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The map label for this gene is acsA [H]

Identifier: 92112993

GI number: 92112993

Start: 968777

End: 970726

Strand: Direct

Name: acsA [H]

Synonym: Csal_0865

Alternate gene names: 92112993

Gene position: 968777-970726 (Clockwise)

Preceding gene: 92112992

Following gene: 92112994

Centisome position: 26.21

GC content: 64.67

Gene sequence:

>1950_bases
ATGACCGAACAGCAGAAAGTCTACCCGGTGGCGGAGGAGTTCGCCGCCAATGCCTGGGCGGATAACGAGACTTACCTGAG
CCTCTATCAGCGCTCCGTCGACGATCCCGAGGGCTTCTGGGCCGAGCAGGCCGAGTCGCTGGAATGGTTCAAGACGCCGA
CCAAGATCAAGAACACGTCATTCGCGTCATCCAACGTGGATATCCGCTGGTTCGAGGATGGCGAACTCAATGCCTCCTAC
AATTGCCTCGACCGCCACCTCGAGACGCGTGGCGATCAGCCGGCGATCATCTGGGAGGGCGACGACCCGAGCCACGACAA
GACCATCACCTACCGCGAGCTGCATGCTCAGGTCTGTCGGCTGGGCAACGCGCTCAAGGAGATGGGCGTCGGCAAGGGGG
ACACCGTCACGCTCTACATGCCGATGATCCCCGAGGCGGCGGTCGCCATGCTGGCGTGTGCCCGCATCGGGGCGGTGCAC
TCGGTGGTGTTCGGCGGCTTCTCGCCGGATGCCCTGGCGCAACGCGTGGTCGATGCCCAGTCTCGCGTGGTCATTACCGC
CGACGAGTCGGTACGCGGCGGCAAGCACGTACCGCTCAAGGACAATGTCGATGCAGCGCTGACACGCGACGGCACCGATA
TCGTCGAGAAGGTGCTGGTGGTCCAGCGGACCGGCGGCGACATCGAGTGGCACGACGGTCGCGACGCCTGGTACCACGAG
TGGGTCGAGCGCCAGTCGAGCGAATGCCCGGCCGAGCGGATGAACGCCGAGGATGCCTTGTTCATCCTGTATACCTCGGG
CTCCACCGGCCGTCCCAAGGGGCTCAAGCATACCACCGGGGGCTATCTGCTCTACGCGGCACTGACGCACCGCTACGTGT
TCGATTACCACGATGGCGAGGTGTACTGGTGCAGCGCCGACGTGGGGTGGGTGACCGGGCACAGCTACATCGTCTATGGC
CCCCTGGCCAACGGCGCCACCACGCTGATGTTCGAAGGCGTGCCGAGCTATCCCTCGCACGGGCGTCTCGGCGAGATCGT
CGACAAGCACGGCGTGTCGATTCTCTATACGTCGCCGACGGCGATTCGTGCCTTGATGGCGCACGGCGAGAACATCATGG
ACTCCAGCCGGCGCGACACTCTGCGCGTGCTGGGGTCGGTGGGCGAGCCGATCAATCCCGAGGCATGGAGCTGGTTCCAC
CGGGTGATCGGCAATTCGCGCTGCCCGATCGTCGATACCTGGTGGCAGACCGAGACCGGCGGGATCATGATCACGCCGCT
GCCCGGTGCCACCGACCTCAAGCCGGGCTCCGCCACACGGCCGTTCTTCGGTGTTCAGCCGGCGCTGCTCGACAACGACG
GCAACCTGCTCGAAGGCGCCACGTCCGGCAACCTGGTGATCCTCGACTCCTGGCCGGGGCAGGCGCGCACCATCTGGAAC
GACCACGAGCGTTTCGTGCAGACGTACTTCTCCGCCTATGAAGGCGTCTATTTCACGGGTGACGGCTGCCGCCGCGACGA
GGACGGCTATTACTGGATCACCGGGCGCATCGACGACGTGCTCAACGTGTCCGGCCATCGCATGGGAACCGCGGAAATCG
AGTCGTCCCTGGTGGCGCACAGCGCCGTGGCCGAGGCAGCCGTGGTAGGGTACCCGCACGACATCAAGGGCCAGGGCATC
TATATCTACGTGACCCTGAGCGACGATGCCGAACCCAGCGAGGAATTGCGCAAGGAGCTCACCCAGTGGGTGCGCAAGGA
CATCGGCCCGATCGCGACGCCGGATGTCATTCAGTGGGCGCCGGGCCTGCCCAAGACGCGCTCCGGCAAGATCATGCGGC
GCATTTTGCGCAAGATTGCCGCCAATGAGTGCGAAGGCCTGGGGGATACGAGTACACTGGCGGATCCGAGCGTGGTCGAT
GAGTTGATCGAGCACCGCGCCAATCGTTGA

Upstream 100 bases:

>100_bases
GCCAGGGGGGCTAGGGGTATATGCTGGTGACACATTCCTGGACGGTCACCTTGGCAAGCGTGTGGCCGATCATCCATTTC
TCGACCCTTGCGAGGCAGTC

Downstream 100 bases:

>100_bases
TACGCGTTAGGGTGGGTAGCCTGCGTCGGTTCGCTCGACACGGGGCGGCACGCCAGCTCGCCTCGGGTGCCCACCCGACT
TTCGCCGGCCGCTGGCCGGC

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MTEQQKVYPVAEEFAANAWADNETYLSLYQRSVDDPEGFWAEQAESLEWFKTPTKIKNTSFASSNVDIRWFEDGELNASY
NCLDRHLETRGDQPAIIWEGDDPSHDKTITYRELHAQVCRLGNALKEMGVGKGDTVTLYMPMIPEAAVAMLACARIGAVH
SVVFGGFSPDALAQRVVDAQSRVVITADESVRGGKHVPLKDNVDAALTRDGTDIVEKVLVVQRTGGDIEWHDGRDAWYHE
WVERQSSECPAERMNAEDALFILYTSGSTGRPKGLKHTTGGYLLYAALTHRYVFDYHDGEVYWCSADVGWVTGHSYIVYG
PLANGATTLMFEGVPSYPSHGRLGEIVDKHGVSILYTSPTAIRALMAHGENIMDSSRRDTLRVLGSVGEPINPEAWSWFH
RVIGNSRCPIVDTWWQTETGGIMITPLPGATDLKPGSATRPFFGVQPALLDNDGNLLEGATSGNLVILDSWPGQARTIWN
DHERFVQTYFSAYEGVYFTGDGCRRDEDGYYWITGRIDDVLNVSGHRMGTAEIESSLVAHSAVAEAAVVGYPHDIKGQGI
YIYVTLSDDAEPSEELRKELTQWVRKDIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAANECEGLGDTSTLADPSVVD
ELIEHRANR

Sequences:

>Translated_649_residues
MTEQQKVYPVAEEFAANAWADNETYLSLYQRSVDDPEGFWAEQAESLEWFKTPTKIKNTSFASSNVDIRWFEDGELNASY
NCLDRHLETRGDQPAIIWEGDDPSHDKTITYRELHAQVCRLGNALKEMGVGKGDTVTLYMPMIPEAAVAMLACARIGAVH
SVVFGGFSPDALAQRVVDAQSRVVITADESVRGGKHVPLKDNVDAALTRDGTDIVEKVLVVQRTGGDIEWHDGRDAWYHE
WVERQSSECPAERMNAEDALFILYTSGSTGRPKGLKHTTGGYLLYAALTHRYVFDYHDGEVYWCSADVGWVTGHSYIVYG
PLANGATTLMFEGVPSYPSHGRLGEIVDKHGVSILYTSPTAIRALMAHGENIMDSSRRDTLRVLGSVGEPINPEAWSWFH
RVIGNSRCPIVDTWWQTETGGIMITPLPGATDLKPGSATRPFFGVQPALLDNDGNLLEGATSGNLVILDSWPGQARTIWN
DHERFVQTYFSAYEGVYFTGDGCRRDEDGYYWITGRIDDVLNVSGHRMGTAEIESSLVAHSAVAEAAVVGYPHDIKGQGI
YIYVTLSDDAEPSEELRKELTQWVRKDIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAANECEGLGDTSTLADPSVVD
ELIEHRANR
>Mature_648_residues
TEQQKVYPVAEEFAANAWADNETYLSLYQRSVDDPEGFWAEQAESLEWFKTPTKIKNTSFASSNVDIRWFEDGELNASYN
CLDRHLETRGDQPAIIWEGDDPSHDKTITYRELHAQVCRLGNALKEMGVGKGDTVTLYMPMIPEAAVAMLACARIGAVHS
VVFGGFSPDALAQRVVDAQSRVVITADESVRGGKHVPLKDNVDAALTRDGTDIVEKVLVVQRTGGDIEWHDGRDAWYHEW
VERQSSECPAERMNAEDALFILYTSGSTGRPKGLKHTTGGYLLYAALTHRYVFDYHDGEVYWCSADVGWVTGHSYIVYGP
LANGATTLMFEGVPSYPSHGRLGEIVDKHGVSILYTSPTAIRALMAHGENIMDSSRRDTLRVLGSVGEPINPEAWSWFHR
VIGNSRCPIVDTWWQTETGGIMITPLPGATDLKPGSATRPFFGVQPALLDNDGNLLEGATSGNLVILDSWPGQARTIWND
HERFVQTYFSAYEGVYFTGDGCRRDEDGYYWITGRIDDVLNVSGHRMGTAEIESSLVAHSAVAEAAVVGYPHDIKGQGIY
IYVTLSDDAEPSEELRKELTQWVRKDIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAANECEGLGDTSTLADPSVVDE
LIEHRANR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=655, Percent_Identity=53.7404580152672, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=668, Percent_Identity=52.6946107784431, Blast_Score=694, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=624, Percent_Identity=50.3205128205128, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=37.9527559055118, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI42544132, Length=579, Percent_Identity=26.7702936096718, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI38505220, Length=555, Percent_Identity=27.5675675675676, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI31982927, Length=643, Percent_Identity=24.1057542768274, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=25.9057971014493, Blast_Score=176, Evalue=9e-44,
Organism=Homo sapiens, GI115511026, Length=540, Percent_Identity=27.037037037037, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI58082049, Length=534, Percent_Identity=25.2808988764045, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI157311624, Length=534, Percent_Identity=24.7191011235955, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI157311622, Length=534, Percent_Identity=24.7191011235955, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI195947378, Length=446, Percent_Identity=23.9910313901345, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=25.9640102827763, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=25.9640102827763, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI42544134, Length=359, Percent_Identity=23.6768802228412, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI156151445, Length=391, Percent_Identity=24.8081841432225, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790505, Length=624, Percent_Identity=67.7884615384615, Blast_Score=918, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=635, Percent_Identity=37.1653543307087, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI221142682, Length=529, Percent_Identity=23.062381852552, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788107, Length=563, Percent_Identity=24.5115452930728, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI145693145, Length=533, Percent_Identity=23.4521575984991, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=660, Percent_Identity=51.0606060606061, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=656, Percent_Identity=51.219512195122, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=619, Percent_Identity=21.8093699515347, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17557194, Length=554, Percent_Identity=22.7436823104693, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=521, Percent_Identity=23.2245681381958, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=539, Percent_Identity=23.191094619666, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=156, Percent_Identity=31.4102564102564, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=645, Percent_Identity=51.0077519379845, Blast_Score=643, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=638, Percent_Identity=47.3354231974922, Blast_Score=587, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319699, Length=539, Percent_Identity=21.5213358070501, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24667955, Length=666, Percent_Identity=51.5015015015015, Blast_Score=684, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=55.5160142348754, Blast_Score=634, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=56.3461538461538, Blast_Score=594, Evalue=1e-170,
Organism=Drosophila melanogaster, GI21355225, Length=643, Percent_Identity=34.5256609642302, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24581924, Length=552, Percent_Identity=21.9202898550725, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24656500, Length=384, Percent_Identity=22.65625, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71891; Mature: 71760

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00018 EF_HAND_1 ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQQKVYPVAEEFAANAWADNETYLSLYQRSVDDPEGFWAEQAESLEWFKTPTKIKNTS
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCCCCCC
FASSNVDIRWFEDGELNASYNCLDRHLETRGDQPAIIWEGDDPSHDKTITYRELHAQVCR
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEHHHHHHHHHHH
LGNALKEMGVGKGDTVTLYMPMIPEAAVAMLACARIGAVHSVVFGGFSPDALAQRVVDAQ
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
SRVVITADESVRGGKHVPLKDNVDAALTRDGTDIVEKVLVVQRTGGDIEWHDGRDAWYHE
CCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHEEECCCCEEEECCCHHHHHH
WVERQSSECPAERMNAEDALFILYTSGSTGRPKGLKHTTGGYLLYAALTHRYVFDYHDGE
HHHHCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCEEEEEECCE
VYWCSADVGWVTGHSYIVYGPLANGATTLMFEGVPSYPSHGRLGEIVDKHGVSILYTSPT
EEEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCEEEEECHH
AIRALMAHGENIMDSSRRDTLRVLGSVGEPINPEAWSWFHRVIGNSRCPIVDTWWQTETG
HHHHHHHCCCHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCC
GIMITPLPGATDLKPGSATRPFFGVQPALLDNDGNLLEGATSGNLVILDSWPGQARTIWN
CEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCEEEEECCCCCCCCHHH
DHERFVQTYFSAYEGVYFTGDGCRRDEDGYYWITGRIDDVLNVSGHRMGTAEIESSLVAH
HHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHH
SAVAEAAVVGYPHDIKGQGIYIYVTLSDDAEPSEELRKELTQWVRKDIGPIATPDVIQWA
HHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCC
PGLPKTRSGKIMRRILRKIAANECEGLGDTSTLADPSVVDELIEHRANR
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEQQKVYPVAEEFAANAWADNETYLSLYQRSVDDPEGFWAEQAESLEWFKTPTKIKNTS
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCCCCCC
FASSNVDIRWFEDGELNASYNCLDRHLETRGDQPAIIWEGDDPSHDKTITYRELHAQVCR
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEHHHHHHHHHHH
LGNALKEMGVGKGDTVTLYMPMIPEAAVAMLACARIGAVHSVVFGGFSPDALAQRVVDAQ
HHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
SRVVITADESVRGGKHVPLKDNVDAALTRDGTDIVEKVLVVQRTGGDIEWHDGRDAWYHE
CCEEEEECCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHEEECCCCEEEECCCHHHHHH
WVERQSSECPAERMNAEDALFILYTSGSTGRPKGLKHTTGGYLLYAALTHRYVFDYHDGE
HHHHCCCCCCHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHHCEEEEEECCE
VYWCSADVGWVTGHSYIVYGPLANGATTLMFEGVPSYPSHGRLGEIVDKHGVSILYTSPT
EEEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHCCCEEEEECHH
AIRALMAHGENIMDSSRRDTLRVLGSVGEPINPEAWSWFHRVIGNSRCPIVDTWWQTETG
HHHHHHHCCCHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCC
GIMITPLPGATDLKPGSATRPFFGVQPALLDNDGNLLEGATSGNLVILDSWPGQARTIWN
CEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCEEEEECCCCCCCCHHH
DHERFVQTYFSAYEGVYFTGDGCRRDEDGYYWITGRIDDVLNVSGHRMGTAEIESSLVAH
HHHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHH
SAVAEAAVVGYPHDIKGQGIYIYVTLSDDAEPSEELRKELTQWVRKDIGPIATPDVIQWA
HHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCC
PGLPKTRSGKIMRRILRKIAANECEGLGDTSTLADPSVVDELIEHRANR
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA