIILL
CCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA