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The map label for this gene is ilvD [H]

Identifier: 92113269

GI number: 92113269

Start: 1304155

End: 1305900

Strand: Direct

Name: ilvD [H]

Synonym: Csal_1142

Alternate gene names: 92113269

Gene position: 1304155-1305900 (Clockwise)

Preceding gene: 92113266

Following gene: 92113272

Centisome position: 35.28

GC content: 65.64

Gene sequence:

>1746_bases
ATGACCCATAAAAAGCGCCCGCTACGCTCGGCCGAATGGTTCGGCAACGATGACAAGAACGGCTTCATGTACCGCAGCTG
GATGAAGAACCAGGGCATTCCCGATCATGAGTTTCGCGGCAAGCCGATCATCGGTATCTGCAACACCTTCTCCGAGCTGA
CACCGTGCAACGCCCATTTCCGCAAGCTGGCCGAGCACGTCAAGAAGGGGGTGCTCGAAGCCGGCGGCTATCCGGTGGAG
TTTCCGGTCTTCTCCAATGGCGAGTCCAATCTGCGTCCCACCGCGATGTTCACGCGCAACCTGGCGAGCATGGATGTCGA
GGAAGCCATCCGCGGAAACCCGCTCGACGCCGTGGTGTTGCTGGTGGGGTGCGACAAGACCACGCCGGCTCTGCTGATGG
GCGCGGCAAGCTGCGATATCCCCACCATCGTGGTCACCGGCGGTCCGATGCTCAACGGCAAGCACAAGGGGCGTGACATC
GGCTCGGGCACGGTCGTCTGGCAGCTCTCCGAGGAGGTCAAGGCCGGCAAGATATCGCTGCATGACTTCATGGCCGCCGA
GGCCGGCATGTCGCGCTCCGCCGGCACCTGCAACACCATGGGGACGGCCTCGACCATGGCCTGCATGGCCGAGTCGCTGG
GCACCTCGCTGCCGCACAATGCCGCGATTCCTGCCGTCGACTCGCGCCGTTACGTACTGGCGCACCTGTCCGGCAATCGC
ATCGTCGAGATGGTCGACGAGGACCTCACCCTGTCCAAGGTGCTCACCAAGTCCGCATTCGAGAATGCCATTCGCACCAA
TGCCGCCATCGGCGGTTCGACCAACGCGGTGATTCACCTCCAGGCCATCGCGGGGCGCATGGGGGTCGATCTCACGCTCG
ACGACTGGACCCGGGTGGGACGCGGCACCCCGACCATCGTCGATCTGCAGCCCTCCGGCCGTTATCTGATGGAGGAGTTC
TATTACGCCGGCGGCCTGCCCGCCGTGCTGCGCCGTCTCGGCGAGGCCGACCGGCTGCCCCACAAGGACGCGCTGACCGT
CAACGGCAAGACGCTGTGGGAAAACGTCCAGGACGCGCCGCTCTACAACGATGCCGTGATTCTGCCGCTGGATGCGCCGC
TTCGCGAGGATGGCGGAATGTGCGTGATGCGCGGCAATCTCGCGCCCAACGGGGCGGTGCTCAAGCCCTCTGCCGCGACC
CCGGCGCTGATGCAGCACCGTGGGCGTGCGGTCGTCTTCGAGAACTTCGACGATTACAAGGCGCGTATCAACGACCCGGA
TCTCGACGTCACCGCCGACGACATTCTGGTGATGAAGAACTGCGGGCCGCGCGGTTACCACGGCATGGCCGAAGTCGGCA
ACATGGGGCTGCCCGCCAAGCTGCTCGAGCAAGGCGTCACCGACATGGTGCGGATCTCCGATGCGCGCATGAGCGGCACG
GCGTATGGCACCGTGGTACTCCACGTGGCGCCGGAAGCCGCGGCGGGCGGGCCGCTGGCCGCGGTTCGCAACGGCGACTG
GATCGCGCTCGACGCCTATTCCGGCAAGTTGCACCTGGAGGTCGACGACGCCGAGATCGCCTCACGGCTGGCCGAGGCGG
ACCCCACCGCCGAGTCGACGCGCATCGCCAGCACCGGCGGATATCGCCAGCTCTACATCGAGCACGTGCTGCAGGCCGAC
CAGGGCTGCGATTTCGACTTCCTGGTGGGATGTCGCGGCGCGGAAGTCCCCCGTCACTCGCACTGA

Upstream 100 bases:

>100_bases
TTGGTATATCGGTTTCGGTGTTTTTTGACATTATCAGGTTATTGAAAGAGGCGTTTATGGTGACGGCAACGCTGATGCGA
CCGTGACTGGAGGAAGACGC

Downstream 100 bases:

>100_bases
GCCGAGTGGCACGGACAGAGCAAGAGGGCGGCCGATCGGTCGCCCTCTTTGCGTATGAGGCAAGAAGACCGGGGCGTGAC
GAGGCGTCTACGCCTGTTGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTHKKRPLRSAEWFGNDDKNGFMYRSWMKNQGIPDHEFRGKPIIGICNTFSELTPCNAHFRKLAEHVKKGVLEAGGYPVE
FPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPLDAVVLLVGCDKTTPALLMGAASCDIPTIVVTGGPMLNGKHKGRDI
GSGTVVWQLSEEVKAGKISLHDFMAAEAGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDSRRYVLAHLSGNR
IVEMVDEDLTLSKVLTKSAFENAIRTNAAIGGSTNAVIHLQAIAGRMGVDLTLDDWTRVGRGTPTIVDLQPSGRYLMEEF
YYAGGLPAVLRRLGEADRLPHKDALTVNGKTLWENVQDAPLYNDAVILPLDAPLREDGGMCVMRGNLAPNGAVLKPSAAT
PALMQHRGRAVVFENFDDYKARINDPDLDVTADDILVMKNCGPRGYHGMAEVGNMGLPAKLLEQGVTDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRNGDWIALDAYSGKLHLEVDDAEIASRLAEADPTAESTRIASTGGYRQLYIEHVLQAD
QGCDFDFLVGCRGAEVPRHSH

Sequences:

>Translated_581_residues
MTHKKRPLRSAEWFGNDDKNGFMYRSWMKNQGIPDHEFRGKPIIGICNTFSELTPCNAHFRKLAEHVKKGVLEAGGYPVE
FPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPLDAVVLLVGCDKTTPALLMGAASCDIPTIVVTGGPMLNGKHKGRDI
GSGTVVWQLSEEVKAGKISLHDFMAAEAGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDSRRYVLAHLSGNR
IVEMVDEDLTLSKVLTKSAFENAIRTNAAIGGSTNAVIHLQAIAGRMGVDLTLDDWTRVGRGTPTIVDLQPSGRYLMEEF
YYAGGLPAVLRRLGEADRLPHKDALTVNGKTLWENVQDAPLYNDAVILPLDAPLREDGGMCVMRGNLAPNGAVLKPSAAT
PALMQHRGRAVVFENFDDYKARINDPDLDVTADDILVMKNCGPRGYHGMAEVGNMGLPAKLLEQGVTDMVRISDARMSGT
AYGTVVLHVAPEAAAGGPLAAVRNGDWIALDAYSGKLHLEVDDAEIASRLAEADPTAESTRIASTGGYRQLYIEHVLQAD
QGCDFDFLVGCRGAEVPRHSH
>Mature_580_residues
THKKRPLRSAEWFGNDDKNGFMYRSWMKNQGIPDHEFRGKPIIGICNTFSELTPCNAHFRKLAEHVKKGVLEAGGYPVEF
PVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPLDAVVLLVGCDKTTPALLMGAASCDIPTIVVTGGPMLNGKHKGRDIG
SGTVVWQLSEEVKAGKISLHDFMAAEAGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDSRRYVLAHLSGNRI
VEMVDEDLTLSKVLTKSAFENAIRTNAAIGGSTNAVIHLQAIAGRMGVDLTLDDWTRVGRGTPTIVDLQPSGRYLMEEFY
YAGGLPAVLRRLGEADRLPHKDALTVNGKTLWENVQDAPLYNDAVILPLDAPLREDGGMCVMRGNLAPNGAVLKPSAATP
ALMQHRGRAVVFENFDDYKARINDPDLDVTADDILVMKNCGPRGYHGMAEVGNMGLPAKLLEQGVTDMVRISDARMSGTA
YGTVVLHVAPEAAAGGPLAAVRNGDWIALDAYSGKLHLEVDDAEIASRLAEADPTAESTRIASTGGYRQLYIEHVLQADQ
GCDFDFLVGCRGAEVPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=567, Percent_Identity=31.7460317460317, Blast_Score=239, Evalue=5e-64,
Organism=Escherichia coli, GI2367371, Length=486, Percent_Identity=34.156378600823, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI1788157, Length=553, Percent_Identity=28.9330922242315, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1786464, Length=445, Percent_Identity=32.8089887640449, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=553, Percent_Identity=31.4647377938517, Blast_Score=243, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62494; Mature: 62363

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHKKRPLRSAEWFGNDDKNGFMYRSWMKNQGIPDHEFRGKPIIGICNTFSELTPCNAHF
CCCCCCCCCCHHCCCCCCCCCCEEEHHHHCCCCCCCCCCCCCEEEECHHHHHCCCCHHHH
RKLAEHVKKGVLEAGGYPVEFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPLDAVVL
HHHHHHHHHHHHHCCCCEEEECEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCEEEE
LVGCDKTTPALLMGAASCDIPTIVVTGGPMLNGKHKGRDIGSGTVVWQLSEEVKAGKISL
EEECCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCCEEEH
HDFMAAEAGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDSRRYVLAHLSGNR
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCE
IVEMVDEDLTLSKVLTKSAFENAIRTNAAIGGSTNAVIHLQAIAGRMGVDLTLDDWTRVG
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEHHHHHHHC
RGTPTIVDLQPSGRYLMEEFYYAGGLPAVLRRLGEADRLPHKDALTVNGKTLWENVQDAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHCHHHCCCCCCEEEECCHHHHCCCCCCC
LYNDAVILPLDAPLREDGGMCVMRGNLAPNGAVLKPSAATPALMQHRGRAVVFENFDDYK
CCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHCCCCEEEEECCCCHH
ARINDPDLDVTADDILVMKNCGPRGYHGMAEVGNMGLPAKLLEQGVTDMVRISDARMSGT
HCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHCCCHHHEEECCCCCCCC
AYGTVVLHVAPEAAAGGPLAAVRNGDWIALDAYSGKLHLEVDDAEIASRLAEADPTAEST
EEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCCEEEEEECHHHHHHHHHHCCCCCCCC
RIASTGGYRQLYIEHVLQADQGCDFDFLVGCRGAEVPRHSH
EEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
THKKRPLRSAEWFGNDDKNGFMYRSWMKNQGIPDHEFRGKPIIGICNTFSELTPCNAHF
CCCCCCCCCHHCCCCCCCCCCEEEHHHHCCCCCCCCCCCCCEEEECHHHHHCCCCHHHH
RKLAEHVKKGVLEAGGYPVEFPVFSNGESNLRPTAMFTRNLASMDVEEAIRGNPLDAVVL
HHHHHHHHHHHHHCCCCEEEECEECCCCCCCCCHHHHHHHHHHCCHHHHHCCCCCCEEEE
LVGCDKTTPALLMGAASCDIPTIVVTGGPMLNGKHKGRDIGSGTVVWQLSEEVKAGKISL
EEECCCCCHHHEEECCCCCCCEEEEECCCEECCCCCCCCCCCCEEEEEECCCCCCCEEEH
HDFMAAEAGMSRSAGTCNTMGTASTMACMAESLGTSLPHNAAIPAVDSRRYVLAHLSGNR
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCE
IVEMVDEDLTLSKVLTKSAFENAIRTNAAIGGSTNAVIHLQAIAGRMGVDLTLDDWTRVG
EEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCEEEHHHHHHHC
RGTPTIVDLQPSGRYLMEEFYYAGGLPAVLRRLGEADRLPHKDALTVNGKTLWENVQDAP
CCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHCHHHCCCCCCEEEECCHHHHCCCCCCC
LYNDAVILPLDAPLREDGGMCVMRGNLAPNGAVLKPSAATPALMQHRGRAVVFENFDDYK
CCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHCCCCEEEEECCCCHH
ARINDPDLDVTADDILVMKNCGPRGYHGMAEVGNMGLPAKLLEQGVTDMVRISDARMSGT
HCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCHHHHHCCCHHHEEECCCCCCCC
AYGTVVLHVAPEAAAGGPLAAVRNGDWIALDAYSGKLHLEVDDAEIASRLAEADPTAEST
EEEEEEEEECCCCCCCCCEEEEECCCEEEEEECCCEEEEEECHHHHHHHHHHCCCCCCCC
RIASTGGYRQLYIEHVLQADQGCDFDFLVGCRGAEVPRHSH
EEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA