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The map label for this gene is ldc [H]

Identifier: 93004868

GI number: 93004868

Start: 44201

End: 45376

Strand: Reverse

Name: ldc [H]

Synonym: Pcryo_0037

Alternate gene names: 93004868

Gene position: 45376-44201 (Counterclockwise)

Preceding gene: 93004869

Following gene: 93004864

Centisome position: 1.48

GC content: 42.01

Gene sequence:

>1176_bases
ATGATTAAAATCGACCAATATTTTGACCCTGCCGGCTGGCAGAAGTTTACTAAAGCGGCTGAAGGTCGTGAAACGCCATT
TTTGGTGGTTGATCTTAATCGCATTAAAATAAAATATCATGAAATGGTTGGTTTTTTTCCTCATGCTAAAATCCATTATG
CGATGAAAGCAAGCCCTGCTGTCGAAGTCATCAATCTGCTTGCTGAGCTTGGTTCAAACTTTGACTGTGCATCGATTTAT
GAGCTTGATCGCGTGCTTGACTGCGGCGTTGAGCCCTCACGTATCTCTTATGGTAATACCATCAAAAAGCCTGAACATGT
CAAATACGCCTTTGAAAAAGGGGTTGATTTGTATGCGACCGACTCAGAAGCAGATTTAAAAAACATTGCAAAACATGCAC
CTGGCTCAAAAATATTTGTACGTATCTTAGTACAAGGGTCAGATACCGCTGAATGGCCATTATCACGCAAATTTGGTTGT
CACCCCAATATGGCGATTGAACTATTGATTCAAGCGCAAGAATTGGGCTTGGTACCTTATGGCATCTCATTCCATGTGGG
CAGTCAGCAAAAAGACGTTGCCGCTTGGGATGATGCTTTAGCCAAAGTTAAATATATGTTTGATTGGATGAAGAACGAAG
AAGGCATAAAGCTTCAAATGATAAATTTGGGTGGCGGCTTTCCGGCAAACTATCTGAGCGAAGTCAATCCTATCAAAGTC
TATGCTGAAGAGATTCAAAGCTACTTAAGCGATGACTATAGTGCTGAAGATATGCCAGAGATTATTTTAGAGCCCGGTCG
TTCATTGGTTGGCGGTTCAGGCGTACTGGTTAGTGACGTGGTATTGATTTCTCGTAAATCGCATACTGATCTGACACGTT
GGGTCTATACCGATGTGGGTTTATTTCAAGGTTTAATTGAAACCTTAGGTGAAGCTATCAAGTACCCCGTTTATACACCT
AAAATGGAAACCTCAACCAGCGCGGGTACGGTGGTATTAGCAGGTCCTACTTGTGACTCAACTGATATCATGTATGAAGA
GGCAGGTTATCAGCTACCAGAAGAGCTGGAGATTGGTGACAAGATATTTTGGTTAACTACGGGTGCTTATACCAACTCGT
ACTCATCTATTGAGTTCAATGGTTTTCCACCGTTAGAAGTGGTCTATGTTGACTAA

Upstream 100 bases:

>100_bases
GTAAAGAATTTGGGTTTTATTATTAGTTTTGGTTAGCATCACTATTTGTTAGCTTCATTCCTTGTTCTCATTAAATACTG
TTTTTATTAAAGGTCTTACT

Downstream 100 bases:

>100_bases
TTTGTGATAAATAATCGTTACTATAAAAAGCGCGGCATTGTGAATAACAGTGCCGCGCTTTTTTATGTTTATTTCGCTAT
AGTATTTATCATTAGCTACT

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MIKIDQYFDPAGWQKFTKAAEGRETPFLVVDLNRIKIKYHEMVGFFPHAKIHYAMKASPAVEVINLLAELGSNFDCASIY
ELDRVLDCGVEPSRISYGNTIKKPEHVKYAFEKGVDLYATDSEADLKNIAKHAPGSKIFVRILVQGSDTAEWPLSRKFGC
HPNMAIELLIQAQELGLVPYGISFHVGSQQKDVAAWDDALAKVKYMFDWMKNEEGIKLQMINLGGGFPANYLSEVNPIKV
YAEEIQSYLSDDYSAEDMPEIILEPGRSLVGGSGVLVSDVVLISRKSHTDLTRWVYTDVGLFQGLIETLGEAIKYPVYTP
KMETSTSAGTVVLAGPTCDSTDIMYEEAGYQLPEELEIGDKIFWLTTGAYTNSYSSIEFNGFPPLEVVYVD

Sequences:

>Translated_391_residues
MIKIDQYFDPAGWQKFTKAAEGRETPFLVVDLNRIKIKYHEMVGFFPHAKIHYAMKASPAVEVINLLAELGSNFDCASIY
ELDRVLDCGVEPSRISYGNTIKKPEHVKYAFEKGVDLYATDSEADLKNIAKHAPGSKIFVRILVQGSDTAEWPLSRKFGC
HPNMAIELLIQAQELGLVPYGISFHVGSQQKDVAAWDDALAKVKYMFDWMKNEEGIKLQMINLGGGFPANYLSEVNPIKV
YAEEIQSYLSDDYSAEDMPEIILEPGRSLVGGSGVLVSDVVLISRKSHTDLTRWVYTDVGLFQGLIETLGEAIKYPVYTP
KMETSTSAGTVVLAGPTCDSTDIMYEEAGYQLPEELEIGDKIFWLTTGAYTNSYSSIEFNGFPPLEVVYVD
>Mature_391_residues
MIKIDQYFDPAGWQKFTKAAEGRETPFLVVDLNRIKIKYHEMVGFFPHAKIHYAMKASPAVEVINLLAELGSNFDCASIY
ELDRVLDCGVEPSRISYGNTIKKPEHVKYAFEKGVDLYATDSEADLKNIAKHAPGSKIFVRILVQGSDTAEWPLSRKFGC
HPNMAIELLIQAQELGLVPYGISFHVGSQQKDVAAWDDALAKVKYMFDWMKNEEGIKLQMINLGGGFPANYLSEVNPIKV
YAEEIQSYLSDDYSAEDMPEIILEPGRSLVGGSGVLVSDVVLISRKSHTDLTRWVYTDVGLFQGLIETLGEAIKYPVYTP
KMETSTSAGTVVLAGPTCDSTDIMYEEAGYQLPEELEIGDKIFWLTTGAYTNSYSSIEFNGFPPLEVVYVD

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=380, Percent_Identity=31.0526315789474, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI16506287, Length=374, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI22538418, Length=362, Percent_Identity=28.7292817679558, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI21361583, Length=362, Percent_Identity=28.7292817679558, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17562780, Length=386, Percent_Identity=30.3108808290155, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322664, Length=395, Percent_Identity=31.6455696202532, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24586472, Length=367, Percent_Identity=30.2452316076294, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24586474, Length=364, Percent_Identity=29.3956043956044, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43568; Mature: 43568

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIDQYFDPAGWQKFTKAAEGRETPFLVVDLNRIKIKYHEMVGFFPHAKIHYAMKASPA
CEECCCCCCCCCHHHHHHHHCCCCCCEEEEECCEEEEEEEHHHCCCCCCEEEEEECCCHH
VEVINLLAELGSNFDCASIYELDRVLDCGVEPSRISYGNTIKKPEHVKYAFEKGVDLYAT
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEE
DSEADLKNIAKHAPGSKIFVRILVQGSDTAEWPLSRKFGCHPNMAIELLIQAQELGLVPY
CCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCEEE
GISFHVGSQQKDVAAWDDALAKVKYMFDWMKNEEGIKLQMINLGGGFPANYLSEVNPIKV
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCCHHHH
YAEEIQSYLSDDYSAEDMPEIILEPGRSLVGGSGVLVSDVVLISRKSHTDLTRWVYTDVG
HHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHEEEEECCCCCHHHHHHHHHHH
LFQGLIETLGEAIKYPVYTPKMETSTSAGTVVLAGPTCDSTDIMYEEAGYQLPEELEIGD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEHHCCCCCCHHHCCCC
KIFWLTTGAYTNSYSSIEFNGFPPLEVVYVD
EEEEEEECCCCCCCCEEEECCCCCEEEEEEC
>Mature Secondary Structure
MIKIDQYFDPAGWQKFTKAAEGRETPFLVVDLNRIKIKYHEMVGFFPHAKIHYAMKASPA
CEECCCCCCCCCHHHHHHHHCCCCCCEEEEECCEEEEEEEHHHCCCCCCEEEEEECCCHH
VEVINLLAELGSNFDCASIYELDRVLDCGVEPSRISYGNTIKKPEHVKYAFEKGVDLYAT
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEE
DSEADLKNIAKHAPGSKIFVRILVQGSDTAEWPLSRKFGCHPNMAIELLIQAQELGLVPY
CCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCEEE
GISFHVGSQQKDVAAWDDALAKVKYMFDWMKNEEGIKLQMINLGGGFPANYLSEVNPIKV
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHCCCHHHH
YAEEIQSYLSDDYSAEDMPEIILEPGRSLVGGSGVLVSDVVLISRKSHTDLTRWVYTDVG
HHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHEEEEECCCCCHHHHHHHHHHH
LFQGLIETLGEAIKYPVYTPKMETSTSAGTVVLAGPTCDSTDIMYEEAGYQLPEELEIGD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEHHCCCCCCHHHCCCC
KIFWLTTGAYTNSYSSIEFNGFPPLEVVYVD
EEEEEEECCCCCCCCEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]