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The map label for this gene is hemE [H]

Identifier: 93006505

GI number: 93006505

Start: 2068734

End: 2069870

Strand: Reverse

Name: hemE [H]

Synonym: Pcryo_1681

Alternate gene names: 93006505

Gene position: 2069870-2068734 (Counterclockwise)

Preceding gene: 93006506

Following gene: 93006504

Centisome position: 67.65

GC content: 43.62

Gene sequence:

>1137_bases
ATGAGTGCTTCAGACAATAATAATTCGCTTGAGCAAAAATTTGCGCCTTTGAAAAATGATAGATTGCTAAGAGCACTTCG
TTTTGAGCCGATCGATACCACACCTGTCTGGATGATGCGTCAAGCTGGTCGTTATTTACCAGAGTATAAAGCGACCCGTG
CTGAAGCAGGTGATTTTATGAGCCTGTGTAAAGATACCGCGCGTGCGACAGAAGTCACCTTACAGCCATTACGTCGTTAT
GATTTAGACGCGGCTATTTTGTTCAGTGATATATTAACCATTCCTGATGCCATGGGATTGGGTCTCTATTTCGAAGCGGG
TGAAGGTCCTAAGTTTAAACATCCTATTCGCCAGCAAGCTGATTTGGATAGATTGCCTGTGCTCGATGTCAATGACTCTC
TTGACTATGTCATGCGTGCGGTAACCAGTATTCGTACCGCGCTCAATGGGCAAGTGCCGTTATTTGGCTTTTCTGGTAGT
CCTTGGACACTAGCCACTTATATGATTGAAGGTGGTAGCTCAAAGGATTATCGCTATACCAAAGGCTTTTTGTATAGCAA
TCCTGATTTTTTACATCAATTGTTAGATAAATTGGCGACATCTGTTATTGATTATTTGGATGCCCAAGTTGTGGCAGGTG
CGCAGATATTACAGATATTTGATAGTTGGGGCGGCGCTCTTGGTCATCGCCAGTTTATTGATTTCTCACATGCTTATAAT
AAGCGCATTGTCGCTGAGTTAAAGGTACGCCATCCTGAAATACCAGTAGTATTATTTACTAAAGGCGGCGGGCTATGGCT
TGATATTCAAGCGGATAGTGAGGCGGATGCATTGGGTTTAGACTGGACAATGCCGATTGATCGTGCCCGTCAAGTTTTGA
CCGAAAGTCAGCGTCAGTTAACCAAGCACCATAAAAAACTACAAAGTAGCAAAGCCATTCAGGGTAATTTAGACCCAGCA
ACTTTGTACGGCTCTCCAGCGACTATCCGTGCTGAAGTCAATGCGATGCTCGATAGTGCTTATGCTAACGGTGAAAAGAC
CGGTTATGTGGCAAACCTAGGTCATGGTATTACCCAGTGGGTTAATCCTGACAATGCCAAAGTGTTCATCGATGCAGTAC
ATGATTATAAAATCTAA

Upstream 100 bases:

>100_bases
TATCTTGATAATAAGCGCTTTGCTATTCTTTCATTTAACGTAATTTATCCAGTGTTATATGCGCTTTGGTGACATATAGT
GCTGTTTTGGAGATTTGTAC

Downstream 100 bases:

>100_bases
AAAGTACGATTTGAGATATGTTCTTAGTTATTTAACTGAGTTTATATCTCATATTTATTAAGTAATAGTAAAGTAGCAGA
AAAGGATATCTTATGATTTC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MSASDNNNSLEQKFAPLKNDRLLRALRFEPIDTTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKDTARATEVTLQPLRRY
DLDAAILFSDILTIPDAMGLGLYFEAGEGPKFKHPIRQQADLDRLPVLDVNDSLDYVMRAVTSIRTALNGQVPLFGFSGS
PWTLATYMIEGGSSKDYRYTKGFLYSNPDFLHQLLDKLATSVIDYLDAQVVAGAQILQIFDSWGGALGHRQFIDFSHAYN
KRIVAELKVRHPEIPVVLFTKGGGLWLDIQADSEADALGLDWTMPIDRARQVLTESQRQLTKHHKKLQSSKAIQGNLDPA
TLYGSPATIRAEVNAMLDSAYANGEKTGYVANLGHGITQWVNPDNAKVFIDAVHDYKI

Sequences:

>Translated_378_residues
MSASDNNNSLEQKFAPLKNDRLLRALRFEPIDTTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKDTARATEVTLQPLRRY
DLDAAILFSDILTIPDAMGLGLYFEAGEGPKFKHPIRQQADLDRLPVLDVNDSLDYVMRAVTSIRTALNGQVPLFGFSGS
PWTLATYMIEGGSSKDYRYTKGFLYSNPDFLHQLLDKLATSVIDYLDAQVVAGAQILQIFDSWGGALGHRQFIDFSHAYN
KRIVAELKVRHPEIPVVLFTKGGGLWLDIQADSEADALGLDWTMPIDRARQVLTESQRQLTKHHKKLQSSKAIQGNLDPA
TLYGSPATIRAEVNAMLDSAYANGEKTGYVANLGHGITQWVNPDNAKVFIDAVHDYKI
>Mature_377_residues
SASDNNNSLEQKFAPLKNDRLLRALRFEPIDTTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKDTARATEVTLQPLRRYD
LDAAILFSDILTIPDAMGLGLYFEAGEGPKFKHPIRQQADLDRLPVLDVNDSLDYVMRAVTSIRTALNGQVPLFGFSGSP
WTLATYMIEGGSSKDYRYTKGFLYSNPDFLHQLLDKLATSVIDYLDAQVVAGAQILQIFDSWGGALGHRQFIDFSHAYNK
RIVAELKVRHPEIPVVLFTKGGGLWLDIQADSEADALGLDWTMPIDRARQVLTESQRQLTKHHKKLQSSKAIQGNLDPAT
LYGSPATIRAEVNAMLDSAYANGEKTGYVANLGHGITQWVNPDNAKVFIDAVHDYKI

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=378, Percent_Identity=43.1216931216931, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI2367337, Length=360, Percent_Identity=58.8888888888889, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6320252, Length=371, Percent_Identity=40.9703504043127, Blast_Score=281, Evalue=9e-77,
Organism=Drosophila melanogaster, GI221330099, Length=368, Percent_Identity=43.4782608695652, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI19921920, Length=368, Percent_Identity=43.2065217391304, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 42186; Mature: 42055

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASDNNNSLEQKFAPLKNDRLLRALRFEPIDTTPVWMMRQAGRYLPEYKATRAEAGDFM
CCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
SLCKDTARATEVTLQPLRRYDLDAAILFSDILTIPDAMGLGLYFEAGEGPKFKHPIRQQA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHC
DLDRLPVLDVNDSLDYVMRAVTSIRTALNGQVPLFGFSGSPWTLATYMIEGGSSKDYRYT
CCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCCCCEEE
KGFLYSNPDFLHQLLDKLATSVIDYLDAQVVAGAQILQIFDSWGGALGHRQFIDFSHAYN
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
KRIVAELKVRHPEIPVVLFTKGGGLWLDIQADSEADALGLDWTMPIDRARQVLTESQRQL
CCEEEEEEECCCCCCEEEEECCCCEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHH
TKHHKKLQSSKAIQGNLDPATLYGSPATIRAEVNAMLDSAYANGEKTGYVANLGHGITQW
HHHHHHHHHCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHCCCCCCCEEEECCCCHHHC
VNPDNAKVFIDAVHDYKI
CCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SASDNNNSLEQKFAPLKNDRLLRALRFEPIDTTPVWMMRQAGRYLPEYKATRAEAGDFM
CCCCCCCHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHH
SLCKDTARATEVTLQPLRRYDLDAAILFSDILTIPDAMGLGLYFEAGEGPKFKHPIRQQA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHHC
DLDRLPVLDVNDSLDYVMRAVTSIRTALNGQVPLFGFSGSPWTLATYMIEGGSSKDYRYT
CCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEECCCCCCCEEE
KGFLYSNPDFLHQLLDKLATSVIDYLDAQVVAGAQILQIFDSWGGALGHRQFIDFSHAYN
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
KRIVAELKVRHPEIPVVLFTKGGGLWLDIQADSEADALGLDWTMPIDRARQVLTESQRQL
CCEEEEEEECCCCCCEEEEECCCCEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHH
TKHHKKLQSSKAIQGNLDPATLYGSPATIRAEVNAMLDSAYANGEKTGYVANLGHGITQW
HHHHHHHHHCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHCCCCCCCEEEECCCCHHHC
VNPDNAKVFIDAVHDYKI
CCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA