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The map label for this gene is lpxB

Identifier: 92112709

GI number: 92112709

Start: 638529

End: 639689

Strand: Direct

Name: lpxB

Synonym: Csal_0576

Alternate gene names: 92112709

Gene position: 638529-639689 (Clockwise)

Preceding gene: 92112708

Following gene: 92112710

Centisome position: 17.27

GC content: 67.53

Gene sequence:

>1161_bases
ATGCGTATTTACCTGGTCGCGGGAGAGCTGTCGGGCGACATCCTGGGCGCCGGGCTGATGCAAGCGTTGAAACGCCGCCA
CCCCGATGCCGAATTTCGCGGCATCGGCGGGCCACGCATGCTGGCCGAGGGCATGCAGTCGCTTTATCCGCTGGAAACGC
TGTCGGTCATGGGGCTGGTCGAGGTGCTCAAGCATCTGCCGGGTTTGATCAAGGTCCGCCGCCATCTGCGGCGTGACGCC
CTGGCCTGGCAGCCGGACGTGATGATCGGAATCGATGCCCCGGACTTCAATCTGGGACTCGAGCGCCAGCTGCGCGCCAC
CGGCATGCGTACCGTCCACTACGTCAGTCCTTCAGTGTGGGCCTGGCGCCAGGGGCGCGTGAAGACCATCGCCCGGTCGG
TCGATGCCATGCTGACCTTTCTGCCCTTCGAGGCGGCCTTCTATGCACGGCACCAGGTACCGGTGGCCTTCGTCGGGCAT
CCCCTGGCAGACGAGCTGCCGCTGGTCAACGACCGTCAGGCGGCGCGCACCGCATTGGGCTTGTCGTCCACTGCGCCGCT
GCTGGCCGTGCTGCCGGGGTCGCGTGGCAACGAGATCCGCTTTCTGGGACCGACTTTCCTGGACAGTGCCGTCTGGCTGC
GCGAGCGCGTGCCGGGCCTGCAGGTGGTGATTCCTGCGGCCTCTCCGGCACGCCGACAGGAACTCGAGGTCTTGCTCGCC
ACGCATCCGGCTCGCGAGTTCGTGCATCTGCGCGACGGCGAGTCGCGCCAGGCAATGACCGCGGCCGACGCCGTGCTGCT
GGCTTCCGGCACCGCGGCGCTCGAAGCCATGCTATGTCATCGTCCCATGGTGGTGGCCTACAAGATGGCGGCTGCGACGC
ACTGGCTGGCCAAGCGCATGGTCAAGACCGAGTGGATTTCGCTGCCCAACCTGATCGCCCAGGAAACCCTGGTACCCGAG
CTGGTGCAGGAAGACGCGTCCTGTGAGGCGATCGGCGAGGCCCTGCTGACGTGGCTGGGCGACGAGACGCATCGCCAGGC
CACGGAAACGCGTTTCGCCGCGCTGCACGCCACCCTCCAGCGTGGGGCCAGCGAGCGCGCCGCCGAGGCCATCGACAGCC
TGGTCGTTCACGGACGCTTGCCCGAGGAGCCCACGGCATGA

Upstream 100 bases:

>100_bases
CGAACGTCTCGAAAACGATTTCGCCGTTCCCGAGGTGGAGACCTTCCTCGCGTCACTCAAGACGTCCCAGCGCGGGATCA
CGCGCTAAACGGAATCTGCC

Downstream 100 bases:

>100_bases
CGGATTTTCCGCCACTGGTGATCGACTACCACGGCTCGCGCCTGGCGGGTGTCGACGAAGTCGGTCGCGGCCCCCTGGTG
GGGGCCGTGGTCGCGGCCGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRIYLVAGELSGDILGAGLMQALKRRHPDAEFRGIGGPRMLAEGMQSLYPLETLSVMGLVEVLKHLPGLIKVRRHLRRDA
LAWQPDVMIGIDAPDFNLGLERQLRATGMRTVHYVSPSVWAWRQGRVKTIARSVDAMLTFLPFEAAFYARHQVPVAFVGH
PLADELPLVNDRQAARTALGLSSTAPLLAVLPGSRGNEIRFLGPTFLDSAVWLRERVPGLQVVIPAASPARRQELEVLLA
THPAREFVHLRDGESRQAMTAADAVLLASGTAALEAMLCHRPMVVAYKMAAATHWLAKRMVKTEWISLPNLIAQETLVPE
LVQEDASCEAIGEALLTWLGDETHRQATETRFAALHATLQRGASERAAEAIDSLVVHGRLPEEPTA

Sequences:

>Translated_386_residues
MRIYLVAGELSGDILGAGLMQALKRRHPDAEFRGIGGPRMLAEGMQSLYPLETLSVMGLVEVLKHLPGLIKVRRHLRRDA
LAWQPDVMIGIDAPDFNLGLERQLRATGMRTVHYVSPSVWAWRQGRVKTIARSVDAMLTFLPFEAAFYARHQVPVAFVGH
PLADELPLVNDRQAARTALGLSSTAPLLAVLPGSRGNEIRFLGPTFLDSAVWLRERVPGLQVVIPAASPARRQELEVLLA
THPAREFVHLRDGESRQAMTAADAVLLASGTAALEAMLCHRPMVVAYKMAAATHWLAKRMVKTEWISLPNLIAQETLVPE
LVQEDASCEAIGEALLTWLGDETHRQATETRFAALHATLQRGASERAAEAIDSLVVHGRLPEEPTA
>Mature_386_residues
MRIYLVAGELSGDILGAGLMQALKRRHPDAEFRGIGGPRMLAEGMQSLYPLETLSVMGLVEVLKHLPGLIKVRRHLRRDA
LAWQPDVMIGIDAPDFNLGLERQLRATGMRTVHYVSPSVWAWRQGRVKTIARSVDAMLTFLPFEAAFYARHQVPVAFVGH
PLADELPLVNDRQAARTALGLSSTAPLLAVLPGSRGNEIRFLGPTFLDSAVWLRERVPGLQVVIPAASPARRQELEVLLA
THPAREFVHLRDGESRQAMTAADAVLLASGTAALEAMLCHRPMVVAYKMAAATHWLAKRMVKTEWISLPNLIAQETLVPE
LVQEDASCEAIGEALLTWLGDETHRQATETRFAALHATLQRGASERAAEAIDSLVVHGRLPEEPTA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=371, Percent_Identity=50.4043126684636, Blast_Score=353, Evalue=7e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CHRSD (Q1R020)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572637.1
- ProteinModelPortal:   Q1R020
- STRING:   Q1R020
- GeneID:   4026313
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0576
- NMPDR:   fig|290398.4.peg.278
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- BioCyc:   CSAL290398:CSAL_0576-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42362; Mature: 42362

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIYLVAGELSGDILGAGLMQALKRRHPDAEFRGIGGPRMLAEGMQSLYPLETLSVMGLV
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHCCHHHHHHHHHH
EVLKHLPGLIKVRRHLRRDALAWQPDVMIGIDAPDFNLGLERQLRATGMRTVHYVSPSVW
HHHHHCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCHH
AWRQGRVKTIARSVDAMLTFLPFEAAFYARHQVPVAFVGHPLADELPLVNDRQAARTALG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHC
LSSTAPLLAVLPGSRGNEIRFLGPTFLDSAVWLRERVPGLQVVIPAASPARRQELEVLLA
CCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHEE
THPAREFVHLRDGESRQAMTAADAVLLASGTAALEAMLCHRPMVVAYKMAAATHWLAKRM
CCCHHHHEEECCCCCHHHHHHHHHHHEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VKTEWISLPNLIAQETLVPELVQEDASCEAIGEALLTWLGDETHRQATETRFAALHATLQ
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RGASERAAEAIDSLVVHGRLPEEPTA
HCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRIYLVAGELSGDILGAGLMQALKRRHPDAEFRGIGGPRMLAEGMQSLYPLETLSVMGLV
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHCCHHHHHHHHHH
EVLKHLPGLIKVRRHLRRDALAWQPDVMIGIDAPDFNLGLERQLRATGMRTVHYVSPSVW
HHHHHCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCHH
AWRQGRVKTIARSVDAMLTFLPFEAAFYARHQVPVAFVGHPLADELPLVNDRQAARTALG
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHC
LSSTAPLLAVLPGSRGNEIRFLGPTFLDSAVWLRERVPGLQVVIPAASPARRQELEVLLA
CCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHEE
THPAREFVHLRDGESRQAMTAADAVLLASGTAALEAMLCHRPMVVAYKMAAATHWLAKRM
CCCHHHHEEECCCCCHHHHHHHHHHHEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
VKTEWISLPNLIAQETLVPELVQEDASCEAIGEALLTWLGDETHRQATETRFAALHATLQ
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RGASERAAEAIDSLVVHGRLPEEPTA
HCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA