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The map label for this gene is pyrD [H]

Identifier: 92113468

GI number: 92113468

Start: 1538785

End: 1539900

Strand: Direct

Name: pyrD [H]

Synonym: Csal_1342

Alternate gene names: 92113468

Gene position: 1538785-1539900 (Clockwise)

Preceding gene: 92113467

Following gene: 92113470

Centisome position: 41.63

GC content: 65.77

Gene sequence:

>1116_bases
ATGCAGGGCCCGTCTCGCCGCATGGCGAGGCGGGCCCTGCGCTTTTGCATGCGCATGAGCTATACTAGCCGCCCGCCGTT
TCCCGCTTTTCGTTTCGCCCGAGGACTCATGTACCCGCTGGCTCGCTCGCTACTGTTCCGTCTCGACCCCGAAACCGCTC
ACGGTCTCGCACTCGCTTCGCTGTCGGGGGCACATCGCCTCGGCCTGACCAAATGGCTCGGCGGTGAACGCGTCGAGGCA
CCGGTGACGCTCATGGGTCTGACGTTCCCCAATCGTGTGGGGCTGGCGGCAGGGCTCGACAAGAACGCCGAGCATCTCGA
TGCGCTGGGTGCGCTGGGGTTCGGCTTCGTCGAAGTGGGCACGGTGACGCCGCGTCCGCAAGCGGGCAATCCCAGGCCGC
GTCTGTTTCGCGTGCCGGAACGCGGCGCGATCATCAACCGCATGGGATTCAACAACGCCGGCGTCGACCGACTCGTCGAC
AACGTGCGCAAGAGCCGGTACGCGGGCGTCATCGGCATCAACATCGGCAAGAACCTGGATACCCCGGTGGAACGCGCGGT
GGACGATTACCTGACGTGCCTGCGCAAGGTGCATGCCCACGCGCATTACGTCACTGTCAATCTGTCGTCGCCCAACACGC
CGGGGTTGCGCAACCTGCAATTCGGCGAGCATCTGGATGCGTTGCTGGGGACGCTGCGCGAGGAAAAGCGCCGCCTCGAC
GAGAGCCACGGTCGGACGGTGCCGCTGGCCGTGAAAATCGCGCCTGACATGCAGGCCGAGGAAGTGGCGCTGGTGGCACG
CTCGCTGGCTGACCATGCAGTGGACGCGGTCATCGCCACCAATACCACGATCGCGCGCGACGCGGTCGAGGGGCTGGCAC
ATGCCGAGGAGTTGGGTGGCCTTTCCGGGCGGCCGGTATTCGAGCCTTCCAATGCGGTGATTCGCGAGTTGCGCCGACAC
CTGCCAACGCTGCCGATCATCGGCGTGGGCGGTATCGACAGCGGTGACGCCGCGAAGGCCAAGCGCGAGGCGGGCGCGGA
TCTCGTCCAGGTTTATACCGGCTTTATCTACCGTGGACCGTCGCTGGTGGGGGAGTGCGCGCGGGCATTGACATAA

Upstream 100 bases:

>100_bases
TGAAGGGCCAGAAGTTCGGCTCCGCGATGAGTGGCGTCAACAACTATACGTTGCGTGTGCAGCAGCTCGATACGCAGCCG
TAAGCGACGCCCGAGTGTCG

Downstream 100 bases:

>100_bases
CGGCGGGATGGCAAGGCGTCGTGGAAGCCGGTGGTGGAGCGTGCATGAAGGTCAACGCATGGCAACTAAAAAGGCCCGCG
CCGCGGGCCTTGTCGTGGAC

Product: dihydroorotate oxidase A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MQGPSRRMARRALRFCMRMSYTSRPPFPAFRFARGLMYPLARSLLFRLDPETAHGLALASLSGAHRLGLTKWLGGERVEA
PVTLMGLTFPNRVGLAAGLDKNAEHLDALGALGFGFVEVGTVTPRPQAGNPRPRLFRVPERGAIINRMGFNNAGVDRLVD
NVRKSRYAGVIGINIGKNLDTPVERAVDDYLTCLRKVHAHAHYVTVNLSSPNTPGLRNLQFGEHLDALLGTLREEKRRLD
ESHGRTVPLAVKIAPDMQAEEVALVARSLADHAVDAVIATNTTIARDAVEGLAHAEELGGLSGRPVFEPSNAVIRELRRH
LPTLPIIGVGGIDSGDAAKAKREAGADLVQVYTGFIYRGPSLVGECARALT

Sequences:

>Translated_371_residues
MQGPSRRMARRALRFCMRMSYTSRPPFPAFRFARGLMYPLARSLLFRLDPETAHGLALASLSGAHRLGLTKWLGGERVEA
PVTLMGLTFPNRVGLAAGLDKNAEHLDALGALGFGFVEVGTVTPRPQAGNPRPRLFRVPERGAIINRMGFNNAGVDRLVD
NVRKSRYAGVIGINIGKNLDTPVERAVDDYLTCLRKVHAHAHYVTVNLSSPNTPGLRNLQFGEHLDALLGTLREEKRRLD
ESHGRTVPLAVKIAPDMQAEEVALVARSLADHAVDAVIATNTTIARDAVEGLAHAEELGGLSGRPVFEPSNAVIRELRRH
LPTLPIIGVGGIDSGDAAKAKREAGADLVQVYTGFIYRGPSLVGECARALT
>Mature_371_residues
MQGPSRRMARRALRFCMRMSYTSRPPFPAFRFARGLMYPLARSLLFRLDPETAHGLALASLSGAHRLGLTKWLGGERVEA
PVTLMGLTFPNRVGLAAGLDKNAEHLDALGALGFGFVEVGTVTPRPQAGNPRPRLFRVPERGAIINRMGFNNAGVDRLVD
NVRKSRYAGVIGINIGKNLDTPVERAVDDYLTCLRKVHAHAHYVTVNLSSPNTPGLRNLQFGEHLDALLGTLREEKRRLD
ESHGRTVPLAVKIAPDMQAEEVALVARSLADHAVDAVIATNTTIARDAVEGLAHAEELGGLSGRPVFEPSNAVIRELRRH
LPTLPIIGVGGIDSGDAAKAKREAGADLVQVYTGFIYRGPSLVGECARALT

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=335, Percent_Identity=42.6865671641791, Blast_Score=220, Evalue=1e-57,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=55.3892215568862, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17509475, Length=355, Percent_Identity=37.7464788732394, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=39.8203592814371, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=39.8203592814371, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 40174; Mature: 40174

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGPSRRMARRALRFCMRMSYTSRPPFPAFRFARGLMYPLARSLLFRLDPETAHGLALAS
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHH
LSGAHRLGLTKWLGGERVEAPVTLMGLTFPNRVGLAAGLDKNAEHLDALGALGFGFVEVG
CCCHHHHCHHHHCCCCCCCCCEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHCCCCEEEC
TVTPRPQAGNPRPRLFRVPERGAIINRMGFNNAGVDRLVDNVRKSRYAGVIGINIGKNLD
CCCCCCCCCCCCCCEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCC
TPVERAVDDYLTCLRKVHAHAHYVTVNLSSPNTPGLRNLQFGEHLDALLGTLREEKRRLD
CHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ESHGRTVPLAVKIAPDMQAEEVALVARSLADHAVDAVIATNTTIARDAVEGLAHAEELGG
HHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
LSGRPVFEPSNAVIRELRRHLPTLPIIGVGGIDSGDAAKAKREAGADLVQVYTGFIYRGP
CCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHCCH
SLVGECARALT
HHHHHHHHHCC
>Mature Secondary Structure
MQGPSRRMARRALRFCMRMSYTSRPPFPAFRFARGLMYPLARSLLFRLDPETAHGLALAS
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHH
LSGAHRLGLTKWLGGERVEAPVTLMGLTFPNRVGLAAGLDKNAEHLDALGALGFGFVEVG
CCCHHHHCHHHHCCCCCCCCCEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHCCCCEEEC
TVTPRPQAGNPRPRLFRVPERGAIINRMGFNNAGVDRLVDNVRKSRYAGVIGINIGKNLD
CCCCCCCCCCCCCCEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCC
TPVERAVDDYLTCLRKVHAHAHYVTVNLSSPNTPGLRNLQFGEHLDALLGTLREEKRRLD
CHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ESHGRTVPLAVKIAPDMQAEEVALVARSLADHAVDAVIATNTTIARDAVEGLAHAEELGG
HHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
LSGRPVFEPSNAVIRELRRHLPTLPIIGVGGIDSGDAAKAKREAGADLVQVYTGFIYRGP
CCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCHHHHHHHHHHHHCCH
SLVGECARALT
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA