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The map label for this gene is ahcY [H]

Identifier: 93006274

GI number: 93006274

Start: 1782558

End: 1783982

Strand: Direct

Name: ahcY [H]

Synonym: Pcryo_1448

Alternate gene names: 93006274

Gene position: 1782558-1783982 (Clockwise)

Preceding gene: 93006273

Following gene: 93006275

Centisome position: 58.26

GC content: 46.39

Gene sequence:

>1425_bases
ATGGACGCAGTGTCTAACACCCCATCTGCCCATACGATCGACCCCTCTTTCACTGACTATAAAGTCGCCGACATCAGCCT
AGCTGATTACGGCCGCCGTGAAATCACTCTAGCCGAAGCCGAAATGCCTGCCCTTATGGGTTTGCGTCGTCGCTACGAAG
CCGATCAGCCGCTTAAAGGCGCAAAAATCGCTGGCTGTATCCACATGACCATCCAAACCGCCGTACTTATCGAGACACTA
GTCGCGCTAGGTGCTGAAGTACGCTGGACATCATGTAACATCTTCTCAACTCAAGACCATGCTGCTGCTGCGATTGCTGC
TGCTGGTATCTCTGTTTACGCTTGGAAAGGCGAAACCGAAGAAGAGTACGAATGGTGCTTACGTCAACAAATCCACGTTG
GTGGTGAAGAATCAGGTCAGCTTTGGGATGCTAACTTAATCTTGGATGACGGCGGTGATTTGACTGCTTTGATTCATAAC
GATTATGCCGAGCTTCTTGATAACATCCATGGTATCTCAGAAGAAACCACCACTGGTGTCCATCGCTTGGTTGAAATGCT
TGGTAAAGGTACGCTTAAAGTACCCGCTATCAACGTTAATGACGCGGTTACTAAGTCTAAAAACGATAATAAATACGGCT
GCCGTCATAGTTTAAATGATGCCATCAAACGTGCTACCGACATGTTCCTTGCTGGTCGCCGCGCCTTAGTTATCGGTTAT
GGCGATGTGGGTAAAGGCTCTACGCAAAGTCTACGTCAAGAAGGCATGATTGTCCGTGTCTCAGAAGTCGATCCTATCTG
TGCCATGCAGGCTTGTATGGACGGCTTTGAAGTATTGTCACCTTATATCAACGGCGATAACACTGGCGGCGCAGAAAACA
TCAATACGCGTCTGTTAGAAGATACCGACATGATTGTTACCACTACTGGTAACTACCATGTTTGTGACAGACATATGCTT
GCAGCATTGAAGCCTGGTGCAGTCGTTTGTAACATCGGTCATTTTGACACCGAAATTGACACCCAATTTATGCGTGACAA
CTGGCGCTGGGTTGAGATTAAACCACAAGTGCATCAAATCTTCCGCTCAGACGACGAAAATGATTACTTGATTTTGCTTG
CTGAAGGTCGTTTGGTAAATTTGGGTAATGCTACTGGTCACCCATCGCGCGTGATGGACGGCTCATTTGCTAACCAAGTA
TTGGCACAAATGTATCTGTATGAAGAAAAATTTGCTGACTTGCCAGCTGATACACGTACTGAAAACTTATACGTCAAAGT
GTTACCGAAAAAGCTAGACGAAGAAGTTGCCGCTGCGATGGTTGCTGGCTTTAATGGTACGCTAACCAAGTTGACTGAAA
AGCAAGCTGAGTATTTAGGCGTACCTGTTGAAGGTCCATTTAAGCCTGACGCTTATAAATACTAA

Upstream 100 bases:

>100_bases
AACTGTTGAATAATCTTTCTCATGATTGTTGACAGCGCAAATAACGGCACCTGCGTTATTATTCTTTTTATCATACATTA
ACCACTGATAGGAGCATATT

Downstream 100 bases:

>100_bases
AAGGAGTCAGACTGTGACTAAGCCTGCTTTCTCCTTTGAGTTTTTCCCAGCCAAAACCGAGCAAGGACACGAAAAGCTCC
TCAGCACTTATGATGAGCTG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDAVSNTPSAHTIDPSFTDYKVADISLADYGRREITLAEAEMPALMGLRRRYEADQPLKGAKIAGCIHMTIQTAVLIETL
VALGAEVRWTSCNIFSTQDHAAAAIAAAGISVYAWKGETEEEYEWCLRQQIHVGGEESGQLWDANLILDDGGDLTALIHN
DYAELLDNIHGISEETTTGVHRLVEMLGKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRATDMFLAGRRALVIGY
GDVGKGSTQSLRQEGMIVRVSEVDPICAMQACMDGFEVLSPYINGDNTGGAENINTRLLEDTDMIVTTTGNYHVCDRHML
AALKPGAVVCNIGHFDTEIDTQFMRDNWRWVEIKPQVHQIFRSDDENDYLILLAEGRLVNLGNATGHPSRVMDGSFANQV
LAQMYLYEEKFADLPADTRTENLYVKVLPKKLDEEVAAAMVAGFNGTLTKLTEKQAEYLGVPVEGPFKPDAYKY

Sequences:

>Translated_474_residues
MDAVSNTPSAHTIDPSFTDYKVADISLADYGRREITLAEAEMPALMGLRRRYEADQPLKGAKIAGCIHMTIQTAVLIETL
VALGAEVRWTSCNIFSTQDHAAAAIAAAGISVYAWKGETEEEYEWCLRQQIHVGGEESGQLWDANLILDDGGDLTALIHN
DYAELLDNIHGISEETTTGVHRLVEMLGKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRATDMFLAGRRALVIGY
GDVGKGSTQSLRQEGMIVRVSEVDPICAMQACMDGFEVLSPYINGDNTGGAENINTRLLEDTDMIVTTTGNYHVCDRHML
AALKPGAVVCNIGHFDTEIDTQFMRDNWRWVEIKPQVHQIFRSDDENDYLILLAEGRLVNLGNATGHPSRVMDGSFANQV
LAQMYLYEEKFADLPADTRTENLYVKVLPKKLDEEVAAAMVAGFNGTLTKLTEKQAEYLGVPVEGPFKPDAYKY
>Mature_474_residues
MDAVSNTPSAHTIDPSFTDYKVADISLADYGRREITLAEAEMPALMGLRRRYEADQPLKGAKIAGCIHMTIQTAVLIETL
VALGAEVRWTSCNIFSTQDHAAAAIAAAGISVYAWKGETEEEYEWCLRQQIHVGGEESGQLWDANLILDDGGDLTALIHN
DYAELLDNIHGISEETTTGVHRLVEMLGKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRATDMFLAGRRALVIGY
GDVGKGSTQSLRQEGMIVRVSEVDPICAMQACMDGFEVLSPYINGDNTGGAENINTRLLEDTDMIVTTTGNYHVCDRHML
AALKPGAVVCNIGHFDTEIDTQFMRDNWRWVEIKPQVHQIFRSDDENDYLILLAEGRLVNLGNATGHPSRVMDGSFANQV
LAQMYLYEEKFADLPADTRTENLYVKVLPKKLDEEVAAAMVAGFNGTLTKLTEKQAEYLGVPVEGPFKPDAYKY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=458, Percent_Identity=56.1135371179039, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI239937451, Length=436, Percent_Identity=55.9633027522936, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI298286489, Length=458, Percent_Identity=45.4148471615721, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI24308043, Length=458, Percent_Identity=45.6331877729258, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI195539337, Length=458, Percent_Identity=45.6331877729258, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI195539349, Length=458, Percent_Identity=45.6331877729258, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI21361647, Length=474, Percent_Identity=44.3037974683544, Blast_Score=393, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17506425, Length=459, Percent_Identity=58.1699346405229, Blast_Score=486, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6320882, Length=468, Percent_Identity=54.7008547008547, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=54.5454545454545, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24656245, Length=459, Percent_Identity=44.6623093681917, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI45553387, Length=458, Percent_Identity=46.2882096069869, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI45553385, Length=457, Percent_Identity=46.1706783369803, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52229; Mature: 52229

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAVSNTPSAHTIDPSFTDYKVADISLADYGRREITLAEAEMPALMGLRRRYEADQPLKG
CCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCCEEEEEHHHCHHHHHHHHHCCCCCCCCC
AKIAGCIHMTIQTAVLIETLVALGAEVRWTSCNIFSTQDHAAAAIAAAGISVYAWKGETE
CCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCEEEEEECCCCH
EEYEWCLRQQIHVGGEESGQLWDANLILDDGGDLTALIHNDYAELLDNIHGISEETTTGV
HHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHHHHHCCCCCHHHHHH
HRLVEMLGKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRATDMFLAGRRALVIGY
HHHHHHHCCCCEEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEE
GDVGKGSTQSLRQEGMIVRVSEVDPICAMQACMDGFEVLSPYINGDNTGGAENINTRLLE
CCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
DTDMIVTTTGNYHVCDRHMLAALKPGAVVCNIGHFDTEIDTQFMRDNWRWVEIKPQVHQI
CCCEEEEECCCEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECHHHHHH
FRSDDENDYLILLAEGRLVNLGNATGHPSRVMDGSFANQVLAQMYLYEEKFADLPADTRT
HHCCCCCCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ENLYVKVLPKKLDEEVAAAMVAGFNGTLTKLTEKQAEYLGVPVEGPFKPDAYKY
CCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDAVSNTPSAHTIDPSFTDYKVADISLADYGRREITLAEAEMPALMGLRRRYEADQPLKG
CCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCCCEEEEEHHHCHHHHHHHHHCCCCCCCCC
AKIAGCIHMTIQTAVLIETLVALGAEVRWTSCNIFSTQDHAAAAIAAAGISVYAWKGETE
CCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCEEEEEECCCCH
EEYEWCLRQQIHVGGEESGQLWDANLILDDGGDLTALIHNDYAELLDNIHGISEETTTGV
HHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECCHHHHHHHHCCCCCHHHHHH
HRLVEMLGKGTLKVPAINVNDAVTKSKNDNKYGCRHSLNDAIKRATDMFLAGRRALVIGY
HHHHHHHCCCCEEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEE
GDVGKGSTQSLRQEGMIVRVSEVDPICAMQACMDGFEVLSPYINGDNTGGAENINTRLLE
CCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
DTDMIVTTTGNYHVCDRHMLAALKPGAVVCNIGHFDTEIDTQFMRDNWRWVEIKPQVHQI
CCCEEEEECCCEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECHHHHHH
FRSDDENDYLILLAEGRLVNLGNATGHPSRVMDGSFANQVLAQMYLYEEKFADLPADTRT
HHCCCCCCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ENLYVKVLPKKLDEEVAAAMVAGFNGTLTKLTEKQAEYLGVPVEGPFKPDAYKY
CCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA