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The map label for this gene is cyaB [H]

Identifier: 93006486

GI number: 93006486

Start: 2045855

End: 2047273

Strand: Reverse

Name: cyaB [H]

Synonym: Pcryo_1662

Alternate gene names: 93006486

Gene position: 2047273-2045855 (Counterclockwise)

Preceding gene: 93006487

Following gene: 93006477

Centisome position: 66.91

GC content: 40.24

Gene sequence:

>1419_bases
ATGGCACTTTTGGACACCTTTAGCCCAAAAAAATCTATACAGGGTACAGATGTCTGTCGATTTGATTATCCTGAAATCTT
TGTTCTCATACTCAGCGTGATACTGCTCGCTATCCATTTTGACTTCAGTCCAACTTCGATGGCACTTTTAATCGTCGTCT
GCTTACCTAGCCTCATGATTTTAGTTTATAACTTTCGTCGTCAAAAAAGCTTTTGGACGTCTAATATAGTTATTATTTTA
TTGTCTTCTGTTATTGGTTCCATTCAGCTTTGTCCTATTATCTCATTAAGTTTAGCGTCGTTGATCGGATTGCGTATTAT
TATTAGCAGCCCTGAGAATCATCTAAAGCTGGTTTCTGTATCCATCGTGACCATCATTATTTTTTACTACGTTAGTGTCA
TTTTGAGTAGTGCCGAGATAGATTGTCACACCACTTGGATAACTCCTATCATCTTGCTAGCAACGATGATGGTAATGCTT
TGTCACTTTCGCCATATATATTATGAGTATATCCATTATGAGGCACGGGCTGAGCAAGTGGTTGGGCGCTTAAGTACGAT
GGTGTCGGTAATCAATAAGTTGACACGTTTCGTACCACCGCAAGTATGGGAGCCTATTGTCAAAGCGGACGGTCCAGTTA
CTGTTGCTAATAAACGCGCTAAACTGACGATTATGTTTTCAGATATCGTTGGTTTCACTGAGCTGTCTGATAGCTTAAGT
GCGGATAATTTGGCTGATATTTTAAACACTTATATGCATTGTATGACTTTGATCGCCAATAAACATGGGGCAGTATTAGA
TAAGTTTATTGGTGATGGCATGGTGTGTTTTTTTGGAGAGCCAAATAGCCGCGGTCCGCGTCAAGATGCCCTAGATTGCG
TAGCTATGGCAATAGATATGCGCCGTGAAATGCGCACATTGAGGCAAAAATGGCGACTGATGGGCTTTGAGGGATTATAT
ATACGCGTAGGTATTAGCACAGGCTACTGTCATGTTGGTAACTTTGGTAGTAATAATCGTCTGAGCTATACGCTGATTGG
CAAAGAGGCCAATCTGGCTTCAAGGCTTGAAGCTGTCGCTGGTAAGGGTGAAATATACATTAGCGAGAGCACTCACGACT
ATATCGCTCATGATTTTGACTGCGAATATGCAGGTGCTTTCCCGCTAAAAGGTTTCGATGATAAAGTAAGTGCTTGGAAA
GTATTGGATCCAGATGAAAATAAAGGCAAGTTATCTAAATGGGTAGACCATACGCTTCCAGGTTTTAATCTGCATTTGAA
CTTTAGAGATATGCAAGATAATGATTATCAAGATATTAGAAGTCGTCTTAATCTTGCACTTGCACGTATTGAGCAAGAAG
AAAAATCTGCCGCTGTTAAAATTGACGCAGCCAGCAAAAAAGAAGGAAAGCATAAATAA

Upstream 100 bases:

>100_bases
ATTTATAAGCATAAATATTTTTTATAAGGATAAGGTACATTATCTATACTATCTTTATGAGTACTTTCAATGATTTTACT
GATTTAAGCGAATAGCTCTC

Downstream 100 bases:

>100_bases
TTTATAGCAATACTATAATGATAGTAAATAATTTTCTTTGCTCATGAATAGATTGTGATTATTTAAAGTATCAGATATTG
GAATAGGAAAAAGCCAGCTA

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MALLDTFSPKKSIQGTDVCRFDYPEIFVLILSVILLAIHFDFSPTSMALLIVVCLPSLMILVYNFRRQKSFWTSNIVIIL
LSSVIGSIQLCPIISLSLASLIGLRIIISSPENHLKLVSVSIVTIIIFYYVSVILSSAEIDCHTTWITPIILLATMMVML
CHFRHIYYEYIHYEARAEQVVGRLSTMVSVINKLTRFVPPQVWEPIVKADGPVTVANKRAKLTIMFSDIVGFTELSDSLS
ADNLADILNTYMHCMTLIANKHGAVLDKFIGDGMVCFFGEPNSRGPRQDALDCVAMAIDMRREMRTLRQKWRLMGFEGLY
IRVGISTGYCHVGNFGSNNRLSYTLIGKEANLASRLEAVAGKGEIYISESTHDYIAHDFDCEYAGAFPLKGFDDKVSAWK
VLDPDENKGKLSKWVDHTLPGFNLHLNFRDMQDNDYQDIRSRLNLALARIEQEEKSAAVKIDAASKKEGKHK

Sequences:

>Translated_472_residues
MALLDTFSPKKSIQGTDVCRFDYPEIFVLILSVILLAIHFDFSPTSMALLIVVCLPSLMILVYNFRRQKSFWTSNIVIIL
LSSVIGSIQLCPIISLSLASLIGLRIIISSPENHLKLVSVSIVTIIIFYYVSVILSSAEIDCHTTWITPIILLATMMVML
CHFRHIYYEYIHYEARAEQVVGRLSTMVSVINKLTRFVPPQVWEPIVKADGPVTVANKRAKLTIMFSDIVGFTELSDSLS
ADNLADILNTYMHCMTLIANKHGAVLDKFIGDGMVCFFGEPNSRGPRQDALDCVAMAIDMRREMRTLRQKWRLMGFEGLY
IRVGISTGYCHVGNFGSNNRLSYTLIGKEANLASRLEAVAGKGEIYISESTHDYIAHDFDCEYAGAFPLKGFDDKVSAWK
VLDPDENKGKLSKWVDHTLPGFNLHLNFRDMQDNDYQDIRSRLNLALARIEQEEKSAAVKIDAASKKEGKHK
>Mature_471_residues
ALLDTFSPKKSIQGTDVCRFDYPEIFVLILSVILLAIHFDFSPTSMALLIVVCLPSLMILVYNFRRQKSFWTSNIVIILL
SSVIGSIQLCPIISLSLASLIGLRIIISSPENHLKLVSVSIVTIIIFYYVSVILSSAEIDCHTTWITPIILLATMMVMLC
HFRHIYYEYIHYEARAEQVVGRLSTMVSVINKLTRFVPPQVWEPIVKADGPVTVANKRAKLTIMFSDIVGFTELSDSLSA
DNLADILNTYMHCMTLIANKHGAVLDKFIGDGMVCFFGEPNSRGPRQDALDCVAMAIDMRREMRTLRQKWRLMGFEGLYI
RVGISTGYCHVGNFGSNNRLSYTLIGKEANLASRLEAVAGKGEIYISESTHDYIAHDFDCEYAGAFPLKGFDDKVSAWKV
LDPDENKGKLSKWVDHTLPGFNLHLNFRDMQDNDYQDIRSRLNLALARIEQEEKSAAVKIDAASKKEGKHK

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI148536830, Length=165, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4557257, Length=167, Percent_Identity=29.940119760479, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI34486092, Length=166, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI24497587, Length=169, Percent_Identity=29.585798816568, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI10947061, Length=166, Percent_Identity=28.9156626506024, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI10181096, Length=166, Percent_Identity=28.9156626506024, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4557255, Length=166, Percent_Identity=28.3132530120482, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI222080083, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI134152694, Length=210, Percent_Identity=30, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17534655, Length=313, Percent_Identity=25.8785942492013, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17534657, Length=226, Percent_Identity=28.3185840707965, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193208534, Length=192, Percent_Identity=27.0833333333333, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561804, Length=272, Percent_Identity=25.7352941176471, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=209, Percent_Identity=29.1866028708134, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17534653, Length=205, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=229, Percent_Identity=26.6375545851528, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534649, Length=192, Percent_Identity=26.5625, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17534651, Length=205, Percent_Identity=27.3170731707317, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71982300, Length=183, Percent_Identity=26.775956284153, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24585694, Length=168, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24667100, Length=190, Percent_Identity=28.4210526315789, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161076872, Length=208, Percent_Identity=29.8076923076923, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28574512, Length=208, Percent_Identity=29.8076923076923, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI62473752, Length=163, Percent_Identity=28.8343558282209, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137448, Length=163, Percent_Identity=28.8343558282209, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366320, Length=167, Percent_Identity=28.7425149700599, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161084260, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24642014, Length=166, Percent_Identity=28.9156626506024, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62484477, Length=215, Percent_Identity=26.046511627907, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484298, Length=215, Percent_Identity=26.046511627907, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116008008, Length=215, Percent_Identity=26.046511627907, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 53109; Mature: 52977

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLDTFSPKKSIQGTDVCRFDYPEIFVLILSVILLAIHFDFSPTSMALLIVVCLPSLMI
CCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LVYNFRRQKSFWTSNIVIILLSSVIGSIQLCPIISLSLASLIGLRIIISSPENHLKLVSV
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHEEEEEECCCCCEEEHHH
SIVTIIIFYYVSVILSSAEIDCHTTWITPIILLATMMVMLCHFRHIYYEYIHYEARAEQV
HHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGRLSTMVSVINKLTRFVPPQVWEPIVKADGPVTVANKRAKLTIMFSDIVGFTELSDSLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCEEEEEEEHHHCCHHHHHCCCC
ADNLADILNTYMHCMTLIANKHGAVLDKFIGDGMVCFFGEPNSRGPRQDALDCVAMAIDM
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
RREMRTLRQKWRLMGFEGLYIRVGISTGYCHVGNFGSNNRLSYTLIGKEANLASRLEAVA
HHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHC
GKGEIYISESTHDYIAHDFDCEYAGAFPLKGFDDKVSAWKVLDPDENKGKLSKWVDHTLP
CCCEEEEECCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCC
GFNLHLNFRDMQDNDYQDIRSRLNLALARIEQEEKSAAVKIDAASKKEGKHK
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
ALLDTFSPKKSIQGTDVCRFDYPEIFVLILSVILLAIHFDFSPTSMALLIVVCLPSLMI
CCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LVYNFRRQKSFWTSNIVIILLSSVIGSIQLCPIISLSLASLIGLRIIISSPENHLKLVSV
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHEEEEEECCCCCEEEHHH
SIVTIIIFYYVSVILSSAEIDCHTTWITPIILLATMMVMLCHFRHIYYEYIHYEARAEQV
HHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGRLSTMVSVINKLTRFVPPQVWEPIVKADGPVTVANKRAKLTIMFSDIVGFTELSDSLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCEEEEEEEHHHCCHHHHHCCCC
ADNLADILNTYMHCMTLIANKHGAVLDKFIGDGMVCFFGEPNSRGPRQDALDCVAMAIDM
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
RREMRTLRQKWRLMGFEGLYIRVGISTGYCHVGNFGSNNRLSYTLIGKEANLASRLEAVA
HHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCEEEEEEECCCCCHHHHHHHHC
GKGEIYISESTHDYIAHDFDCEYAGAFPLKGFDDKVSAWKVLDPDENKGKLSKWVDHTLP
CCCEEEEECCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCC
GFNLHLNFRDMQDNDYQDIRSRLNLALARIEQEEKSAAVKIDAASKKEGKHK
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]