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The map label for this gene is xdhB [H]

Identifier: 93005968

GI number: 93005968

Start: 1379104

End: 1380762

Strand: Direct

Name: xdhB [H]

Synonym: Pcryo_1140

Alternate gene names: 93005968

Gene position: 1379104-1380762 (Clockwise)

Preceding gene: 93005967

Following gene: 93005969

Centisome position: 45.07

GC content: 45.39

Gene sequence:

>1659_bases
ATGATTCATTTTTATTTGAACGGTCAATATAAGCAATTAACTGACCTCAATCCGAATACCACGGTGCTTGAGTATTTGCG
CTTGCACGAACGCCAGACTGATACCAAAGAAGGCTGCGGCAGTGGCGACTGCGGAGCCTGTACGGTGATGGCGCAGCGCT
TACCTAGCAGTGATGAAGATTCTTCTGATTTGCCTTTTTATACCCTTAACGCCTGTATCACGCTACTGTCATTGATGGAT
GGTCATCATATAATGACGTCAGCTTATATCGCGGACAATCCTGAACATCATCCAGAACGTGCTTTATTGCACCCAGCGCA
GCAAGCAATGGTCGAATGCCATGGCTCGCAGTGCGGGTTTTGTACGCCTGGATTTGTGATGACACTGGCCAGCACCTACG
AGAATCATCGTCTGCAAGTCGCAAAGGGAACCATCAAAGATGATTTGAGCTACGATGATATTGTGGCTGCAATTGGTGGG
AATCTTTGCCGCTGTACGGGCTATCGTCCTATTATCGAGGCGGGCTTGGCAATGAGTGAGATTGGTAGACAACGCGATGC
TGATCAGACGATCGCCAAAGACTTGACCATCAGTTTAGCGACAGATGCGATGGCAAATAGCAGACAAACCGTTTCAAGCG
AAATGGGTACTATTGAGCCTGCGCTTAATCAAGGGTCACGTAAGTTATTCATTCCAAAGTCTGTTGCTGAGCTCAATCAA
GTGCTCGCTGCCCATCCAAAAGCGACCATTTGGGCAGGTGGTACGGACTTAGGTTTGAGTGTGACGCAACACTTGGTGGA
TCACGATATTATCGTACAACTGTCAGCGATTGACGAGCTAAAATCTTGGTCACTACAAGCGTTAAGCTTAAATACCGATG
AGCAGTCTAAAAGCGATAGCGAAGTAGAGTTTTTAGTATTGGGTGCTGGCATGAGCTATAAGAGCATGCTGCCTGCGCTT
GAACAACATTTCCCTGCGTTTGCCAATTTGTTTGAACGTATTGCTTCTCCGCAAATCCGTAATATGGGCACTATCGGCGG
TAACGTCGCTAACGCTTCACCGATTGGCGATTTGCCTCCCATTCTATTGGCATTAGATACTCATATTCATCTGCGTCATT
GTGCTGCTATTGACAATTCTATTAACAGCGCTACTGACAATATCAATGTTAATAATGTCCATTCAAATCAAGTATCTAGT
ATTGATGAAATCATTCCTTTATCTAAATTCTTTTTAGATTATAAAAAGACCAAACTACGTGCTGGTAGTTACGTGGTAGC
CCTTCATATTCCGCTAATGCAAGATAATCAGTATCTCTATATTCATAAGATTAGTAAGCGTTACGAAGATGATATCTCAG
CGTGCTTGCTTGCTGCGCGACTTGATTTGTCAGCGGATGGCATGACTATCCAAGATGCAAAATTTGGACTTGGCGGCATG
GCGGCGATACCTTTATTGGCAGCAGAATGTCAGCAGGCACTAATTGGACAAGCAGTAAATGTTGCCAGTTTCGAGCAGGC
AGCACAAAGGCTACCTAATGATGTCTCACCGATGACCGATGTGAGAGCCAGCCGAGAGTATCGTATGCATGTGATGCAGC
GGTTAATCATTAAGTGTGGCAAGCAATTGGTTGCTGATGTGCAAGCGGTAGATGCGTAA

Upstream 100 bases:

>100_bases
TGCAGTTATCCTTTAAGATACTGATTGTTAAGATTTTATGATTCGATTAAAGATAAAGCAGTTTTTTATCTTCCTTTTAT
TCTGACAGCTGAGCATTGCT

Downstream 100 bases:

>100_bases
GTAAACATATAGCAAGTAAGCTCGGCAAGAGCTAAATAGACGGCATTAGTGTTTGAACTTGCTTGATTATGCTAACTCAC
CTGACTTTCGCATCGCTAAA

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MIHFYLNGQYKQLTDLNPNTTVLEYLRLHERQTDTKEGCGSGDCGACTVMAQRLPSSDEDSSDLPFYTLNACITLLSLMD
GHHIMTSAYIADNPEHHPERALLHPAQQAMVECHGSQCGFCTPGFVMTLASTYENHRLQVAKGTIKDDLSYDDIVAAIGG
NLCRCTGYRPIIEAGLAMSEIGRQRDADQTIAKDLTISLATDAMANSRQTVSSEMGTIEPALNQGSRKLFIPKSVAELNQ
VLAAHPKATIWAGGTDLGLSVTQHLVDHDIIVQLSAIDELKSWSLQALSLNTDEQSKSDSEVEFLVLGAGMSYKSMLPAL
EQHFPAFANLFERIASPQIRNMGTIGGNVANASPIGDLPPILLALDTHIHLRHCAAIDNSINSATDNINVNNVHSNQVSS
IDEIIPLSKFFLDYKKTKLRAGSYVVALHIPLMQDNQYLYIHKISKRYEDDISACLLAARLDLSADGMTIQDAKFGLGGM
AAIPLLAAECQQALIGQAVNVASFEQAAQRLPNDVSPMTDVRASREYRMHVMQRLIIKCGKQLVADVQAVDA

Sequences:

>Translated_552_residues
MIHFYLNGQYKQLTDLNPNTTVLEYLRLHERQTDTKEGCGSGDCGACTVMAQRLPSSDEDSSDLPFYTLNACITLLSLMD
GHHIMTSAYIADNPEHHPERALLHPAQQAMVECHGSQCGFCTPGFVMTLASTYENHRLQVAKGTIKDDLSYDDIVAAIGG
NLCRCTGYRPIIEAGLAMSEIGRQRDADQTIAKDLTISLATDAMANSRQTVSSEMGTIEPALNQGSRKLFIPKSVAELNQ
VLAAHPKATIWAGGTDLGLSVTQHLVDHDIIVQLSAIDELKSWSLQALSLNTDEQSKSDSEVEFLVLGAGMSYKSMLPAL
EQHFPAFANLFERIASPQIRNMGTIGGNVANASPIGDLPPILLALDTHIHLRHCAAIDNSINSATDNINVNNVHSNQVSS
IDEIIPLSKFFLDYKKTKLRAGSYVVALHIPLMQDNQYLYIHKISKRYEDDISACLLAARLDLSADGMTIQDAKFGLGGM
AAIPLLAAECQQALIGQAVNVASFEQAAQRLPNDVSPMTDVRASREYRMHVMQRLIIKCGKQLVADVQAVDA
>Mature_552_residues
MIHFYLNGQYKQLTDLNPNTTVLEYLRLHERQTDTKEGCGSGDCGACTVMAQRLPSSDEDSSDLPFYTLNACITLLSLMD
GHHIMTSAYIADNPEHHPERALLHPAQQAMVECHGSQCGFCTPGFVMTLASTYENHRLQVAKGTIKDDLSYDDIVAAIGG
NLCRCTGYRPIIEAGLAMSEIGRQRDADQTIAKDLTISLATDAMANSRQTVSSEMGTIEPALNQGSRKLFIPKSVAELNQ
VLAAHPKATIWAGGTDLGLSVTQHLVDHDIIVQLSAIDELKSWSLQALSLNTDEQSKSDSEVEFLVLGAGMSYKSMLPAL
EQHFPAFANLFERIASPQIRNMGTIGGNVANASPIGDLPPILLALDTHIHLRHCAAIDNSINSATDNINVNNVHSNQVSS
IDEIIPLSKFFLDYKKTKLRAGSYVVALHIPLMQDNQYLYIHKISKRYEDDISACLLAARLDLSADGMTIQDAKFGLGGM
AAIPLLAAECQQALIGQAVNVASFEQAAQRLPNDVSPMTDVRASREYRMHVMQRLIIKCGKQLVADVQAVDA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=503, Percent_Identity=27.2365805168986, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI71773480, Length=553, Percent_Identity=26.4014466546112, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1789231, Length=315, Percent_Identity=24.4444444444444, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786480, Length=176, Percent_Identity=30.1136363636364, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789232, Length=171, Percent_Identity=30.9941520467836, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17540638, Length=610, Percent_Identity=25.4098360655738, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17539860, Length=371, Percent_Identity=26.6846361185984, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=178, Percent_Identity=34.2696629213483, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737937, Length=543, Percent_Identity=25.414364640884, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24647197, Length=465, Percent_Identity=27.5268817204301, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24647195, Length=387, Percent_Identity=28.6821705426357, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24647199, Length=554, Percent_Identity=24.5487364620939, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24647201, Length=540, Percent_Identity=22.5925925925926, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24647193, Length=376, Percent_Identity=28.4574468085106, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 60203; Mature: 60203

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00197 2FE2S_FER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHFYLNGQYKQLTDLNPNTTVLEYLRLHERQTDTKEGCGSGDCGACTVMAQRLPSSDED
CEEEEECCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
SSDLPFYTLNACITLLSLMDGHHIMTSAYIADNPEHHPERALLHPAQQAMVECHGSQCGF
CCCCCEEEHHHHHHHHHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
CTPGFVMTLASTYENHRLQVAKGTIKDDLSYDDIVAAIGGNLCRCTGYRPIIEAGLAMSE
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHCCHHHH
IGRQRDADQTIAKDLTISLATDAMANSRQTVSSEMGTIEPALNQGSRKLFIPKSVAELNQ
HHHHCCHHHHHHHHHEEEEHHHHHHCCHHHHHHHHCCCCHHHCCCCCEEECCHHHHHHHH
VLAAHPKATIWAGGTDLGLSVTQHLVDHDIIVQLSAIDELKSWSLQALSLNTDEQSKSDS
HHHCCCCCEEEECCCCCHHHHHHHHHCHHHEEEEHHHHHHHCCCEEEEEECCCCCCCCCC
EVEFLVLGAGMSYKSMLPALEQHFPAFANLFERIASPQIRNMGTIGGNVANASPIGDLPP
CEEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCH
ILLALDTHIHLRHCAAIDNSINSATDNINVNNVHSNQVSSIDEIIPLSKFFLDYKKTKLR
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AGSYVVALHIPLMQDNQYLYIHKISKRYEDDISACLLAARLDLSADGMTIQDAKFGLGGM
CCCEEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCH
AAIPLLAAECQQALIGQAVNVASFEQAAQRLPNDVSPMTDVRASREYRMHVMQRLIIKCG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KQLVADVQAVDA
HHHHHHHHHCCC
>Mature Secondary Structure
MIHFYLNGQYKQLTDLNPNTTVLEYLRLHERQTDTKEGCGSGDCGACTVMAQRLPSSDED
CEEEEECCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
SSDLPFYTLNACITLLSLMDGHHIMTSAYIADNPEHHPERALLHPAQQAMVECHGSQCGF
CCCCCEEEHHHHHHHHHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
CTPGFVMTLASTYENHRLQVAKGTIKDDLSYDDIVAAIGGNLCRCTGYRPIIEAGLAMSE
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHCCHHHH
IGRQRDADQTIAKDLTISLATDAMANSRQTVSSEMGTIEPALNQGSRKLFIPKSVAELNQ
HHHHCCHHHHHHHHHEEEEHHHHHHCCHHHHHHHHCCCCHHHCCCCCEEECCHHHHHHHH
VLAAHPKATIWAGGTDLGLSVTQHLVDHDIIVQLSAIDELKSWSLQALSLNTDEQSKSDS
HHHCCCCCEEEECCCCCHHHHHHHHHCHHHEEEEHHHHHHHCCCEEEEEECCCCCCCCCC
EVEFLVLGAGMSYKSMLPALEQHFPAFANLFERIASPQIRNMGTIGGNVANASPIGDLPP
CEEEEEEECCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCH
ILLALDTHIHLRHCAAIDNSINSATDNINVNNVHSNQVSSIDEIIPLSKFFLDYKKTKLR
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AGSYVVALHIPLMQDNQYLYIHKISKRYEDDISACLLAARLDLSADGMTIQDAKFGLGGM
CCCEEEEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCH
AAIPLLAAECQQALIGQAVNVASFEQAAQRLPNDVSPMTDVRASREYRMHVMQRLIIKCG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KQLVADVQAVDA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]