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The map label for this gene is guaB [H]

Identifier: 92112862

GI number: 92112862

Start: 818519

End: 819988

Strand: Direct

Name: guaB [H]

Synonym: Csal_0730

Alternate gene names: 92112862

Gene position: 818519-819988 (Clockwise)

Preceding gene: 92112861

Following gene: 92112863

Centisome position: 22.14

GC content: 66.39

Gene sequence:

>1470_bases
ATGCTACGTATAGCGCAAGAAGCTCTTACGTTCGATGATGTATTACTCGTCCCCGGCTATTCCGACGTCCTGCCCAAAGA
CGTCAGCCTGAAATCCCGCCTGACTCGCGACCTTCACCTCAACATCCCGCTGCTTTCCTCCGCGATGGATACCGTGACCG
AAGCCCGCCTGGCGATTGCCATGGCCCAGGAAGGCGGCATCGGGATCATTCACAAGAGCATGACCATCGCCGCGCAGGCG
GCGGAAGTGCGCAAGGTGAAGAAGCACGAGAGCGTGATCGTCAAGGATCCGGTGACCGTCAGCCCCAAGGCGAAGCTGGC
CGATCTGCTCGAGATGGCCGACGAGTACGGCTATTCCGGGTTTCCGGTGGTCGAGGGCGACACCCTGATGGGCATCGTCA
CCGGGCGCGACATGCGCTTCCGCCCCGACAAGGGCGACAGCGTCGCGGAAATCATGACGCCGCGCGAGAAGCTGGTCACC
GTGCCCGAAGGCACCTCGCTGGACATCATCAAGTCCAAGCTGCAGGAACACCGCATCGAGAAGATCCTGGTGGTCGACGA
TCAGTTCCGCCTGCGTGGCCTGGTGACCGTGCGTGACATCGAGAAGGCGCGCACCTACCCGCACGCCGCCAAGGACGGCG
ACGGCCGCCTGCTGGCCGGCGCCGCCGTGGGCACCGGGCCGGAAACACCGGATCGCATCGCCGCGCTGGCCGAGGCCGGG
GTGGACGTGATCGTGGTCGACACCGCGCATGGCCATTCCCAGGGCGTCATCGAGCGCGTGCGCTGGGTCAAGGAGCATTA
TCCGCAGGTGCAGGTGATCGGCGGCAACATCGCCACCGCCGCCGCCGCCAAGGCGCTGGCCGAGGCTGGCGCGGACGGCG
TCAAGGTCGGCATCGGCCCCGGCTCCATCTGCACCACGCGCATCGTCGCCGGGGTGGGTGTGCCGCAGATCTCCGCCATC
TCCGACGTGGCCGACGCGCTCAAGCCGTACGACATCCCGCTCGTCGCCGATGGCGGCATCCGCTTCTCCGGCGACCTGGC
CAAGGCCATCGCCGCCGGCGCCAGCACGGTGATGATCGGCGGGCTGCTGGCCGGCACCGAGGAAGCGCCGGGCGAGATCG
AGCTCTACCAGGGCCGGACCTACAAGGCCTATCGCGGCATGGGCTCCATGGGCGCCATGTCCCAGAGCCAGGGCTCCTCC
GACCGCTACTTCCAGGACAAGAATGCCGGGGTCGAGAAGCTGGTACCGGAAGGCATCGAAGGCCGCGTGCCCTACAAGGG
CCAGATGAGCGCCATCGTCCATCAGCTGATGGGCGGCCTGCGTGCCTCCATGGGCTACACCGGCTGCCACGATATCGACG
AGATGCGCACCAAGCCGGAGTTCGTGAAGATCACCGGCGCGGGCTTCGCCGAATCCCACGTGCATGACGTGCAGATCACG
AAAGAGGCCCCCAACTACCGGGCGGGCTAA

Upstream 100 bases:

>100_bases
GCGCATTGACAAACGCGCGCAACGTTGAGAGGACGGGGATAGGGGTTTATAATGGCGGATTAATCTTCCCCGCACCCGCT
TTCCCCACAGGTGTCGCAAC

Downstream 100 bases:

>100_bases
CTCAAGCTTGATGCCGGAAGCTTGAAGCTGGAAGTGGCCATGCCGCTTCCAGCTTTCGCATTTTCGGCCCTTGTTGCTTC
TCAAAGGAACGCCAGATGAC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLRIAQEALTFDDVLLVPGYSDVLPKDVSLKSRLTRDLHLNIPLLSSAMDTVTEARLAIAMAQEGGIGIIHKSMTIAAQA
AEVRKVKKHESVIVKDPVTVSPKAKLADLLEMADEYGYSGFPVVEGDTLMGIVTGRDMRFRPDKGDSVAEIMTPREKLVT
VPEGTSLDIIKSKLQEHRIEKILVVDDQFRLRGLVTVRDIEKARTYPHAAKDGDGRLLAGAAVGTGPETPDRIAALAEAG
VDVIVVDTAHGHSQGVIERVRWVKEHYPQVQVIGGNIATAAAAKALAEAGADGVKVGIGPGSICTTRIVAGVGVPQISAI
SDVADALKPYDIPLVADGGIRFSGDLAKAIAAGASTVMIGGLLAGTEEAPGEIELYQGRTYKAYRGMGSMGAMSQSQGSS
DRYFQDKNAGVEKLVPEGIEGRVPYKGQMSAIVHQLMGGLRASMGYTGCHDIDEMRTKPEFVKITGAGFAESHVHDVQIT
KEAPNYRAG

Sequences:

>Translated_489_residues
MLRIAQEALTFDDVLLVPGYSDVLPKDVSLKSRLTRDLHLNIPLLSSAMDTVTEARLAIAMAQEGGIGIIHKSMTIAAQA
AEVRKVKKHESVIVKDPVTVSPKAKLADLLEMADEYGYSGFPVVEGDTLMGIVTGRDMRFRPDKGDSVAEIMTPREKLVT
VPEGTSLDIIKSKLQEHRIEKILVVDDQFRLRGLVTVRDIEKARTYPHAAKDGDGRLLAGAAVGTGPETPDRIAALAEAG
VDVIVVDTAHGHSQGVIERVRWVKEHYPQVQVIGGNIATAAAAKALAEAGADGVKVGIGPGSICTTRIVAGVGVPQISAI
SDVADALKPYDIPLVADGGIRFSGDLAKAIAAGASTVMIGGLLAGTEEAPGEIELYQGRTYKAYRGMGSMGAMSQSQGSS
DRYFQDKNAGVEKLVPEGIEGRVPYKGQMSAIVHQLMGGLRASMGYTGCHDIDEMRTKPEFVKITGAGFAESHVHDVQIT
KEAPNYRAG
>Mature_489_residues
MLRIAQEALTFDDVLLVPGYSDVLPKDVSLKSRLTRDLHLNIPLLSSAMDTVTEARLAIAMAQEGGIGIIHKSMTIAAQA
AEVRKVKKHESVIVKDPVTVSPKAKLADLLEMADEYGYSGFPVVEGDTLMGIVTGRDMRFRPDKGDSVAEIMTPREKLVT
VPEGTSLDIIKSKLQEHRIEKILVVDDQFRLRGLVTVRDIEKARTYPHAAKDGDGRLLAGAAVGTGPETPDRIAALAEAG
VDVIVVDTAHGHSQGVIERVRWVKEHYPQVQVIGGNIATAAAAKALAEAGADGVKVGIGPGSICTTRIVAGVGVPQISAI
SDVADALKPYDIPLVADGGIRFSGDLAKAIAAGASTVMIGGLLAGTEEAPGEIELYQGRTYKAYRGMGSMGAMSQSQGSS
DRYFQDKNAGVEKLVPEGIEGRVPYKGQMSAIVHQLMGGLRASMGYTGCHDIDEMRTKPEFVKITGAGFAESHVHDVQIT
KEAPNYRAG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=457, Percent_Identity=44.6389496717724, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=457, Percent_Identity=44.6389496717724, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=457, Percent_Identity=44.6389496717724, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=457, Percent_Identity=44.6389496717724, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=41.6149068322981, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=45.067264573991, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI217035148, Length=457, Percent_Identity=43.5448577680525, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI217035150, Length=457, Percent_Identity=41.3566739606127, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.8421052631579, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.8421052631579, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI156104880, Length=244, Percent_Identity=35.2459016393443, Blast_Score=162, Evalue=9e-40,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=63.6734693877551, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=35.2678571428571, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=473, Percent_Identity=39.9577167019027, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=42.9594272076372, Blast_Score=300, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=37.344398340249, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=37.8099173553719, Blast_Score=335, Evalue=7e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=461, Percent_Identity=38.8286334056399, Blast_Score=333, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6323464, Length=453, Percent_Identity=40.3973509933775, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=36.9822485207101, Blast_Score=246, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=115, Percent_Identity=40, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=42.0289855072464, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=42.0289855072464, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=41.4965986394558, Blast_Score=318, Evalue=5e-87,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51953; Mature: 51953

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAQEALTFDDVLLVPGYSDVLPKDVSLKSRLTRDLHLNIPLLSSAMDTVTEARLAIA
CCCCHHHHCCCCCEEEECCCHHHCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHHEE
MAQEGGIGIIHKSMTIAAQAAEVRKVKKHESVIVKDPVTVSPKAKLADLLEMADEYGYSG
EECCCCEEEEECCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
FPVVEGDTLMGIVTGRDMRFRPDKGDSVAEIMTPREKLVTVPEGTSLDIIKSKLQEHRIE
CCEECCCEEEEEEECCCEEECCCCCCCHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHCC
KILVVDDQFRLRGLVTVRDIEKARTYPHAAKDGDGRLLAGAAVGTGPETPDRIAALAEAG
EEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCC
VDVIVVDTAHGHSQGVIERVRWVKEHYPQVQVIGGNIATAAAAKALAEAGADGVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCC
GSICTTRIVAGVGVPQISAISDVADALKPYDIPLVADGGIRFSGDLAKAIAAGASTVMIG
CCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCCCEEEE
GLLAGTEEAPGEIELYQGRTYKAYRGMGSMGAMSQSQGSSDRYFQDKNAGVEKLVPEGIE
HEEECCCCCCCCEEEEECCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
GRVPYKGQMSAIVHQLMGGLRASMGYTGCHDIDEMRTKPEFVKITGAGFAESHVHDVQIT
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCCCCCEEEEEEE
KEAPNYRAG
CCCCCCCCC
>Mature Secondary Structure
MLRIAQEALTFDDVLLVPGYSDVLPKDVSLKSRLTRDLHLNIPLLSSAMDTVTEARLAIA
CCCCHHHHCCCCCEEEECCCHHHCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHHEE
MAQEGGIGIIHKSMTIAAQAAEVRKVKKHESVIVKDPVTVSPKAKLADLLEMADEYGYSG
EECCCCEEEEECCHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
FPVVEGDTLMGIVTGRDMRFRPDKGDSVAEIMTPREKLVTVPEGTSLDIIKSKLQEHRIE
CCEECCCEEEEEEECCCEEECCCCCCCHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHCC
KILVVDDQFRLRGLVTVRDIEKARTYPHAAKDGDGRLLAGAAVGTGPETPDRIAALAEAG
EEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCC
VDVIVVDTAHGHSQGVIERVRWVKEHYPQVQVIGGNIATAAAAKALAEAGADGVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCC
GSICTTRIVAGVGVPQISAISDVADALKPYDIPLVADGGIRFSGDLAKAIAAGASTVMIG
CCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCCCEEEE
GLLAGTEEAPGEIELYQGRTYKAYRGMGSMGAMSQSQGSSDRYFQDKNAGVEKLVPEGIE
HEEECCCCCCCCEEEEECCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
GRVPYKGQMSAIVHQLMGGLRASMGYTGCHDIDEMRTKPEFVKITGAGFAESHVHDVQIT
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCCCCCCEEEEEEE
KEAPNYRAG
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA