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The map label for this gene is lpxD

Identifier: 92112706

GI number: 92112706

Start: 636141

End: 637184

Strand: Direct

Name: lpxD

Synonym: Csal_0573

Alternate gene names: 92112706

Gene position: 636141-637184 (Clockwise)

Preceding gene: 92112705

Following gene: 92112707

Centisome position: 17.21

GC content: 65.8

Gene sequence:

>1044_bases
ATGAAGACCCTTACTCCCTGCGCCTTCACGCTCGGTGAACTGGCCGAGCGTCTCAAGGCCCGCCTGGTCGGCGACAGCGA
CCGCCGTGTGACCGGCCTCGCCACGTTACTCGATGCAGGCCCGAACGACATTACGTTCCTGGCCAACAAGACGTATCTCA
AGTACCTGCCCGACACTCGTGCCGCTGCCGTGCTGGTGCATCCCGCCCATGGCACGGACGCGCCCTGTGCGCGACTCGAG
CTGGAGAACCCCTATCTGGGTTACGCCGAACTGTCGCGCTTGTTCGACCCCTTGGCGGGTCAGGCGCCCGAGGGCGTGCA
TCCCAGCGCGGTTGTTGCCGAGAGTGCGCGTATCGGCGAGCACGTATCGGTGGGGCCGCAGTGCGTGATCGAAGCGGGCG
CGGTCATCGGCGATGGCTGCGTGATCGGCGCCGGCAGCATCGTCGGTGCCGACAGTGAAATCGGCGCCGACTCCCGGCTG
CATGCCAATGTCACCGTCTACCATGGCGTCAGCGTCGGCCGACGTGCCATCTTGCACAGCGGCTGCGTGATCGGTGCCGA
CGGTTTCGGCTTCGCGCATGACGGGCAAGGCTGGCACAAGATCGCCCAGTTGGGCGGTGTCATCGTGGGCGACGATGTCG
AGATCGGCAGCTGCTCGAGCATCGACCGGGGGGCATTGGGCGATACCGTGATCGGTAACGACGTCAAGATCGACAGTCAG
GTGCAGATCGCGCACAACGTGCAAATCGGCGATCACAGTGCCCTCGCGGGGTGCGTGGGCATCGCGGGCTCGACGCGCGT
GGGCAGTCATTGCATGCTGGGTGGCGGCGTCGGGCTGTCGGGACATCTGACGCTGTGCGACGGCGTGCAAGTCACCGGCA
TGAGTCTGGTCACCAATTCCATTCACGAGCCCGGCGTGTACTCCTCGGGGACCGGCGCCATGCCCAACGGGCTGTGGCGC
AAGAACGCGGTGCGTTTCAAGCAGTTGGACGAGCTCGCCAAGCGTCTGTCACGTCTGGAGCGGGGCGCCTCGGACACACC
GTGA

Upstream 100 bases:

>100_bases
ACGGGCTCGACGTCACCGAGGAAGTCACTCGCATCTTTAACTCGCTCAACTGAGCCCACCGGGCGCCGCGAGCGCCCATG
GCTAGCGATTCCAAGCGCAC

Downstream 100 bases:

>100_bases
GCCGATTGGCTGCCAGCGAAGGGCTGGGCCTGTATAATCCCCGCCTTATCCAGGCAGGCGGATCATTCCGCCCTCGTGTG
CCTGCCAACGCGGCAGGCAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKTLTPCAFTLGELAERLKARLVGDSDRRVTGLATLLDAGPNDITFLANKTYLKYLPDTRAAAVLVHPAHGTDAPCARLE
LENPYLGYAELSRLFDPLAGQAPEGVHPSAVVAESARIGEHVSVGPQCVIEAGAVIGDGCVIGAGSIVGADSEIGADSRL
HANVTVYHGVSVGRRAILHSGCVIGADGFGFAHDGQGWHKIAQLGGVIVGDDVEIGSCSSIDRGALGDTVIGNDVKIDSQ
VQIAHNVQIGDHSALAGCVGIAGSTRVGSHCMLGGGVGLSGHLTLCDGVQVTGMSLVTNSIHEPGVYSSGTGAMPNGLWR
KNAVRFKQLDELAKRLSRLERGASDTP

Sequences:

>Translated_347_residues
MKTLTPCAFTLGELAERLKARLVGDSDRRVTGLATLLDAGPNDITFLANKTYLKYLPDTRAAAVLVHPAHGTDAPCARLE
LENPYLGYAELSRLFDPLAGQAPEGVHPSAVVAESARIGEHVSVGPQCVIEAGAVIGDGCVIGAGSIVGADSEIGADSRL
HANVTVYHGVSVGRRAILHSGCVIGADGFGFAHDGQGWHKIAQLGGVIVGDDVEIGSCSSIDRGALGDTVIGNDVKIDSQ
VQIAHNVQIGDHSALAGCVGIAGSTRVGSHCMLGGGVGLSGHLTLCDGVQVTGMSLVTNSIHEPGVYSSGTGAMPNGLWR
KNAVRFKQLDELAKRLSRLERGASDTP
>Mature_347_residues
MKTLTPCAFTLGELAERLKARLVGDSDRRVTGLATLLDAGPNDITFLANKTYLKYLPDTRAAAVLVHPAHGTDAPCARLE
LENPYLGYAELSRLFDPLAGQAPEGVHPSAVVAESARIGEHVSVGPQCVIEAGAVIGDGCVIGAGSIVGADSEIGADSRL
HANVTVYHGVSVGRRAILHSGCVIGADGFGFAHDGQGWHKIAQLGGVIVGDDVEIGSCSSIDRGALGDTVIGNDVKIDSQ
VQIAHNVQIGDHSALAGCVGIAGSTRVGSHCMLGGGVGLSGHLTLCDGVQVTGMSLVTNSIHEPGVYSSGTGAMPNGLWR
KNAVRFKQLDELAKRLSRLERGASDTP

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=334, Percent_Identity=48.2035928143713, Blast_Score=320, Evalue=9e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_CHRSD (Q1R023)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572634.1
- ProteinModelPortal:   Q1R023
- SMR:   Q1R023
- STRING:   Q1R023
- GeneID:   4026310
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0573
- NMPDR:   fig|290398.4.peg.275
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- ProtClustDB:   PRK00892
- BioCyc:   CSAL290398:CSAL_0573-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35763; Mature: 35763

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTPCAFTLGELAERLKARLVGDSDRRVTGLATLLDAGPNDITFLANKTYLKYLPDTR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCC
AAAVLVHPAHGTDAPCARLELENPYLGYAELSRLFDPLAGQAPEGVHPSAVVAESARIGE
CEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
HVSVGPQCVIEAGAVIGDGCVIGAGSIVGADSEIGADSRLHANVTVYHGVSVGRRAILHS
CCCCCCHHEEECCCEEECCEEEECCCEECCCCCCCCCCEEEEEEEEEECCHHHHHHHHHC
GCVIGADGFGFAHDGQGWHKIAQLGGVIVGDDVEIGSCSSIDRGALGDTVIGNDVKIDSQ
CCEEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCE
VQIAHNVQIGDHSALAGCVGIAGSTRVGSHCMLGGGVGLSGHLTLCDGVQVTGMSLVTNS
EEEEEEEEECCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCEECCHHHHHHC
IHEPGVYSSGTGAMPNGLWRKNAVRFKQLDELAKRLSRLERGASDTP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTLTPCAFTLGELAERLKARLVGDSDRRVTGLATLLDAGPNDITFLANKTYLKYLPDTR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCC
AAAVLVHPAHGTDAPCARLELENPYLGYAELSRLFDPLAGQAPEGVHPSAVVAESARIGE
CEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
HVSVGPQCVIEAGAVIGDGCVIGAGSIVGADSEIGADSRLHANVTVYHGVSVGRRAILHS
CCCCCCHHEEECCCEEECCEEEECCCEECCCCCCCCCCEEEEEEEEEECCHHHHHHHHHC
GCVIGADGFGFAHDGQGWHKIAQLGGVIVGDDVEIGSCSSIDRGALGDTVIGNDVKIDSQ
CCEEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCE
VQIAHNVQIGDHSALAGCVGIAGSTRVGSHCMLGGGVGLSGHLTLCDGVQVTGMSLVTNS
EEEEEEEEECCCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCEECCHHHHHHC
IHEPGVYSSGTGAMPNGLWRKNAVRFKQLDELAKRLSRLERGASDTP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA