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The map label for this gene is fruR [H]

Identifier: 92114767

GI number: 92114767

Start: 2963937

End: 2964950

Strand: Direct

Name: fruR [H]

Synonym: Csal_2649

Alternate gene names: 92114767

Gene position: 2963937-2964950 (Clockwise)

Preceding gene: 92114763

Following gene: 92114768

Centisome position: 80.18

GC content: 67.65

Gene sequence:

>1014_bases
ATGACTCTCGCAGAAATCGCTCGGCTGGCGGGCGTCTCGCGCACCACGGCCAGTTACGTGATCAACGGCCAGGCCGCCGA
GCGGCGCATCCGACCGGAGACGGTGGCTCACGTCATGGCCGTGGTCGCCAAGTACGACTACCGCATCGACGCTCAGGCGG
CGGCGCTGCGACGTGGCGCGAGTCGCACGCTGGGATTCATCGTGCCGGACCTGGAAAACACCAGCTATGCACGGCTGGCC
AAGCGCCTGGAAAACGGGGCGCGTCGTCAAGGCTATCAATTGCTGATCGCCGGGTCGGACGACGACCCGGATACCGAGCG
CGAGCTGGCCCGCGCCCTGCGTGCGCAACGCTGCGATGCCTTGATCGTCGCCAGCAGCCTGGCCATGGACGATCCCTTCT
ACCTCGACCTGATGGCGGGCGGGCTTCCGGTCATCGCGCTGGATCGCGCCCTCGACCCCGAGCGCTTCGTCTGCGTGGTC
AGCAACAACCATCAGGCCGCCGGCGCCCTGACGCGCTCGGTCATCGACGACGATGTCACCCGCATCGCCTGGCTGGATGC
GGTCCCCGAACTGTCGATCAGCGTGGAACGTCGTGCCGGTTTTCTGGATACCACCCGCGAGGCCAGGCTCGATGCCCCGC
TGCTGCTCAGCGGCGCGCGTTACGACCGCGCCACCGGCGCCGCCCTCATGCGACGCCTGATCGACGAACACGGCGTTCCC
GATGCCCTGGTCACCGCCTCTTACGTGTTGCTGGACGGTGTCTTCGACGTGCTGCTCGAGCAAGGCGGCCTGCCCGAGCG
GCTGCGCCTGGCGACATTCGGCGACGACCGCCTGCTGGACTTCCTGCCCCTGGCGGTCAATTCCCTGCCCCAGCACCACG
ACCGCATCGCCGAGCTGGCCCTGACCCGCGCCATGCAAGCGGCATCCGGCGATTATCGCCCCGGCATCGACATCGTCGAA
CGTTCTCTGCACGACCGTCGCAGCCTCAAAAGGATGCACGCCCCGACACCTTGA

Upstream 100 bases:

>100_bases
GCGGCACGACACTAGACCTTCGCAGGGTCAGGCAGGCAAGACTGCCCGTCAGCCTCTAGAATAGGCGCCTTCGTGTCACC
GGCTCGCTCAAGGAATGTCC

Downstream 100 bases:

>100_bases
TCGGCGGGGTTGGCCCGGGCGCAAAAAACTGGCCATGCTGTCTTCACCATTGCCTGCATCCGACGAGGCACGTCATGAAG
GAACTCCCCCTGCAAGATCG

Product: DNA-binding transcriptional regulator FruR

Products: NA

Alternate protein names: Catabolite repressor/activator [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTLAEIARLAGVSRTTASYVINGQAAERRIRPETVAHVMAVVAKYDYRIDAQAAALRRGASRTLGFIVPDLENTSYARLA
KRLENGARRQGYQLLIAGSDDDPDTERELARALRAQRCDALIVASSLAMDDPFYLDLMAGGLPVIALDRALDPERFVCVV
SNNHQAAGALTRSVIDDDVTRIAWLDAVPELSISVERRAGFLDTTREARLDAPLLLSGARYDRATGAALMRRLIDEHGVP
DALVTASYVLLDGVFDVLLEQGGLPERLRLATFGDDRLLDFLPLAVNSLPQHHDRIAELALTRAMQAASGDYRPGIDIVE
RSLHDRRSLKRMHAPTP

Sequences:

>Translated_337_residues
MTLAEIARLAGVSRTTASYVINGQAAERRIRPETVAHVMAVVAKYDYRIDAQAAALRRGASRTLGFIVPDLENTSYARLA
KRLENGARRQGYQLLIAGSDDDPDTERELARALRAQRCDALIVASSLAMDDPFYLDLMAGGLPVIALDRALDPERFVCVV
SNNHQAAGALTRSVIDDDVTRIAWLDAVPELSISVERRAGFLDTTREARLDAPLLLSGARYDRATGAALMRRLIDEHGVP
DALVTASYVLLDGVFDVLLEQGGLPERLRLATFGDDRLLDFLPLAVNSLPQHHDRIAELALTRAMQAASGDYRPGIDIVE
RSLHDRRSLKRMHAPTP
>Mature_336_residues
TLAEIARLAGVSRTTASYVINGQAAERRIRPETVAHVMAVVAKYDYRIDAQAAALRRGASRTLGFIVPDLENTSYARLAK
RLENGARRQGYQLLIAGSDDDPDTERELARALRAQRCDALIVASSLAMDDPFYLDLMAGGLPVIALDRALDPERFVCVVS
NNHQAAGALTRSVIDDDVTRIAWLDAVPELSISVERRAGFLDTTREARLDAPLLLSGARYDRATGAALMRRLIDEHGVPD
ALVTASYVLLDGVFDVLLEQGGLPERLRLATFGDDRLLDFLPLAVNSLPQHHDRIAELALTRAMQAASGDYRPGIDIVER
SLHDRRSLKRMHAPTP

Specific function: Represses some operons but activates others. It is implicated in the regulation of a large number of operons encoding enzymes which comprise central pathways of carbon metabolism. Binds D-fructose as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786268, Length=339, Percent_Identity=44.5427728613569, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788474, Length=324, Percent_Identity=27.7777777777778, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790194, Length=305, Percent_Identity=24.2622950819672, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789068, Length=279, Percent_Identity=26.1648745519713, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789202, Length=276, Percent_Identity=26.4492753623188, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787906, Length=204, Percent_Identity=29.9019607843137, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787580, Length=287, Percent_Identity=22.2996515679443, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012781
- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36984; Mature: 36852

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAEIARLAGVSRTTASYVINGQAAERRIRPETVAHVMAVVAKYDYRIDAQAAALRRGA
CCHHHHHHHHCCCCCHHHHEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
SRTLGFIVPDLENTSYARLAKRLENGARRQGYQLLIAGSDDDPDTERELARALRAQRCDA
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCH
LIVASSLAMDDPFYLDLMAGGLPVIALDRALDPERFVCVVSNNHQAAGALTRSVIDDDVT
HEEHHHHCCCCCCEEHHHHCCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
RIAWLDAVPELSISVERRAGFLDTTREARLDAPLLLSGARYDRATGAALMRRLIDEHGVP
HHHHHHCCCCCCEEHHHHCCCCCCCHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCCC
DALVTASYVLLDGVFDVLLEQGGLPERLRLATFGDDRLLDFLPLAVNSLPQHHDRIAELA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHH
LTRAMQAASGDYRPGIDIVERSLHDRRSLKRMHAPTP
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLAEIARLAGVSRTTASYVINGQAAERRIRPETVAHVMAVVAKYDYRIDAQAAALRRGA
CHHHHHHHHCCCCCHHHHEECCHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
SRTLGFIVPDLENTSYARLAKRLENGARRQGYQLLIAGSDDDPDTERELARALRAQRCDA
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCH
LIVASSLAMDDPFYLDLMAGGLPVIALDRALDPERFVCVVSNNHQAAGALTRSVIDDDVT
HEEHHHHCCCCCCEEHHHHCCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
RIAWLDAVPELSISVERRAGFLDTTREARLDAPLLLSGARYDRATGAALMRRLIDEHGVP
HHHHHHCCCCCCEEHHHHCCCCCCCHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCCC
DALVTASYVLLDGVFDVLLEQGGLPERLRLATFGDDRLLDFLPLAVNSLPQHHDRIAELA
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHH
LTRAMQAASGDYRPGIDIVERSLHDRRSLKRMHAPTP
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]