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The map label for this gene is hldE

Identifier: 92112153

GI number: 92112153

Start: 20911

End: 22341

Strand: Direct

Name: hldE

Synonym: Csal_0017

Alternate gene names: 92112153

Gene position: 20911-22341 (Clockwise)

Preceding gene: 92112152

Following gene: 92112154

Centisome position: 0.57

GC content: 66.81

Gene sequence:

>1431_bases
ATGAAACTTGATCTGACCGTCCTCGAACAGGCCCGCTTGCTGGTAGTGGGCGATGTCATGCTCGACCGCTATTGGCATGG
CGGCACCTCGCGCATCTCGCCGGAAGCGCCGGTACCGGTGGTCAAGGTCGGCGAATCGGAAGACCGTCCCGGCGGTGCCG
CCAACGTGGCGCTCAACATCGCCGCGCTGGGCGCCCATGCGGCCCTGGCGGGCGTGGTCGGCGAGGATGAAAACGCCGAC
TTGCTGGCGGCACGTCTCGAAGCTTGCGATGTAAGTACTTACTTCTACCGTAGCCCCGAGATACCCACGATCACCAAGCT
GCGCGTGATGAGCCGCAACCAGCAGTTGCTGCGTCTGGACTTCGAGGAATCGCTGTGGGAAATCGACACCCAGGGCCTGA
CCGAGCGCGTCGAAGCGGCGCTGCCCGAGGCCGACGTGGTCATCCTCTCCGATTACGGCAAGGGCAGCCTCAATCGTGTC
GAGACGCTGATCGCCACCGCGCGTGGCGCCGGCAAGCGAGTGTTGGTCGATCCCAAGGGGCATGACTTCGCCAAGTATCG
CGGCGCGAGCATCATCACGCCCAATCTCGGGGAATTCGAGGCGGTGGTGGGTCCGTGCCCCGACGATGCCACGCTGGCCG
AGAAGGGCGAGCGCCTGCGTGCCGAGCTGGAGCTCGAGGCGCTGCTGGTCACGCGCAGCGAGAAGGGCATGACGCTGATT
CGCGAGGGACACGCGCCGTTGCACCTGCCGACCCATGCCCGCGAGGTCTATGACGTGACCGGCGCCGGGGATACCGTCAT
CGGCGTGCTCGGCCTGGCACTGGCGGCGGGGCATGGCTACCCGGAGGCGATCATGCTGGCCAACCTGGCAGCGGGGCTGG
TGGTGGCCAAGCCGGGCACCGCGACATTGTCCATCGCCGAGCTCTACACGGCACTGCATGGCGACAAGCTCGCCGAGTTC
GGTCCCATCGAGGAAAGCGCGCTGATCGACGCGGTGCGCGCGGCCAAGTTGCGTGGCGAGCGGGTGGTGATGACCAATGG
CTGCTTCGACATCCTGCATGCCGGCCACGTGGCGTACCTCGAGCAGGCCAAGCGCCTGGGAGATCGGCTGGTGGTGGCGG
TCAACGACGATGCCTCCGTGGGGCGCCTCAAGGGGCCCAAGCGTCCGATCAACGCCCTCGAGCGCCGCATGCAGGTGCTG
GCGGGCTTGAGTGCCGTCGACTGGGTGGTGCCTTTCGGCGAGGAAACCCCGGCGCGACTGATCGCCGAGGTGCTGCCCGA
TGTGCTGGTCAAGGGCGGCGACTATCGTCCCGAGGACATCGCCGGCGGCGAAGCGGTCATGGCCGCCGGGGGCGAGGTTC
GCGTGCTGAACTTCGAGGACGGCGTCTCGACTACCGCCATGATCGACACCATTCTCGACCGGGAAGGCTAA

Upstream 100 bases:

>100_bases
CCCGATGCCATGAGCCTGATCCACGCCGACGACGTCATCGCGCAGTTCGATGCCTTGCTGAACGCCGCGCCGTCCGCCTC
GTCCCGCCCGGAGCCCGACC

Downstream 100 bases:

>100_bases
GGCGCGATGCTCACGCCCCGTCTCGCGCGCGGCCTCTACAGCGGCGCGTTGTATCTCCTGTCGCCCTTGATCTGGTGGCG
CGTGTGGCGTGAGCATGCGC

Product: bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKLDLTVLEQARLLVVGDVMLDRYWHGGTSRISPEAPVPVVKVGESEDRPGGAANVALNIAALGAHAALAGVVGEDENAD
LLAARLEACDVSTYFYRSPEIPTITKLRVMSRNQQLLRLDFEESLWEIDTQGLTERVEAALPEADVVILSDYGKGSLNRV
ETLIATARGAGKRVLVDPKGHDFAKYRGASIITPNLGEFEAVVGPCPDDATLAEKGERLRAELELEALLVTRSEKGMTLI
REGHAPLHLPTHAREVYDVTGAGDTVIGVLGLALAAGHGYPEAIMLANLAAGLVVAKPGTATLSIAELYTALHGDKLAEF
GPIEESALIDAVRAAKLRGERVVMTNGCFDILHAGHVAYLEQAKRLGDRLVVAVNDDASVGRLKGPKRPINALERRMQVL
AGLSAVDWVVPFGEETPARLIAEVLPDVLVKGGDYRPEDIAGGEAVMAAGGEVRVLNFEDGVSTTAMIDTILDREG

Sequences:

>Translated_476_residues
MKLDLTVLEQARLLVVGDVMLDRYWHGGTSRISPEAPVPVVKVGESEDRPGGAANVALNIAALGAHAALAGVVGEDENAD
LLAARLEACDVSTYFYRSPEIPTITKLRVMSRNQQLLRLDFEESLWEIDTQGLTERVEAALPEADVVILSDYGKGSLNRV
ETLIATARGAGKRVLVDPKGHDFAKYRGASIITPNLGEFEAVVGPCPDDATLAEKGERLRAELELEALLVTRSEKGMTLI
REGHAPLHLPTHAREVYDVTGAGDTVIGVLGLALAAGHGYPEAIMLANLAAGLVVAKPGTATLSIAELYTALHGDKLAEF
GPIEESALIDAVRAAKLRGERVVMTNGCFDILHAGHVAYLEQAKRLGDRLVVAVNDDASVGRLKGPKRPINALERRMQVL
AGLSAVDWVVPFGEETPARLIAEVLPDVLVKGGDYRPEDIAGGEAVMAAGGEVRVLNFEDGVSTTAMIDTILDREG
>Mature_476_residues
MKLDLTVLEQARLLVVGDVMLDRYWHGGTSRISPEAPVPVVKVGESEDRPGGAANVALNIAALGAHAALAGVVGEDENAD
LLAARLEACDVSTYFYRSPEIPTITKLRVMSRNQQLLRLDFEESLWEIDTQGLTERVEAALPEADVVILSDYGKGSLNRV
ETLIATARGAGKRVLVDPKGHDFAKYRGASIITPNLGEFEAVVGPCPDDATLAEKGERLRAELELEALLVTRSEKGMTLI
REGHAPLHLPTHAREVYDVTGAGDTVIGVLGLALAAGHGYPEAIMLANLAAGLVVAKPGTATLSIAELYTALHGDKLAEF
GPIEESALIDAVRAAKLRGERVVMTNGCFDILHAGHVAYLEQAKRLGDRLVVAVNDDASVGRLKGPKRPINALERRMQVL
AGLSAVDWVVPFGEETPARLIAEVLPDVLVKGGDYRPEDIAGGEAVMAAGGEVRVLNFEDGVSTTAMIDTILDREG

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=477, Percent_Identity=60.7966457023061, Blast_Score=557, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_CHRSD (Q1R1M6)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572081.1
- ProteinModelPortal:   Q1R1M6
- SMR:   Q1R1M6
- STRING:   Q1R1M6
- GeneID:   4027336
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0017
- NMPDR:   fig|290398.4.peg.186
- eggNOG:   COG2870
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- ProtClustDB:   PRK11316
- BioCyc:   CSAL290398:CSAL_0017-MONOMER
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 50711; Mature: 50711

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 264-264

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDLTVLEQARLLVVGDVMLDRYWHGGTSRISPEAPVPVVKVGESEDRPGGAANVALNI
CCCCCEECCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEE
AALGAHAALAGVVGEDENADLLAARLEACDVSTYFYRSPEIPTITKLRVMSRNQQLLRLD
EEHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEE
FEESLWEIDTQGLTERVEAALPEADVVILSDYGKGSLNRVETLIATARGAGKRVLVDPKG
HHHHHHHHCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCC
HDFAKYRGASIITPNLGEFEAVVGPCPDDATLAEKGERLRAELELEALLVTRSEKGMTLI
CCHHHHCCCEEECCCCCCCHHEECCCCCCCHHHHCCHHHHHHHEEEEEEEEECCCCCEEE
REGHAPLHLPTHAREVYDVTGAGDTVIGVLGLALAAGHGYPEAIMLANLAAGLVVAKPGT
ECCCCCEECCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCC
ATLSIAELYTALHGDKLAEFGPIEESALIDAVRAAKLRGERVVMTNGCFDILHAGHVAYL
CEEEHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCHHHHH
EQAKRLGDRLVVAVNDDASVGRLKGPKRPINALERRMQVLAGLSAVDWVVPFGEETPARL
HHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCCHHHH
IAEVLPDVLVKGGDYRPEDIAGGEAVMAAGGEVRVLNFEDGVSTTAMIDTILDREG
HHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKLDLTVLEQARLLVVGDVMLDRYWHGGTSRISPEAPVPVVKVGESEDRPGGAANVALNI
CCCCCEECCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEE
AALGAHAALAGVVGEDENADLLAARLEACDVSTYFYRSPEIPTITKLRVMSRNQQLLRLD
EEHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEE
FEESLWEIDTQGLTERVEAALPEADVVILSDYGKGSLNRVETLIATARGAGKRVLVDPKG
HHHHHHHHCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCC
HDFAKYRGASIITPNLGEFEAVVGPCPDDATLAEKGERLRAELELEALLVTRSEKGMTLI
CCHHHHCCCEEECCCCCCCHHEECCCCCCCHHHHCCHHHHHHHEEEEEEEEECCCCCEEE
REGHAPLHLPTHAREVYDVTGAGDTVIGVLGLALAAGHGYPEAIMLANLAAGLVVAKPGT
ECCCCCEECCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCC
ATLSIAELYTALHGDKLAEFGPIEESALIDAVRAAKLRGERVVMTNGCFDILHAGHVAYL
CEEEHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCHHHHH
EQAKRLGDRLVVAVNDDASVGRLKGPKRPINALERRMQVLAGLSAVDWVVPFGEETPARL
HHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCCHHHH
IAEVLPDVLVKGGDYRPEDIAGGEAVMAAGGEVRVLNFEDGVSTTAMIDTILDREG
HHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA