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The map label for this gene is fdhA [H]

Identifier: 92112468

GI number: 92112468

Start: 372718

End: 373905

Strand: Direct

Name: fdhA [H]

Synonym: Csal_0335

Alternate gene names: 92112468

Gene position: 372718-373905 (Clockwise)

Preceding gene: 92112467

Following gene: 92112471

Centisome position: 10.08

GC content: 64.14

Gene sequence:

>1188_bases
ATGGCTAATAATCGTGGTGTCGTCTATACCGGGCCCGGCAAGGTCGAGGTTCAGGACATTGCTTACCCCAAGATGCAAGC
GCCCAGTGGCAAGGCCATTGAACATGGGGTGATCCTCAAGGTGGTTTCCACCAATATCTGCGGTTCCGACCAGCACATGG
TGCGTGGCCGCACGACGGCGCCGGCGGGCATGGTGCTGGGTCACGAGATCACCGGCGAGGTCATCGAGAAGGGCAAGGAT
GTCGAGTTTCTCGACATCGGGGACCTGGTCTCGGTGCCGTTCAACGTCGCGTGCGGTCGCTGCCGGACCTGCAAGGAAGG
CCACACCGGGCTGTGTCTGCACGTCAACGACGAGCGTGCCGGCGGGGCGTACGGCTACGTCGACATGGGCGGCTGGGTCG
GTGGTCAGGCGCACTATGTCATGGTGCCGTATGCCGACTTCAACTTGCTCAAGTTTCCGGATCGCGATCAGGCGATGGAC
AGGATCCGCGACCTGACGATGCTGAGCGATATCCTGCCGACCGGCTTCCATGGTGCCTTGAATGCCAAGGTGGGTGCGGG
CTCGACGGTCTATGTGGCAGGGGCCGGCCCGGTCGGGCTTGCCGCGGCGGCATCGGCGCACCTGCTGGGGGCCGCGGTGG
TCATGATCGGGGACTTCAACCAGCAGCGCCTGGAACATGCCCGCAAGATGGGCTTCGAGCCCATCGACTTGAGCCGTCAC
GATCGCCTGGGCGAGATGATCGCCGCCGTGGTGGGCGAGCCGAAGGTCGACAGTGCCATCGACGCCGTGGGCTTCGAGGC
CGTGGGCCATGGCGGCAAGGAACAGCCGGCGGTGGTGCTCAACCAGATGATGGAAGTGACTCGTGAAGCCGGCTCGATCG
GCATCCCCGGGCTCTATGTCACCGAGGATCCCGGTGCCGCCGAGAAGGCGGCCCAGAGCGGCAATCTCAGCCTGCGCTTC
GGCCTGGGCTGGGCCAAGGGACATTCCTTCCATACCGGGCAGACGCCGGTGGTGCAATACAATCGCCAGTTGATGCAGGC
GATCCTGCACGGGCGGCTCAATATCGCCGAGATCGTCAACGCCCAGGTCATTTCCCTGGAAGATGCACCGCAGGGCTATC
AGCAGTTCGACTCCGGCGTGGCCAGCAAATTCGTGCTGGATCCGCATGGGCTGCTTGGCGCGGCGTGA

Upstream 100 bases:

>100_bases
ATACGATGATGGACTAGGTGCCATGCGTCAGGTGGGCGCCGGTCCCGCTATGCCGATACCGGGTGCGGTATCGGCCCATT
CTCAGCAGGAGAGGTCGAAG

Downstream 100 bases:

>100_bases
CGATGCCGATGTGAAAATCGCCAGGGTGAATACGAAAAGGACTGGGTAGCGGCTACCCAGTCCTTTCGGCGACGCTCGGC
AATAAATGGTGTTTTGCCGA

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MANNRGVVYTGPGKVEVQDIAYPKMQAPSGKAIEHGVILKVVSTNICGSDQHMVRGRTTAPAGMVLGHEITGEVIEKGKD
VEFLDIGDLVSVPFNVACGRCRTCKEGHTGLCLHVNDERAGGAYGYVDMGGWVGGQAHYVMVPYADFNLLKFPDRDQAMD
RIRDLTMLSDILPTGFHGALNAKVGAGSTVYVAGAGPVGLAAAASAHLLGAAVVMIGDFNQQRLEHARKMGFEPIDLSRH
DRLGEMIAAVVGEPKVDSAIDAVGFEAVGHGGKEQPAVVLNQMMEVTREAGSIGIPGLYVTEDPGAAEKAAQSGNLSLRF
GLGWAKGHSFHTGQTPVVQYNRQLMQAILHGRLNIAEIVNAQVISLEDAPQGYQQFDSGVASKFVLDPHGLLGAA

Sequences:

>Translated_395_residues
MANNRGVVYTGPGKVEVQDIAYPKMQAPSGKAIEHGVILKVVSTNICGSDQHMVRGRTTAPAGMVLGHEITGEVIEKGKD
VEFLDIGDLVSVPFNVACGRCRTCKEGHTGLCLHVNDERAGGAYGYVDMGGWVGGQAHYVMVPYADFNLLKFPDRDQAMD
RIRDLTMLSDILPTGFHGALNAKVGAGSTVYVAGAGPVGLAAAASAHLLGAAVVMIGDFNQQRLEHARKMGFEPIDLSRH
DRLGEMIAAVVGEPKVDSAIDAVGFEAVGHGGKEQPAVVLNQMMEVTREAGSIGIPGLYVTEDPGAAEKAAQSGNLSLRF
GLGWAKGHSFHTGQTPVVQYNRQLMQAILHGRLNIAEIVNAQVISLEDAPQGYQQFDSGVASKFVLDPHGLLGAA
>Mature_394_residues
ANNRGVVYTGPGKVEVQDIAYPKMQAPSGKAIEHGVILKVVSTNICGSDQHMVRGRTTAPAGMVLGHEITGEVIEKGKDV
EFLDIGDLVSVPFNVACGRCRTCKEGHTGLCLHVNDERAGGAYGYVDMGGWVGGQAHYVMVPYADFNLLKFPDRDQAMDR
IRDLTMLSDILPTGFHGALNAKVGAGSTVYVAGAGPVGLAAAASAHLLGAAVVMIGDFNQQRLEHARKMGFEPIDLSRHD
RLGEMIAAVVGEPKVDSAIDAVGFEAVGHGGKEQPAVVLNQMMEVTREAGSIGIPGLYVTEDPGAAEKAAQSGNLSLRFG
LGWAKGHSFHTGQTPVVQYNRQLMQAILHGRLNIAEIVNAQVISLEDAPQGYQQFDSGVASKFVLDPHGLLGAA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=229, Percent_Identity=30.1310043668122, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI34577061, Length=229, Percent_Identity=29.6943231441048, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4501929, Length=229, Percent_Identity=29.2576419213974, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI262073058, Length=392, Percent_Identity=23.2142857142857, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI71743840, Length=392, Percent_Identity=23.2142857142857, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI71565154, Length=394, Percent_Identity=24.3654822335025, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786825, Length=401, Percent_Identity=33.9152119700748, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=29.1208791208791, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788073, Length=237, Percent_Identity=28.2700421940928, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790718, Length=261, Percent_Identity=26.4367816091954, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=268, Percent_Identity=30.9701492537313, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082125, Length=204, Percent_Identity=31.3725490196078, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787863, Length=216, Percent_Identity=30.5555555555556, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=252, Percent_Identity=29.3650793650794, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=280, Percent_Identity=27.5, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=233, Percent_Identity=32.1888412017167, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=233, Percent_Identity=32.1888412017167, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=264, Percent_Identity=25.3787878787879, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=251, Percent_Identity=32.6693227091633, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737895, Length=213, Percent_Identity=31.924882629108, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR007698
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF01262 AlaDh_PNT_C [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 41744; Mature: 41613

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNRGVVYTGPGKVEVQDIAYPKMQAPSGKAIEHGVILKVVSTNICGSDQHMVRGRTTA
CCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCC
PAGMVLGHEITGEVIEKGKDVEFLDIGDLVSVPFNVACGRCRTCKEGHTGLCLHVNDERA
CCCEEECCHHHHHHHHCCCCEEEEECCCHHCCCCHHCCCCCCCCCCCCCEEEEEECCCCC
GGAYGYVDMGGWVGGQAHYVMVPYADFNLLKFPDRDQAMDRIRDLTMLSDILPTGFHGAL
CCEEEEEECCCCCCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCE
NAKVGAGSTVYVAGAGPVGLAAAASAHLLGAAVVMIGDFNQQRLEHARKMGFEPIDLSRH
ECCCCCCCEEEEECCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCCCCCCCCHH
DRLGEMIAAVVGEPKVDSAIDAVGFEAVGHGGKEQPAVVLNQMMEVTREAGSIGIPGLYV
HHHHHHHHHHHCCCCCCHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
TEDPGAAEKAAQSGNLSLRFGLGWAKGHSFHTGQTPVVQYNRQLMQAILHGRLNIAEIVN
ECCCCHHHHHHCCCCEEEEEECEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCC
AQVISLEDAPQGYQQFDSGVASKFVLDPHGLLGAA
EEEEEECCCCCHHHHHHCCHHHEEEECCCCCCCCC
>Mature Secondary Structure 
ANNRGVVYTGPGKVEVQDIAYPKMQAPSGKAIEHGVILKVVSTNICGSDQHMVRGRTTA
CCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCC
PAGMVLGHEITGEVIEKGKDVEFLDIGDLVSVPFNVACGRCRTCKEGHTGLCLHVNDERA
CCCEEECCHHHHHHHHCCCCEEEEECCCHHCCCCHHCCCCCCCCCCCCCEEEEEECCCCC
GGAYGYVDMGGWVGGQAHYVMVPYADFNLLKFPDRDQAMDRIRDLTMLSDILPTGFHGAL
CCEEEEEECCCCCCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCE
NAKVGAGSTVYVAGAGPVGLAAAASAHLLGAAVVMIGDFNQQRLEHARKMGFEPIDLSRH
ECCCCCCCEEEEECCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHCCCCCCCCCHH
DRLGEMIAAVVGEPKVDSAIDAVGFEAVGHGGKEQPAVVLNQMMEVTREAGSIGIPGLYV
HHHHHHHHHHHCCCCCCHHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
TEDPGAAEKAAQSGNLSLRFGLGWAKGHSFHTGQTPVVQYNRQLMQAILHGRLNIAEIVN
ECCCCHHHHHHCCCCEEEEEECEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCC
AQVISLEDAPQGYQQFDSGVASKFVLDPHGLLGAA
EEEEEECCCCCHHHHHHCCHHHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169197 [H]