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The map label for this gene is mutY [H]

Identifier: 92112655

GI number: 92112655

Start: 578600

End: 579661

Strand: Direct

Name: mutY [H]

Synonym: Csal_0522

Alternate gene names: 92112655

Gene position: 578600-579661 (Clockwise)

Preceding gene: 92112654

Following gene: 92112656

Centisome position: 15.65

GC content: 65.25

Gene sequence:

>1062_bases
ATGCAGGACATTCCGCTTACCGCCGAGGCCTTTCGTCAGCGGCTCTTCGCATGGTTCGACGAGCATGGACGCAAGACGCT
GCCCTGGCAGTTCGACAAGACGCCCTACCGTGTCTGGGTCTCGGAAATCATGCTGCAGCAGACCCAGGTCGCCACGGTAA
TCCCATATTACCAGCGCTTCATGGATCGCTTTCCCGATGTGTTTGCCCTGGCCGAGGCGCCGCAAGACGAGGTGCTGCAC
TTGTGGACGGGCCTGGGCTACTACGCACGTGCCCGCAACCTCCACAAGGCTGCTCGTGTCGTGGTGGAGGAACATGGCGG
CGAATTCCCCGTGGACAGCGTCGAGGCGCTGTCCACGCTTCCCGGCATCGGCCGCTCCACGGCCGGCGCCATCATCAGCA
TCAGTACCGGCCGGCGCGCGCCGATTCTCGACGGTAACGTCAAGCGTGTGCTGACTCGCCTGCACGGCGTGGAAGGCTGG
CCCGGTCGGCCGGCGGTGGAGCGTGAGCTCTGGGTGCTGGCGGAGCGTTACACGCCCGAGGAGCGTCTGCCCGATTACAC
CCAGGCGATGATGGATGTGGGAGCGACGCTGTGCACCCGCGGCAAGCCCGCGTGTCTGTTATGCCCCTTCAACGATGTGT
GCGTGGCGCATGCGCGTGGCGAGGAAACGCGCTTCCCCGAATCCAAGCCGCGCAAGACACTGCCCGAACGTACCACGCGG
ATGCTGGTACTGCGTGACCCGGAGGGCCGCGTGTTCCTTCAGCAGCGGCCCGCGAGCGGTCTGTGGGGCGGGCTATGGAG
CTTGCCGCAATTCGATGACGAAGCGGCGTTGCGTGCCTGGCTCGACCAGCGCTTTCCACGGGCTCAACGCGAAGCGGACG
GTGCCGCCTTCACGCACACGTTCAGCCACTTCCGGCTGGTGATCACGCCGTCTCCCGCGCGTCTGCACGAGCCATTCAGC
AGCGTCGGCGAGACGGGCGAATTGTGGTACGACGTGCAGGCCCCGGCTAGTGTAGGATTGGCCGCACCGGTCAAGACGCT
GCTCGATCAAGCCGTTACTTGA

Upstream 100 bases:

>100_bases
ACACCCGTCGGCGCTTTTTTTGGTATCCGTCGTGCCTGACACCTTCACACCTGACATCCATGGCTTGACGGCGTCTTCGC
CGTCTGGACGATAACGCACA

Downstream 100 bases:

>100_bases
AACCGTGCCATGACGAACCGCAACTTTCAGGAGCCAGCGCCATGAGCGATACCGTCTTTTGCCGCAAGTACCAGAAGGAA
CTCGATGCCCTGCCGTTTCC

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MQDIPLTAEAFRQRLFAWFDEHGRKTLPWQFDKTPYRVWVSEIMLQQTQVATVIPYYQRFMDRFPDVFALAEAPQDEVLH
LWTGLGYYARARNLHKAARVVVEEHGGEFPVDSVEALSTLPGIGRSTAGAIISISTGRRAPILDGNVKRVLTRLHGVEGW
PGRPAVERELWVLAERYTPEERLPDYTQAMMDVGATLCTRGKPACLLCPFNDVCVAHARGEETRFPESKPRKTLPERTTR
MLVLRDPEGRVFLQQRPASGLWGGLWSLPQFDDEAALRAWLDQRFPRAQREADGAAFTHTFSHFRLVITPSPARLHEPFS
SVGETGELWYDVQAPASVGLAAPVKTLLDQAVT

Sequences:

>Translated_353_residues
MQDIPLTAEAFRQRLFAWFDEHGRKTLPWQFDKTPYRVWVSEIMLQQTQVATVIPYYQRFMDRFPDVFALAEAPQDEVLH
LWTGLGYYARARNLHKAARVVVEEHGGEFPVDSVEALSTLPGIGRSTAGAIISISTGRRAPILDGNVKRVLTRLHGVEGW
PGRPAVERELWVLAERYTPEERLPDYTQAMMDVGATLCTRGKPACLLCPFNDVCVAHARGEETRFPESKPRKTLPERTTR
MLVLRDPEGRVFLQQRPASGLWGGLWSLPQFDDEAALRAWLDQRFPRAQREADGAAFTHTFSHFRLVITPSPARLHEPFS
SVGETGELWYDVQAPASVGLAAPVKTLLDQAVT
>Mature_353_residues
MQDIPLTAEAFRQRLFAWFDEHGRKTLPWQFDKTPYRVWVSEIMLQQTQVATVIPYYQRFMDRFPDVFALAEAPQDEVLH
LWTGLGYYARARNLHKAARVVVEEHGGEFPVDSVEALSTLPGIGRSTAGAIISISTGRRAPILDGNVKRVLTRLHGVEGW
PGRPAVERELWVLAERYTPEERLPDYTQAMMDVGATLCTRGKPACLLCPFNDVCVAHARGEETRFPESKPRKTLPERTTR
MLVLRDPEGRVFLQQRPASGLWGGLWSLPQFDDEAALRAWLDQRFPRAQREADGAAFTHTFSHFRLVITPSPARLHEPFS
SVGETGELWYDVQAPASVGLAAPVKTLLDQAVT

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=359, Percent_Identity=36.7688022284123, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI115298654, Length=359, Percent_Identity=36.7688022284123, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI115298652, Length=359, Percent_Identity=36.7688022284123, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI115298648, Length=359, Percent_Identity=36.7688022284123, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI190358497, Length=359, Percent_Identity=36.7688022284123, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI6912520, Length=359, Percent_Identity=36.7688022284123, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1789331, Length=348, Percent_Identity=56.6091954022989, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1787920, Length=128, Percent_Identity=31.25, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550361, Length=193, Percent_Identity=27.4611398963731, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39845; Mature: 39845

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIPLTAEAFRQRLFAWFDEHGRKTLPWQFDKTPYRVWVSEIMLQQTQVATVIPYYQRF
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MDRFPDVFALAEAPQDEVLHLWTGLGYYARARNLHKAARVVVEEHGGEFPVDSVEALSTL
HHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
PGIGRSTAGAIISISTGRRAPILDGNVKRVLTRLHGVEGWPGRPAVERELWVLAERYTPE
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCH
ERLPDYTQAMMDVGATLCTRGKPACLLCPFNDVCVAHARGEETRFPESKPRKTLPERTTR
HHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHEEECCCCCCCCCCCCCCCCCCHHHCE
MLVLRDPEGRVFLQQRPASGLWGGLWSLPQFDDEAALRAWLDQRFPRAQREADGAAFTHT
EEEEECCCCCEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHEEE
FSHFRLVITPSPARLHEPFSSVGETGELWYDVQAPASVGLAAPVKTLLDQAVT
ECCEEEEECCCHHHHHCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDIPLTAEAFRQRLFAWFDEHGRKTLPWQFDKTPYRVWVSEIMLQQTQVATVIPYYQRF
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MDRFPDVFALAEAPQDEVLHLWTGLGYYARARNLHKAARVVVEEHGGEFPVDSVEALSTL
HHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
PGIGRSTAGAIISISTGRRAPILDGNVKRVLTRLHGVEGWPGRPAVERELWVLAERYTPE
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCH
ERLPDYTQAMMDVGATLCTRGKPACLLCPFNDVCVAHARGEETRFPESKPRKTLPERTTR
HHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHEEECCCCCCCCCCCCCCCCCCHHHCE
MLVLRDPEGRVFLQQRPASGLWGGLWSLPQFDDEAALRAWLDQRFPRAQREADGAAFTHT
EEEEECCCCCEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHEEE
FSHFRLVITPSPARLHEPFSSVGETGELWYDVQAPASVGLAAPVKTLLDQAVT
ECCEEEEECCCHHHHHCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]