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The map label for this gene is trpC [H]

Identifier: 93006269

GI number: 93006269

Start: 1775537

End: 1776424

Strand: Direct

Name: trpC [H]

Synonym: Pcryo_1443

Alternate gene names: 93006269

Gene position: 1775537-1776424 (Clockwise)

Preceding gene: 93006268

Following gene: 93006270

Centisome position: 58.03

GC content: 43.36

Gene sequence:

>888_bases
ATGACTACTAACAAAACAGTTGGCTCACATATTCCTTCAGTATTACAACGTATCGTTGCTACCAAACATGAAGAGGTTGC
TGCTGCTCGTAATCTGTTATCACTTGAGGACTTACAAGCGAAAGTCGCGGCAGATAAACAACCTCGTCGCGGTTTTGCCA
GTGCCTTGCGCGCCGCTAATATCGGTATTATTGCTGAGATAAAAAAAGCCTCGCCTTCTAAAGGTATTATCAATCACAAC
TTTGCGCCGGCTTTATTTGCTAAGCAGTATGAGCAATCAGGCGCAAGCTGTCTGTCTGTATTGACAGATCGCGATTACTT
CCAAGGTGATGATAGCTACTTGGTCCAAGCACGTGAAGCTTGTAATCTGCCGATATTACGTAAAGATTTTATGATTGATC
TCTATCAGATTTATCAGTCATATCTACTTGGCGCAGATTGTATATTACTGATTATGGCTTGCCTTGATGATGCACAGGTG
CAAGAGCTACATGCGCTTAGCATCGAGCTTGGTATGGATGTGTTGATAGAAGTGCATACGGCAGAAGAGCTTGAACGTGC
CCTACAACTGCCACATTCAGAGCACAATATCTACGGTATCAATAACCGTGACTTAAATACCTTTGATGTGGATTTGCAGA
CGACACTTGATTTAAAGAACGCCCTATTACGCGAGCTTGCCATTGATGATGCATTTTCTGCTAACTCTAATGATAGCTTG
CTACGACCGCTTATCGTGACCGAAAGTGGCATTCACAGCAGTAACGATATCCGCATGATGCTAAGCCATAATATTCAGCA
CTTTTTAATCGGGGAGCAATTTATGAAAACCGATCATCCTGGACAAGCATTACAATCCTTACTTGCGAGCGTCGCAGCAC
AGGCGTAA

Upstream 100 bases:

>100_bases
GGCACAATATACGCAGCAATTGGCAGCCAATGCTTAACTTATAAGTACATAAACCTAGCCATCATAGACTATTTATCTTT
AACCATATTTGGATACCGCC

Downstream 100 bases:

>100_bases
AGTAAGTGAGATAGTTTAGATAAAGCCAATATGAAAATAGTCATTATCTTTATTACTTACTTAATTAATCATTTATTCAC
TAACCAACGATACATTAATT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MTTNKTVGSHIPSVLQRIVATKHEEVAAARNLLSLEDLQAKVAADKQPRRGFASALRAANIGIIAEIKKASPSKGIINHN
FAPALFAKQYEQSGASCLSVLTDRDYFQGDDSYLVQAREACNLPILRKDFMIDLYQIYQSYLLGADCILLIMACLDDAQV
QELHALSIELGMDVLIEVHTAEELERALQLPHSEHNIYGINNRDLNTFDVDLQTTLDLKNALLRELAIDDAFSANSNDSL
LRPLIVTESGIHSSNDIRMMLSHNIQHFLIGEQFMKTDHPGQALQSLLASVAAQA

Sequences:

>Translated_295_residues
MTTNKTVGSHIPSVLQRIVATKHEEVAAARNLLSLEDLQAKVAADKQPRRGFASALRAANIGIIAEIKKASPSKGIINHN
FAPALFAKQYEQSGASCLSVLTDRDYFQGDDSYLVQAREACNLPILRKDFMIDLYQIYQSYLLGADCILLIMACLDDAQV
QELHALSIELGMDVLIEVHTAEELERALQLPHSEHNIYGINNRDLNTFDVDLQTTLDLKNALLRELAIDDAFSANSNDSL
LRPLIVTESGIHSSNDIRMMLSHNIQHFLIGEQFMKTDHPGQALQSLLASVAAQA
>Mature_294_residues
TTNKTVGSHIPSVLQRIVATKHEEVAAARNLLSLEDLQAKVAADKQPRRGFASALRAANIGIIAEIKKASPSKGIINHNF
APALFAKQYEQSGASCLSVLTDRDYFQGDDSYLVQAREACNLPILRKDFMIDLYQIYQSYLLGADCILLIMACLDDAQVQ
ELHALSIELGMDVLIEVHTAEELERALQLPHSEHNIYGINNRDLNTFDVDLQTTLDLKNALLRELAIDDAFSANSNDSLL
RPLIVTESGIHSSNDIRMMLSHNIQHFLIGEQFMKTDHPGQALQSLLASVAAQA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=277, Percent_Identity=38.9891696750903, Blast_Score=147, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6322638, Length=278, Percent_Identity=32.7338129496403, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 32590; Mature: 32458

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNKTVGSHIPSVLQRIVATKHEEVAAARNLLSLEDLQAKVAADKQPRRGFASALRAAN
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
IGIIAEIKKASPSKGIINHNFAPALFAKQYEQSGASCLSVLTDRDYFQGDDSYLVQAREA
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CNLPILRKDFMIDLYQIYQSYLLGADCILLIMACLDDAQVQELHALSIELGMDVLIEVHT
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEHH
AEELERALQLPHSEHNIYGINNRDLNTFDVDLQTTLDLKNALLRELAIDDAFSANSNDSL
HHHHHHHHHCCCCCCCEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
LRPLIVTESGIHSSNDIRMMLSHNIQHFLIGEQFMKTDHPGQALQSLLASVAAQA
HHHHEEECCCCCCCCCCEEHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTNKTVGSHIPSVLQRIVATKHEEVAAARNLLSLEDLQAKVAADKQPRRGFASALRAAN
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
IGIIAEIKKASPSKGIINHNFAPALFAKQYEQSGASCLSVLTDRDYFQGDDSYLVQAREA
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CNLPILRKDFMIDLYQIYQSYLLGADCILLIMACLDDAQVQELHALSIELGMDVLIEVHT
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEHH
AEELERALQLPHSEHNIYGINNRDLNTFDVDLQTTLDLKNALLRELAIDDAFSANSNDSL
HHHHHHHHHCCCCCCCEEECCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
LRPLIVTESGIHSSNDIRMMLSHNIQHFLIGEQFMKTDHPGQALQSLLASVAAQA
HHHHEEECCCCCCCCCCEEHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA