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The map label for this gene is cpxA [H]

Identifier: 93006052

GI number: 93006052

Start: 1483631

End: 1485322

Strand: Direct

Name: cpxA [H]

Synonym: Pcryo_1224

Alternate gene names: 93006052

Gene position: 1483631-1485322 (Clockwise)

Preceding gene: 93006051

Following gene: 93006053

Centisome position: 48.49

GC content: 43.97

Gene sequence:

>1692_bases
ATGACAGAAGCTGCCCAAAATCCTACAGCGATAAACAAATCGAAGCTGAGCATACCTGTGTCGCTATTTTGGCGACTCTT
TTTGAGTTTGCTATTTATGATTCTGATCACTTCTATCTTATCTATAGCAGTAGAGCGCTGGCTTAATGAGCGAGAGCTTG
CTAATCGTATGGATTCTCAAATTGATAAGCTGCTTATTCAGCGTGAGCGGCTGGTCATATCCTTGGAAGCGGGTGACTTA
TCTACTGTAAAGCAGATTTATAACGAAGATCGAAGACTCATGAGCCAAATCAGGATATACGATGAGCAGGGCGCTATTAT
ATTTCCAAGATATCGGTTTCGAGAAAATCGTGTCAAGCGGCGTCAAGCACGTGACGTGGCAAGTATAAAGGCAATAGACT
TGCAGATAGAAGGTGAGCAATCATCTGTACCACTGAATATGCACAATTCTGTGAGTAGCAGTACTGACAATAAAACATCT
GATTATCATGAAATTAGTGATAAAGAGCGTGTCGATAAGAACCCTTATAGGGCGTATTCCTTTGATAAGGATGGCGTCAA
AAGCGCGCACCCAAATAATAAACCTTTTAGCCTCGATGATATTTTAAAACCAATGCCGTCTCATAAAGCCATTGCTGACA
TTGATAGCCGACCTGAGTTAGCTGAGGTTACAGTGGTTATGCCAAATAATGACAGCGTTATCATACAGCTGCGTCCGCAC
CTATTATTTAAAGATGTGTTAGAGCTACAGCGGGGCAATTTTATGCTGCGGCTCTTGCTGATTATACTCTTTAGCGTGTT
GGTGTGCTTTTGGCTCAGTCGTACGTTGACTCGGCGTATTGGGCGTGTGCAGGATACCGTACACCGGATGATAGATGGCA
ACTATGAAGTCAATCCGCAGTTATCAAGTCTGGGTTCTGACGAATTGGGGTTATTAGCAAAAGATGTCGCTTTACTATCA
ACGCGGCTCGCTGACAGTGAGCTGGCACGCAAGCAGATGTTAAGTGATATCTCGCATGAGCTGCGCTCGCCGCTGGCCCG
TCTCGATGTAGCGACTGAGCTGACACGAGATTTTGCGCCCAACGCCAGTCGTTATCTTGACCGTATCGATAAAGAGTCAA
CGCGGATGAATGAGCTGATTGAGCAAATTATCCGTATTCAATCGTTGCAAATGCAGCAATATACCGTCGACACTCTAGAA
AATGAGGCAGTAGACATCTGTGAAATTATCAATGAGATTGGTCAAGATGTCTGTTTTGAGTTTCAGCATAAAAATATATA
TTGGCAATGGCATGTGAATCCGTCTTTATTGCCAGATTCTTGCACAGTAATGGGCAATCAAGAACAGCTGCATAGTGCCC
TTGAAAATATCATCCGTAATGCTTTTATGCATACTGCTTTTGATTCGGCAGTGATGGCTGAGATACAAGCAGTGAAGATG
AATAATAAAATGTCAGCTATTGAAATAAGCATCACTGACGAGGGGGGCGGTGTTGCAGAACAGGATCTGGAGCGTATTTT
TCAGCCTTTCGTTAGGCTTGATACGGCGCGCCATCGCGAAACGGGCGGTTATGGACTGGGGTTGGCAATCGTCCATGCCG
TAGTGATGGCACATAGAGGTCAGATCACTGTCCATAATCGCCAAGATGGTATATTGGGGCTTGTGATAAAAGTAATACTA
CCTATTAAATAG

Upstream 100 bases:

>100_bases
GCCTTGATGTCCATGTCTCGCGCCTGCGTAAAAAACTTCAACCTTTCCATGATGAGCCAATCAAGGCAATTCGTGGTAAA
GGCTATCAGTTGGTACTCTA

Downstream 100 bases:

>100_bases
AAATAACCTCAAATGAGAACGTATTTCATCAACATATATTCACTAATAAGAATATAACCGATGGACGGTAGTAAATTGCC
GATGTGTGGTATTGAGACTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTEAAQNPTAINKSKLSIPVSLFWRLFLSLLFMILITSILSIAVERWLNERELANRMDSQIDKLLIQRERLVISLEAGDL
STVKQIYNEDRRLMSQIRIYDEQGAIIFPRYRFRENRVKRRQARDVASIKAIDLQIEGEQSSVPLNMHNSVSSSTDNKTS
DYHEISDKERVDKNPYRAYSFDKDGVKSAHPNNKPFSLDDILKPMPSHKAIADIDSRPELAEVTVVMPNNDSVIIQLRPH
LLFKDVLELQRGNFMLRLLLIILFSVLVCFWLSRTLTRRIGRVQDTVHRMIDGNYEVNPQLSSLGSDELGLLAKDVALLS
TRLADSELARKQMLSDISHELRSPLARLDVATELTRDFAPNASRYLDRIDKESTRMNELIEQIIRIQSLQMQQYTVDTLE
NEAVDICEIINEIGQDVCFEFQHKNIYWQWHVNPSLLPDSCTVMGNQEQLHSALENIIRNAFMHTAFDSAVMAEIQAVKM
NNKMSAIEISITDEGGGVAEQDLERIFQPFVRLDTARHRETGGYGLGLAIVHAVVMAHRGQITVHNRQDGILGLVIKVIL
PIK

Sequences:

>Translated_563_residues
MTEAAQNPTAINKSKLSIPVSLFWRLFLSLLFMILITSILSIAVERWLNERELANRMDSQIDKLLIQRERLVISLEAGDL
STVKQIYNEDRRLMSQIRIYDEQGAIIFPRYRFRENRVKRRQARDVASIKAIDLQIEGEQSSVPLNMHNSVSSSTDNKTS
DYHEISDKERVDKNPYRAYSFDKDGVKSAHPNNKPFSLDDILKPMPSHKAIADIDSRPELAEVTVVMPNNDSVIIQLRPH
LLFKDVLELQRGNFMLRLLLIILFSVLVCFWLSRTLTRRIGRVQDTVHRMIDGNYEVNPQLSSLGSDELGLLAKDVALLS
TRLADSELARKQMLSDISHELRSPLARLDVATELTRDFAPNASRYLDRIDKESTRMNELIEQIIRIQSLQMQQYTVDTLE
NEAVDICEIINEIGQDVCFEFQHKNIYWQWHVNPSLLPDSCTVMGNQEQLHSALENIIRNAFMHTAFDSAVMAEIQAVKM
NNKMSAIEISITDEGGGVAEQDLERIFQPFVRLDTARHRETGGYGLGLAIVHAVVMAHRGQITVHNRQDGILGLVIKVIL
PIK
>Mature_562_residues
TEAAQNPTAINKSKLSIPVSLFWRLFLSLLFMILITSILSIAVERWLNERELANRMDSQIDKLLIQRERLVISLEAGDLS
TVKQIYNEDRRLMSQIRIYDEQGAIIFPRYRFRENRVKRRQARDVASIKAIDLQIEGEQSSVPLNMHNSVSSSTDNKTSD
YHEISDKERVDKNPYRAYSFDKDGVKSAHPNNKPFSLDDILKPMPSHKAIADIDSRPELAEVTVVMPNNDSVIIQLRPHL
LFKDVLELQRGNFMLRLLLIILFSVLVCFWLSRTLTRRIGRVQDTVHRMIDGNYEVNPQLSSLGSDELGLLAKDVALLST
RLADSELARKQMLSDISHELRSPLARLDVATELTRDFAPNASRYLDRIDKESTRMNELIEQIIRIQSLQMQQYTVDTLEN
EAVDICEIINEIGQDVCFEFQHKNIYWQWHVNPSLLPDSCTVMGNQEQLHSALENIIRNAFMHTAFDSAVMAEIQAVKMN
NKMSAIEISITDEGGGVAEQDLERIFQPFVRLDTARHRETGGYGLGLAIVHAVVMAHRGQITVHNRQDGILGLVIKVILP
IK

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=31.3167259786477, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788393, Length=294, Percent_Identity=27.891156462585, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=28.3333333333333, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790861, Length=295, Percent_Identity=27.1186440677966, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=27.3504273504274, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786783, Length=299, Percent_Identity=24.4147157190635, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=346, Percent_Identity=26.0115606936416, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789149, Length=238, Percent_Identity=25.6302521008403, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=307, Percent_Identity=24.7557003257329, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790436, Length=255, Percent_Identity=25.0980392156863, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64291; Mature: 64160

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAAQNPTAINKSKLSIPVSLFWRLFLSLLFMILITSILSIAVERWLNERELANRMDSQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IDKLLIQRERLVISLEAGDLSTVKQIYNEDRRLMSQIRIYDEQGAIIFPRYRFRENRVKR
HHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
RQARDVASIKAIDLQIEGEQSSVPLNMHNSVSSSTDNKTSDYHEISDKERVDKNPYRAYS
HHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCEECC
FDKDGVKSAHPNNKPFSLDDILKPMPSHKAIADIDSRPELAEVTVVMPNNDSVIIQLRPH
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHCCCCCCCEEEEEEEEECCCEEEEEECCH
LLFKDVLELQRGNFMLRLLLIILFSVLVCFWLSRTLTRRIGRVQDTVHRMIDGNYEVNPQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LSSLGSDELGLLAKDVALLSTRLADSELARKQMLSDISHELRSPLARLDVATELTRDFAP
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NASRYLDRIDKESTRMNELIEQIIRIQSLQMQQYTVDTLENEAVDICEIINEIGQDVCFE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHE
FQHKNIYWQWHVNPSLLPDSCTVMGNQEQLHSALENIIRNAFMHTAFDSAVMAEIQAVKM
EECCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NNKMSAIEISITDEGGGVAEQDLERIFQPFVRLDTARHRETGGYGLGLAIVHAVVMAHRG
CCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
QITVHNRQDGILGLVIKVILPIK
EEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TEAAQNPTAINKSKLSIPVSLFWRLFLSLLFMILITSILSIAVERWLNERELANRMDSQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IDKLLIQRERLVISLEAGDLSTVKQIYNEDRRLMSQIRIYDEQGAIIFPRYRFRENRVKR
HHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
RQARDVASIKAIDLQIEGEQSSVPLNMHNSVSSSTDNKTSDYHEISDKERVDKNPYRAYS
HHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCEECC
FDKDGVKSAHPNNKPFSLDDILKPMPSHKAIADIDSRPELAEVTVVMPNNDSVIIQLRPH
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHCCCCCCCEEEEEEEEECCCEEEEEECCH
LLFKDVLELQRGNFMLRLLLIILFSVLVCFWLSRTLTRRIGRVQDTVHRMIDGNYEVNPQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LSSLGSDELGLLAKDVALLSTRLADSELARKQMLSDISHELRSPLARLDVATELTRDFAP
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NASRYLDRIDKESTRMNELIEQIIRIQSLQMQQYTVDTLENEAVDICEIINEIGQDVCFE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHE
FQHKNIYWQWHVNPSLLPDSCTVMGNQEQLHSALENIIRNAFMHTAFDSAVMAEIQAVKM
EECCEEEEEEECCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NNKMSAIEISITDEGGGVAEQDLERIFQPFVRLDTARHRETGGYGLGLAIVHAVVMAHRG
CCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
QITVHNRQDGILGLVIKVILPIK
EEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]