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The map label for this gene is cvrA [H]

Identifier: 93005364

GI number: 93005364

Start: 630722

End: 631996

Strand: Reverse

Name: cvrA [H]

Synonym: Pcryo_0534

Alternate gene names: 93005364

Gene position: 631996-630722 (Counterclockwise)

Preceding gene: 93005365

Following gene: 93005360

Centisome position: 20.65

GC content: 43.29

Gene sequence:

>1275_bases
ATGGACCCTACGAGCAGCCTGACCATACTCGAAATTAGCGCGATATTTTTATCTATCACTGCCCTATTAACTTACGTTAA
CCATCGATTTATTGGCCTACCAACAACTATCGGTGTAATGGTTATCTCGATATTATTGTCGATCGGGGCGATATTTTTAG
GATTTTTAGGGTTTGATCAGCTTATTGATTATGAAGTCAGTCTATTAGGCCAGCTTGATTTCACTGAAGTCTTACTTGAT
GGCATGCTGTCTATGCTGTTATTTGCTGCCGCTTTGCACGTCAATATTGGTGATCTAAAACGTTATAAGCTGCCTATTGG
CATTCTAGCTTTCATAGGTACTTTAGTATCAGCACTGCTGATTGCAGGTGCTCTATATCTAATGTTGCCGCTGTTTGGTT
TCGAGCTGTCTTTTTTATGGTGCTTACTATTTGGCGCTTTGATATCTCCAACCGACCCTATTGCAGTGATGGGTATTTTA
GACTCTGCTGGCGCCCCAAAAAGCATAGAAACGGTCATCGCGGGCGAATCGCTATTTAACGATGGTATCGGCGTCGTCAT
CTTTGTACTGCTGCTCGGTATTTTATCGAGTGGTGATATCCCAACCGCCAATTATGTGGTGCACACCTTGGCAGTCGAGG
CTGGTGGCGGTATTATTTTTGGCTTAGTACTTGGCGCGATTTTATATTACATGCTCAAAAGCATCGATAGCTATCAAGAA
GAGGTTCTATTGACCCTTGCTGGTGTCATAGGCGGCTATGCGCTGGCCAGTCATTGGCATTTATCGGGACCACTAGCAAT
GGTAATGATGGGGCTGATGCTTGGTAATCGCGGACGAGCACTAGCGATGAGTGATAAGACGCGCCATTATGTTGATTTGT
TTTGGGAATTGATCGATGAGATTTTGAACGCAATTTTATTTGTATTAATCGGTCTTGAAGTGGTGATGATTGCTTATTCA
GCCAATTTATTTATCGCTGGCGCTTTAACGATTGTGATTGCCTTACTTGCTCGATTTATTGTGGTCGGCATGACCACCAA
AACCTTTCATCGACAACTTGACTTGCCAGCAGGGGCTTGGAAGGTGCTAACATGGGGTGGACTACGAGGTGGTATTTCAG
TTGCTTTAGTATTGCAACTCCCAACAGGATCTGAACGCGATATACTATTGGCCCTAACTTATGCAGTCGTTATATTCTCT
ATACTGGTACAAGGGTTAAGTGTAGGCAAGGTCGCCAAAAGCATTCGTACTGATGAAAAAACAGCCAATATATAA

Upstream 100 bases:

>100_bases
GTTAGTGATTTTGATGCCCATATTCGTCAGGCACTACAAGCCCAATCGAAACAAGTCAGAGCATAGTTGACACCTTTTAT
TACCCACTTGAGACTTTTTT

Downstream 100 bases:

>100_bases
ATCTTAGATTACGTTATTTATAAAAAAGCCAGTTTAAGATAAATATCTTAAGCTGGCTTTTTAAATTGTCATTTGAAATT
AAGGAAACCTGATTAGATTA

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDPTSSLTILEISAIFLSITALLTYVNHRFIGLPTTIGVMVISILLSIGAIFLGFLGFDQLIDYEVSLLGQLDFTEVLLD
GMLSMLLFAAALHVNIGDLKRYKLPIGILAFIGTLVSALLIAGALYLMLPLFGFELSFLWCLLFGALISPTDPIAVMGIL
DSAGAPKSIETVIAGESLFNDGIGVVIFVLLLGILSSGDIPTANYVVHTLAVEAGGGIIFGLVLGAILYYMLKSIDSYQE
EVLLTLAGVIGGYALASHWHLSGPLAMVMMGLMLGNRGRALAMSDKTRHYVDLFWELIDEILNAILFVLIGLEVVMIAYS
ANLFIAGALTIVIALLARFIVVGMTTKTFHRQLDLPAGAWKVLTWGGLRGGISVALVLQLPTGSERDILLALTYAVVIFS
ILVQGLSVGKVAKSIRTDEKTANI

Sequences:

>Translated_424_residues
MDPTSSLTILEISAIFLSITALLTYVNHRFIGLPTTIGVMVISILLSIGAIFLGFLGFDQLIDYEVSLLGQLDFTEVLLD
GMLSMLLFAAALHVNIGDLKRYKLPIGILAFIGTLVSALLIAGALYLMLPLFGFELSFLWCLLFGALISPTDPIAVMGIL
DSAGAPKSIETVIAGESLFNDGIGVVIFVLLLGILSSGDIPTANYVVHTLAVEAGGGIIFGLVLGAILYYMLKSIDSYQE
EVLLTLAGVIGGYALASHWHLSGPLAMVMMGLMLGNRGRALAMSDKTRHYVDLFWELIDEILNAILFVLIGLEVVMIAYS
ANLFIAGALTIVIALLARFIVVGMTTKTFHRQLDLPAGAWKVLTWGGLRGGISVALVLQLPTGSERDILLALTYAVVIFS
ILVQGLSVGKVAKSIRTDEKTANI
>Mature_424_residues
MDPTSSLTILEISAIFLSITALLTYVNHRFIGLPTTIGVMVISILLSIGAIFLGFLGFDQLIDYEVSLLGQLDFTEVLLD
GMLSMLLFAAALHVNIGDLKRYKLPIGILAFIGTLVSALLIAGALYLMLPLFGFELSFLWCLLFGALISPTDPIAVMGIL
DSAGAPKSIETVIAGESLFNDGIGVVIFVLLLGILSSGDIPTANYVVHTLAVEAGGGIIFGLVLGAILYYMLKSIDSYQE
EVLLTLAGVIGGYALASHWHLSGPLAMVMMGLMLGNRGRALAMSDKTRHYVDLFWELIDEILNAILFVLIGLEVVMIAYS
ANLFIAGALTIVIALLARFIVVGMTTKTFHRQLDLPAGAWKVLTWGGLRGGISVALVLQLPTGSERDILLALTYAVVIFS
ILVQGLSVGKVAKSIRTDEKTANI

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=337, Percent_Identity=24.3323442136499, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI15529998, Length=316, Percent_Identity=24.6835443037975, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI294997330, Length=355, Percent_Identity=21.9718309859155, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790501, Length=321, Percent_Identity=24.9221183800623, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71987559, Length=327, Percent_Identity=24.7706422018349, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71987545, Length=327, Percent_Identity=24.7706422018349, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=333, Percent_Identity=24.9249249249249, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=333, Percent_Identity=24.9249249249249, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999819, Length=333, Percent_Identity=24.9249249249249, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=333, Percent_Identity=23.1231231231231, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71987535, Length=333, Percent_Identity=23.1231231231231, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71990924, Length=337, Percent_Identity=25.2225519287834, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25150332, Length=312, Percent_Identity=24.0384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=337, Percent_Identity=25.2225519287834, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147678, Length=297, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=339, Percent_Identity=23.598820058997, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=339, Percent_Identity=23.598820058997, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993590, Length=350, Percent_Identity=25.4285714285714, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71993582, Length=350, Percent_Identity=25.4285714285714, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71980847, Length=328, Percent_Identity=24.6951219512195, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=327, Percent_Identity=25.3822629969419, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221510740, Length=327, Percent_Identity=24.4648318042813, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585580, Length=327, Percent_Identity=24.4648318042813, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585578, Length=327, Percent_Identity=24.4648318042813, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281364513, Length=371, Percent_Identity=25.6064690026954, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221473212, Length=371, Percent_Identity=25.6064690026954, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221473215, Length=371, Percent_Identity=25.6064690026954, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221473222, Length=371, Percent_Identity=25.6064690026954, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281360447, Length=361, Percent_Identity=27.4238227146814, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221510734, Length=325, Percent_Identity=24.3076923076923, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI221510738, Length=325, Percent_Identity=24.3076923076923, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510736, Length=325, Percent_Identity=24.3076923076923, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221510732, Length=325, Percent_Identity=24.3076923076923, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 45334; Mature: 45334

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPTSSLTILEISAIFLSITALLTYVNHRFIGLPTTIGVMVISILLSIGAIFLGFLGFDQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIDYEVSLLGQLDFTEVLLDGMLSMLLFAAALHVNIGDLKRYKLPIGILAFIGTLVSALL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHH
IAGALYLMLPLFGFELSFLWCLLFGALISPTDPIAVMGILDSAGAPKSIETVIAGESLFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCCCHHHHHHCCHHHHH
DGIGVVIFVLLLGILSSGDIPTANYVVHTLAVEAGGGIIFGLVLGAILYYMLKSIDSYQE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVLLTLAGVIGGYALASHWHLSGPLAMVMMGLMLGNRGRALAMSDKTRHYVDLFWELIDE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
ILNAILFVLIGLEVVMIAYSANLFIAGALTIVIALLARFIVVGMTTKTFHRQLDLPAGAW
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCE
KVLTWGGLRGGISVALVLQLPTGSERDILLALTYAVVIFSILVQGLSVGKVAKSIRTDEK
EEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
TANI
CCCC
>Mature Secondary Structure
MDPTSSLTILEISAIFLSITALLTYVNHRFIGLPTTIGVMVISILLSIGAIFLGFLGFDQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIDYEVSLLGQLDFTEVLLDGMLSMLLFAAALHVNIGDLKRYKLPIGILAFIGTLVSALL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHH
IAGALYLMLPLFGFELSFLWCLLFGALISPTDPIAVMGILDSAGAPKSIETVIAGESLFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCCCCHHHHHHCCHHHHH
DGIGVVIFVLLLGILSSGDIPTANYVVHTLAVEAGGGIIFGLVLGAILYYMLKSIDSYQE
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVLLTLAGVIGGYALASHWHLSGPLAMVMMGLMLGNRGRALAMSDKTRHYVDLFWELIDE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
ILNAILFVLIGLEVVMIAYSANLFIAGALTIVIALLARFIVVGMTTKTFHRQLDLPAGAW
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCE
KVLTWGGLRGGISVALVLQLPTGSERDILLALTYAVVIFSILVQGLSVGKVAKSIRTDEK
EEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
TANI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA