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The map label for this gene is ilvD [H]

Identifier: 92113272

GI number: 92113272

Start: 1309547

End: 1311349

Strand: Direct

Name: ilvD [H]

Synonym: Csal_1145

Alternate gene names: 92113272

Gene position: 1309547-1311349 (Clockwise)

Preceding gene: 92113269

Following gene: 92113275

Centisome position: 35.43

GC content: 65.95

Gene sequence:

>1803_bases
ATGAACGATCACAAGATCACCCCCGACCAGCTGCGCTCGCGCTGGTGGTTCGACAACCCCGAGCATCCGGGAACCACCGC
GCTGTGCATCGAACGCTACATGAACTACGGCCTGACCTTGGAAGAGCTCAAGAGCGGCAAGCCGATCATCGGCATTGCCC
AGTCGGGCTCCGACTTGACGCCTTGCAACCGTCATCACATCGAGCTGGTGAAGCGCGTCAAGGACGGTATCCGTGCGGCG
GGGGGCGTGCCGTTCGAGTTTCCGCTGCACCCGATTCACGAGAACGTGCGTCGACCCACCGCGGCGCTGGATCGCAACCT
GGCGTACCTGGGGCTGGTGGAAGTGCTGCATGGCTACCCGCTCGATGGCGTGGTGTTGACCACCGGCTGCGACAAGACCA
CGCCGGCGTGCTTGATGGCCGCCGCGACCGTCAACATCCCGGCGATCGTGCTCTCCGGTGGACCGATGCTCAACGGCTGG
CGCGGCAGTCAGGAACGCGTGGGCTCGGGCACCATCATCTGGGAGCTGCGCAAGCGTCTCGCGGCGGGCGATATCGACTA
CGAGGAATTCCTGTCCCGGGCCACCGACTCGGCGCCTTCCATCGGTCACTGCAATACCATGGGCACCGCGTCGACGATGA
ACTCCATGGCCGAGGCGCTGGGCATGAGCCTGCCCGGCTCGGCGATGATCCCGGCGCCTTACAAGGAGCGCTCGATGGTC
GCCTATCAGACCGGGACGCGCATCGTCGACATGGTGTGGGAAGATCTGCGCCCGCTGGACATCCTCACGCGTGAGGCGTG
CGAGAACGCCATCGTGGTGTGTTCGGCGCTGGGCGGTTCCTCCAACGCGCCGGTGCACATCAACGCCATCGCCCGTCATG
CCGGCGTCGAGTTGACCAACGACGACTGGCAACGGCTGGGCCATGACGTGCCGCTGCTGGCCAATGTCATGCCCGCGGGT
GCGTATCTGTCGGAGGAATTCCACCGTGCCGGTGGCGTTCCCGCGGTACTCAGCGAGCTGCTCAAGGCGGGGCGCGTGCA
TGGCGACGTGCCGACGGTCAACGGCAGGACGCTGGCGGAGAACGTCGCCGGGCGTGAAACCCTGGACGACGACATCATCC
GCCGCTACGACAATCCTCTGGTCGAGGCTGCCGGCTTCATCAACCTCAAGGGCAACCTGTTCGACTCGGCGTTGATGAAG
ACCAGCGTGATCGCCAGCGACTTCCGGCAGCGTTTCCTGAGCCGTGCCGAGGATCCCGATGCCTTCGAAGGGCGGGTCGT
GGTGTTCGACGGCTCCGAGGACTACCACGCACGGATCGACGATCCGGCCCTCGAGGTCGACGAGAACACCATTCTGGTGA
TGCGCGGGGCCGGCCCCGTGGGGCACCCCGGCAGCGCCGAGGTCGTCAACATGCAGCCGCCGGAAGCCTTGATCAAGCAG
GGGATCGAATCGCTGCCGTGTCTCGGCGACGGGCGCCAGTCGGGTACCTCGGGCTCGCCGTCGATTCTCAACGCCGCGCC
GGAAGCTGCCGTGGGCGGTGGCCTGGCGTTGCTGGAAACGGGCGATCGGGTGCGTATCGATCTCAAGCGCGGGGAGGCCA
ACCTGCTCGTCGACGACGCCGAATTGTCCCGTCGTCGCCAGGCGCTGGCATCGCGCGGCGGGTACATTTATCCGGTGGAT
CAAACGCCCTGGCAGGAAATCCAGCGCGGCATGGTCGAGCAGCTCGATCGCGGCATGACCCTGGGCCCGGCGACCAAGTA
TCGGGATGTCGCACGTCAGAGTCCGCCCCGGGACAATCACTGA

Upstream 100 bases:

>100_bases
TCCTTTTGTTCAACATACAGGCCGTCTGCTATGAATTACGCTGACAGCAAGGCATGGCCTTTTTTCGAAAACGAGTGTCA
TTGAGCAAAGGCGTCAGATC

Downstream 100 bases:

>100_bases
GCGGCAGGCCGCTGGACCGACACGGGCTTCGCATGGCGAAGCCCGTTTTACATCTGGTACCCGAAGGCGTGCTGTCGCGT
CCGGCGTCAGGTCGGCGAGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MNDHKITPDQLRSRWWFDNPEHPGTTALCIERYMNYGLTLEELKSGKPIIGIAQSGSDLTPCNRHHIELVKRVKDGIRAA
GGVPFEFPLHPIHENVRRPTAALDRNLAYLGLVEVLHGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGW
RGSQERVGSGTIIWELRKRLAAGDIDYEEFLSRATDSAPSIGHCNTMGTASTMNSMAEALGMSLPGSAMIPAPYKERSMV
AYQTGTRIVDMVWEDLRPLDILTREACENAIVVCSALGGSSNAPVHINAIARHAGVELTNDDWQRLGHDVPLLANVMPAG
AYLSEEFHRAGGVPAVLSELLKAGRVHGDVPTVNGRTLAENVAGRETLDDDIIRRYDNPLVEAAGFINLKGNLFDSALMK
TSVIASDFRQRFLSRAEDPDAFEGRVVVFDGSEDYHARIDDPALEVDENTILVMRGAGPVGHPGSAEVVNMQPPEALIKQ
GIESLPCLGDGRQSGTSGSPSILNAAPEAAVGGGLALLETGDRVRIDLKRGEANLLVDDAELSRRRQALASRGGYIYPVD
QTPWQEIQRGMVEQLDRGMTLGPATKYRDVARQSPPRDNH

Sequences:

>Translated_600_residues
MNDHKITPDQLRSRWWFDNPEHPGTTALCIERYMNYGLTLEELKSGKPIIGIAQSGSDLTPCNRHHIELVKRVKDGIRAA
GGVPFEFPLHPIHENVRRPTAALDRNLAYLGLVEVLHGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGW
RGSQERVGSGTIIWELRKRLAAGDIDYEEFLSRATDSAPSIGHCNTMGTASTMNSMAEALGMSLPGSAMIPAPYKERSMV
AYQTGTRIVDMVWEDLRPLDILTREACENAIVVCSALGGSSNAPVHINAIARHAGVELTNDDWQRLGHDVPLLANVMPAG
AYLSEEFHRAGGVPAVLSELLKAGRVHGDVPTVNGRTLAENVAGRETLDDDIIRRYDNPLVEAAGFINLKGNLFDSALMK
TSVIASDFRQRFLSRAEDPDAFEGRVVVFDGSEDYHARIDDPALEVDENTILVMRGAGPVGHPGSAEVVNMQPPEALIKQ
GIESLPCLGDGRQSGTSGSPSILNAAPEAAVGGGLALLETGDRVRIDLKRGEANLLVDDAELSRRRQALASRGGYIYPVD
QTPWQEIQRGMVEQLDRGMTLGPATKYRDVARQSPPRDNH
>Mature_600_residues
MNDHKITPDQLRSRWWFDNPEHPGTTALCIERYMNYGLTLEELKSGKPIIGIAQSGSDLTPCNRHHIELVKRVKDGIRAA
GGVPFEFPLHPIHENVRRPTAALDRNLAYLGLVEVLHGYPLDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGW
RGSQERVGSGTIIWELRKRLAAGDIDYEEFLSRATDSAPSIGHCNTMGTASTMNSMAEALGMSLPGSAMIPAPYKERSMV
AYQTGTRIVDMVWEDLRPLDILTREACENAIVVCSALGGSSNAPVHINAIARHAGVELTNDDWQRLGHDVPLLANVMPAG
AYLSEEFHRAGGVPAVLSELLKAGRVHGDVPTVNGRTLAENVAGRETLDDDIIRRYDNPLVEAAGFINLKGNLFDSALMK
TSVIASDFRQRFLSRAEDPDAFEGRVVVFDGSEDYHARIDDPALEVDENTILVMRGAGPVGHPGSAEVVNMQPPEALIKQ
GIESLPCLGDGRQSGTSGSPSILNAAPEAAVGGGLALLETGDRVRIDLKRGEANLLVDDAELSRRRQALASRGGYIYPVD
QTPWQEIQRGMVEQLDRGMTLGPATKYRDVARQSPPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=563, Percent_Identity=30.550621669627, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1788157, Length=447, Percent_Identity=31.5436241610738, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI2367371, Length=530, Percent_Identity=28.4905660377358, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1786464, Length=541, Percent_Identity=27.7264325323475, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322476, Length=531, Percent_Identity=29.9435028248588, Blast_Score=214, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64954; Mature: 64954

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDHKITPDQLRSRWWFDNPEHPGTTALCIERYMNYGLTLEELKSGKPIIGIAQSGSDLT
CCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRHHIELVKRVKDGIRAAGGVPFEFPLHPIHENVRRPTAALDRNLAYLGLVEVLHGYP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHCCC
LDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGWRGSQERVGSGTIIWELRKRL
CCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHH
AAGDIDYEEFLSRATDSAPSIGHCNTMGTASTMNSMAEALGMSLPGSAMIPAPYKERSMV
HCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
AYQTGTRIVDMVWEDLRPLDILTREACENAIVVCSALGGSSNAPVHINAIARHAGVELTN
EECCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEHHHCCCEECC
DDWQRLGHDVPLLANVMPAGAYLSEEFHRAGGVPAVLSELLKAGRVHGDVPTVNGRTLAE
HHHHHCCCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHH
NVAGRETLDDDIIRRYDNPLVEAAGFINLKGNLFDSALMKTSVIASDFRQRFLSRAEDPD
HHCCCCCHHHHHHHHHCCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AFEGRVVVFDGSEDYHARIDDPALEVDENTILVMRGAGPVGHPGSAEVVNMQPPEALIKQ
CCCCEEEEEECCCCCCEECCCCCEEECCCEEEEEECCCCCCCCCCCEEEECCCHHHHHHH
GIESLPCLGDGRQSGTSGSPSILNAAPEAAVGGGLALLETGDRVRIDLKRGEANLLVDDA
HHHHCCCCCCCCCCCCCCCCHHHCCCCCHHCCCCEEEEECCCEEEEEEECCCCEEEEEHH
ELSRRRQALASRGGYIYPVDQTPWQEIQRGMVEQLDRGMTLGPATKYRDVARQSPPRDNH
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNDHKITPDQLRSRWWFDNPEHPGTTALCIERYMNYGLTLEELKSGKPIIGIAQSGSDLT
CCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRHHIELVKRVKDGIRAAGGVPFEFPLHPIHENVRRPTAALDRNLAYLGLVEVLHGYP
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHHHCCC
LDGVVLTTGCDKTTPACLMAAATVNIPAIVLSGGPMLNGWRGSQERVGSGTIIWELRKRL
CCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHH
AAGDIDYEEFLSRATDSAPSIGHCNTMGTASTMNSMAEALGMSLPGSAMIPAPYKERSMV
HCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
AYQTGTRIVDMVWEDLRPLDILTREACENAIVVCSALGGSSNAPVHINAIARHAGVELTN
EECCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECCCCCCCCEEEEEEHHHCCCEECC
DDWQRLGHDVPLLANVMPAGAYLSEEFHRAGGVPAVLSELLKAGRVHGDVPTVNGRTLAE
HHHHHCCCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHH
NVAGRETLDDDIIRRYDNPLVEAAGFINLKGNLFDSALMKTSVIASDFRQRFLSRAEDPD
HHCCCCCHHHHHHHHHCCCHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AFEGRVVVFDGSEDYHARIDDPALEVDENTILVMRGAGPVGHPGSAEVVNMQPPEALIKQ
CCCCEEEEEECCCCCCEECCCCCEEECCCEEEEEECCCCCCCCCCCEEEECCCHHHHHHH
GIESLPCLGDGRQSGTSGSPSILNAAPEAAVGGGLALLETGDRVRIDLKRGEANLLVDDA
HHHHCCCCCCCCCCCCCCCCHHHCCCCCHHCCCCEEEEECCCEEEEEEECCCCEEEEEHH
ELSRRRQALASRGGYIYPVDQTPWQEIQRGMVEQLDRGMTLGPATKYRDVARQSPPRDNH
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]