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The map label for this gene is betA [H]

Identifier: 93005702

GI number: 93005702

Start: 1033794

End: 1035491

Strand: Direct

Name: betA [H]

Synonym: Pcryo_0874

Alternate gene names: 93005702

Gene position: 1033794-1035491 (Clockwise)

Preceding gene: 93005701

Following gene: 93005703

Centisome position: 33.79

GC content: 48.23

Gene sequence:

>1698_bases
ATGACATCAACCACACCTGAGTATGACTACATCATCGTTGGCGCAGGATCAGCAGGAAATGTGCTGGCTACACGCTTGAC
CGAAGATGCCAGTATTAAAGTGCTGCTGCTAGAAGCGGGTCGCCCAGACCATCGTTTGGATTTCCGCACCCAAATGCCAG
CGGCGCTCGCAATGCCGTTACAAGGAACGACTTATAACTGGGGCTACAAAACCGATCCTGAGCCGAATATGAATAATCGT
GTGATGGACTGCGGTCGCGGTAAAGGACTTGGCGGCTCGTCATTGATTAACGGTATGTGTTATATCCGTGGTAATGCACT
AGATTTTGATGACTGGTCTGAGATTAAAGGCTTAGAAGATTGGACGTATCTGGATTGCCTGCCGTATTTTAAAAAGTTAG
AAAACCGCGATGCTGGTGAGAACAACTATCATGGTGTGGGTGGTCCTGTTGAGATGACGACCTCAAAACCAGGGGTCAAT
CCACTGTTTCAAGCGATGATTGAAGCAGGTGTGCAAGCTGGCTATCCAAGTACCGACGATTTAAACGGCTATCAGCAAGA
AGGCTTTGGGCCGATGGATCGTTTCGTGACGCCTAATGGTCGCCGTGCCTCAACGTCCCGTGGCTATCTGGACCGTGCCA
AACCGCGCAGCAATATCACGATTTTGACGGGTGCATTGACCGATGTAATCTTGTTCGATGGTAAGCGTGCCATCGGTGTC
AAAGTCGAGCATCAAGGTCAAACCAAGAACTTTCATGCCTCTCGTGAAGTGATTGTCTCATCAGGTGCGATTGCTTCGCC
ACAATTATTGCAGCGTTCTGGTATTGGCCCTGGTCAATGGTTAAAAGATCTAGGTGTTAATGAAATTCTAGATTTACCAG
GCGTTGGTAATAACTTGCAAGATCATTTAGAGCTGTATATGCAGTATGAATGTAAGCTGCCAGTGTCGATTGCACCTGCC
AATAAATGGTGGAACAAGCCCGCCATCGGTGCTGAGTGGTTATTCAATGGTACTGGGCTGGGCGCGTCAAATCAGTTCGA
AGGTGGCGGCTTTATTCGTACCGATGAGAAATTTACCCATCCTAATATTCAGTACCATTTCTTGCCATTAGCAGTACGCT
ACGATGGTCGTAGTGCGGTTAAATCACATAGTTTCCAAGCACACGTGGGCTCATTACGCTCGCCAAGTCGTGGTCGCGTC
AAGCTAACCTCAAAAGATCCAAGCGCGCATCCGAGTATCTTGTTTAACTATATGTCTCATGATCAAGATTGGCAAGAGTT
CCGTGCTGCCATGCGCATCACTCGTGAGATTATGCATCAGCCAGCGCTTGACCCTTATCGTGGTCGCTCGATTGCACCAA
CGGATGATTTAGTGACGGACGCCCAGTTAGACGAGTATGTCCGTAATCACAGCGAGACGGCTTATCATCCATCTTGTACC
TGTGCGATGGGCGAAGACAATGATTCGGTCGTCAATGGCGAAGGTTTGGTAAATGGTATCGATGGCTTGCGCGTGGTTGA
TGCGTCAATTATGCCAAATATCATCAGTGGCAATCTAAACGCGACCACCATTATGCTGGCAGAAAAAATCGTCGATAAAA
TGCGCGGTGTGCAGTTGCCACGTTCGACGGTAGATTATTATGTCGCTAATGGTGCACCATTGAGAGCTGAGCCGATGCGT
GCTTATGGTTCTGTTTAA

Upstream 100 bases:

>100_bases
ATTCTTAATCAGTAAAGTGGTTCAGTAGTAGAGCTAATTTGTTCTTTGTTCGACTTTACTGATAGTAAATGATTTATTTT
TCAATATTATGGAGCGTTTT

Downstream 100 bases:

>100_bases
ATTAAATATTAATAAGAAGGCCTTTTTATAAAGGTCTTTTTTATCCGCGCTACTGTTTTAGAAAACGAACACCATTAAAA
TTGATTTTTTAATGACTTAC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MTSTTPEYDYIIVGAGSAGNVLATRLTEDASIKVLLLEAGRPDHRLDFRTQMPAALAMPLQGTTYNWGYKTDPEPNMNNR
VMDCGRGKGLGGSSLINGMCYIRGNALDFDDWSEIKGLEDWTYLDCLPYFKKLENRDAGENNYHGVGGPVEMTTSKPGVN
PLFQAMIEAGVQAGYPSTDDLNGYQQEGFGPMDRFVTPNGRRASTSRGYLDRAKPRSNITILTGALTDVILFDGKRAIGV
KVEHQGQTKNFHASREVIVSSGAIASPQLLQRSGIGPGQWLKDLGVNEILDLPGVGNNLQDHLELYMQYECKLPVSIAPA
NKWWNKPAIGAEWLFNGTGLGASNQFEGGGFIRTDEKFTHPNIQYHFLPLAVRYDGRSAVKSHSFQAHVGSLRSPSRGRV
KLTSKDPSAHPSILFNYMSHDQDWQEFRAAMRITREIMHQPALDPYRGRSIAPTDDLVTDAQLDEYVRNHSETAYHPSCT
CAMGEDNDSVVNGEGLVNGIDGLRVVDASIMPNIISGNLNATTIMLAEKIVDKMRGVQLPRSTVDYYVANGAPLRAEPMR
AYGSV

Sequences:

>Translated_565_residues
MTSTTPEYDYIIVGAGSAGNVLATRLTEDASIKVLLLEAGRPDHRLDFRTQMPAALAMPLQGTTYNWGYKTDPEPNMNNR
VMDCGRGKGLGGSSLINGMCYIRGNALDFDDWSEIKGLEDWTYLDCLPYFKKLENRDAGENNYHGVGGPVEMTTSKPGVN
PLFQAMIEAGVQAGYPSTDDLNGYQQEGFGPMDRFVTPNGRRASTSRGYLDRAKPRSNITILTGALTDVILFDGKRAIGV
KVEHQGQTKNFHASREVIVSSGAIASPQLLQRSGIGPGQWLKDLGVNEILDLPGVGNNLQDHLELYMQYECKLPVSIAPA
NKWWNKPAIGAEWLFNGTGLGASNQFEGGGFIRTDEKFTHPNIQYHFLPLAVRYDGRSAVKSHSFQAHVGSLRSPSRGRV
KLTSKDPSAHPSILFNYMSHDQDWQEFRAAMRITREIMHQPALDPYRGRSIAPTDDLVTDAQLDEYVRNHSETAYHPSCT
CAMGEDNDSVVNGEGLVNGIDGLRVVDASIMPNIISGNLNATTIMLAEKIVDKMRGVQLPRSTVDYYVANGAPLRAEPMR
AYGSV
>Mature_564_residues
TSTTPEYDYIIVGAGSAGNVLATRLTEDASIKVLLLEAGRPDHRLDFRTQMPAALAMPLQGTTYNWGYKTDPEPNMNNRV
MDCGRGKGLGGSSLINGMCYIRGNALDFDDWSEIKGLEDWTYLDCLPYFKKLENRDAGENNYHGVGGPVEMTTSKPGVNP
LFQAMIEAGVQAGYPSTDDLNGYQQEGFGPMDRFVTPNGRRASTSRGYLDRAKPRSNITILTGALTDVILFDGKRAIGVK
VEHQGQTKNFHASREVIVSSGAIASPQLLQRSGIGPGQWLKDLGVNEILDLPGVGNNLQDHLELYMQYECKLPVSIAPAN
KWWNKPAIGAEWLFNGTGLGASNQFEGGGFIRTDEKFTHPNIQYHFLPLAVRYDGRSAVKSHSFQAHVGSLRSPSRGRVK
LTSKDPSAHPSILFNYMSHDQDWQEFRAAMRITREIMHQPALDPYRGRSIAPTDDLVTDAQLDEYVRNHSETAYHPSCTC
AMGEDNDSVVNGEGLVNGIDGLRVVDASIMPNIISGNLNATTIMLAEKIVDKMRGVQLPRSTVDYYVANGAPLRAEPMRA
YGSV

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=537, Percent_Identity=46.7411545623836, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1786503, Length=554, Percent_Identity=70.0361010830325, Blast_Score=823, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=563, Percent_Identity=45.6483126110124, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24642048, Length=589, Percent_Identity=35.1443123938879, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24642042, Length=571, Percent_Identity=35.5516637478109, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24642059, Length=578, Percent_Identity=35.2941176470588, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=33.3333333333333, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=33.3333333333333, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17137792, Length=553, Percent_Identity=34.5388788426763, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642055, Length=576, Percent_Identity=33.8541666666667, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=33.6221837088388, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24642039, Length=579, Percent_Identity=34.8877374784111, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=33.8568935427574, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24642051, Length=565, Percent_Identity=30.6194690265487, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=33.7979094076655, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24642035, Length=579, Percent_Identity=30.9153713298791, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24642037, Length=572, Percent_Identity=31.8181818181818, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24645930, Length=569, Percent_Identity=26.3620386643234, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62096; Mature: 61964

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTTPEYDYIIVGAGSAGNVLATRLTEDASIKVLLLEAGRPDHRLDFRTQMPAALAMPL
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHCCCHHHCCCC
QGTTYNWGYKTDPEPNMNNRVMDCGRGKGLGGSSLINGMCYIRGNALDFDDWSEIKGLED
CCCEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHCCEEEEECCCCCCCCHHHHCCCCC
WTYLDCLPYFKKLENRDAGENNYHGVGGPVEMTTSKPGVNPLFQAMIEAGVQAGYPSTDD
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
LNGYQQEGFGPMDRFVTPNGRRASTSRGYLDRAKPRSNITILTGALTDVILFDGKRAIGV
CCCHHHCCCCCHHHCCCCCCCCCCCCCCCHHCCCCCCCEEEEECCCEEEEEECCCEEEEE
KVEHQGQTKNFHASREVIVSSGAIASPQLLQRSGIGPGQWLKDLGVNEILDLPGVGNNLQ
EEECCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCHHHHHHHCCHHHHHCCCCCCCCHH
DHLELYMQYECKLPVSIAPANKWWNKPAIGAEWLFNGTGLGASNQFEGGGFIRTDEKFTH
HHHHHHEEEECCCCEEECCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCC
PNIQYHFLPLAVRYDGRSAVKSHSFQAHVGSLRSPSRGRVKLTSKDPSAHPSILFNYMSH
CCCEEEEEEEEEEECCHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHC
DQDWQEFRAAMRITREIMHQPALDPYRGRSIAPTDDLVTDAQLDEYVRNHSETAYHPSCT
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
CAMGEDNDSVVNGEGLVNGIDGLRVVDASIMPNIISGNLNATTIMLAEKIVDKMRGVQLP
EEECCCCCCEECCCCCEECCCCCEEEEHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCCC
RSTVDYYVANGAPLRAEPMRAYGSV
CHHHCEEEECCCCCCCCHHHHHCCC
>Mature Secondary Structure 
TSTTPEYDYIIVGAGSAGNVLATRLTEDASIKVLLLEAGRPDHRLDFRTQMPAALAMPL
CCCCCCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCHHHCCCHHHCCCC
QGTTYNWGYKTDPEPNMNNRVMDCGRGKGLGGSSLINGMCYIRGNALDFDDWSEIKGLED
CCCEEECCCCCCCCCCCCCCEEECCCCCCCCHHHHHCCEEEEECCCCCCCCHHHHCCCCC
WTYLDCLPYFKKLENRDAGENNYHGVGGPVEMTTSKPGVNPLFQAMIEAGVQAGYPSTDD
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
LNGYQQEGFGPMDRFVTPNGRRASTSRGYLDRAKPRSNITILTGALTDVILFDGKRAIGV
CCCHHHCCCCCHHHCCCCCCCCCCCCCCCHHCCCCCCCEEEEECCCEEEEEECCCEEEEE
KVEHQGQTKNFHASREVIVSSGAIASPQLLQRSGIGPGQWLKDLGVNEILDLPGVGNNLQ
EEECCCCCCCCCCCCEEEEECCCCCCHHHHHHCCCCHHHHHHHCCHHHHHCCCCCCCCHH
DHLELYMQYECKLPVSIAPANKWWNKPAIGAEWLFNGTGLGASNQFEGGGFIRTDEKFTH
HHHHHHEEEECCCCEEECCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCC
PNIQYHFLPLAVRYDGRSAVKSHSFQAHVGSLRSPSRGRVKLTSKDPSAHPSILFNYMSH
CCCEEEEEEEEEEECCHHHHHHCCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHC
DQDWQEFRAAMRITREIMHQPALDPYRGRSIAPTDDLVTDAQLDEYVRNHSETAYHPSCT
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
CAMGEDNDSVVNGEGLVNGIDGLRVVDASIMPNIISGNLNATTIMLAEKIVDKMRGVQLP
EEECCCCCCEECCCCCEECCCCCEEEEHHHCCHHHCCCCCHHHHHHHHHHHHHHHCCCCC
RSTVDYYVANGAPLRAEPMRAYGSV
CHHHCEEEECCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA