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The map label for this gene is adk [H]

Identifier: 93006563

GI number: 93006563

Start: 2153173

End: 2153829

Strand: Reverse

Name: adk [H]

Synonym: Pcryo_1739

Alternate gene names: 93006563

Gene position: 2153829-2153173 (Counterclockwise)

Preceding gene: 93006564

Following gene: 93006558

Centisome position: 70.39

GC content: 44.6

Gene sequence:

>657_bases
ATGATGCGTATTATTTTGCTAGGTCCACCAGGCGCCGGTAAAGGTACCCAAGCTCAGTTTATTTCTAAAGAATATGATAT
TCCGCAGATCTCAACGGGTGATATGCTGCGTGCAGCAATCAAAGAAGGCACTGAGCTTGGCAAACAAGCCAAAGACGTGA
TGAACGCTGGTGGTTTGGTTTCTGATGATCTAATCATTAACCTCGTGCAAGAACGCATCGCTAAGCCTGATTGTGTTAAC
GGCTGTATTTTAGATGGTTTCCCGCGTACCATTCCACAAGCGCAAGCGCTTGCAGATGCCAACGTGACGATTGATCATGT
AATTGAAATCAGTGTACCTGATGATGAAATCGTCAAGCGATTATCAGGTCGTCGCCAACATGCTGGCTCTGGTCGTGTAT
ATCATATTGATCACAATCCACCAAAGCAAGAAGGCATTGATGATGTTACTGGTGAAGCGCTTATCCAACGTGAAGACGAT
AAAGAGTCAACCATTCGTGACCGCTTAGCTACGTATCATGAGCAAACATCAGCCCTCGTTGGCTTTTATCAGAACAAAGC
TAAAGAAGGCGGCGATGCGCCTAAGTATGATAAGTTCGATGGTACCCAAGGTATTGATGACGTTAAGCAACAAATATTTT
CTGCCCTAAAAGGCTAA

Upstream 100 bases:

>100_bases
CTTGAGGTTTTGAAAGCCACAAGGTAAGGTAAGCTCTGCAAACCACCAATCCCTAAGTTTTATTAGTCCCAAAATCCTAT
TTATTAAGGAGAATCGTGTA

Downstream 100 bases:

>100_bases
TATTTATACTGACGCTAGAATATAGCGGATTAATCGAATAGTGTTATGAAAGACCCTGCCGCTAGTAATAGCAATCAGCA
GGGTTTTTTAATGGGTCAAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MMRIILLGPPGAGKGTQAQFISKEYDIPQISTGDMLRAAIKEGTELGKQAKDVMNAGGLVSDDLIINLVQERIAKPDCVN
GCILDGFPRTIPQAQALADANVTIDHVIEISVPDDEIVKRLSGRRQHAGSGRVYHIDHNPPKQEGIDDVTGEALIQREDD
KESTIRDRLATYHEQTSALVGFYQNKAKEGGDAPKYDKFDGTQGIDDVKQQIFSALKG

Sequences:

>Translated_218_residues
MMRIILLGPPGAGKGTQAQFISKEYDIPQISTGDMLRAAIKEGTELGKQAKDVMNAGGLVSDDLIINLVQERIAKPDCVN
GCILDGFPRTIPQAQALADANVTIDHVIEISVPDDEIVKRLSGRRQHAGSGRVYHIDHNPPKQEGIDDVTGEALIQREDD
KESTIRDRLATYHEQTSALVGFYQNKAKEGGDAPKYDKFDGTQGIDDVKQQIFSALKG
>Mature_218_residues
MMRIILLGPPGAGKGTQAQFISKEYDIPQISTGDMLRAAIKEGTELGKQAKDVMNAGGLVSDDLIINLVQERIAKPDCVN
GCILDGFPRTIPQAQALADANVTIDHVIEISVPDDEIVKRLSGRRQHAGSGRVYHIDHNPPKQEGIDDVTGEALIQREDD
KESTIRDRLATYHEQTSALVGFYQNKAKEGGDAPKYDKFDGTQGIDDVKQQIFSALKG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=219, Percent_Identity=43.37899543379, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI7524346, Length=219, Percent_Identity=43.37899543379, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI19923437, Length=186, Percent_Identity=45.1612903225806, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI310110345, Length=186, Percent_Identity=40.8602150537634, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832003, Length=186, Percent_Identity=40.8602150537634, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI8051579, Length=186, Percent_Identity=40.8602150537634, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI53832001, Length=186, Percent_Identity=40.8602150537634, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI22749187, Length=203, Percent_Identity=27.0935960591133, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=26.6304347826087, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI21450759, Length=147, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI237858799, Length=146, Percent_Identity=28.7671232876712, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=25.2688172043011, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI28144897, Length=186, Percent_Identity=25.2688172043011, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1786680, Length=208, Percent_Identity=62.5, Blast_Score=272, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=45.7446808510638, Blast_Score=184, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=191, Percent_Identity=32.4607329842932, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=187, Percent_Identity=29.9465240641711, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=185, Percent_Identity=25.4054054054054, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=195, Percent_Identity=48.2051282051282, Blast_Score=195, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=189, Percent_Identity=40.2116402116402, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=26.5957446808511, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=49.7267759562842, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737899, Length=186, Percent_Identity=45.6989247311828, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24645822, Length=186, Percent_Identity=45.6989247311828, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24663208, Length=214, Percent_Identity=27.5700934579439, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17647141, Length=214, Percent_Identity=27.5700934579439, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23766; Mature: 23766

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRIILLGPPGAGKGTQAQFISKEYDIPQISTGDMLRAAIKEGTELGKQAKDVMNAGGLV
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDDLIINLVQERIAKPDCVNGCILDGFPRTIPQAQALADANVTIDHVIEISVPDDEIVKR
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHCCCCEEEEEEEEECCHHHHHHH
LSGRRQHAGSGRVYHIDHNPPKQEGIDDVTGEALIQREDDKESTIRDRLATYHEQTSALV
HHCCCCCCCCCCEEEECCCCCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GFYQNKAKEGGDAPKYDKFDGTQGIDDVKQQIFSALKG
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMRIILLGPPGAGKGTQAQFISKEYDIPQISTGDMLRAAIKEGTELGKQAKDVMNAGGLV
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDDLIINLVQERIAKPDCVNGCILDGFPRTIPQAQALADANVTIDHVIEISVPDDEIVKR
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHCCCCEEEEEEEEECCHHHHHHH
LSGRRQHAGSGRVYHIDHNPPKQEGIDDVTGEALIQREDDKESTIRDRLATYHEQTSALV
HHCCCCCCCCCCEEEECCCCCHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GFYQNKAKEGGDAPKYDKFDGTQGIDDVKQQIFSALKG
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA