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The map label for this gene is xdhA [H]

Identifier: 93005969

GI number: 93005969

Start: 1380929

End: 1383499

Strand: Direct

Name: xdhA [H]

Synonym: Pcryo_1141

Alternate gene names: 93005969

Gene position: 1380929-1383499 (Clockwise)

Preceding gene: 93005968

Following gene: 93005970

Centisome position: 45.13

GC content: 45.55

Gene sequence:

>2571_bases
ATGAGCCACCATTCTTCATTATTTGACAGCTATAGTACCCGCAGACAGCGTCCACCAAAAGACAAGATTGGCACCCAAGC
AAAGCATGACAGTGCTATTAGTCACGTTATGGGCACTGCCACTTATGTGGACGATATGCTAAAACCACAAAACACCCTGC
ATTTAGCAATTGGTAAAAGTGCTCACGCGCATGCTCGTGTATTGAATATGGATTTGAGCGCCGTACAAGCAGCGGACGGG
GTAATCGATGTCATCACTTTTAAAGATTTACCAGCCAAGACTGATATCGGAGCAGTGTTTGATGGCGATCCACTCATGGT
CGATCAGATCACAGAATATGTCGGTCAAACGCTATTTACGGTGGTTGCCACCAGTCACCGTGCAGCAAAAAAAGCCGTGC
TCAAAGCCATTGTGGAATATGAGCCGCTGCCCGCAATCCTCACTATTGATGAGGCGCTAAAGCAAGAGCAGTTTGTACGT
CCAAGTCACTTTATGACGCGCGGTGATGCTCAGGCTGAGCTTGAGAGTGCACCTACTCGTATTGCAGGGCATATTCATAT
GTTGGGGCAAGAGCATTTTTATTTGGAAGGGCAAGTATCTTATGTTATTCCTTGCGATGATGGTGGGCTTGAAGTCTATA
CTTCCTCACAGCATCCGAGTGAAGTGCAGCAGCTGGTCGCCGAAGTGGTCGATTTACCTTTTCATGCCGTGACGACAGTT
GTGCGCCGAATGGGCGGTGGTTTTGGTGGTAAAGAAACGCAAGCTGCCGCATGGGCGTGTCTGTGCGGTATCGTTGCCAA
ACGCCATAATGTGCCAGTGAGTATGCGCTTAGACCGTCAAGATGATATGGTTGTCACTGGTAAACGTCATGAATTTGCCA
ATCGCTACGATGTCGGTGTCAATGATGCTGGTCAAGTGCTTGGCGTTGATATGCAGCTATCAGGATTGTGCGGTTATTCA
CCAGATTTGTCCGATGCTATTGTCGATCGGGCGATGTTCCATTGTGACAACGCCTATTATTATCCAGCGGCTCAGATCGC
TGGTCATCGCTGCAAGACTCATACAGTATCAAATACCGCTTATCGAGGTTTTGGTGGCCCACAAGGTTTGCTAACTGCTG
AATACATGATGGATGATATCGCCTACAGTCTGGGTAAAGATCCTTTGCAGGTACGTTTGGCAAATCTATATCAAAATGGT
CAAAGCACCCATTATGGGCAGCCGATTGAACATTTTGATTTGGCGACTATCATACAGACGTTAGCTGATGACAACGATTA
TGCTAAGCGACGTGAACAAATCACAGTCGCTAATCGAAAAGCTGAAGCCGAAGGTAGTGACAAACGTTTTGGTCTGGCTC
TAACGCCGGTCAAATTTGGTATCTCATTTACGGTACAGACGCTAAACCAAGCGGGTGCTTTGGTTCATATCTATACCGAC
GGTACCATTCAAATCAATCATGGTGGTACTGAAATGGGGCAAGGGCTATATATTAAGATTGCCCAAATCGTTGCTAATGA
ATTCGATGTAGATTTAGATACCGTAAAAGTAACCGCAACTCGTACCGATAAAGTGCCAAATACTTCGCCAACAGCGGCGT
CGTCAGGTACTGATATGAATGGCAAAGCCGCACAAAACGCTTGTATTACTATTAGAGATCGCTTGGTTGAATTTGCTACT
GAACATTTTGAAGTAAGTGCAGAAGATGTCAAATTTGAGCGCAATCATGTTCATATCGGTGATAAAGAAACACTAACCTT
TGCTGAAATGGTGTTACTCGCATATCAGCACCGCGTTAGCTTATCGTCTACTGGCTACTATAAAACACCAAAGATATTTT
ATGATCGCTCAAAAGCGTGGGGTCGCCCATTCTTTTACTTTGCCTTGGGTGCCTCTTGTTCTGAGGTTGAGATTGATATT
TTAACGGGTGAATATAGGGTATTGCGCTGCGATATCTTACACGATGTTGGGCAGTCGATTAATCCTGCAATTGATATCGG
TCAGATTGAAGGCGGTTTTGTTCAAGGTATGGGCTGGCTTACTGCTGAAGAGCTGGTTTGGGATAAAAAAGGAAACCTTG
CGTCAAACAGTGCCGCCAATTATAAAATTCCAATGGCGCATGACTTACCAAAACAATGGAGCGTCAAACTGTTCGATCGC
AAAAACGAAGAGCAAACTATTTATAACTCCAAAGCCGTTGGCGAACCGCCATTTATGCTAGCCGCTAGTGTTTGGTGCGC
GATTAACAACGCGATTGCAAGCTTAGGTGATTACCGGAAAAACCCTGAGCTGACCATGCCGGCAACGCCAGAAGCGGTAT
TAAAATCGGTCATGCGTATGCAAGGTCAAGAATGGGAAATCGCTTCTAAAGCGGATACAGATACGATTACTAGCCTAACA
GTAACCGATGATAATTGCGGTATTGATGATGATAAAGTCAAGCCGCAGCAAGTCGCACATGGTAAGGATATTAATCCAAC
AGAAGTCGAAGGTAAGCTAACGGATGATCAGCCTGAAGCGATACAAAACCCAAATGTATCAACGGCTCGCGGACCGGCAC
ATAGTGAATAA

Upstream 100 bases:

>100_bases
TTATGCTAACTCACCTGACTTTCGCATCGCTAAAAGATACAGTCAAAACGCTATTGTTAGAGAGATAGGTTTTGCTAAAA
ATATAAGAGAGAGAGCCATT

Downstream 100 bases:

>100_bases
GTCACTAATCACACCGATGCCACCAACAAAGTGGTATAACGGACTGGCGCAATATCAGCAGCAAGGTATTGCGCACGTTT
TGGCGACGGTCGTTGCGGTG

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MSHHSSLFDSYSTRRQRPPKDKIGTQAKHDSAISHVMGTATYVDDMLKPQNTLHLAIGKSAHAHARVLNMDLSAVQAADG
VIDVITFKDLPAKTDIGAVFDGDPLMVDQITEYVGQTLFTVVATSHRAAKKAVLKAIVEYEPLPAILTIDEALKQEQFVR
PSHFMTRGDAQAELESAPTRIAGHIHMLGQEHFYLEGQVSYVIPCDDGGLEVYTSSQHPSEVQQLVAEVVDLPFHAVTTV
VRRMGGGFGGKETQAAAWACLCGIVAKRHNVPVSMRLDRQDDMVVTGKRHEFANRYDVGVNDAGQVLGVDMQLSGLCGYS
PDLSDAIVDRAMFHCDNAYYYPAAQIAGHRCKTHTVSNTAYRGFGGPQGLLTAEYMMDDIAYSLGKDPLQVRLANLYQNG
QSTHYGQPIEHFDLATIIQTLADDNDYAKRREQITVANRKAEAEGSDKRFGLALTPVKFGISFTVQTLNQAGALVHIYTD
GTIQINHGGTEMGQGLYIKIAQIVANEFDVDLDTVKVTATRTDKVPNTSPTAASSGTDMNGKAAQNACITIRDRLVEFAT
EHFEVSAEDVKFERNHVHIGDKETLTFAEMVLLAYQHRVSLSSTGYYKTPKIFYDRSKAWGRPFFYFALGASCSEVEIDI
LTGEYRVLRCDILHDVGQSINPAIDIGQIEGGFVQGMGWLTAEELVWDKKGNLASNSAANYKIPMAHDLPKQWSVKLFDR
KNEEQTIYNSKAVGEPPFMLAASVWCAINNAIASLGDYRKNPELTMPATPEAVLKSVMRMQGQEWEIASKADTDTITSLT
VTDDNCGIDDDKVKPQQVAHGKDINPTEVEGKLTDDQPEAIQNPNVSTARGPAHSE

Sequences:

>Translated_856_residues
MSHHSSLFDSYSTRRQRPPKDKIGTQAKHDSAISHVMGTATYVDDMLKPQNTLHLAIGKSAHAHARVLNMDLSAVQAADG
VIDVITFKDLPAKTDIGAVFDGDPLMVDQITEYVGQTLFTVVATSHRAAKKAVLKAIVEYEPLPAILTIDEALKQEQFVR
PSHFMTRGDAQAELESAPTRIAGHIHMLGQEHFYLEGQVSYVIPCDDGGLEVYTSSQHPSEVQQLVAEVVDLPFHAVTTV
VRRMGGGFGGKETQAAAWACLCGIVAKRHNVPVSMRLDRQDDMVVTGKRHEFANRYDVGVNDAGQVLGVDMQLSGLCGYS
PDLSDAIVDRAMFHCDNAYYYPAAQIAGHRCKTHTVSNTAYRGFGGPQGLLTAEYMMDDIAYSLGKDPLQVRLANLYQNG
QSTHYGQPIEHFDLATIIQTLADDNDYAKRREQITVANRKAEAEGSDKRFGLALTPVKFGISFTVQTLNQAGALVHIYTD
GTIQINHGGTEMGQGLYIKIAQIVANEFDVDLDTVKVTATRTDKVPNTSPTAASSGTDMNGKAAQNACITIRDRLVEFAT
EHFEVSAEDVKFERNHVHIGDKETLTFAEMVLLAYQHRVSLSSTGYYKTPKIFYDRSKAWGRPFFYFALGASCSEVEIDI
LTGEYRVLRCDILHDVGQSINPAIDIGQIEGGFVQGMGWLTAEELVWDKKGNLASNSAANYKIPMAHDLPKQWSVKLFDR
KNEEQTIYNSKAVGEPPFMLAASVWCAINNAIASLGDYRKNPELTMPATPEAVLKSVMRMQGQEWEIASKADTDTITSLT
VTDDNCGIDDDKVKPQQVAHGKDINPTEVEGKLTDDQPEAIQNPNVSTARGPAHSE
>Mature_855_residues
SHHSSLFDSYSTRRQRPPKDKIGTQAKHDSAISHVMGTATYVDDMLKPQNTLHLAIGKSAHAHARVLNMDLSAVQAADGV
IDVITFKDLPAKTDIGAVFDGDPLMVDQITEYVGQTLFTVVATSHRAAKKAVLKAIVEYEPLPAILTIDEALKQEQFVRP
SHFMTRGDAQAELESAPTRIAGHIHMLGQEHFYLEGQVSYVIPCDDGGLEVYTSSQHPSEVQQLVAEVVDLPFHAVTTVV
RRMGGGFGGKETQAAAWACLCGIVAKRHNVPVSMRLDRQDDMVVTGKRHEFANRYDVGVNDAGQVLGVDMQLSGLCGYSP
DLSDAIVDRAMFHCDNAYYYPAAQIAGHRCKTHTVSNTAYRGFGGPQGLLTAEYMMDDIAYSLGKDPLQVRLANLYQNGQ
STHYGQPIEHFDLATIIQTLADDNDYAKRREQITVANRKAEAEGSDKRFGLALTPVKFGISFTVQTLNQAGALVHIYTDG
TIQINHGGTEMGQGLYIKIAQIVANEFDVDLDTVKVTATRTDKVPNTSPTAASSGTDMNGKAAQNACITIRDRLVEFATE
HFEVSAEDVKFERNHVHIGDKETLTFAEMVLLAYQHRVSLSSTGYYKTPKIFYDRSKAWGRPFFYFALGASCSEVEIDIL
TGEYRVLRCDILHDVGQSINPAIDIGQIEGGFVQGMGWLTAEELVWDKKGNLASNSAANYKIPMAHDLPKQWSVKLFDRK
NEEQTIYNSKAVGEPPFMLAASVWCAINNAIASLGDYRKNPELTMPATPEAVLKSVMRMQGQEWEIASKADTDTITSLTV
TDDNCGIDDDKVKPQQVAHGKDINPTEVEGKLTDDQPEAIQNPNVSTARGPAHSE

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=796, Percent_Identity=38.4422110552764, Blast_Score=554, Evalue=1e-157,
Organism=Homo sapiens, GI71773480, Length=776, Percent_Identity=34.9226804123711, Blast_Score=473, Evalue=1e-133,
Organism=Escherichia coli, GI1789230, Length=777, Percent_Identity=26.2548262548263, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI1789246, Length=819, Percent_Identity=24.5421245421245, Blast_Score=175, Evalue=9e-45,
Organism=Escherichia coli, GI1786478, Length=703, Percent_Identity=24.1820768136558, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540638, Length=773, Percent_Identity=37.6455368693402, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI32566215, Length=728, Percent_Identity=32.6923076923077, Blast_Score=339, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17539860, Length=740, Percent_Identity=32.027027027027, Blast_Score=315, Evalue=7e-86,
Organism=Drosophila melanogaster, GI17737937, Length=746, Percent_Identity=38.6058981233244, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24647199, Length=757, Percent_Identity=28.5336856010568, Blast_Score=278, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24647197, Length=760, Percent_Identity=28.4210526315789, Blast_Score=264, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24647193, Length=791, Percent_Identity=28.1921618204804, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24647195, Length=760, Percent_Identity=28.4210526315789, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24647201, Length=756, Percent_Identity=27.9100529100529, Blast_Score=257, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 93976; Mature: 93845

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHHSSLFDSYSTRRQRPPKDKIGTQAKHDSAISHVMGTATYVDDMLKPQNTLHLAIGKS
CCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
AHAHARVLNMDLSAVQAADGVIDVITFKDLPAKTDIGAVFDGDPLMVDQITEYVGQTLFT
CCCCEEEEECCHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
VVATSHRAAKKAVLKAIVEYEPLPAILTIDEALKQEQFVRPSHFMTRGDAQAELESAPTR
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCHHHEECCCCHHHHHHCCHH
IAGHIHMLGQEHFYLEGQVSYVIPCDDGGLEVYTSSQHPSEVQQLVAEVVDLPFHAVTTV
HHHEEEEECCCEEEEECEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHH
VRRMGGGFGGKETQAAAWACLCGIVAKRHNVPVSMRLDRQDDMVVTGKRHEFANRYDVGV
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCHHCCCCCCCCC
NDAGQVLGVDMQLSGLCGYSPDLSDAIVDRAMFHCDNAYYYPAAQIAGHRCKTHTVSNTA
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEECCHHHHCCCCCCEEECCCCC
YRGFGGPQGLLTAEYMMDDIAYSLGKDPLQVRLANLYQNGQSTHYGQPIEHFDLATIIQT
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LADDNDYAKRREQITVANRKAEAEGSDKRFGLALTPVKFGISFTVQTLNQAGALVHIYTD
HCCCCHHHHHHHHEEEECCCCCCCCCCCEEEEEECCEEECCEEEEEEHHCCCCEEEEEEC
GTIQINHGGTEMGQGLYIKIAQIVANEFDVDLDTVKVTATRTDKVPNTSPTAASSGTDMN
CEEEECCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCC
GKAAQNACITIRDRLVEFATEHFEVSAEDVKFERNHVHIGDKETLTFAEMVLLAYQHRVS
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHEEEECCEEECCCCCHHHHHHHHHHHHHHHCC
LSSTGYYKTPKIFYDRSKAWGRPFFYFALGASCSEVEIDILTGEYRVLRCDILHDVGQSI
CCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEEHHHHHCCCCC
NPAIDIGQIEGGFVQGMGWLTAEELVWDKKGNLASNSAANYKIPMAHDLPKQWSVKLFDR
CCCEEEECCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEECC
KNEEQTIYNSKAVGEPPFMLAASVWCAINNAIASLGDYRKNPELTMPATPEAVLKSVMRM
CCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHH
QGQEWEIASKADTDTITSLTVTDDNCGIDDDKVKPQQVAHGKDINPTEVEGKLTDDQPEA
CCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCCHH
IQNPNVSTARGPAHSE
HCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHHSSLFDSYSTRRQRPPKDKIGTQAKHDSAISHVMGTATYVDDMLKPQNTLHLAIGKS
CCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
AHAHARVLNMDLSAVQAADGVIDVITFKDLPAKTDIGAVFDGDPLMVDQITEYVGQTLFT
CCCCEEEEECCHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
VVATSHRAAKKAVLKAIVEYEPLPAILTIDEALKQEQFVRPSHFMTRGDAQAELESAPTR
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCHHHEECCCCHHHHHHCCHH
IAGHIHMLGQEHFYLEGQVSYVIPCDDGGLEVYTSSQHPSEVQQLVAEVVDLPFHAVTTV
HHHEEEEECCCEEEEECEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHH
VRRMGGGFGGKETQAAAWACLCGIVAKRHNVPVSMRLDRQDDMVVTGKRHEFANRYDVGV
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCHHCCCCCCCCC
NDAGQVLGVDMQLSGLCGYSPDLSDAIVDRAMFHCDNAYYYPAAQIAGHRCKTHTVSNTA
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEECCHHHHCCCCCCEEECCCCC
YRGFGGPQGLLTAEYMMDDIAYSLGKDPLQVRLANLYQNGQSTHYGQPIEHFDLATIIQT
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
LADDNDYAKRREQITVANRKAEAEGSDKRFGLALTPVKFGISFTVQTLNQAGALVHIYTD
HCCCCHHHHHHHHEEEECCCCCCCCCCCEEEEEECCEEECCEEEEEEHHCCCCEEEEEEC
GTIQINHGGTEMGQGLYIKIAQIVANEFDVDLDTVKVTATRTDKVPNTSPTAASSGTDMN
CEEEECCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCC
GKAAQNACITIRDRLVEFATEHFEVSAEDVKFERNHVHIGDKETLTFAEMVLLAYQHRVS
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHEEEECCEEECCCCCHHHHHHHHHHHHHHHCC
LSSTGYYKTPKIFYDRSKAWGRPFFYFALGASCSEVEIDILTGEYRVLRCDILHDVGQSI
CCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEEHHHHHCCCCC
NPAIDIGQIEGGFVQGMGWLTAEELVWDKKGNLASNSAANYKIPMAHDLPKQWSVKLFDR
CCCEEEECCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEECC
KNEEQTIYNSKAVGEPPFMLAASVWCAINNAIASLGDYRKNPELTMPATPEAVLKSVMRM
CCCCHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHH
QGQEWEIASKADTDTITSLTVTDDNCGIDDDKVKPQQVAHGKDINPTEVEGKLTDDQPEA
CCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCCHH
IQNPNVSTARGPAHSE
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]