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The map label for this gene is cyoE [H]

Identifier: 92113086

GI number: 92113086

Start: 1075956

End: 1076846

Strand: Direct

Name: cyoE [H]

Synonym: Csal_0958

Alternate gene names: 92113086

Gene position: 1075956-1076846 (Clockwise)

Preceding gene: 92113085

Following gene: 92113088

Centisome position: 29.11

GC content: 60.61

Gene sequence:

>891_bases
GTGATGCTCAAACCCTTCGTCTCCATCACCAAGCCGGGCATCATCTTCGGCAATCTGATTTCCGTGGCCGGGGGGTTCTT
CCTCGCTTCACAAGGGAGCGTGGATGGTGGGCTCTTCCTGGCCACGGTCATCGGCATTGCGCTGGTGATTGCCTCGGGGT
GCGTGTTCAATAACTACATCGATCGCGATATCGATCGGCTCATGGAGCGCACCCAGGGGCGTGTCACGGTGCAGGGCTTG
ATCCCGCCCGGCGTCACCCTGGCCTACGGTGGTGTGCTGGGGGTCGCGGGCTTCTCTGTCCTGTGGTTCGGCACCAATGC
ATTGGCGACGGCGTTCGCTCTGCTCGGTTTCGTCGTCTATGTCGGGTTGTACAGCCTGTATCTGAAACGGCATTCCATCT
ATGGGACGCTGGTAGGCAGCCTGTCCGGCGCGGCACCACCGGTGGTGGGCTACTGTGCCGTCAGCGGGCAATTCGACCTG
GGTGCCTTGACCCTGCTCTTGATCTTCTGTCTGTGGCAGATGCCGCATTCCTATGCGATCGCCATCTTCCGCTTTCACGA
CTATCGCGCGGCGTCGATCCCCGTGCTGCCGGTCGAGCGCGGTGTACGGGCGGCGAAGCATCATATCTTCTGGTACATCC
TGGCGTTTCTGGGGGCGACCCTGATGCTCACGCTGGGAGGCTATGCCGGGTATGGTTACTTCGCGGTCGCGGCGGCCATG
GGGCTTTACTGGCTCGTCATGGCGCTTCGCGGCTATCGCGCCGGTGACGATCAGGTCTGGGCCAAGAAGGTGTTCATCTT
CTCGATATTCACCATCACGGCACTGAGCATCATGATGTCGATCGACTTTCAGGTCACGGAGACCGAAGTGCTGATGACAT
CGCTGCGTTGA

Upstream 100 bases:

>100_bases
ATCTTCACGGCCCTGATCCTGGTCATCCTGGTGGGCGGTTCGCTGTGGATCATGCAGAACCTGCACGCCAACATGATGCT
CGGTGGGTGAGTCGTCTGGC

Downstream 100 bases:

>100_bases
TCCCGAACGTGCTCCGATACTGAAAAGCCACGCTGTAACAGCGTGGCTTTTTTCGTGTTGCCGACGTCTTGCGGCTCACA
CCTTCCGATAGAGCGTTTTT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MMLKPFVSITKPGIIFGNLISVAGGFFLASQGSVDGGLFLATVIGIALVIASGCVFNNYIDRDIDRLMERTQGRVTVQGL
IPPGVTLAYGGVLGVAGFSVLWFGTNALATAFALLGFVVYVGLYSLYLKRHSIYGTLVGSLSGAAPPVVGYCAVSGQFDL
GALTLLLIFCLWQMPHSYAIAIFRFHDYRAASIPVLPVERGVRAAKHHIFWYILAFLGATLMLTLGGYAGYGYFAVAAAM
GLYWLVMALRGYRAGDDQVWAKKVFIFSIFTITALSIMMSIDFQVTETEVLMTSLR

Sequences:

>Translated_296_residues
MMLKPFVSITKPGIIFGNLISVAGGFFLASQGSVDGGLFLATVIGIALVIASGCVFNNYIDRDIDRLMERTQGRVTVQGL
IPPGVTLAYGGVLGVAGFSVLWFGTNALATAFALLGFVVYVGLYSLYLKRHSIYGTLVGSLSGAAPPVVGYCAVSGQFDL
GALTLLLIFCLWQMPHSYAIAIFRFHDYRAASIPVLPVERGVRAAKHHIFWYILAFLGATLMLTLGGYAGYGYFAVAAAM
GLYWLVMALRGYRAGDDQVWAKKVFIFSIFTITALSIMMSIDFQVTETEVLMTSLR
>Mature_296_residues
MMLKPFVSITKPGIIFGNLISVAGGFFLASQGSVDGGLFLATVIGIALVIASGCVFNNYIDRDIDRLMERTQGRVTVQGL
IPPGVTLAYGGVLGVAGFSVLWFGTNALATAFALLGFVVYVGLYSLYLKRHSIYGTLVGSLSGAAPPVVGYCAVSGQFDL
GALTLLLIFCLWQMPHSYAIAIFRFHDYRAASIPVLPVERGVRAAKHHIFWYILAFLGATLMLTLGGYAGYGYFAVAAAM
GLYWLVMALRGYRAGDDQVWAKKVFIFSIFTITALSIMMSIDFQVTETEVLMTSLR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=35.7142857142857, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786631, Length=295, Percent_Identity=66.4406779661017, Blast_Score=413, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71998235, Length=266, Percent_Identity=28.1954887218045, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325085, Length=187, Percent_Identity=27.807486631016, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921064, Length=261, Percent_Identity=28.3524904214559, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 31982; Mature: 31982

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLKPFVSITKPGIIFGNLISVAGGFFLASQGSVDGGLFLATVIGIALVIASGCVFNNYI
CCCCCCHHHCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
DRDIDRLMERTQGRVTVQGLIPPGVTLAYGGVLGVAGFSVLWFGTNALATAFALLGFVVY
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VGLYSLYLKRHSIYGTLVGSLSGAAPPVVGYCAVSGQFDLGALTLLLIFCLWQMPHSYAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHEE
AIFRFHDYRAASIPVLPVERGVRAAKHHIFWYILAFLGATLMLTLGGYAGYGYFAVAAAM
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GLYWLVMALRGYRAGDDQVWAKKVFIFSIFTITALSIMMSIDFQVTETEVLMTSLR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHCC
>Mature Secondary Structure
MMLKPFVSITKPGIIFGNLISVAGGFFLASQGSVDGGLFLATVIGIALVIASGCVFNNYI
CCCCCCHHHCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
DRDIDRLMERTQGRVTVQGLIPPGVTLAYGGVLGVAGFSVLWFGTNALATAFALLGFVVY
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VGLYSLYLKRHSIYGTLVGSLSGAAPPVVGYCAVSGQFDLGALTLLLIFCLWQMPHSYAI
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCHHEE
AIFRFHDYRAASIPVLPVERGVRAAKHHIFWYILAFLGATLMLTLGGYAGYGYFAVAAAM
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GLYWLVMALRGYRAGDDQVWAKKVFIFSIFTITALSIMMSIDFQVTETEVLMTSLR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA