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The map label for this gene is acdA [H]

Identifier: 93005175

GI number: 93005175

Start: 417727

End: 418914

Strand: Direct

Name: acdA [H]

Synonym: Pcryo_0344

Alternate gene names: 93005175

Gene position: 417727-418914 (Clockwise)

Preceding gene: 93005174

Following gene: 93005178

Centisome position: 13.65

GC content: 46.8

Gene sequence:

>1188_bases
ATGAGTTTACCTGGATTGAATTTTCAGCTTGGCGAAGATATCGATGCCTTACGTGATATGGTACAACAGTTTGCGGCTAA
TGAAATAGCCCCACGTGCTGCCGAGATTGACAGTAGCGATGAGTTCCCAATGGATTTATGGCAAAAGATGGGTGATATTG
GCCTACACGGTATTACCGTTCCTGAAGAGTACGGTGGCTCTAATATGGGCTACGTCGCACATATGGTGGCGATGGAAGAG
ATTAGCCGCGCTTCTGCCTCTGTAGCGCTGAGCTATGGCGCGCACTCAAACCTATGTATCAACCAAATCAAACGTAATGG
CTCTGAGGCACAAAAGCAAAAGTACCTGCCAAAACTCATTAGTGGCGAATTCATCGGTGCATTGGCAATGAGTGAGACAG
GCGCTGGCTCAGATGTCGTTAGTATGAAGCTAAAAGCCGAAGAAAAAGATGGCAGTTACGTGTTGAATGGTAGCAAAATG
TGGATTACCAATGGTCCTGATGCGGACGTTATGGTTGTTTATGCTAAGACCAATCCTGAGCTGGGTGCTAAAGGCATGAC
GGCTTTTATCGTTGAAAAAGGCATGGAAGGCTTTGGCACCGCTCAAAAGCTTGATAAGCTTGGCATGCGTGGTAGCCATA
CTGGTGAGATGACTTTTAAAAATGTAGAAGTACCAAGCGAAAATATTTTGGGCGGTCTAAACGAAGGCGTTAAGGTATTG
ATGAGCGGGCTGGATTATGAGCGTGCGGTATTGGCCGCAGGTCCTATCGGTATTATGCAAGCCGTGATGGACAATGTCGT
GCCTTATATTCATGATCGTAAGCAGTTTGGTCAAGCTATCGGTGAGTTTCAGCTTATTCAAGGTAAAGTTGCAGACATGT
ATACGATACTGCAAGCAGGTCGTAGCTTCTTATATACGGTCGGGAAAAACCTCGATATGTTGGACGCGCGCGGTGCCGGT
CATAGTCGAGAAGTACGTAAAGATTGTGCCAGTGTGATTTTATGGTGTGCTGAAAAAGCCACTTGGATGGCAGGCGAGGG
CATTCAAATATTTGGTGGTAATGGCTATACCAACGAGTATCCACTTGGTCGTTACTGGCGCGATGCCAAGCTTTATGAGA
TTGGCGCGGGTACCAGTGAGATTCGCCGCATGCTAGTCGGTCGTGAGTTGTTTAACGAGACTAAGTAA

Upstream 100 bases:

>100_bases
TCGCACAGCAAGCGAGGAAAATTTGTCCCAGCTATATCATCTATTTTTAAATTGACACAGCGCTAGTAAAAAATTAAACA
TCAAAATACAAGGAATGGCT

Downstream 100 bases:

>100_bases
GAATTATTGAGTGTTCATTAGATATTAAGTTCAAAATAAAATCGATACATTAATATCCTCCTGCTAATGGGCTAAATTTT
TCTTGCGTGCTGTTCGCAGG

Product: acyl-CoA dehydrogenase-like protein

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSLPGLNFQLGEDIDALRDMVQQFAANEIAPRAAEIDSSDEFPMDLWQKMGDIGLHGITVPEEYGGSNMGYVAHMVAMEE
ISRASASVALSYGAHSNLCINQIKRNGSEAQKQKYLPKLISGEFIGALAMSETGAGSDVVSMKLKAEEKDGSYVLNGSKM
WITNGPDADVMVVYAKTNPELGAKGMTAFIVEKGMEGFGTAQKLDKLGMRGSHTGEMTFKNVEVPSENILGGLNEGVKVL
MSGLDYERAVLAAGPIGIMQAVMDNVVPYIHDRKQFGQAIGEFQLIQGKVADMYTILQAGRSFLYTVGKNLDMLDARGAG
HSREVRKDCASVILWCAEKATWMAGEGIQIFGGNGYTNEYPLGRYWRDAKLYEIGAGTSEIRRMLVGRELFNETK

Sequences:

>Translated_395_residues
MSLPGLNFQLGEDIDALRDMVQQFAANEIAPRAAEIDSSDEFPMDLWQKMGDIGLHGITVPEEYGGSNMGYVAHMVAMEE
ISRASASVALSYGAHSNLCINQIKRNGSEAQKQKYLPKLISGEFIGALAMSETGAGSDVVSMKLKAEEKDGSYVLNGSKM
WITNGPDADVMVVYAKTNPELGAKGMTAFIVEKGMEGFGTAQKLDKLGMRGSHTGEMTFKNVEVPSENILGGLNEGVKVL
MSGLDYERAVLAAGPIGIMQAVMDNVVPYIHDRKQFGQAIGEFQLIQGKVADMYTILQAGRSFLYTVGKNLDMLDARGAG
HSREVRKDCASVILWCAEKATWMAGEGIQIFGGNGYTNEYPLGRYWRDAKLYEIGAGTSEIRRMLVGRELFNETK
>Mature_394_residues
SLPGLNFQLGEDIDALRDMVQQFAANEIAPRAAEIDSSDEFPMDLWQKMGDIGLHGITVPEEYGGSNMGYVAHMVAMEEI
SRASASVALSYGAHSNLCINQIKRNGSEAQKQKYLPKLISGEFIGALAMSETGAGSDVVSMKLKAEEKDGSYVLNGSKMW
ITNGPDADVMVVYAKTNPELGAKGMTAFIVEKGMEGFGTAQKLDKLGMRGSHTGEMTFKNVEVPSENILGGLNEGVKVLM
SGLDYERAVLAAGPIGIMQAVMDNVVPYIHDRKQFGQAIGEFQLIQGKVADMYTILQAGRSFLYTVGKNLDMLDARGAGH
SREVRKDCASVILWCAEKATWMAGEGIQIFGGNGYTNEYPLGRYWRDAKLYEIGAGTSEIRRMLVGRELFNETK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=387, Percent_Identity=61.2403100775194, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI226958414, Length=356, Percent_Identity=63.2022471910112, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI4557233, Length=389, Percent_Identity=36.7609254498715, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=34.7593582887701, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI4557231, Length=394, Percent_Identity=34.5177664974619, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI187960098, Length=394, Percent_Identity=34.5177664974619, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI21361497, Length=387, Percent_Identity=36.6925064599483, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4501857, Length=391, Percent_Identity=31.7135549872123, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=36.0230547550432, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=36.0230547550432, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI7656849, Length=388, Percent_Identity=29.3814432989691, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=31.5245478036176, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=32.3204419889503, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI48976061, Length=403, Percent_Identity=24.0694789081886, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI211971008, Length=403, Percent_Identity=24.0694789081886, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI38505218, Length=383, Percent_Identity=21.1488250652742, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI87081958, Length=391, Percent_Identity=29.6675191815857, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786223, Length=391, Percent_Identity=27.3657289002558, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI87082384, Length=276, Percent_Identity=28.6231884057971, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081702, Length=312, Percent_Identity=24.6794871794872, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=388, Percent_Identity=59.5360824742268, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17506239, Length=392, Percent_Identity=34.1836734693878, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=391, Percent_Identity=35.0383631713555, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=33.9572192513369, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=33.3333333333333, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI17534899, Length=390, Percent_Identity=34.8717948717949, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17533517, Length=391, Percent_Identity=30.9462915601023, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=256, Percent_Identity=40.625, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=362, Percent_Identity=34.2541436464088, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=39.5652173913043, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=31.266149870801, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=33.8181818181818, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=288, Percent_Identity=36.4583333333333, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=357, Percent_Identity=31.6526610644258, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=376, Percent_Identity=28.7234042553192, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=249, Percent_Identity=27.710843373494, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=26.1648745519713, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=26.1648745519713, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562446, Length=284, Percent_Identity=23.5915492957746, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355753, Length=394, Percent_Identity=59.6446700507614, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21356377, Length=384, Percent_Identity=36.71875, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24646207, Length=384, Percent_Identity=35.4166666666667, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24660351, Length=394, Percent_Identity=34.5177664974619, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24666513, Length=386, Percent_Identity=35.4922279792746, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI281363737, Length=390, Percent_Identity=32.5641025641026, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=30.5912596401028, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24652780, Length=295, Percent_Identity=23.3898305084746, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 43003; Mature: 42872

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPGLNFQLGEDIDALRDMVQQFAANEIAPRAAEIDSSDEFPMDLWQKMGDIGLHGITV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHCCCCCCCCC
PEEYGGSNMGYVAHMVAMEEISRASASVALSYGAHSNLCINQIKRNGSEAQKQKYLPKLI
CHHHCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHH
SGEFIGALAMSETGAGSDVVSMKLKAEEKDGSYVLNGSKMWITNGPDADVMVVYAKTNPE
CCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEECCCEEEEECCCCCCEEEEEEECCCC
LGAKGMTAFIVEKGMEGFGTAQKLDKLGMRGSHTGEMTFKNVEVPSENILGGLNEGVKVL
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHCCHHHHHHHH
MSGLDYERAVLAAGPIGIMQAVMDNVVPYIHDRKQFGQAIGEFQLIQGKVADMYTILQAG
HHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
RSFLYTVGKNLDMLDARGAGHSREVRKDCASVILWCAEKATWMAGEGIQIFGGNGYTNEY
HHEEHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCC
PLGRYWRDAKLYEIGAGTSEIRRMLVGRELFNETK
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLPGLNFQLGEDIDALRDMVQQFAANEIAPRAAEIDSSDEFPMDLWQKMGDIGLHGITV
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHCCCCCCCCC
PEEYGGSNMGYVAHMVAMEEISRASASVALSYGAHSNLCINQIKRNGSEAQKQKYLPKLI
CHHHCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHH
SGEFIGALAMSETGAGSDVVSMKLKAEEKDGSYVLNGSKMWITNGPDADVMVVYAKTNPE
CCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEECCCEEEEECCCCCCEEEEEEECCCC
LGAKGMTAFIVEKGMEGFGTAQKLDKLGMRGSHTGEMTFKNVEVPSENILGGLNEGVKVL
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHCCHHHHHHHH
MSGLDYERAVLAAGPIGIMQAVMDNVVPYIHDRKQFGQAIGEFQLIQGKVADMYTILQAG
HHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
RSFLYTVGKNLDMLDARGAGHSREVRKDCASVILWCAEKATWMAGEGIQIFGGNGYTNEY
HHEEHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCCC
PLGRYWRDAKLYEIGAGTSEIRRMLVGRELFNETK
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]