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The map label for this gene is lysA [H]

Identifier: 92115227

GI number: 92115227

Start: 3466985

End: 3468241

Strand: Direct

Name: lysA [H]

Synonym: Csal_3112

Alternate gene names: 92115227

Gene position: 3466985-3468241 (Clockwise)

Preceding gene: 92115226

Following gene: 92115228

Centisome position: 93.79

GC content: 66.27

Gene sequence:

>1257_bases
ATGGATCATTTCAATTACCGCGACGGCCACCTGCATGCCGAGAACGTACCGCTGACCGACATCGCCGAGCGCTTCGGCAC
GCCGTGCTACGTGTATTCGCGGGCGACCTTCACACGTCACTTCAAGGCCTACAGCGACGCACTCGGCGATCATCCCCATC
TGATCTGCTACGCGGTGAAGGCCAATTCCAACCTCGCTGTGCTCGACCTGCTGGCGCGTCTCGGCGCCGGCTTCGACATC
GTCTCCCGGGGCGAGCTCGAGCGCGTGCTGGCCGCCGGCGGCGATCCCGCCAAAGTGGTATTTTCCGGCGTCGCCAAGCA
GGCCGGCGAAATGGCCCGCGCGCTGGAAGTGGGCATCAAGTGCTTCAACGTGGAGTCCCTGCCGGAACTCGAGCGCCTGA
ACCAGGTGGCGGGCGAATGCGGCCAGGTGGCAAGGGTCTCGCTGCGCGTCAATCCCGACGTCGATGCCAAGACCCATCCG
TACATCTCCACCGGCCTCAAGGCCAACAAGTTCGGCATCGCCGTCGACGAGGCCTTCGCGGTCTATCAGCGCGCCGCCGA
GCTGCCGAACCTCGAGATCGTCGGCCTGGATTGCCATATCGGTTCGCAACTGACCGAGCTGGCGCCTTTCCTCGATGCCC
TGGACCGTCTGCTGATACTCCTCGACCGTCTGAACGAGGCGGGCATTACCATCGAACATCTCGATCTGGGCGGCGGCCTC
GGCGTGCCCTATCAGGACGAGCAGCCGCCGGCCCCCTACGACTATGCCCGCGCCCTGCTCGAGCGACTCGACGGCCGCGA
CCTGACGCTGCTGTTCGAGCCGGGGCGCTCGATCGCCGCCAATGCCGGCGTGATGCTCACCCGTGTCGAATACCTGAAGC
CCGGCGAGACGCAGCACTTCGCCATCGTCGATGCCGGCATGAACGATCTGATTCGCCCCGCGCTGTACCAGGCGTGGCAG
CGCATCGTACCGGTCGATACCCGTCAGGCGCGCGAGACGGCGGTCTACGACGTCGTCGGCCCGGTCTGCGAAACCGGCGA
CTTCCTGGGCAAGGCACGTGAACTGGCCATCGCGCCGGGCGACCTGCTCGCGGTACGCTCGGCCGGGGCCTACGGCTTCG
TGATGGCCTCCCACTACAACAGCCGCCCACGCCCCGCCGAACTCATGGTCGATGGCGACAACGTGCAGGTGGTGCGCGAG
CGCGAGACACTCGATGCCTTGTGGGCCGGCGAACACCGTCTGGCGGAGACGTCCTGA

Upstream 100 bases:

>100_bases
ACGATCCGGCGGGTGCCTACGAGGACGACACCGCCGAGCCGGATACCGGCGATGCAGACGACGCGGCAACGCCCCAACCC
GAGAGCGACGCAGACTGACG

Downstream 100 bases:

>100_bases
TGCTGCTGCACTTCACCAAGATGCACGGGCTCGGCAACGACTTCGTGGTGATCGACCTGATCACCCAGCGGGCACGGCTC
GACACCGAGCGCATTCGGCA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MDHFNYRDGHLHAENVPLTDIAERFGTPCYVYSRATFTRHFKAYSDALGDHPHLICYAVKANSNLAVLDLLARLGAGFDI
VSRGELERVLAAGGDPAKVVFSGVAKQAGEMARALEVGIKCFNVESLPELERLNQVAGECGQVARVSLRVNPDVDAKTHP
YISTGLKANKFGIAVDEAFAVYQRAAELPNLEIVGLDCHIGSQLTELAPFLDALDRLLILLDRLNEAGITIEHLDLGGGL
GVPYQDEQPPAPYDYARALLERLDGRDLTLLFEPGRSIAANAGVMLTRVEYLKPGETQHFAIVDAGMNDLIRPALYQAWQ
RIVPVDTRQARETAVYDVVGPVCETGDFLGKARELAIAPGDLLAVRSAGAYGFVMASHYNSRPRPAELMVDGDNVQVVRE
RETLDALWAGEHRLAETS

Sequences:

>Translated_418_residues
MDHFNYRDGHLHAENVPLTDIAERFGTPCYVYSRATFTRHFKAYSDALGDHPHLICYAVKANSNLAVLDLLARLGAGFDI
VSRGELERVLAAGGDPAKVVFSGVAKQAGEMARALEVGIKCFNVESLPELERLNQVAGECGQVARVSLRVNPDVDAKTHP
YISTGLKANKFGIAVDEAFAVYQRAAELPNLEIVGLDCHIGSQLTELAPFLDALDRLLILLDRLNEAGITIEHLDLGGGL
GVPYQDEQPPAPYDYARALLERLDGRDLTLLFEPGRSIAANAGVMLTRVEYLKPGETQHFAIVDAGMNDLIRPALYQAWQ
RIVPVDTRQARETAVYDVVGPVCETGDFLGKARELAIAPGDLLAVRSAGAYGFVMASHYNSRPRPAELMVDGDNVQVVRE
RETLDALWAGEHRLAETS
>Mature_418_residues
MDHFNYRDGHLHAENVPLTDIAERFGTPCYVYSRATFTRHFKAYSDALGDHPHLICYAVKANSNLAVLDLLARLGAGFDI
VSRGELERVLAAGGDPAKVVFSGVAKQAGEMARALEVGIKCFNVESLPELERLNQVAGECGQVARVSLRVNPDVDAKTHP
YISTGLKANKFGIAVDEAFAVYQRAAELPNLEIVGLDCHIGSQLTELAPFLDALDRLLILLDRLNEAGITIEHLDLGGGL
GVPYQDEQPPAPYDYARALLERLDGRDLTLLFEPGRSIAANAGVMLTRVEYLKPGETQHFAIVDAGMNDLIRPALYQAWQ
RIVPVDTRQARETAVYDVVGPVCETGDFLGKARELAIAPGDLLAVRSAGAYGFVMASHYNSRPRPAELMVDGDNVQVVRE
RETLDALWAGEHRLAETS

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=354, Percent_Identity=25.1412429378531, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI22538418, Length=360, Percent_Identity=26.1111111111111, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI21361583, Length=360, Percent_Identity=26.1111111111111, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI16506287, Length=184, Percent_Identity=27.1739130434783, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=33.1764705882353, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=353, Percent_Identity=22.3796033994334, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=24.0331491712707, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586474, Length=340, Percent_Identity=24.7058823529412, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586472, Length=341, Percent_Identity=23.7536656891496, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45642; Mature: 45642

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFNYRDGHLHAENVPLTDIAERFGTPCYVYSRATFTRHFKAYSDALGDHPHLICYAVK
CCCCCCCCCCEEECCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCEEEEEEEE
ANSNLAVLDLLARLGAGFDIVSRGELERVLAAGGDPAKVVFSGVAKQAGEMARALEVGIK
CCCCCHHHHHHHHHCCCCCEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCE
CFNVESLPELERLNQVAGECGQVARVSLRVNPDVDAKTHPYISTGLKANKFGIAVDEAFA
EECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCEEHHHHHH
VYQRAAELPNLEIVGLDCHIGSQLTELAPFLDALDRLLILLDRLNEAGITIEHLDLGGGL
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
GVPYQDEQPPAPYDYARALLERLDGRDLTLLFEPGRSIAANAGVMLTRVEYLKPGETQHF
CCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHCCCCEEEEEEHHCCCCCCCEE
AIVDAGMNDLIRPALYQAWQRIVPVDTRQARETAVYDVVGPVCETGDFLGKARELAIAPG
EEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCHHHHHHHHHEEECCC
DLLAVRSAGAYGFVMASHYNSRPRPAELMVDGDNVQVVRERETLDALWAGEHRLAETS
CEEEEECCCCEEEEEEECCCCCCCCCEEEEECCCEEEEECHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDHFNYRDGHLHAENVPLTDIAERFGTPCYVYSRATFTRHFKAYSDALGDHPHLICYAVK
CCCCCCCCCCEEECCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCEEEEEEEE
ANSNLAVLDLLARLGAGFDIVSRGELERVLAAGGDPAKVVFSGVAKQAGEMARALEVGIK
CCCCCHHHHHHHHHCCCCCEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCE
CFNVESLPELERLNQVAGECGQVARVSLRVNPDVDAKTHPYISTGLKANKFGIAVDEAFA
EECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCEEHHHHHH
VYQRAAELPNLEIVGLDCHIGSQLTELAPFLDALDRLLILLDRLNEAGITIEHLDLGGGL
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
GVPYQDEQPPAPYDYARALLERLDGRDLTLLFEPGRSIAANAGVMLTRVEYLKPGETQHF
CCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHCCCCEEEEEEHHCCCCCCCEE
AIVDAGMNDLIRPALYQAWQRIVPVDTRQARETAVYDVVGPVCETGDFLGKARELAIAPG
EEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCHHHHHHHHHEEECCC
DLLAVRSAGAYGFVMASHYNSRPRPAELMVDGDNVQVVRERETLDALWAGEHRLAETS
CEEEEECCCCEEEEEEECCCCCCCCCEEEEECCCEEEEECHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]