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The map label for this gene is coaBC [H]

Identifier: 92115097

GI number: 92115097

Start: 3319964

End: 3321214

Strand: Direct

Name: coaBC [H]

Synonym: Csal_2981

Alternate gene names: 92115097

Gene position: 3319964-3321214 (Clockwise)

Preceding gene: 92115096

Following gene: 92115098

Centisome position: 89.81

GC content: 68.67

Gene sequence:

>1251_bases
ATGTCACAGTTGAGTCCCATGCCACTGGCGGGCAAGCGCGTCTTGCTCGGTATCAGCGCGGGTATCGCCGCTTATAAAAG
CGCCCATCTCGCACGCCTGCTGAAAAAGGCGGGCTGCGAGGTGCGGGTGGTCATGACCGAAGGGGCGCAGGCCTTCATCA
CGCCGCTGACGCTGCAGGCGCTGACCGGAGAGGCGGTACGCACGTCACTGCTCGACCCCGAGGCCGAAGCCGGCATGGGC
CATATCGAGCTGGCGCGCTGGGCCGAACTGATCCTCGTCGCGCCGGCCACCGCCGACGTGATGGCACGCCTGGCCCACGG
CCATGCCGACGATCTGTTGACCACGCTGTGTCTGGCCAGCGACGCCGAGTGCATCATGGCACCGGCGATGAACCAGGCGA
TGTGGGCCCATCCGGCGACCCAGGCCAACGTCGCGACACTCCACCGCCTGGGCTGGCGCTTGCTGGGCCCCGACGGCGGC
GAGCAGGCATGCGGCGATGTCGGCCCCGGCCGCATGCGCGAGCCGGAGGCGCTGCTCGCCGAGCTGGCGGAGGCACCGGT
CGTGCGCGATGCCGAGGCGTTGCGGGTGACGATCACCGCCGGGCCGACCCGGGAGGCGCTCGACCCGGTGCGTTACCTCT
CCAATCACAGTTCCGGCAAGATGGGCTACGCCCTGGCCGAGGCCTGGGCCCGACGTGGTGCCCAGGTACGCTTGATCAGT
GGACCGGTCACCCTGGCGGCGCCCACGAATGTCGAGCGCGTCGATGTCACTTCAGCCAGCGAGATGCTGAGCGCCGCCGA
GCAATCCGCCGCCGAGAGCGACATCTTCATCGGCTGCGCGGCGGTCGCCGACTACCGTGCCGACACGGTGGCCGAGCACA
AGCTCAAGAAGGCCGACGCAAGCGATACCATGACGCTCACCCTGGTCAAGAATCCCGACATCGTGGCGACCATCGCCGCC
CGTTCCCCGCGTCCGCTGGTGGTGGGATTTGCCGCCGAGACACGGGACCTGGAGCGTTACGCTCGCGACAAGCTCACACG
CAAGGGCATGGACATGATCGTCGCCAACGATGTCTCGAGCGCGGGGCTCGGCTTCGGTGCCGACGACAACGCCGCGCTCT
TGCTCTGGCACGCCGACGACACCATCGAGCGTCAGGCGCTGCCCGCGCAAGCCAAGACCGACCTGGCCGACGCCATCGTC
GACCGGGTCTTGAGCCTTTACGCCAACCGCGCCGCCACGGCGCACGACTGA

Upstream 100 bases:

>100_bases
ACAACTCGCGATCTAGCGCTCCCAGGAGGGGGACGGGTCATACGCAGCTAGCTGACAGAATGGTAGTATCATCGCTGGAG
CCTCCCAGGGATGAGCCACC

Downstream 100 bases:

>100_bases
CGGACCGATTTCCCATGTCAGAAGCTTCGTTGTCCGCCGACACACGCCTGTCGGTGAAGATACTGGACGAACGCGTACGC
GACTTCCCCCTGCCCAGCTA

Product: phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSQLSPMPLAGKRVLLGISAGIAAYKSAHLARLLKKAGCEVRVVMTEGAQAFITPLTLQALTGEAVRTSLLDPEAEAGMG
HIELARWAELILVAPATADVMARLAHGHADDLLTTLCLASDAECIMAPAMNQAMWAHPATQANVATLHRLGWRLLGPDGG
EQACGDVGPGRMREPEALLAELAEAPVVRDAEALRVTITAGPTREALDPVRYLSNHSSGKMGYALAEAWARRGAQVRLIS
GPVTLAAPTNVERVDVTSASEMLSAAEQSAAESDIFIGCAAVADYRADTVAEHKLKKADASDTMTLTLVKNPDIVATIAA
RSPRPLVVGFAAETRDLERYARDKLTRKGMDMIVANDVSSAGLGFGADDNAALLLWHADDTIERQALPAQAKTDLADAIV
DRVLSLYANRAATAHD

Sequences:

>Translated_416_residues
MSQLSPMPLAGKRVLLGISAGIAAYKSAHLARLLKKAGCEVRVVMTEGAQAFITPLTLQALTGEAVRTSLLDPEAEAGMG
HIELARWAELILVAPATADVMARLAHGHADDLLTTLCLASDAECIMAPAMNQAMWAHPATQANVATLHRLGWRLLGPDGG
EQACGDVGPGRMREPEALLAELAEAPVVRDAEALRVTITAGPTREALDPVRYLSNHSSGKMGYALAEAWARRGAQVRLIS
GPVTLAAPTNVERVDVTSASEMLSAAEQSAAESDIFIGCAAVADYRADTVAEHKLKKADASDTMTLTLVKNPDIVATIAA
RSPRPLVVGFAAETRDLERYARDKLTRKGMDMIVANDVSSAGLGFGADDNAALLLWHADDTIERQALPAQAKTDLADAIV
DRVLSLYANRAATAHD
>Mature_415_residues
SQLSPMPLAGKRVLLGISAGIAAYKSAHLARLLKKAGCEVRVVMTEGAQAFITPLTLQALTGEAVRTSLLDPEAEAGMGH
IELARWAELILVAPATADVMARLAHGHADDLLTTLCLASDAECIMAPAMNQAMWAHPATQANVATLHRLGWRLLGPDGGE
QACGDVGPGRMREPEALLAELAEAPVVRDAEALRVTITAGPTREALDPVRYLSNHSSGKMGYALAEAWARRGAQVRLISG
PVTLAAPTNVERVDVTSASEMLSAAEQSAAESDIFIGCAAVADYRADTVAEHKLKKADASDTMTLTLVKNPDIVATIAAR
SPRPLVVGFAAETRDLERYARDKLTRKGMDMIVANDVSSAGLGFGADDNAALLLWHADDTIERQALPAQAKTDLADAIVD
RVLSLYANRAATAHD

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=36.6666666666667, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=54.7029702970297, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17560194, Length=197, Percent_Identity=34.5177664974619, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24657262, Length=96, Percent_Identity=34.375, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43944; Mature: 43812

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLSPMPLAGKRVLLGISAGIAAYKSAHLARLLKKAGCEVRVVMTEGAQAFITPLTLQA
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEHHHHHHH
LTGEAVRTSLLDPEAEAGMGHIELARWAELILVAPATADVMARLAHGHADDLLTTLCLAS
HCCHHHHHHHCCCHHHCCCCHHHHHHHEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCC
DAECIMAPAMNQAMWAHPATQANVATLHRLGWRLLGPDGGEQACGDVGPGRMREPEALLA
CCCEEECCCCCHHHHCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHH
ELAEAPVVRDAEALRVTITAGPTREALDPVRYLSNHSSGKMGYALAEAWARRGAQVRLIS
HHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEE
GPVTLAAPTNVERVDVTSASEMLSAAEQSAAESDIFIGCAAVADYRADTVAEHKLKKADA
CCEEEECCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCC
SDTMTLTLVKNPDIVATIAARSPRPLVVGFAAETRDLERYARDKLTRKGMDMIVANDVSS
CCCEEEEEEECCCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCC
AGLGFGADDNAALLLWHADDTIERQALPAQAKTDLADAIVDRVLSLYANRAATAHD
CCCCCCCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SQLSPMPLAGKRVLLGISAGIAAYKSAHLARLLKKAGCEVRVVMTEGAQAFITPLTLQA
CCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEHHHHHHH
LTGEAVRTSLLDPEAEAGMGHIELARWAELILVAPATADVMARLAHGHADDLLTTLCLAS
HCCHHHHHHHCCCHHHCCCCHHHHHHHEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCC
DAECIMAPAMNQAMWAHPATQANVATLHRLGWRLLGPDGGEQACGDVGPGRMREPEALLA
CCCEEECCCCCHHHHCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHH
ELAEAPVVRDAEALRVTITAGPTREALDPVRYLSNHSSGKMGYALAEAWARRGAQVRLIS
HHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEE
GPVTLAAPTNVERVDVTSASEMLSAAEQSAAESDIFIGCAAVADYRADTVAEHKLKKADA
CCEEEECCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCC
SDTMTLTLVKNPDIVATIAARSPRPLVVGFAAETRDLERYARDKLTRKGMDMIVANDVSS
CCCEEEEEEECCCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCCC
AGLGFGADDNAALLLWHADDTIERQALPAQAKTDLADAIVDRVLSLYANRAATAHD
CCCCCCCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]