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The map label for this gene is proA

Identifier: 92113665

GI number: 92113665

Start: 1753806

End: 1755092

Strand: Direct

Name: proA

Synonym: Csal_1541

Alternate gene names: 92113665

Gene position: 1753806-1755092 (Clockwise)

Preceding gene: 92113661

Following gene: 92113666

Centisome position: 47.44

GC content: 66.05

Gene sequence:

>1287_bases
ATGGCCCTTGAAACTTCCGCTCCCGAGATCGCCGACGTCGAGGCCTACATGCGCGCGCTGGGCGAGCGGGCGCGCGATGC
GTCGCGTATGCTGGCGCGAGCCACGACTGCGCAAAAGAACCGAGCCCTGCACGCCATGGCCGAGGCCCTGGACGCCGCCC
GAGAGACACTCGAGACGGCCAATCGCCGCGACCTCGAGGCAGGGCGTGCCAATGGCCTCGACGAGGCGCTGCTGGACCGC
CTCGCACTCACCCCTGCGCGCATCGATTCGATGATCGAGGGGTTGCGCCAGGTGGCCGCCTTGCCCGATCCCGTCGGCGA
GATTCGCGACATGCGTTATCTCCCTTCTGGCATTCAGGTCGGCAAGATGCGCGTGGCACTCGGCGTGGTCGGCATCGTCT
ACGAATCGCGTCCCAATGTCACGGTGGATGCGGCCAGTCTATGCCTCAAGTCCGGTAACGCCACCATCTTGCGTGGTGGT
TCGGAGGCGATTCAATCCAACCGTGCGATCGCCGACTGCATTCGTCAGGGCTTGGCGGCGGCGGATCTCGACGCTGCCTG
CGTGCAGGTGGTGGCGACCACGGATCGCGCGGCCGTGGGGGCGCTGATCGCCATGCCCGAGTACGTGGATGTGATCGTGC
CGCGTGGCGGCAAGGGGTTGATCGAGCGCATCTCGCGCGACGCCAGGGTCCCGGTGATCAAGCATCTCGACGGCGTATGC
CATGTCTACGTCGACAGGGCGGCCGATGATGCCAAGGCTGTGGCGATCGCCGACAACGCCAAGACGCAACGTTATTCGCC
CTGCAATACCATGGAAACCCTGCTGGTGCATGTCGACGCCGCCCCGCGGGTGCTGCCCGAGCTGGCTCGGCTCTATGCGA
GCAAGGGCGTCGAGCTGCGCGCCTGCGAACGGGCACGAGCCTGGCTGGCCGATGCCGTGGCTGCCACCGAGGATGACTGG
CATGCCGAATACCTGGCGCCGATTCTGGCGGTACGCGTGGTCGACTCCCTGGAGGAGGCGATCGCGCATATCAATACCTA
CGGCTCGCATCACACTGATGCCATCGTGACCGAGAGCGTGACCGATGCCCGGCGCTTCCTCGCCGAGGTGGATTCCAGCT
CGGTCATGGTCAACGCCTCGACGCGTTTCGCCGACGGCTTCGAGTATGGCCTGGGGGCCGAGATCGGCATCTCCACCGAC
AAGCTGCATGCCCGCGGCCCGGTCGGACTCGAAGGCCTCACCAGCGAAAAGTACATCGTGTACGGCGACGGCCATGTGCG
CAGCTGA

Upstream 100 bases:

>100_bases
ACGGTGCCGGCAGTATAGCCGCTGTTCACCTGTCGTCATGCTCCGGAAAGCGCTGCAAAACACGTGCTTCCCACCGTATA
CCTAGGAGAAGACTGCCCGC

Downstream 100 bases:

>100_bases
GGCGCGTCCGGCCCGGGTGGCCATGCTCGGCGGAACCTTCGACCCTGTGCACATGGGGCATCTGCGAAGCGCCGTCGAGC
TGCGCGAAGCACTCGAGCTG

Product: glutamate-5-semialdehyde dehydrogenase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MALETSAPEIADVEAYMRALGERARDASRMLARATTAQKNRALHAMAEALDAARETLETANRRDLEAGRANGLDEALLDR
LALTPARIDSMIEGLRQVAALPDPVGEIRDMRYLPSGIQVGKMRVALGVVGIVYESRPNVTVDAASLCLKSGNATILRGG
SEAIQSNRAIADCIRQGLAAADLDAACVQVVATTDRAAVGALIAMPEYVDVIVPRGGKGLIERISRDARVPVIKHLDGVC
HVYVDRAADDAKAVAIADNAKTQRYSPCNTMETLLVHVDAAPRVLPELARLYASKGVELRACERARAWLADAVAATEDDW
HAEYLAPILAVRVVDSLEEAIAHINTYGSHHTDAIVTESVTDARRFLAEVDSSSVMVNASTRFADGFEYGLGAEIGISTD
KLHARGPVGLEGLTSEKYIVYGDGHVRS

Sequences:

>Translated_428_residues
MALETSAPEIADVEAYMRALGERARDASRMLARATTAQKNRALHAMAEALDAARETLETANRRDLEAGRANGLDEALLDR
LALTPARIDSMIEGLRQVAALPDPVGEIRDMRYLPSGIQVGKMRVALGVVGIVYESRPNVTVDAASLCLKSGNATILRGG
SEAIQSNRAIADCIRQGLAAADLDAACVQVVATTDRAAVGALIAMPEYVDVIVPRGGKGLIERISRDARVPVIKHLDGVC
HVYVDRAADDAKAVAIADNAKTQRYSPCNTMETLLVHVDAAPRVLPELARLYASKGVELRACERARAWLADAVAATEDDW
HAEYLAPILAVRVVDSLEEAIAHINTYGSHHTDAIVTESVTDARRFLAEVDSSSVMVNASTRFADGFEYGLGAEIGISTD
KLHARGPVGLEGLTSEKYIVYGDGHVRS
>Mature_427_residues
ALETSAPEIADVEAYMRALGERARDASRMLARATTAQKNRALHAMAEALDAARETLETANRRDLEAGRANGLDEALLDRL
ALTPARIDSMIEGLRQVAALPDPVGEIRDMRYLPSGIQVGKMRVALGVVGIVYESRPNVTVDAASLCLKSGNATILRGGS
EAIQSNRAIADCIRQGLAAADLDAACVQVVATTDRAAVGALIAMPEYVDVIVPRGGKGLIERISRDARVPVIKHLDGVCH
VYVDRAADDAKAVAIADNAKTQRYSPCNTMETLLVHVDAAPRVLPELARLYASKGVELRACERARAWLADAVAATEDDWH
AEYLAPILAVRVVDSLEEAIAHINTYGSHHTDAIVTESVTDARRFLAEVDSSSVMVNASTRFADGFEYGLGAEIGISTDK
LHARGPVGLEGLTSEKYIVYGDGHVRS

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=37.621359223301, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=37.621359223301, Blast_Score=265, Evalue=7e-71,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=47.5961538461538, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17569969, Length=408, Percent_Identity=36.7647058823529, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17569967, Length=408, Percent_Identity=36.7647058823529, Blast_Score=270, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6324899, Length=432, Percent_Identity=38.8888888888889, Blast_Score=299, Evalue=5e-82,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=40.0977995110024, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CHRSD (Q1QXB4)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573593.1
- ProteinModelPortal:   Q1QXB4
- SMR:   Q1QXB4
- STRING:   Q1QXB4
- GeneID:   4027639
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1541
- NMPDR:   fig|290398.4.peg.2596
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- BioCyc:   CSAL290398:CSAL_1541-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45828; Mature: 45696

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALETSAPEIADVEAYMRALGERARDASRMLARATTAQKNRALHAMAEALDAARETLETA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRRDLEAGRANGLDEALLDRLALTPARIDSMIEGLRQVAALPDPVGEIRDMRYLPSGIQV
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
GKMRVALGVVGIVYESRPNVTVDAASLCLKSGNATILRGGSEAIQSNRAIADCIRQGLAA
HHHHHHHHHHHHEEECCCCEEEHHHHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHCCCC
ADLDAACVQVVATTDRAAVGALIAMPEYVDVIVPRGGKGLIERISRDARVPVIKHLDGVC
CCHHHHHHHHHHCCCHHHHHHHHHCCCHHEEEECCCCHHHHHHHCCCCCCCHHHHCCCCE
HVYVDRAADDAKAVAIADNAKTQRYSPCNTMETLLVHVDAAPRVLPELARLYASKGVELR
EEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEH
ACERARAWLADAVAATEDDWHAEYLAPILAVRVVDSLEEAIAHINTYGSHHTDAIVTESV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TDARRFLAEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSEKYIV
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEE
YGDGHVRS
ECCCCCCC
>Mature Secondary Structure 
ALETSAPEIADVEAYMRALGERARDASRMLARATTAQKNRALHAMAEALDAARETLETA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRRDLEAGRANGLDEALLDRLALTPARIDSMIEGLRQVAALPDPVGEIRDMRYLPSGIQV
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
GKMRVALGVVGIVYESRPNVTVDAASLCLKSGNATILRGGSEAIQSNRAIADCIRQGLAA
HHHHHHHHHHHHEEECCCCEEEHHHHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHCCCC
ADLDAACVQVVATTDRAAVGALIAMPEYVDVIVPRGGKGLIERISRDARVPVIKHLDGVC
CCHHHHHHHHHHCCCHHHHHHHHHCCCHHEEEECCCCHHHHHHHCCCCCCCHHHHCCCCE
HVYVDRAADDAKAVAIADNAKTQRYSPCNTMETLLVHVDAAPRVLPELARLYASKGVELR
EEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEH
ACERARAWLADAVAATEDDWHAEYLAPILAVRVVDSLEEAIAHINTYGSHHTDAIVTESV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
TDARRFLAEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKLHARGPVGLEGLTSEKYIV
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCEEE
YGDGHVRS
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA