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The map label for this gene is ndk

Identifier: 92114967

GI number: 92114967

Start: 3180992

End: 3181417

Strand: Direct

Name: ndk

Synonym: Csal_2850

Alternate gene names: 92114967

Gene position: 3180992-3181417 (Clockwise)

Preceding gene: 92114966

Following gene: 92114968

Centisome position: 86.05

GC content: 63.38

Gene sequence:

>426_bases
ATGGCCAACGAACGCACCCTGTCCATCATCAAGCCCGACGCCGTCGCCAAGAACGTCATCGGCGAAATCGAAAGCCGCTT
CGAAAAGGCCGGCCTGAAAATCGTCGCCGCCAAGATGCTGCAGCTTTCCCAGGCCCAGGCCGAAGGGTTCTACGCCGAGC
ACAAGGAACGCCCCTTCTTCGGCGACCTGGTCGGCTTCATGACGTCCGGGCCGGTGATCGTGCAGGTGCTGGAAGGCGAG
AATGCCATCGCCGCCAACCGTGACCTGATGGGCGCCACCAATCCCAAGGAAGCCGCCGCCGGCACCATTCGCGCCGACTT
CGCGCAGTCCATCGACGCCAATGCCGTGCACGGCTCCGACTCGCCGGAATCCGCCGAGCGCGAGATTGCTTACTTCTTCG
GCAACGAAGAGATCTGCGCACGCTGA

Upstream 100 bases:

>100_bases
TTTTTCGACATCCGTCGAGCGTCATGCAACGCGTCGCCCCGAGCGGCGCGTTGCCGTCTCGACCCAGACCATCGCTTTCC
GTCACGGAGAATTTGACCTC

Downstream 100 bases:

>100_bases
TCGCTTCGCGCGGGGGCCGCGAGGCCCCCGCACCGCCATCCACCGAGCGTACGACCCACCATGACCCTCGATACCGTCAC
GCCCCGTACCAACCTTCTCG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MANERTLSIIKPDAVAKNVIGEIESRFEKAGLKIVAAKMLQLSQAQAEGFYAEHKERPFFGDLVGFMTSGPVIVQVLEGE
NAIAANRDLMGATNPKEAAAGTIRADFAQSIDANAVHGSDSPESAEREIAYFFGNEEICAR

Sequences:

>Translated_141_residues
MANERTLSIIKPDAVAKNVIGEIESRFEKAGLKIVAAKMLQLSQAQAEGFYAEHKERPFFGDLVGFMTSGPVIVQVLEGE
NAIAANRDLMGATNPKEAAAGTIRADFAQSIDANAVHGSDSPESAEREIAYFFGNEEICAR
>Mature_140_residues
ANERTLSIIKPDAVAKNVIGEIESRFEKAGLKIVAAKMLQLSQAQAEGFYAEHKERPFFGDLVGFMTSGPVIVQVLEGEN
AIAANRDLMGATNPKEAAAGTIRADFAQSIDANAVHGSDSPESAEREIAYFFGNEEICAR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=48.9051094890511, Blast_Score=144, Evalue=2e-35,
Organism=Homo sapiens, GI66392203, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=9e-33,
Organism=Homo sapiens, GI66392227, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392205, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4505409, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392192, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=46.7625899280576, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=40.7142857142857, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=40.2877697841727, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=40.2877697841727, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI4505413, Length=133, Percent_Identity=37.593984962406, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=39.7058823529412, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI30023828, Length=142, Percent_Identity=34.5070422535211, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=32.1167883211679, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=67.3758865248227, Blast_Score=196, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=46.0431654676259, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=45.985401459854, Blast_Score=135, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=45.2554744525547, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=37.3134328358209, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CHRSD (Q1QTL2)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574895.1
- ProteinModelPortal:   Q1QTL2
- SMR:   Q1QTL2
- STRING:   Q1QTL2
- GeneID:   4028652
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2850
- NMPDR:   fig|290398.4.peg.2434
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- BioCyc:   CSAL290398:CSAL_2850-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15160; Mature: 15029

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANERTLSIIKPDAVAKNVIGEIESRFEKAGLKIVAAKMLQLSQAQAEGFYAEHKERPFF
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHCCCCCCH
GDLVGFMTSGPVIVQVLEGENAIAANRDLMGATNPKEAAAGTIRADFAQSIDANAVHGSD
HHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCC
SPESAEREIAYFFGNEEICAR
CCCCHHHEEEEEECCHHHHCC
>Mature Secondary Structure 
ANERTLSIIKPDAVAKNVIGEIESRFEKAGLKIVAAKMLQLSQAQAEGFYAEHKERPFF
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHCCCCCCH
GDLVGFMTSGPVIVQVLEGENAIAANRDLMGATNPKEAAAGTIRADFAQSIDANAVHGSD
HHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCC
SPESAEREIAYFFGNEEICAR
CCCCHHHEEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA