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The map label for this gene is apt [H]

Identifier: 93006029

GI number: 93006029

Start: 1455294

End: 1455863

Strand: Direct

Name: apt [H]

Synonym: Pcryo_1201

Alternate gene names: 93006029

Gene position: 1455294-1455863 (Clockwise)

Preceding gene: 93006026

Following gene: 93006032

Centisome position: 47.56

GC content: 45.96

Gene sequence:

>570_bases
ATGAGCGCAAACACCGCTGTTACAGCAGTTGATACCGCAATCGAGTCATCGAATACGCTCAATACCGATCATCCATTTTG
GAACATCATTCGCACAGTACCAGACTTCCCTAAAGTCGGTATTGATTTTTATGATATTACACCGTTACTATGCAGTCACA
TTAATGAAGTCATTGATGCACTGCTGGCTGTCCTACCTGAAGGCATAATGGATGAGGTGGATTGTTTGGGTGCTGTTGAA
GCCCGTGGATTCGTGTTTGCAAGTTTGCTGGCAGGACGTCTGGGTAAAGGCATGATTCTGCTACGTAAACCCGGCAAGTT
ACCACCGCCTGTTGCCAATAAAGCTTACGCGTTAGAGTACGGTAAAGATACCCTTGAGATGCAGAACAATCTGCCACCAG
AGCGCGTGCTATTGATTGATGATATCTTGGCAACGGGCGGCACATTGACCACCGCTTATGAGCTATGTCAATCAGCCGAT
CATACGGTCGTTGGTGCATTAGTCTTATTAGATTTGGTGGATTTACATGGCGATTTTCCAGTGCCTGTTTATACGGTATT
GAAGGCGTAA

Upstream 100 bases:

>100_bases
TAAAGGCAATTATGCTATAATAACCGCCGTTAATTTTCTGATACATAGATTATTTGCTATTGTTACATCATTATCTAAGT
TATAGACGTTAAGGGTTATT

Downstream 100 bases:

>100_bases
ATGAGTGGCGGTTTTACTTACAGTGGGTAAAAATAAAAAGTAATATCGATACATTATGTACTGCTGGTATTAATTTTTCT
TGCTTGCTGTGCCTACGCAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MSANTAVTAVDTAIESSNTLNTDHPFWNIIRTVPDFPKVGIDFYDITPLLCSHINEVIDALLAVLPEGIMDEVDCLGAVE
ARGFVFASLLAGRLGKGMILLRKPGKLPPPVANKAYALEYGKDTLEMQNNLPPERVLLIDDILATGGTLTTAYELCQSAD
HTVVGALVLLDLVDLHGDFPVPVYTVLKA

Sequences:

>Translated_189_residues
MSANTAVTAVDTAIESSNTLNTDHPFWNIIRTVPDFPKVGIDFYDITPLLCSHINEVIDALLAVLPEGIMDEVDCLGAVE
ARGFVFASLLAGRLGKGMILLRKPGKLPPPVANKAYALEYGKDTLEMQNNLPPERVLLIDDILATGGTLTTAYELCQSAD
HTVVGALVLLDLVDLHGDFPVPVYTVLKA
>Mature_188_residues
SANTAVTAVDTAIESSNTLNTDHPFWNIIRTVPDFPKVGIDFYDITPLLCSHINEVIDALLAVLPEGIMDEVDCLGAVEA
RGFVFASLLAGRLGKGMILLRKPGKLPPPVANKAYALEYGKDTLEMQNNLPPERVLLIDDILATGGTLTTAYELCQSADH
TVVGALVLLDLVDLHGDFPVPVYTVLKA

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=166, Percent_Identity=39.1566265060241, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=42.1487603305785, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI1786675, Length=155, Percent_Identity=38.0645161290323, Blast_Score=91, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17509087, Length=158, Percent_Identity=39.873417721519, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=34.7305389221557, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136334, Length=156, Percent_Identity=38.4615384615385, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20328; Mature: 20197

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANTAVTAVDTAIESSNTLNTDHPFWNIIRTVPDFPKVGIDFYDITPLLCSHINEVIDA
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLAVLPEGIMDEVDCLGAVEARGFVFASLLAGRLGKGMILLRKPGKLPPPVANKAYALEY
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEECC
GKDTLEMQNNLPPERVLLIDDILATGGTLTTAYELCQSADHTVVGALVLLDLVDLHGDFP
CCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
VPVYTVLKA
CHHHHHHCC
>Mature Secondary Structure 
SANTAVTAVDTAIESSNTLNTDHPFWNIIRTVPDFPKVGIDFYDITPLLCSHINEVIDA
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLAVLPEGIMDEVDCLGAVEARGFVFASLLAGRLGKGMILLRKPGKLPPPVANKAYALEY
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEECC
GKDTLEMQNNLPPERVLLIDDILATGGTLTTAYELCQSADHTVVGALVLLDLVDLHGDFP
CCHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
VPVYTVLKA
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA