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The map label for this gene is mtlK [H]

Identifier: 92112776

GI number: 92112776

Start: 720168

End: 721661

Strand: Direct

Name: mtlK [H]

Synonym: Csal_0643

Alternate gene names: 92112776

Gene position: 720168-721661 (Clockwise)

Preceding gene: 92112775

Following gene: 92112777

Centisome position: 19.48

GC content: 65.26

Gene sequence:

>1494_bases
ATGACTGAACTGACCAACGCTACCCTGGCGCGTCTCGATGCCGCCGTCGCCACGCCGAGCTACGACCGCTCGCAGCTCAC
CCCGGGCATCGTCCATATCGGCGTGGGCGGGTTTCATCGGGCTCATCAGGCGATGTATCTCGATGCGCTGATGAATCGGG
GCGAGGCGCTCGACTGGGCCATCATCGGTGTCGGCGTGATGCCCGGCGATACGCGCATGCGCGATGCCCTGGCCGCGCAG
GATCATCTGTACACGCTGGTGGTCAAGCACCCCGATGGTCGCTATGAACCGCGAGTGATCGGCTCGCTCATCGATTATCT
CTTCGCGCCCGACGATCCCGAGGCGGTCATCGAGGCCATGAGCGATCCCGCGATTCGCATCGTCTCCCTGACGGTCACCG
AAGGGGGCTACAACATCGATCCCGCCAATGGCGAATACGATCTCGCGACCCCCGATGTGCGCCATGACCTGGCCTCGCCC
CAGACGCCACGCACCACCTTCGGGCTGGTCATCGCGGCGCTCCAGCGGCGGCGCGAACGGGGCATCGCACCGTTCACGGT
GATGTCGTGCGACAACATCGAAGGCAATGGCGATGTCGCCCGCAAGATGTTCACCGCCCATGCCCGGGCGCTGGATGCCG
AATTGGGCGCCTGGGTGGAAGCCGAGGTCAGCTTCCCCAACGCCATGGTCGATCGCATCACGCCGGTGACGACCCCGGCC
GATTGTCAGGCGCTGGCGAAACGCTTCGGCGTGGAAGACCAGTGGCCGGTGGTCTGCGAACCGTTCACCCAATGGGTGCT
CGAGGACCATTTCTCGCTCGGCCGCCCGCCCTACGAACGGGTCGGCGTGCAGATGGTCGAGGATGTCGTGCCCTATGAGC
TGATGAAACTGCGCCTGCTCAACGCCAGCCATCAGGCGTTGACCTACTTCGGCTATCTCGCCGGCTATCGCTATGCCCAC
GAAGTGTGCCAAGACCCGCTGTTCGTCGAGTTCCTGCTCGATTACATGCGACTCGAGGCCACGCCGACCCTGTCGCCGGT
ACCGGGCGTCGACCTGGCCGACTACCGGCAGACGCTGATCGAGCGTTTCGCCAACCCCGAGATCAAGGACACCCTGGCAC
GCCTGTGTGCCGAGAGTTCCGACCGCATCCCCAAATGGTTGCTGCCGGTGATTCGCGAGCAGCTCGCGCGCGGTGGCGAT
ATTCACCGCAGTGCCGCCGTGGTCGCCAGCTGGGCGCGTTACGCCGAGGGCGTCGACGAGCAGGGTGAGCCCATCGAGGT
GGTCGATCGGCTCAAGGAGCGCTTGATGGCGGTTGCTAGCAAGAATCGCGAGCACCCCACGGCATTCATCGAGCAGACCG
CGCTGTTCGGCGAGCTGGCACGCGACGCGCGTTTCCGCGATGCTTACCTGCATGCGCTGCATGGCCTGCACACCGCAGGC
GCGCGTGCGACACTGCACGAGGTGGTCGAGGGGCGTATGGCGTCACGCGACTAG

Upstream 100 bases:

>100_bases
CTCAACGCACGGCTGGTCAACGATCGCTCGGCGGCGCCGGACTGGCGCTGGCAATTTCACGCTGCTATTCGACACTCGCT
CGGCCCCAAGGAGTCTTCCC

Downstream 100 bases:

>100_bases
GCAGCGGATACTCGAGGTCTTGCCCCATGCGGGCCATACACTGCAGCGCAAGGAGAGAGCATGTACGTTGGCGTGGATTG
TGGAACGCAAAGCACCAAGG

Product: mannitol dehydrogenase-like protein

Products: NA

Alternate protein names: M2DH; MDH [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTELTNATLARLDAAVATPSYDRSQLTPGIVHIGVGGFHRAHQAMYLDALMNRGEALDWAIIGVGVMPGDTRMRDALAAQ
DHLYTLVVKHPDGRYEPRVIGSLIDYLFAPDDPEAVIEAMSDPAIRIVSLTVTEGGYNIDPANGEYDLATPDVRHDLASP
QTPRTTFGLVIAALQRRRERGIAPFTVMSCDNIEGNGDVARKMFTAHARALDAELGAWVEAEVSFPNAMVDRITPVTTPA
DCQALAKRFGVEDQWPVVCEPFTQWVLEDHFSLGRPPYERVGVQMVEDVVPYELMKLRLLNASHQALTYFGYLAGYRYAH
EVCQDPLFVEFLLDYMRLEATPTLSPVPGVDLADYRQTLIERFANPEIKDTLARLCAESSDRIPKWLLPVIREQLARGGD
IHRSAAVVASWARYAEGVDEQGEPIEVVDRLKERLMAVASKNREHPTAFIEQTALFGELARDARFRDAYLHALHGLHTAG
ARATLHEVVEGRMASRD

Sequences:

>Translated_497_residues
MTELTNATLARLDAAVATPSYDRSQLTPGIVHIGVGGFHRAHQAMYLDALMNRGEALDWAIIGVGVMPGDTRMRDALAAQ
DHLYTLVVKHPDGRYEPRVIGSLIDYLFAPDDPEAVIEAMSDPAIRIVSLTVTEGGYNIDPANGEYDLATPDVRHDLASP
QTPRTTFGLVIAALQRRRERGIAPFTVMSCDNIEGNGDVARKMFTAHARALDAELGAWVEAEVSFPNAMVDRITPVTTPA
DCQALAKRFGVEDQWPVVCEPFTQWVLEDHFSLGRPPYERVGVQMVEDVVPYELMKLRLLNASHQALTYFGYLAGYRYAH
EVCQDPLFVEFLLDYMRLEATPTLSPVPGVDLADYRQTLIERFANPEIKDTLARLCAESSDRIPKWLLPVIREQLARGGD
IHRSAAVVASWARYAEGVDEQGEPIEVVDRLKERLMAVASKNREHPTAFIEQTALFGELARDARFRDAYLHALHGLHTAG
ARATLHEVVEGRMASRD
>Mature_496_residues
TELTNATLARLDAAVATPSYDRSQLTPGIVHIGVGGFHRAHQAMYLDALMNRGEALDWAIIGVGVMPGDTRMRDALAAQD
HLYTLVVKHPDGRYEPRVIGSLIDYLFAPDDPEAVIEAMSDPAIRIVSLTVTEGGYNIDPANGEYDLATPDVRHDLASPQ
TPRTTFGLVIAALQRRRERGIAPFTVMSCDNIEGNGDVARKMFTAHARALDAELGAWVEAEVSFPNAMVDRITPVTTPAD
CQALAKRFGVEDQWPVVCEPFTQWVLEDHFSLGRPPYERVGVQMVEDVVPYELMKLRLLNASHQALTYFGYLAGYRYAHE
VCQDPLFVEFLLDYMRLEATPTLSPVPGVDLADYRQTLIERFANPEIKDTLARLCAESSDRIPKWLLPVIREQLARGGDI
HRSAAVVASWARYAEGVDEQGEPIEVVDRLKERLMAVASKNREHPTAFIEQTALFGELARDARFRDAYLHALHGLHTAGA
RATLHEVVEGRMASRD

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=480, Percent_Identity=41.4583333333333, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788497, Length=474, Percent_Identity=41.1392405063291, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1787823, Length=483, Percent_Identity=39.9585921325052, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI48994885, Length=433, Percent_Identity=24.9422632794457, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790028, Length=223, Percent_Identity=27.8026905829596, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324401, Length=495, Percent_Identity=44.6464646464646, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320765, Length=495, Percent_Identity=44.6464646464646, Blast_Score=429, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.67 [H]

Molecular weight: Translated: 55224; Mature: 55093

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTNATLARLDAAVATPSYDRSQLTPGIVHIGVGGFHRAHQAMYLDALMNRGEALDWA
CCCCHHHHHHHHHHHHCCCCCCHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEE
IIGVGVMPGDTRMRDALAAQDHLYTLVVKHPDGRYEPRVIGSLIDYLFAPDDPEAVIEAM
EEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
SDPAIRIVSLTVTEGGYNIDPANGEYDLATPDVRHDLASPQTPRTTFGLVIAALQRRRER
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
GIAPFTVMSCDNIEGNGDVARKMFTAHARALDAELGAWVEAEVSFPNAMVDRITPVTTPA
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCCH
DCQALAKRFGVEDQWPVVCEPFTQWVLEDHFSLGRPPYERVGVQMVEDVVPYELMKLRLL
HHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NASHQALTYFGYLAGYRYAHEVCQDPLFVEFLLDYMRLEATPTLSPVPGVDLADYRQTLI
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ERFANPEIKDTLARLCAESSDRIPKWLLPVIREQLARGGDIHRSAAVVASWARYAEGVDE
HHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
QGEPIEVVDRLKERLMAVASKNREHPTAFIEQTALFGELARDARFRDAYLHALHGLHTAG
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ARATLHEVVEGRMASRD
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TELTNATLARLDAAVATPSYDRSQLTPGIVHIGVGGFHRAHQAMYLDALMNRGEALDWA
CCCHHHHHHHHHHHHCCCCCCHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEE
IIGVGVMPGDTRMRDALAAQDHLYTLVVKHPDGRYEPRVIGSLIDYLFAPDDPEAVIEAM
EEEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
SDPAIRIVSLTVTEGGYNIDPANGEYDLATPDVRHDLASPQTPRTTFGLVIAALQRRRER
CCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
GIAPFTVMSCDNIEGNGDVARKMFTAHARALDAELGAWVEAEVSFPNAMVDRITPVTTPA
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCCH
DCQALAKRFGVEDQWPVVCEPFTQWVLEDHFSLGRPPYERVGVQMVEDVVPYELMKLRLL
HHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NASHQALTYFGYLAGYRYAHEVCQDPLFVEFLLDYMRLEATPTLSPVPGVDLADYRQTLI
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
ERFANPEIKDTLARLCAESSDRIPKWLLPVIREQLARGGDIHRSAAVVASWARYAEGVDE
HHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
QGEPIEVVDRLKERLMAVASKNREHPTAFIEQTALFGELARDARFRDAYLHALHGLHTAG
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ARATLHEVVEGRMASRD
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8254318 [H]