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The map label for this gene is folK [H]

Identifier: 92115179

GI number: 92115179

Start: 3413831

End: 3414322

Strand: Direct

Name: folK [H]

Synonym: Csal_3064

Alternate gene names: 92115179

Gene position: 3413831-3414322 (Clockwise)

Preceding gene: 92115178

Following gene: 92115180

Centisome position: 92.35

GC content: 66.67

Gene sequence:

>492_bases
ATGAGTGAGCGCGCGCTGCCCGCCTATATCGGGCTGGGCAGCAACCTGGATTCTCCCCGCGCACACGTCACCCGCGCCCT
GGACGAACTCGACTCCCTGCCGCTGACGCGGCTGGCATGTCATTCCTCCCTCTATGCGTCATCCCCGGTGGGTCCCCAGG
ATCAGCCCGACTTCGTCAATGCCGTTGCCCGGCTGGAAACGCGACTGTCACCCTTGGCGCTGCTCGACCAGTTACAGGCC
CTCGAACAACGCCACCGACGGATTCGAAAACGCCGCTGGGGGCCCCGCACGCTGGATCTCGACCTGCTGTGCTATGCGAC
ACTGCGCTGGCAGACGCCGCGCTTGATCCTGCCGCACCCTGCCATGCGGGAACGCGGTTTCGTGCTGGTGCCCCTGGCGG
AAATCGCACCCGAGCTGCTGCTCGATGGCGACACGGCCGCCTCGCTGGCCGTGCCCCATCAAGGACGGGACTTGCGTCGA
CTCGTCCCCTAA

Upstream 100 bases:

>100_bases
ACGGGCGGCCACCCCGCAGGAACGTCGGACCGCCCCAAGCGCCGACCGCGCCGCCGCCGGCGTCGCAACTCGAATGCCGG
GCAGCCTAACGACGGCCGCG

Downstream 100 bases:

>100_bases
AAGTAGAGTTGCACCCGATTTGTTACCGATCCACACTCCCACCACCCTCGGGTAACGCCTGCGGTAACACTTGCCGTCCG
GGTCCGCCAGGACCGACAAA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MSERALPAYIGLGSNLDSPRAHVTRALDELDSLPLTRLACHSSLYASSPVGPQDQPDFVNAVARLETRLSPLALLDQLQA
LEQRHRRIRKRRWGPRTLDLDLLCYATLRWQTPRLILPHPAMRERGFVLVPLAEIAPELLLDGDTAASLAVPHQGRDLRR
LVP

Sequences:

>Translated_163_residues
MSERALPAYIGLGSNLDSPRAHVTRALDELDSLPLTRLACHSSLYASSPVGPQDQPDFVNAVARLETRLSPLALLDQLQA
LEQRHRRIRKRRWGPRTLDLDLLCYATLRWQTPRLILPHPAMRERGFVLVPLAEIAPELLLDGDTAASLAVPHQGRDLRR
LVP
>Mature_162_residues
SERALPAYIGLGSNLDSPRAHVTRALDELDSLPLTRLACHSSLYASSPVGPQDQPDFVNAVARLETRLSPLALLDQLQAL
EQRHRRIRKRRWGPRTLDLDLLCYATLRWQTPRLILPHPAMRERGFVLVPLAEIAPELLLDGDTAASLAVPHQGRDLRRL
VP

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=49.6402877697842, Blast_Score=132, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6324073, Length=145, Percent_Identity=33.7931034482759, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18272; Mature: 18141

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERALPAYIGLGSNLDSPRAHVTRALDELDSLPLTRLACHSSLYASSPVGPQDQPDFVN
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
AVARLETRLSPLALLDQLQALEQRHRRIRKRRWGPRTLDLDLLCYATLRWQTPRLILPHP
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEECCCC
AMRERGFVLVPLAEIAPELLLDGDTAASLAVPHQGRDLRRLVP
CHHHCCEEEEEHHHHHHHHHCCCCCCCEEECCCCCCHHHHCCC
>Mature Secondary Structure 
SERALPAYIGLGSNLDSPRAHVTRALDELDSLPLTRLACHSSLYASSPVGPQDQPDFVN
CCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
AVARLETRLSPLALLDQLQALEQRHRRIRKRRWGPRTLDLDLLCYATLRWQTPRLILPHP
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEECCCC
AMRERGFVLVPLAEIAPELLLDGDTAASLAVPHQGRDLRRLVP
CHHHCCEEEEEHHHHHHHHHCCCCCCCEEECCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]