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The map label for this gene is pdxB

Identifier: 92113472

GI number: 92113472

Start: 1543228

End: 1544379

Strand: Direct

Name: pdxB

Synonym: Csal_1346

Alternate gene names: 92113472

Gene position: 1543228-1544379 (Clockwise)

Preceding gene: 92113470

Following gene: 92113477

Centisome position: 41.75

GC content: 66.93

Gene sequence:

>1152_bases
ATGCGCATCCTGGTCGATGAAAACATTCCCCTGGCGGACGAATTCTTCGGAGAGCTGGGCGACATCACCCGCTTGCCCGG
CCGCGATATCGACGCGGCGGCGGTACGCGAGCAAGACCTGCTGGTCGTGCGCTCGATCACCCGCGTGGATGCGGCGCTTC
TGGAAGGTTCCCGCGTGCGCTTCGTCGGCACCTGCACCATCGGTACCGATCACGTCGATCTCGATTACCTGCGCGAGGCG
GGCATCGGGTTCGCCAATGCTCCGGGATGCAATGCCGACTCGGTGGTCGACTACGTGCTCTCGAGCCTGCTGCTGCTGGC
CGAGGAGGATGGCTTCCATCTGGCCGGCAAGACCATCGGCATCGTCGGAGTCGGCAACGTGGGCAGCCGCCTGGCGGAGC
GTCTCGACGATCTCGACGTCGAATGCCTGCTGTGCGATCCGCCACGCGCCGAGGCGGAAGGGCGCGAGGATTTCCTGTCG
CTCGATGCGCTGCTCGAGCGGGCCGAGATCGTCTGCCTGCATACGCCGCTGGTGACGGAGGGCGAGCATGCGACCCGGCA
CCTGCTCGACGCGTCGCGCATCGACGCCCTGGCGCCGGGCACGGTGCTGATCAACGCCGGGCGTGGCGCCTGTGTCGATA
ACCAGGCCCTGCGCGAGCGGCTGCAGCGCGCCAACGACCTGCGGGTGGTGCTCGACGTGTGGGAAAACGAGCCCGGCATC
GACCCCGCACTCTACGATCTCGTGGACATCGCCACGCCGCATATCGCCGGGCACAGCATCGACGGCAAGATGCGCGGCAC
CGAGCTGGTCTATCAGGCGGCGATGCGTCAGTTCGGGCTGCCGGCACGCAAGAAGCTGGGGCAGCTCAAGCCCGACCCCT
GGCTGCGCAAGATCGTGCTGACGCCCTGGGCGCCGCCGCTGGAAGCACTCTCGCTATGCACGCGGGCCTGTTACGACGTG
CGCCGCGACATGCTGGCATTCGACCGCTACCGGCGGCGCATGGGCATGGCAACGGGCTTCGACGCCTACCGTGCCGAGTA
TCCGCTGCGTCGCGAGTTTTCCACCTTGCGGGTCGAGCTCAAGCAGAACAAGGGCGGCCTGCGCGATGCCCTCGAAGGCT
TTGGCTTCAAGGTCAAGCTGTCCAGCAAGTAG

Upstream 100 bases:

>100_bases
CCCCGGATGCCTGTATCGGGGCGGCCGTGACCGGCCAAGAGGCGCCTTGCGCGTATTGTAACCGGCCGCCGGACTTGGAC
AAGGGAGAAAAGAGAAGGTC

Downstream 100 bases:

>100_bases
CACGTGGCAAGTAGCAAGCGGCACGTGGCATGTCGCCTGACGTCATGCAGCGTGCCGAGATGAAAACACCCACCGACCTT
TTGATGACATTCAGGGCCGG

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MRILVDENIPLADEFFGELGDITRLPGRDIDAAAVREQDLLVVRSITRVDAALLEGSRVRFVGTCTIGTDHVDLDYLREA
GIGFANAPGCNADSVVDYVLSSLLLLAEEDGFHLAGKTIGIVGVGNVGSRLAERLDDLDVECLLCDPPRAEAEGREDFLS
LDALLERAEIVCLHTPLVTEGEHATRHLLDASRIDALAPGTVLINAGRGACVDNQALRERLQRANDLRVVLDVWENEPGI
DPALYDLVDIATPHIAGHSIDGKMRGTELVYQAAMRQFGLPARKKLGQLKPDPWLRKIVLTPWAPPLEALSLCTRACYDV
RRDMLAFDRYRRRMGMATGFDAYRAEYPLRREFSTLRVELKQNKGGLRDALEGFGFKVKLSSK

Sequences:

>Translated_383_residues
MRILVDENIPLADEFFGELGDITRLPGRDIDAAAVREQDLLVVRSITRVDAALLEGSRVRFVGTCTIGTDHVDLDYLREA
GIGFANAPGCNADSVVDYVLSSLLLLAEEDGFHLAGKTIGIVGVGNVGSRLAERLDDLDVECLLCDPPRAEAEGREDFLS
LDALLERAEIVCLHTPLVTEGEHATRHLLDASRIDALAPGTVLINAGRGACVDNQALRERLQRANDLRVVLDVWENEPGI
DPALYDLVDIATPHIAGHSIDGKMRGTELVYQAAMRQFGLPARKKLGQLKPDPWLRKIVLTPWAPPLEALSLCTRACYDV
RRDMLAFDRYRRRMGMATGFDAYRAEYPLRREFSTLRVELKQNKGGLRDALEGFGFKVKLSSK
>Mature_383_residues
MRILVDENIPLADEFFGELGDITRLPGRDIDAAAVREQDLLVVRSITRVDAALLEGSRVRFVGTCTIGTDHVDLDYLREA
GIGFANAPGCNADSVVDYVLSSLLLLAEEDGFHLAGKTIGIVGVGNVGSRLAERLDDLDVECLLCDPPRAEAEGREDFLS
LDALLERAEIVCLHTPLVTEGEHATRHLLDASRIDALAPGTVLINAGRGACVDNQALRERLQRANDLRVVLDVWENEPGI
DPALYDLVDIATPHIAGHSIDGKMRGTELVYQAAMRQFGLPARKKLGQLKPDPWLRKIVLTPWAPPLEALSLCTRACYDV
RRDMLAFDRYRRRMGMATGFDAYRAEYPLRREFSTLRVELKQNKGGLRDALEGFGFKVKLSSK

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily

Homologues:

Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=28.030303030303, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI145580578, Length=252, Percent_Identity=25.7936507936508, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI4557499, Length=252, Percent_Identity=25.7936507936508, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=27.0916334661355, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1788660, Length=359, Percent_Identity=49.5821727019499, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI87082289, Length=239, Percent_Identity=31.3807531380753, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=28.125, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=256, Percent_Identity=27.734375, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=299, Percent_Identity=28.7625418060201, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=292, Percent_Identity=26.7123287671233, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=299, Percent_Identity=28.4280936454849, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=258, Percent_Identity=24.031007751938, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=258, Percent_Identity=24.8062015503876, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24646446, Length=224, Percent_Identity=29.9107142857143, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646448, Length=224, Percent_Identity=29.9107142857143, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646452, Length=224, Percent_Identity=29.9107142857143, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646450, Length=224, Percent_Identity=29.9107142857143, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62472511, Length=221, Percent_Identity=29.8642533936652, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=24.7058823529412, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXB_CHRSD (Q1QXV7)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_573400.1
- ProteinModelPortal:   Q1QXV7
- SMR:   Q1QXV7
- STRING:   Q1QXV7
- GeneID:   4029130
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_1346
- NMPDR:   fig|290398.4.peg.1336
- eggNOG:   COG0111
- HOGENOM:   HBG289972
- OMA:   SAPGCNA
- ProtClustDB:   PRK00257
- BioCyc:   CSAL290398:CSAL_1346-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01825
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF4

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.290

Molecular weight: Translated: 42299; Mature: 42299

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 208-208 ACT_SITE 237-237 ACT_SITE 254-254 BINDING 45-45 BINDING 66-66 BINDING 146-146 BINDING 175-175 BINDING 232-232 BINDING 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVDENIPLADEFFGELGDITRLPGRDIDAAAVREQDLLVVRSITRVDAALLEGSRVR
CEEEECCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FVGTCTIGTDHVDLDYLREAGIGFANAPGCNADSVVDYVLSSLLLLAEEDGFHLAGKTIG
EEEEEECCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCEEE
IVGVGNVGSRLAERLDDLDVECLLCDPPRAEAEGREDFLSLDALLERAEIVCLHTPLVTE
EEEECCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCC
GEHATRHLLDASRIDALAPGTVLINAGRGACVDNQALRERLQRANDLRVVLDVWENEPGI
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCC
DPALYDLVDIATPHIAGHSIDGKMRGTELVYQAAMRQFGLPARKKLGQLKPDPWLRKIVL
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHEEE
TPWAPPLEALSLCTRACYDVRRDMLAFDRYRRRMGMATGFDAYRAEYPLRREFSTLRVEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHEEEE
KQNKGGLRDALEGFGFKVKLSSK
CCCCCCHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MRILVDENIPLADEFFGELGDITRLPGRDIDAAAVREQDLLVVRSITRVDAALLEGSRVR
CEEEECCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FVGTCTIGTDHVDLDYLREAGIGFANAPGCNADSVVDYVLSSLLLLAEEDGFHLAGKTIG
EEEEEECCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCEEE
IVGVGNVGSRLAERLDDLDVECLLCDPPRAEAEGREDFLSLDALLERAEIVCLHTPLVTE
EEEECCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCC
GEHATRHLLDASRIDALAPGTVLINAGRGACVDNQALRERLQRANDLRVVLDVWENEPGI
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCC
DPALYDLVDIATPHIAGHSIDGKMRGTELVYQAAMRQFGLPARKKLGQLKPDPWLRKIVL
CHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHEEE
TPWAPPLEALSLCTRACYDVRRDMLAFDRYRRRMGMATGFDAYRAEYPLRREFSTLRVEL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHEEEE
KQNKGGLRDALEGFGFKVKLSSK
CCCCCCHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA