Click here to switch to the map view.

The map label for this gene is sthA [H]

Identifier: 93005864

GI number: 93005864

Start: 1236119

End: 1237762

Strand: Direct

Name: sthA [H]

Synonym: Pcryo_1036

Alternate gene names: 93005864

Gene position: 1236119-1237762 (Clockwise)

Preceding gene: 93005863

Following gene: 93005869

Centisome position: 40.4

GC content: 43.19

Gene sequence:

>1644_bases
ATGGGAAGCAAAACGATAGGCGACGCGACCAATGATACTGGTAAAGATATTAAAACTGAGGTATCTAATAAGGAAAGTGG
TCGTGTGCCAAACCCCGAGCATACTGAGGGTAAAAATAAAAAAGAGAAAATCGAACAAACGCATGAGCAAGTTACTGAAG
ACATCATGCATCATCCAGATTTGGTCAATCCACTAGATGATACACGTATCGACGTAAAATCGGGCTTTACTAAGGATTCA
CAACGTCTAAAAAGCGATAAGCATGAGTTTGAATATGATGCGGTCGTATTAGGTGCAGGTCCTGCGGGTGAAGCTGCTGC
CATGAAACTTGCCAAATCGGGCAAGAAGGTAGTGGTTATTGACCCGCGCGAGCAAGTAGGCGGTAACTGTACTCACGTTG
GTACGATTCCAAGTAAAGCTTTGCGCCAGTCCGTTTTTAACTTGATTAACTTTCGCCGTGACCAAATGTTTACTAAGGCC
ATGGACTATCATCAAGTCCCGCTGAATATCGTGTTAGCTAAAGCTCGAAAAGTGATTTTGCAACAGGTTCAGACGCACAC
CAGATTCTATGAGCGCAACCAAATCGAAGTGATTCATGGTTGGGCAAATTTTATCGATAAAAACACGATACGTATCGAAA
TTGATGAAAATACCTTTGAAACGATCACCTTTAACAAAGCTATCATTACGGTCGGCAGCCGTCCATACCGCCCTGATATC
TTAGACTTCAATCATCCACGCGTATTTGATTCTGATAAAATCCTACAGATGGATTATGTGGTTAAGAAAATCATTATTTA
TGGCGCTGGCGTGATTGGCTGTGAGTATGCGTCTATCTTCACCGGTCTTGGCTATAAAGTAGATTTGATTAATAACCAAA
ACCAACTGCTAAGCTATTTGGATAGTGAAATCAGTGACGCCATCGCTCATGACTTTCGTCAATTTGGCGTAGTTATCCGT
AGCAATGAAGAGATTGACCATTTAGAAACGCATGATGACTGTGTGATTTTGCATCTAAAAAGTGGTAAGAAAATCAAGTC
AGACGCTATTTTATGGTCGAATGGACGCTCAGGTAATACTGAAGGCTTAAATTTAGAATGCCTAGGTCTAGAAGCCAATA
GCCGCGGTCAGCTGAAAGTTGATGATACTTACTGTACCGAAGTTGAAAACATCTATGCAGCGGGCGATGTTATCGGTTGG
CCTTCATTAGCTTCTGCTGCTTACGACCAAGGGCGCTGTGCGGCGGCATTTATGGTCGGTGACCGTGATGCAGAGCCCGT
ATCGAGCGTACCAACAGGTATTTATACTATTCCTGAGATTTCATGTATCGGTAAAACGGAACAAGAATTAACCGATGCCA
AAGTTCCTTATGAGGTCGGTCAGGCTTTCTTTAAGCATCTTGCACGCGCGCAAATCATTGGTGAGCGTTCAGGCGTTCTA
AAAATCTTGTTCCACCGTGAGACGTTAGAGATTTTAGGGATTCACTGCTACGGCAATCATGCCTCTGAGATTATCCACAT
TGGGCAAGCAGTGATGAAATGTAATGCCACGCTTGAATACTTTGTCAATACCACCTTTAACTACCCAACAATGGCAGAAG
CCTATCGCGTTGCGGCATTGAATGGTCTTAATCGGGTGTTCTAA

Upstream 100 bases:

>100_bases
GACACACTTTAGCACCATGGATATTTTTATCTAGACATTTATAAAGATGAAGGCATCCGCGAGCTAAAAAACAGATTCAT
AAATGAATAAAGAGGACACG

Downstream 100 bases:

>100_bases
CGATTAATGATATTAAACTGAGTCAATAAAAAAGCGTCTGTAATTATACAGGCGCTTTTTTTATCATGGTTAATATGGTT
AATATGTTATTAACTTTAAT

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MGSKTIGDATNDTGKDIKTEVSNKESGRVPNPEHTEGKNKKEKIEQTHEQVTEDIMHHPDLVNPLDDTRIDVKSGFTKDS
QRLKSDKHEFEYDAVVLGAGPAGEAAAMKLAKSGKKVVVIDPREQVGGNCTHVGTIPSKALRQSVFNLINFRRDQMFTKA
MDYHQVPLNIVLAKARKVILQQVQTHTRFYERNQIEVIHGWANFIDKNTIRIEIDENTFETITFNKAIITVGSRPYRPDI
LDFNHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNQNQLLSYLDSEISDAIAHDFRQFGVVIR
SNEEIDHLETHDDCVILHLKSGKKIKSDAILWSNGRSGNTEGLNLECLGLEANSRGQLKVDDTYCTEVENIYAAGDVIGW
PSLASAAYDQGRCAAAFMVGDRDAEPVSSVPTGIYTIPEISCIGKTEQELTDAKVPYEVGQAFFKHLARAQIIGERSGVL
KILFHRETLEILGIHCYGNHASEIIHIGQAVMKCNATLEYFVNTTFNYPTMAEAYRVAALNGLNRVF

Sequences:

>Translated_547_residues
MGSKTIGDATNDTGKDIKTEVSNKESGRVPNPEHTEGKNKKEKIEQTHEQVTEDIMHHPDLVNPLDDTRIDVKSGFTKDS
QRLKSDKHEFEYDAVVLGAGPAGEAAAMKLAKSGKKVVVIDPREQVGGNCTHVGTIPSKALRQSVFNLINFRRDQMFTKA
MDYHQVPLNIVLAKARKVILQQVQTHTRFYERNQIEVIHGWANFIDKNTIRIEIDENTFETITFNKAIITVGSRPYRPDI
LDFNHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNQNQLLSYLDSEISDAIAHDFRQFGVVIR
SNEEIDHLETHDDCVILHLKSGKKIKSDAILWSNGRSGNTEGLNLECLGLEANSRGQLKVDDTYCTEVENIYAAGDVIGW
PSLASAAYDQGRCAAAFMVGDRDAEPVSSVPTGIYTIPEISCIGKTEQELTDAKVPYEVGQAFFKHLARAQIIGERSGVL
KILFHRETLEILGIHCYGNHASEIIHIGQAVMKCNATLEYFVNTTFNYPTMAEAYRVAALNGLNRVF
>Mature_546_residues
GSKTIGDATNDTGKDIKTEVSNKESGRVPNPEHTEGKNKKEKIEQTHEQVTEDIMHHPDLVNPLDDTRIDVKSGFTKDSQ
RLKSDKHEFEYDAVVLGAGPAGEAAAMKLAKSGKKVVVIDPREQVGGNCTHVGTIPSKALRQSVFNLINFRRDQMFTKAM
DYHQVPLNIVLAKARKVILQQVQTHTRFYERNQIEVIHGWANFIDKNTIRIEIDENTFETITFNKAIITVGSRPYRPDIL
DFNHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNQNQLLSYLDSEISDAIAHDFRQFGVVIRS
NEEIDHLETHDDCVILHLKSGKKIKSDAILWSNGRSGNTEGLNLECLGLEANSRGQLKVDDTYCTEVENIYAAGDVIGWP
SLASAAYDQGRCAAAFMVGDRDAEPVSSVPTGIYTIPEISCIGKTEQELTDAKVPYEVGQAFFKHLARAQIIGERSGVLK
ILFHRETLEILGIHCYGNHASEIIHIGQAVMKCNATLEYFVNTTFNYPTMAEAYRVAALNGLNRVF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=28.2105263157895, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=24.6187363834423, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI22035672, Length=490, Percent_Identity=25.7142857142857, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI291045266, Length=527, Percent_Identity=23.9089184060721, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI148277065, Length=480, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI148277071, Length=480, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI33519430, Length=480, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI33519428, Length=480, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI33519426, Length=480, Percent_Identity=24.1666666666667, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI291045268, Length=521, Percent_Identity=22.4568138195777, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=57.3275862068966, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=28.322440087146, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=27.9017857142857, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=26.5909090909091, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=29.0393013100437, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=23.1914893617021, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=339, Percent_Identity=25.3687315634218, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71983419, Length=339, Percent_Identity=25.3687315634218, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=23.1237322515213, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=491, Percent_Identity=26.4765784114053, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=24.1452991452991, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=26.3498920086393, Blast_Score=140, Evalue=5e-34,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=29.4623655913978, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24640551, Length=504, Percent_Identity=25.7936507936508, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=26.7782426778243, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=26.7782426778243, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=26.4887063655031, Blast_Score=135, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 61024; Mature: 60893

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKTIGDATNDTGKDIKTEVSNKESGRVPNPEHTEGKNKKEKIEQTHEQVTEDIMHHPD
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
LVNPLDDTRIDVKSGFTKDSQRLKSDKHEFEYDAVVLGAGPAGEAAAMKLAKSGKKVVVI
CCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEE
DPREQVGGNCTHVGTIPSKALRQSVFNLINFRRDQMFTKAMDYHQVPLNIVLAKARKVIL
CCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QQVQTHTRFYERNQIEVIHGWANFIDKNTIRIEIDENTFETITFNKAIITVGSRPYRPDI
HHHHHHHHHHHCCCEEEEECHHHHCCCCEEEEEECCCCEEEEEECEEEEEECCCCCCCCC
LDFNHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNQNQLLSYL
CCCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
DSEISDAIAHDFRQFGVVIRSNEEIDHLETHDDCVILHLKSGKKIKSDAILWSNGRSGNT
HHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCEEEEEECCCCEECCCEEEEECCCCCCC
EGLNLECLGLEANSRGQLKVDDTYCTEVENIYAAGDVIGWPSLASAAYDQGRCAAAFMVG
CCCEEEEEEECCCCCCCEEECCHHHHHHHHHEECCCCCCCCHHHHHHCCCCCEEEEEEEC
DRDAEPVSSVPTGIYTIPEISCIGKTEQELTDAKVPYEVGQAFFKHLARAQIIGERSGVL
CCCCCCHHHCCCCEEECCCEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
KILFHRETLEILGIHCYGNHASEIIHIGQAVMKCNATLEYFVNTTFNYPTMAEAYRVAAL
EEEEECCEEEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHH
NGLNRVF
HHHHHCC
>Mature Secondary Structure 
GSKTIGDATNDTGKDIKTEVSNKESGRVPNPEHTEGKNKKEKIEQTHEQVTEDIMHHPD
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
LVNPLDDTRIDVKSGFTKDSQRLKSDKHEFEYDAVVLGAGPAGEAAAMKLAKSGKKVVVI
CCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEE
DPREQVGGNCTHVGTIPSKALRQSVFNLINFRRDQMFTKAMDYHQVPLNIVLAKARKVIL
CCHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QQVQTHTRFYERNQIEVIHGWANFIDKNTIRIEIDENTFETITFNKAIITVGSRPYRPDI
HHHHHHHHHHHCCCEEEEECHHHHCCCCEEEEEECCCCEEEEEECEEEEEECCCCCCCCC
LDFNHPRVFDSDKILQMDYVVKKIIIYGAGVIGCEYASIFTGLGYKVDLINNQNQLLSYL
CCCCCCCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHH
DSEISDAIAHDFRQFGVVIRSNEEIDHLETHDDCVILHLKSGKKIKSDAILWSNGRSGNT
HHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCEEEEEECCCCEECCCEEEEECCCCCCC
EGLNLECLGLEANSRGQLKVDDTYCTEVENIYAAGDVIGWPSLASAAYDQGRCAAAFMVG
CCCEEEEEEECCCCCCCEEECCHHHHHHHHHEECCCCCCCCHHHHHHCCCCCEEEEEEEC
DRDAEPVSSVPTGIYTIPEISCIGKTEQELTDAKVPYEVGQAFFKHLARAQIIGERSGVL
CCCCCCHHHCCCCEEECCCEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
KILFHRETLEILGIHCYGNHASEIIHIGQAVMKCNATLEYFVNTTFNYPTMAEAYRVAAL
EEEEECCEEEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHH
NGLNRVF
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA