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The map label for this gene is pepA

Identifier: 92115034

GI number: 92115034

Start: 3250545

End: 3252068

Strand: Direct

Name: pepA

Synonym: Csal_2918

Alternate gene names: 92115034

Gene position: 3250545-3252068 (Clockwise)

Preceding gene: 92115031

Following gene: 92115035

Centisome position: 87.93

GC content: 68.44

Gene sequence:

>1524_bases
ATGGAATTCCCCGTACTCACCGTCAATCCGGCCAAAATCGAAACGGCATGTCTGGTCGTGCCGGTCTTCAAGGATGGTGA
CCTGCTACCCGCGGCGGACAAGCTCGACGACGCCAGCGAACGCCTGATCGGCCAACTGCTCGACCGGGGCGACTTCGAGC
CCAGCCTCGGCAACGTGCAGCTGATCCCGTTCGCGCCCGGCCTCGGCGCCGAGCGCCTGCTGCTCGTCGGTCTCGGCGAG
CGCGCCAAGTGCGGCGAGAGCCAGCTCATCAAGGCCCTGGATGCCGCGTTCGGTGCCATCGCCAAGCTGCCGCTGGATGA
CGTGGCGGCGACCTTCACCGACGTGCCCGTCGGCGAGCGCGACACCGCCTGGAAGGCCCGCGTGACGCTGGAGGCCGCGC
ACCGTGCCTGCTACCGCTTCGACGAGTTCAAGTCGGAGCCCGCACCAGCGCCGCGCCTCTCCAGCCTGACGCTGCTGGTC
GGCGACGAGGACCAGGCCGCCCAGGCCGAGCTCGGCGCGCGCGTGGGCGCGGCCGTCGGCGAAGGGGTCTCCCTGACCCG
TACGCTGGGCAACCTGCCCGGCAATGTCTGCACGCCGCGCTATCTCGCCGACCAGGCCCAGCGTCTGGCCGATGGCGCCG
ACGGTGCGCTGAACGTCGAGATCCTCGACGAGGATGCGCTGGAAGCACTGGGCGCCAATGCCCTGCTCGCGGTCGGCCAG
GGCAGCGCGGAGCCCTCGCGGCTGATCGTCATGGAATATCGCGGCGCCGAGGACCCGGAAGAAGCGCCGCACATCCTGGT
CGGCAAGGGCATCACCTTCGACTCCGGCGGCATCTCGCTCAAGCCGGGGGCCGGCATGGACGAGATGAAGTTCGACATGT
GCGGCGCCGCCAGCGTCTTCGGCACCATGAAGACGGTGCTCGGGCTCAAGCCCAGGATCAATGTCATCGGCGTGGTAGCA
AGTGCCGAGAACATGCCCGACGGCCGCGCCATCAAGCCCGGCGACATCGTCAAGACACTCAAGGGGCTCAACGTCGAGAT
CCTCAACACCGACGCCGAAGGACGGATGGTGCTGTGCGACGCGCTGAGCTATGTCGAGCGTTTCAAGCCCGCCAGCGTGG
TGGACATCGCCACCCTGACCGGTGCCGCGATCATCGCGCTTGGTCATCATGCCTCTGGGCTTCTGTCCAACGACGACGAC
CTGGCGCTCGACCTGCTCGACGCCGGCGAGAACGCCTGGGACCGCGCCTGGCACCTGCCGCTGTGGGACGAGTACCAGAG
CCAGCTGGACTCCAACTTCGCCGACCTGGCTCATATCGGCGGTCGCCCCGCCGGTACCATCACGGCAGCCTGCTTCCTGT
CACGCTTCGCCGATGCCTATCCGTGGGCGCACCTGGACATCGCCGGCACCGCCTGGGCCTCGGGCGACAAGAAAGGCGCC
AGCGGGCGGCCGGTGGGGCTGCTGACCCAGTACTTGCTCGACCGCGAAACCGAAGCCGCCGAGACGCGTCCCAGCGTCGA
GTGA

Upstream 100 bases:

>100_bases
GTACGTTCAGCGCCGGCATCCTTGTCGGCATTATCCAGAATCCCCGGACACTTGTCTCGCCACGAGACAGGTCATGTCAG
CCCAGTCGTTTGGAGACGCC

Downstream 100 bases:

>100_bases
TGCTTCGCAGGCAACTATTTGCATGCTAACGTAAACCTCAGGCGTGTCGGACTTTCCCCCTCCGACGCGCCTGTGTCATT
CTCGGCGTCCGTGCGGCCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MEFPVLTVNPAKIETACLVVPVFKDGDLLPAADKLDDASERLIGQLLDRGDFEPSLGNVQLIPFAPGLGAERLLLVGLGE
RAKCGESQLIKALDAAFGAIAKLPLDDVAATFTDVPVGERDTAWKARVTLEAAHRACYRFDEFKSEPAPAPRLSSLTLLV
GDEDQAAQAELGARVGAAVGEGVSLTRTLGNLPGNVCTPRYLADQAQRLADGADGALNVEILDEDALEALGANALLAVGQ
GSAEPSRLIVMEYRGAEDPEEAPHILVGKGITFDSGGISLKPGAGMDEMKFDMCGAASVFGTMKTVLGLKPRINVIGVVA
SAENMPDGRAIKPGDIVKTLKGLNVEILNTDAEGRMVLCDALSYVERFKPASVVDIATLTGAAIIALGHHASGLLSNDDD
LALDLLDAGENAWDRAWHLPLWDEYQSQLDSNFADLAHIGGRPAGTITAACFLSRFADAYPWAHLDIAGTAWASGDKKGA
SGRPVGLLTQYLLDRETEAAETRPSVE

Sequences:

>Translated_507_residues
MEFPVLTVNPAKIETACLVVPVFKDGDLLPAADKLDDASERLIGQLLDRGDFEPSLGNVQLIPFAPGLGAERLLLVGLGE
RAKCGESQLIKALDAAFGAIAKLPLDDVAATFTDVPVGERDTAWKARVTLEAAHRACYRFDEFKSEPAPAPRLSSLTLLV
GDEDQAAQAELGARVGAAVGEGVSLTRTLGNLPGNVCTPRYLADQAQRLADGADGALNVEILDEDALEALGANALLAVGQ
GSAEPSRLIVMEYRGAEDPEEAPHILVGKGITFDSGGISLKPGAGMDEMKFDMCGAASVFGTMKTVLGLKPRINVIGVVA
SAENMPDGRAIKPGDIVKTLKGLNVEILNTDAEGRMVLCDALSYVERFKPASVVDIATLTGAAIIALGHHASGLLSNDDD
LALDLLDAGENAWDRAWHLPLWDEYQSQLDSNFADLAHIGGRPAGTITAACFLSRFADAYPWAHLDIAGTAWASGDKKGA
SGRPVGLLTQYLLDRETEAAETRPSVE
>Mature_507_residues
MEFPVLTVNPAKIETACLVVPVFKDGDLLPAADKLDDASERLIGQLLDRGDFEPSLGNVQLIPFAPGLGAERLLLVGLGE
RAKCGESQLIKALDAAFGAIAKLPLDDVAATFTDVPVGERDTAWKARVTLEAAHRACYRFDEFKSEPAPAPRLSSLTLLV
GDEDQAAQAELGARVGAAVGEGVSLTRTLGNLPGNVCTPRYLADQAQRLADGADGALNVEILDEDALEALGANALLAVGQ
GSAEPSRLIVMEYRGAEDPEEAPHILVGKGITFDSGGISLKPGAGMDEMKFDMCGAASVFGTMKTVLGLKPRINVIGVVA
SAENMPDGRAIKPGDIVKTLKGLNVEILNTDAEGRMVLCDALSYVERFKPASVVDIATLTGAAIIALGHHASGLLSNDDD
LALDLLDAGENAWDRAWHLPLWDEYQSQLDSNFADLAHIGGRPAGTITAACFLSRFADAYPWAHLDIAGTAWASGDKKGA
SGRPVGLLTQYLLDRETEAAETRPSVE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=436, Percent_Identity=35.7798165137615, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI47155554, Length=327, Percent_Identity=31.1926605504587, Blast_Score=109, Evalue=7e-24,
Organism=Escherichia coli, GI1790710, Length=496, Percent_Identity=48.1854838709677, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=40.0630914826498, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=304, Percent_Identity=33.2236842105263, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17565172, Length=252, Percent_Identity=29.3650793650794, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24661038, Length=352, Percent_Identity=32.9545454545455, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI21355725, Length=355, Percent_Identity=32.3943661971831, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20129969, Length=390, Percent_Identity=34.3589743589744, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24662227, Length=530, Percent_Identity=30.377358490566, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI161077148, Length=375, Percent_Identity=31.4666666666667, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI20130057, Length=375, Percent_Identity=31.4666666666667, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI21355645, Length=391, Percent_Identity=31.7135549872123, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24662223, Length=391, Percent_Identity=31.7135549872123, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI19922386, Length=376, Percent_Identity=31.9148936170213, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129963, Length=448, Percent_Identity=28.7946428571429, Blast_Score=155, Evalue=9e-38,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=30.0940438871473, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=30.0940438871473, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=30.0940438871473, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646701, Length=175, Percent_Identity=37.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=175, Percent_Identity=37.7142857142857, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=175, Percent_Identity=37.7142857142857, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CHRSD (Q1QTE5)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574962.1
- ProteinModelPortal:   Q1QTE5
- SMR:   Q1QTE5
- STRING:   Q1QTE5
- MEROPS:   M17.003
- GeneID:   4028313
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2918
- NMPDR:   fig|290398.4.peg.3017
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- BioCyc:   CSAL290398:CSAL_2918-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53426; Mature: 53426

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 281-281 ACT_SITE 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFPVLTVNPAKIETACLVVPVFKDGDLLPAADKLDDASERLIGQLLDRGDFEPSLGNVQ
CCCCEEEECCCCEEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCEE
LIPFAPGLGAERLLLVGLGERAKCGESQLIKALDAAFGAIAKLPLDDVAATFTDVPVGER
EEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
DTAWKARVTLEAAHRACYRFDEFKSEPAPAPRLSSLTLLVGDEDQAAQAELGARVGAAVG
CCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
EGVSLTRTLGNLPGNVCTPRYLADQAQRLADGADGALNVEILDEDALEALGANALLAVGQ
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHCCCCEEEEECC
GSAEPSRLIVMEYRGAEDPEEAPHILVGKGITFDSGGISLKPGAGMDEMKFDMCGAASVF
CCCCCCEEEEEEECCCCCCCCCCCEEEECCEEECCCCEEECCCCCCCHHHHHHCCHHHHH
GTMKTVLGLKPRINVIGVVASAENMPDGRAIKPGDIVKTLKGLNVEILNTDAEGRMVLCD
HHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCEEHHH
ALSYVERFKPASVVDIATLTGAAIIALGHHASGLLSNDDDLALDLLDAGENAWDRAWHLP
HHHHHHHCCCCCEEEHHHHCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHEECCC
LWDEYQSQLDSNFADLAHIGGRPAGTITAACFLSRFADAYPWAHLDIAGTAWASGDKKGA
CHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCC
SGRPVGLLTQYLLDRETEAAETRPSVE
CCCCHHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure
MEFPVLTVNPAKIETACLVVPVFKDGDLLPAADKLDDASERLIGQLLDRGDFEPSLGNVQ
CCCCEEEECCCCEEEEEEEEEEECCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCEE
LIPFAPGLGAERLLLVGLGERAKCGESQLIKALDAAFGAIAKLPLDDVAATFTDVPVGER
EEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
DTAWKARVTLEAAHRACYRFDEFKSEPAPAPRLSSLTLLVGDEDQAAQAELGARVGAAVG
CCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
EGVSLTRTLGNLPGNVCTPRYLADQAQRLADGADGALNVEILDEDALEALGANALLAVGQ
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHCCCCEEEEECC
GSAEPSRLIVMEYRGAEDPEEAPHILVGKGITFDSGGISLKPGAGMDEMKFDMCGAASVF
CCCCCCEEEEEEECCCCCCCCCCCEEEECCEEECCCCEEECCCCCCCHHHHHHCCHHHHH
GTMKTVLGLKPRINVIGVVASAENMPDGRAIKPGDIVKTLKGLNVEILNTDAEGRMVLCD
HHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCEEHHH
ALSYVERFKPASVVDIATLTGAAIIALGHHASGLLSNDDDLALDLLDAGENAWDRAWHLP
HHHHHHHCCCCCEEEHHHHCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHEECCC
LWDEYQSQLDSNFADLAHIGGRPAGTITAACFLSRFADAYPWAHLDIAGTAWASGDKKGA
CHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCC
SGRPVGLLTQYLLDRETEAAETRPSVE
CCCCHHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA