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The map label for this gene is icd [H]

Identifier: 93005145

GI number: 93005145

Start: 379392

End: 380651

Strand: Direct

Name: icd [H]

Synonym: Pcryo_0314

Alternate gene names: 93005145

Gene position: 379392-380651 (Clockwise)

Preceding gene: 93005142

Following gene: 93005147

Centisome position: 12.4

GC content: 44.44

Gene sequence:

>1260_bases
ATGTCATATAACAAGGTTATCGTACCAATAAACGGCGAAAAAATAACCGTAAATGCTGATTTATCCTTCAATATTCCAAA
TCATCCGATCATTCCCTTTATCGAAGGCGATGGCATCGGCGTTGATATCACACCTGTCATGATTGAAGTGATTGATGCGG
CAGTTGAAAAAGCTTATAAAGGCAAAAAGTCCATCGTTTGGATGGAGACCTATTGCGGTGAAAAAGCCTCTAAAATTTAT
GACGGCGAATTTATGCCAGAAGAGACGCTTGATGTGTTGTGTGATTATGTCATCAGTATAAAAGGTCCGCTGACCACGCC
AGTTGGCGGTGGTATGCGCTCGCTGAACGTGGCAATGCGACAAGAGCTTGATTTGTACGTTTGTCAGCGTCCTGTACGTT
GGTTCGAAGGCGTTCCAAGTCCTGTCCAACATCCTGAGTTGACTGATATGATTATTTTCCGCGAAAACTCAGAAGATATC
TATGCCGGTATCGAGTGGAAAGCAGGCAGTGAGGATGCCAAAAAAGTCATTAAGTTTTTAAAAGAAGAGATGGGCGTGAC
ACAGATTCGCTTTTCAGAAGATTGTGGCATTGGTATCAAGCCAGTATCAAAAGAGGGCTCACAGCGTTTGATTTGTAAAG
CGATTCAGCACGCCATCGACAATGACTTGCCCAATGTGACGCTTGTGCATAAAGGCAATATTATGAAGTTCACTGAAGGC
GCTTTTAAAGAGTGGGGATATGAAGTTGCTACTGAGTGCTTTGGTGCTCAATTACTAGATGGTGGCCCTTGGATGACGAT
AACAAATCCTAAGACGGGTCATAAGATTGTGATTAAAGATGTGATTGCGGATGCGTTTTTGCAGCAAATCCTGATGCGTC
CAGCTGACTACTCAGTGATTGCGACATTAAACCTAAACGGCGACTACATCTCTGACGCGTTAGCCGCGCAAGTCGGTGGT
ATCGGTATTGCTCCGGGTGCTAATAAAGGAGTTGCTATTGCCGTATATGAGGCAACCCATGGTACAGCTCCAAAGTACGC
CGGACAAAACAAAGTCAATCCGGGTTCGCTTATTTTGTCAGCTGAGATGATGTTACGTGATATGGGCTGGACAAAGGCCG
CTGACTTGGTCATCGAAGGTATCCAAGGTGCTATCAAAAATAAGACCGTGACCTACGATTTTGAACGCTTGATGCCGGAT
GCCACCTTACTGAGTACCTCTGAGTTTGGTAAAGCAATCATCAAACATATGAATGCGTAA

Upstream 100 bases:

>100_bases
CAAACATTTATAATGCTGTCATCACCATGATAAAACAGCTAGCATAACAGAATGCCAAGGACGCTTAAAACACATAATAC
ATATCAAGGAGTATCACCTC

Downstream 100 bases:

>100_bases
GAAAATGATGTCTTTTACACAATGTCTTGTAAATAGTCTCTGACATAAAAATCACTCATTAATAAAAGACAAAAAAACAC
CCCAAAATCTAAGATATTTG

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSYNKVIVPINGEKITVNADLSFNIPNHPIIPFIEGDGIGVDITPVMIEVIDAAVEKAYKGKKSIVWMETYCGEKASKIY
DGEFMPEETLDVLCDYVISIKGPLTTPVGGGMRSLNVAMRQELDLYVCQRPVRWFEGVPSPVQHPELTDMIIFRENSEDI
YAGIEWKAGSEDAKKVIKFLKEEMGVTQIRFSEDCGIGIKPVSKEGSQRLICKAIQHAIDNDLPNVTLVHKGNIMKFTEG
AFKEWGYEVATECFGAQLLDGGPWMTITNPKTGHKIVIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAQVGG
IGIAPGANKGVAIAVYEATHGTAPKYAGQNKVNPGSLILSAEMMLRDMGWTKAADLVIEGIQGAIKNKTVTYDFERLMPD
ATLLSTSEFGKAIIKHMNA

Sequences:

>Translated_419_residues
MSYNKVIVPINGEKITVNADLSFNIPNHPIIPFIEGDGIGVDITPVMIEVIDAAVEKAYKGKKSIVWMETYCGEKASKIY
DGEFMPEETLDVLCDYVISIKGPLTTPVGGGMRSLNVAMRQELDLYVCQRPVRWFEGVPSPVQHPELTDMIIFRENSEDI
YAGIEWKAGSEDAKKVIKFLKEEMGVTQIRFSEDCGIGIKPVSKEGSQRLICKAIQHAIDNDLPNVTLVHKGNIMKFTEG
AFKEWGYEVATECFGAQLLDGGPWMTITNPKTGHKIVIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAQVGG
IGIAPGANKGVAIAVYEATHGTAPKYAGQNKVNPGSLILSAEMMLRDMGWTKAADLVIEGIQGAIKNKTVTYDFERLMPD
ATLLSTSEFGKAIIKHMNA
>Mature_418_residues
SYNKVIVPINGEKITVNADLSFNIPNHPIIPFIEGDGIGVDITPVMIEVIDAAVEKAYKGKKSIVWMETYCGEKASKIYD
GEFMPEETLDVLCDYVISIKGPLTTPVGGGMRSLNVAMRQELDLYVCQRPVRWFEGVPSPVQHPELTDMIIFRENSEDIY
AGIEWKAGSEDAKKVIKFLKEEMGVTQIRFSEDCGIGIKPVSKEGSQRLICKAIQHAIDNDLPNVTLVHKGNIMKFTEGA
FKEWGYEVATECFGAQLLDGGPWMTITNPKTGHKIVIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAQVGGI
GIAPGANKGVAIAVYEATHGTAPKYAGQNKVNPGSLILSAEMMLRDMGWTKAADLVIEGIQGAIKNKTVTYDFERLMPDA
TLLSTSEFGKAIIKHMNA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=367, Percent_Identity=31.6076294277929, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI28178821, Length=392, Percent_Identity=26.2755102040816, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI28178816, Length=354, Percent_Identity=26.5536723163842, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI28178838, Length=281, Percent_Identity=27.7580071174377, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4758582, Length=307, Percent_Identity=27.3615635179153, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI28178819, Length=222, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787381, Length=415, Percent_Identity=70.8433734939759, Blast_Score=622, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71986051, Length=376, Percent_Identity=31.9148936170213, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI25144293, Length=295, Percent_Identity=28.8135593220339, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17505779, Length=391, Percent_Identity=25.0639386189258, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17550882, Length=280, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324709, Length=392, Percent_Identity=29.8469387755102, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=369, Percent_Identity=27.6422764227642, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324291, Length=391, Percent_Identity=26.0869565217391, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24643270, Length=346, Percent_Identity=32.9479768786127, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24643268, Length=346, Percent_Identity=32.9479768786127, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24661184, Length=391, Percent_Identity=28.6445012787724, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI161078639, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161078635, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161078633, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24650122, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161078637, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362242, Length=397, Percent_Identity=25.4408060453401, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648872, Length=397, Percent_Identity=25.4408060453401, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45850; Mature: 45718

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYNKVIVPINGEKITVNADLSFNIPNHPIIPFIEGDGIGVDITPVMIEVIDAAVEKAYK
CCCCEEEEEECCCEEEEEEEEEECCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHC
GKKSIVWMETYCGEKASKIYDGEFMPEETLDVLCDYVISIKGPLTTPVGGGMRSLNVAMR
CCCCEEEEHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
QELDLYVCQRPVRWFEGVPSPVQHPELTDMIIFRENSEDIYAGIEWKAGSEDAKKVIKFL
HHHHHHHHHCHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHH
KEEMGVTQIRFSEDCGIGIKPVSKEGSQRLICKAIQHAIDNDLPNVTLVHKGNIMKFTEG
HHHCCCEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCH
AFKEWGYEVATECFGAQLLDGGPWMTITNPKTGHKIVIKDVIADAFLQQILMRPADYSVI
HHHHHCHHHHHHHHCCEEECCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEE
ATLNLNGDYISDALAAQVGGIGIAPGANKGVAIAVYEATHGTAPKYAGQNKVNPGSLILS
EEEECCCCHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEE
AEMMLRDMGWTKAADLVIEGIQGAIKNKTVTYDFERLMPDATLLSTSEFGKAIIKHMNA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEECHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYNKVIVPINGEKITVNADLSFNIPNHPIIPFIEGDGIGVDITPVMIEVIDAAVEKAYK
CCCEEEEEECCCEEEEEEEEEECCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHC
GKKSIVWMETYCGEKASKIYDGEFMPEETLDVLCDYVISIKGPLTTPVGGGMRSLNVAMR
CCCCEEEEHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
QELDLYVCQRPVRWFEGVPSPVQHPELTDMIIFRENSEDIYAGIEWKAGSEDAKKVIKFL
HHHHHHHHHCHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCHHHHHHHHHH
KEEMGVTQIRFSEDCGIGIKPVSKEGSQRLICKAIQHAIDNDLPNVTLVHKGNIMKFTEG
HHHCCCEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCH
AFKEWGYEVATECFGAQLLDGGPWMTITNPKTGHKIVIKDVIADAFLQQILMRPADYSVI
HHHHHCHHHHHHHHCCEEECCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEE
ATLNLNGDYISDALAAQVGGIGIAPGANKGVAIAVYEATHGTAPKYAGQNKVNPGSLILS
EEEECCCCHHHHHHHHHHCCEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEE
AEMMLRDMGWTKAADLVIEGIQGAIKNKTVTYDFERLMPDATLLSTSEFGKAIIKHMNA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCEECHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]