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The map label for this gene is cpxR [H]

Identifier: 93006051

GI number: 93006051

Start: 1482939

End: 1483631

Strand: Direct

Name: cpxR [H]

Synonym: Pcryo_1223

Alternate gene names: 93006051

Gene position: 1482939-1483631 (Clockwise)

Preceding gene: 93006048

Following gene: 93006052

Centisome position: 48.46

GC content: 45.31

Gene sequence:

>693_bases
ATGTCAAATATTTTATTGGGTGACGATGACGAAGAGTTGACTCAATTACTGCAAGAATATCTGCATAATCACGGTGTTCG
TTGTGACTGCGTGCATGATGGAGAAGCGGTCATAGAGCGATTAAAGACGACGATGCAAGATAGTTCGCCTTATGATTTGT
TGGTGCTCGATATCATGATGCCAAAAATAGACGGGCTCAGTGTGTTACGTCAGCTGCCTGCTATTAGTGATATCCCTGTC
ATTATGCTTACCGCAAAAGGGGAGGAGATAGACCGTATCATCGGGCTGGAGCTTGGCGCTGATGATTATATTACCAAGCC
TTGTAATCCACGTGAGCTGCTGGCACGCATCAATGCGGTGATTAAGCGCACCAGTATTGCGGTCAGTTTTACCGAGCAAT
TACCGCTGCCGAGTAGTCGCTTATATCTTGACCAACAGCAAAGGCTTTGCCAGATAGATGGCGTTGAGCTGCAATTAACA
GGTACAGAGTTTGATTTATTGCTGGCTTTATTACGACAAAAAGGTGAGGTAGTCAGTAAATCGTGGCTATCACAGCATGT
CTTGCAGCGAGAATTACAGCCTTTTGACCGTAGCCTTGATGTCCATGTCTCGCGCCTGCGTAAAAAACTTCAACCTTTCC
ATGATGAGCCAATCAAGGCAATTCGTGGTAAAGGCTATCAGTTGGTACTCTAA

Upstream 100 bases:

>100_bases
TGAAACATTAAGAAAGGTAACGTTTATAGCGCATAGGTAGCGCTTGCTTGATAATATGAGCCATAAAATGGTTGAGAGGT
ACAATAATAAGGTGATAACA

Downstream 100 bases:

>100_bases
TGACAGAAGCTGCCCAAAATCCTACAGCGATAAACAAATCGAAGCTGAGCATACCTGTGTCGCTATTTTGGCGACTCTTT
TTGAGTTTGCTATTTATGAT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSNILLGDDDEELTQLLQEYLHNHGVRCDCVHDGEAVIERLKTTMQDSSPYDLLVLDIMMPKIDGLSVLRQLPAISDIPV
IMLTAKGEEIDRIIGLELGADDYITKPCNPRELLARINAVIKRTSIAVSFTEQLPLPSSRLYLDQQQRLCQIDGVELQLT
GTEFDLLLALLRQKGEVVSKSWLSQHVLQRELQPFDRSLDVHVSRLRKKLQPFHDEPIKAIRGKGYQLVL

Sequences:

>Translated_230_residues
MSNILLGDDDEELTQLLQEYLHNHGVRCDCVHDGEAVIERLKTTMQDSSPYDLLVLDIMMPKIDGLSVLRQLPAISDIPV
IMLTAKGEEIDRIIGLELGADDYITKPCNPRELLARINAVIKRTSIAVSFTEQLPLPSSRLYLDQQQRLCQIDGVELQLT
GTEFDLLLALLRQKGEVVSKSWLSQHVLQRELQPFDRSLDVHVSRLRKKLQPFHDEPIKAIRGKGYQLVL
>Mature_229_residues
SNILLGDDDEELTQLLQEYLHNHGVRCDCVHDGEAVIERLKTTMQDSSPYDLLVLDIMMPKIDGLSVLRQLPAISDIPVI
MLTAKGEEIDRIIGLELGADDYITKPCNPRELLARINAVIKRTSIAVSFTEQLPLPSSRLYLDQQQRLCQIDGVELQLTG
TEFDLLLALLRQKGEVVSKSWLSQHVLQRELQPFDRSLDVHVSRLRKKLQPFHDEPIKAIRGKGYQLVL

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=239, Percent_Identity=45.1882845188285, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=40.343347639485, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=37.4449339207048, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=36.5217391304348, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=33.1896551724138, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790863, Length=189, Percent_Identity=36.5079365079365, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=33.920704845815, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=33.0396475770925, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.7510917030568, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=32.6271186440678, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=32.3008849557522, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=33.0396475770925, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786911, Length=233, Percent_Identity=32.1888412017167, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787375, Length=178, Percent_Identity=34.8314606741573, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26116; Mature: 25984

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNILLGDDDEELTQLLQEYLHNHGVRCDCVHDGEAVIERLKTTMQDSSPYDLLVLDIMM
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEHHH
PKIDGLSVLRQLPAISDIPVIMLTAKGEEIDRIIGLELGADDYITKPCNPRELLARINAV
CCCCHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHH
IKRTSIAVSFTEQLPLPSSRLYLDQQQRLCQIDGVELQLTGTEFDLLLALLRQKGEVVSK
HHHHHHEEEEHHCCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCHHHHH
SWLSQHVLQRELQPFDRSLDVHVSRLRKKLQPFHDEPIKAIRGKGYQLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEC
>Mature Secondary Structure 
SNILLGDDDEELTQLLQEYLHNHGVRCDCVHDGEAVIERLKTTMQDSSPYDLLVLDIMM
CCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEHHH
PKIDGLSVLRQLPAISDIPVIMLTAKGEEIDRIIGLELGADDYITKPCNPRELLARINAV
CCCCHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHH
IKRTSIAVSFTEQLPLPSSRLYLDQQQRLCQIDGVELQLTGTEFDLLLALLRQKGEVVSK
HHHHHHEEEEHHCCCCCCHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCHHHHH
SWLSQHVLQRELQPFDRSLDVHVSRLRKKLQPFHDEPIKAIRGKGYQLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]