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The map label for this gene is hpt [H]

Identifier: 93006121

GI number: 93006121

Start: 1579036

End: 1579599

Strand: Reverse

Name: hpt [H]

Synonym: Pcryo_1293

Alternate gene names: 93006121

Gene position: 1579599-1579036 (Counterclockwise)

Preceding gene: 93006122

Following gene: 93006117

Centisome position: 51.62

GC content: 38.3

Gene sequence:

>564_bases
ATGACCCAAATCAGCAATCAAGAAATTGAAAAAACATTACGTAACTCAGAATGCCTAATCAGCAGTATAGAAGTTGCTGC
CGCTTATGAGCGTTTAGCTGCACAGCTTAATCTGCACTATGCTGGTCTAAATCCGATTGTTATGGTCGTTATGAATGGCG
GGCTTATCCCAGCCGGTCAATTATTGACTCACCTTACTTTTTATCATCGTATGCATTATATCCATGCATCACGCTATCGT
GATAACGAAGGAACCAATGAGCTTGATTGGAAATTTAAGCCTGATGTTAACATTGAAGGCGAGCATGTCTTATTGATCGA
TGATATTTTTGATGAAGGCATCACCTTAAAAGCAGTGGTTGAAGAATTGAGCAAGGAAAAACCTTTATCGATTGAATCAT
GTGTTCTCCTTAATAAAGAGCATGATCGTAAAGTTAAAGGTTTCGATGTTGATTTCGTTGGTATTAATGTTGCAGATCGC
TATGTTTATGGCTGTGGTATGGACTTCCATGGTTATTTACGTCATCTGCCTGGTATCTACGCTATTAAAGAAGACAAGAT
TTAA

Upstream 100 bases:

>100_bases
GCCAATATTTGATTAATTTTGCCTCAAAAGCCAGTTGGCATTGGGCATATTCACGAAAATTTGCTAAAATAAGCGGCACT
TTTTACCAAAGGCACGTCCG

Downstream 100 bases:

>100_bases
TCAGTTTTTGATTGACTTGATAGCATAGTAAAAAAGCATCCAATGGGTGCTTTTTTATTGCTTATTGATAAGTATATATA
TTTGAGTGTGATAATACATG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MTQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQLLTHLTFYHRMHYIHASRYR
DNEGTNELDWKFKPDVNIEGEHVLLIDDIFDEGITLKAVVEELSKEKPLSIESCVLLNKEHDRKVKGFDVDFVGINVADR
YVYGCGMDFHGYLRHLPGIYAIKEDKI

Sequences:

>Translated_187_residues
MTQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQLLTHLTFYHRMHYIHASRYR
DNEGTNELDWKFKPDVNIEGEHVLLIDDIFDEGITLKAVVEELSKEKPLSIESCVLLNKEHDRKVKGFDVDFVGINVADR
YVYGCGMDFHGYLRHLPGIYAIKEDKI
>Mature_186_residues
TQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQLLTHLTFYHRMHYIHASRYRD
NEGTNELDWKFKPDVNIEGEHVLLIDDIFDEGITLKAVVEELSKEKPLSIESCVLLNKEHDRKVKGFDVDFVGINVADRY
VYGCGMDFHGYLRHLPGIYAIKEDKI

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI87081689, Length=167, Percent_Identity=31.7365269461078, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21290; Mature: 21158

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQ
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCHHH
LLTHLTFYHRMHYIHASRYRDNEGTNELDWKFKPDVNIEGEHVLLIDDIFDEGITLKAVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHH
EELSKEKPLSIESCVLLNKEHDRKVKGFDVDFVGINVADRYVYGCGMDFHGYLRHLPGIY
HHHHCCCCCCHHHEEEECCCCCCCCCCCCEEEEEEEEEHEEEEECCCCHHHHHHHCCCEE
AIKEDKI
EEECCCC
>Mature Secondary Structure 
TQISNQEIEKTLRNSECLISSIEVAAAYERLAAQLNLHYAGLNPIVMVVMNGGLIPAGQ
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCHHH
LLTHLTFYHRMHYIHASRYRDNEGTNELDWKFKPDVNIEGEHVLLIDDIFDEGITLKAVV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHH
EELSKEKPLSIESCVLLNKEHDRKVKGFDVDFVGINVADRYVYGCGMDFHGYLRHLPGIY
HHHHCCCCCCHHHEEEECCCCCCCCCCCCEEEEEEEEEHEEEEECCCCHHHHHHHCCCEE
AIKEDKI
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]