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The map label for this gene is guaA [H]

Identifier: 92112863

GI number: 92112863

Start: 820084

End: 821661

Strand: Direct

Name: guaA [H]

Synonym: Csal_0731

Alternate gene names: 92112863

Gene position: 820084-821661 (Clockwise)

Preceding gene: 92112862

Following gene: 92112864

Centisome position: 22.18

GC content: 64.7

Gene sequence:

>1578_bases
ATGACCGACATTCACGCCCACAAGATCCTGATTCTCGACTTCGGCTCCCAGTACACCCAGCTCATCGCGCGCCGCGTGCG
CGAGATCGGCGTCTACTCCGAAGTGCGCGCCTTCGACATCAGCGAGGAAGAGATCCGCGAGTACCGGCCCAACGGCATCA
TCCTCGCCGGCGGGCCGGAATCCGTCACCGAGCTGGCCTCGCCGCGCGCTCCGCAGTGCGTGTTCGAGATGGGCCTGCCG
GTGCTGGGGATCTGCTACGGCATGCAGACCATGGCCGAGCAGCTGGGCGGCAAGGTCGAGGGCTCGCAGAAACAGGAATT
CGGCTATGCGCAGGTGCGCATCGACGCCGACAACGCCCTGCTCAAGGACATCAAGGACCATGTCGACCATGACACCGGAC
GCGCGCTGCTCGACGTCTGGATGAGCCATGGCGACAAGGTCGCCCAGGTGCCGGAGACCTTCACCGTCACCGCCTCCACC
CCGAGCTGCCCGATCGCCGCCATGGCGTGGGAAGACAAGCAGTTCTACGGCGTGCAGTTCCACCCCGAGGTGACCCACAC
CCAGCAGGGCCAGCGCATTCTCGAGCACTTCGTGCTGGGGATCTGCCAGGCCGAGCGCCTGTGGACCCCGGCCCAGATCA
TCGACGACCTCTGCGTGCGCGTGCGCGAGCAGGTCGGCGACCGCCACGTGCTGCTCGGCCTCTCCGGCGGGGTGGATTCC
TCCGTGGTCGCCGCGCTGCTGCACAAGGCCATCGGCGATCAGCTCACCTGCGTGTTCGTCGACAACGGCCTGCTGCGCAA
GAACGAAGGCGACCAGGTGATGGAAACCTTCGCCAGCCACATGGGCGTGCGGGTGCTGCGTGTCGACGCCGAGGACGAGT
TCCTCACCAAGCTGGAAGGCGAAAACGACCCCGAAGCCAAGCGCAAGATCATCGGCAACACCTTCATCGACGTCTTCGAC
CGTGAAGCTGCCAAGATCGAGGGCGTGGACTTCCTCGCCCAGGGCACCATCTACCCGGACGTGATCGAATCCGCCGCCAG
CAAGACCGGCAAGGCGCATGTCATCAAGTCGCACCACAACGTCGGCGGCCTGCCCGAGACCATGAAGCTCAAGCTGGTCG
AACCGCTGCGCGAGCTGTTCAAGGACGAAGTGCGCAAGCTCGGTCTCGAACTCGGCCTGCCGTACGACATGGTCTACCGC
CACCCGTTCCCCGGGCCGGGCCTCGGCGTGCGTATTCTCGGCGAAGTGAAGAAAGAGTACGCCGACATCCTGCGTGAAGC
CGACGCCATCTTCATCGAGGAACTGCACAACGCCGACTGGTACCACAAGACCAGCCAGGCCTTCGCCGTCTTCCTCCCGG
TGAAATCCGTCGGCGTCGTCGGCGACGGCCGCCGCTACGAATGGGTCATCGCCCTGCGCGCCGTCGAAACCATCGACTTC
ATGACTGCAAGATGGGCGCACCTGCCGTATGAGCTGCTGGAGAAGGTCTCCAACCGCATCATCAACGAGATCAGTGGCGT
CTCCCGCGTGACGTACGACGTCAGCAGCAAGCCGCCCGCGACGATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCTAACTCAAGCTTGATGCCGGAAGCTTGAAGCTGGAAGTGGCCATGCCGCTTCCAGCTTTCGCATTTTCGGCCCTTGTT
GCTTCTCAAAGGAACGCCAG

Downstream 100 bases:

>100_bases
TCGCTGGGGAGGGGTGTTGATAGACGCCTAGCTCGGCCGTATCGCCGGTCTCATACGAAAGCCTGCCATTACTGGCAGGC
TTTTTTGTTGCACAACGTTA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MTDIHAHKILILDFGSQYTQLIARRVREIGVYSEVRAFDISEEEIREYRPNGIILAGGPESVTELASPRAPQCVFEMGLP
VLGICYGMQTMAEQLGGKVEGSQKQEFGYAQVRIDADNALLKDIKDHVDHDTGRALLDVWMSHGDKVAQVPETFTVTAST
PSCPIAAMAWEDKQFYGVQFHPEVTHTQQGQRILEHFVLGICQAERLWTPAQIIDDLCVRVREQVGDRHVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRKNEGDQVMETFASHMGVRVLRVDAEDEFLTKLEGENDPEAKRKIIGNTFIDVFD
REAAKIEGVDFLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRKLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADILREADAIFIEELHNADWYHKTSQAFAVFLPVKSVGVVGDGRRYEWVIALRAVETIDF
MTARWAHLPYELLEKVSNRIINEISGVSRVTYDVSSKPPATIEWE

Sequences:

>Translated_525_residues
MTDIHAHKILILDFGSQYTQLIARRVREIGVYSEVRAFDISEEEIREYRPNGIILAGGPESVTELASPRAPQCVFEMGLP
VLGICYGMQTMAEQLGGKVEGSQKQEFGYAQVRIDADNALLKDIKDHVDHDTGRALLDVWMSHGDKVAQVPETFTVTAST
PSCPIAAMAWEDKQFYGVQFHPEVTHTQQGQRILEHFVLGICQAERLWTPAQIIDDLCVRVREQVGDRHVLLGLSGGVDS
SVVAALLHKAIGDQLTCVFVDNGLLRKNEGDQVMETFASHMGVRVLRVDAEDEFLTKLEGENDPEAKRKIIGNTFIDVFD
REAAKIEGVDFLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRKLGLELGLPYDMVYR
HPFPGPGLGVRILGEVKKEYADILREADAIFIEELHNADWYHKTSQAFAVFLPVKSVGVVGDGRRYEWVIALRAVETIDF
MTARWAHLPYELLEKVSNRIINEISGVSRVTYDVSSKPPATIEWE
>Mature_524_residues
TDIHAHKILILDFGSQYTQLIARRVREIGVYSEVRAFDISEEEIREYRPNGIILAGGPESVTELASPRAPQCVFEMGLPV
LGICYGMQTMAEQLGGKVEGSQKQEFGYAQVRIDADNALLKDIKDHVDHDTGRALLDVWMSHGDKVAQVPETFTVTASTP
SCPIAAMAWEDKQFYGVQFHPEVTHTQQGQRILEHFVLGICQAERLWTPAQIIDDLCVRVREQVGDRHVLLGLSGGVDSS
VVAALLHKAIGDQLTCVFVDNGLLRKNEGDQVMETFASHMGVRVLRVDAEDEFLTKLEGENDPEAKRKIIGNTFIDVFDR
EAAKIEGVDFLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPETMKLKLVEPLRELFKDEVRKLGLELGLPYDMVYRH
PFPGPGLGVRILGEVKKEYADILREADAIFIEELHNADWYHKTSQAFAVFLPVKSVGVVGDGRRYEWVIALRAVETIDFM
TARWAHLPYELLEKVSNRIINEISGVSRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=584, Percent_Identity=34.9315068493151, Blast_Score=283, Evalue=3e-76,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=71.8929254302103, Blast_Score=795, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=36.7241379310345, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=36.7241379310345, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=36.7241379310345, Blast_Score=289, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=51.3307984790874, Blast_Score=536, Evalue=1e-153,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=34.8837209302326, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58653; Mature: 58521

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIHAHKILILDFGSQYTQLIARRVREIGVYSEVRAFDISEEEIREYRPNGIILAGGPE
CCCCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHEECCCHHHHHHHCCCCEEEECCCH
SVTELASPRAPQCVFEMGLPVLGICYGMQTMAEQLGGKVEGSQKQEFGYAQVRIDADNAL
HHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCHHH
LKDIKDHVDHDTGRALLDVWMSHGDKVAQVPETFTVTASTPSCPIAAMAWEDKQFYGVQF
HHHHHHHCCCCCHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCEEEEEECCCEEEEEEE
HPEVTHTQQGQRILEHFVLGICQAERLWTPAQIIDDLCVRVREQVGDRHVLLGLSGGVDS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDNGLLRKNEGDQVMETFASHMGVRVLRVDAEDEFLTKLEG
HHHHHHHHHHHCCCEEEEEECCCCEECCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHCC
ENDPEAKRKIIGNTFIDVFDREAAKIEGVDFLAQGTIYPDVIESAASKTGKAHVIKSHHN
CCCHHHHHHHHCCHHHHHHCCHHHHCCCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPETMKLKLVEPLRELFKDEVRKLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
ADILREADAIFIEELHNADWYHKTSQAFAVFLPVKSVGVVGDGRRYEWVIALRAVETIDF
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCEECCCCCEEEEEEEHHHHHHHH
MTARWAHLPYELLEKVSNRIINEISGVSRVTYDVSSKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TDIHAHKILILDFGSQYTQLIARRVREIGVYSEVRAFDISEEEIREYRPNGIILAGGPE
CCCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHEECCCHHHHHHHCCCCEEEECCCH
SVTELASPRAPQCVFEMGLPVLGICYGMQTMAEQLGGKVEGSQKQEFGYAQVRIDADNAL
HHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCHHH
LKDIKDHVDHDTGRALLDVWMSHGDKVAQVPETFTVTASTPSCPIAAMAWEDKQFYGVQF
HHHHHHHCCCCCHHHHHHHHHHCCCCEECCCCEEEEEECCCCCCEEEEEECCCEEEEEEE
HPEVTHTQQGQRILEHFVLGICQAERLWTPAQIIDDLCVRVREQVGDRHVLLGLSGGVDS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAALLHKAIGDQLTCVFVDNGLLRKNEGDQVMETFASHMGVRVLRVDAEDEFLTKLEG
HHHHHHHHHHHCCCEEEEEECCCCEECCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHCC
ENDPEAKRKIIGNTFIDVFDREAAKIEGVDFLAQGTIYPDVIESAASKTGKAHVIKSHHN
CCCHHHHHHHHCCHHHHHHCCHHHHCCCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCC
VGGLPETMKLKLVEPLRELFKDEVRKLGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
ADILREADAIFIEELHNADWYHKTSQAFAVFLPVKSVGVVGDGRRYEWVIALRAVETIDF
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCEECCCCCEEEEEEEHHHHHHHH
MTARWAHLPYELLEKVSNRIINEISGVSRVTYDVSSKPPATIEWE
HHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA