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The map label for this gene is tktA [H]

Identifier: 91785214

GI number: 91785214

Start: 4261140

End: 4263128

Strand: Reverse

Name: tktA [H]

Synonym: Bxe_A0565

Alternate gene names: 91785214

Gene position: 4263128-4261140 (Counterclockwise)

Preceding gene: 91785219

Following gene: 91785213

Centisome position: 87.08

GC content: 64.15

Gene sequence:

>1989_bases
ATGGCCAACGCAATCCGCGCGCTGTCCATGGACGCCGTTCAAAAAGCGAACTCCGGCCACCCCGGCATGCCAATGGGCAT
GGCCGAAATCGGCGTGGCGTTGTGGTCGCGTCATCTGCGCCACAACCCGAAGAACCCGCAATGGGCCGATCGCGACCGTT
TCGTGCTGTCGAACGGTCACGGCTCGATGCTGCTGTACTCGCTGCTGCACCTGACCGGCTACGATCTGCCGATCGAAGAG
CTGAAGAACTTCCGCCAGATGCATTCGAAGACGCCGGGCCACCCGGAATACGGCATCACGCCGGGCGTCGAGACGACCAC
CGGCCCGCTCGGCCAGGGTCTGGCGAATGCGGTCGGCATGGCGCTCGCCGAGTCGCTGCTCGCCACCGAATTCAACAAGC
CTGACGCAACGATCGTCGACCACCACACGTACGTGTTCGTCGGCGACGGCTGCCTGATGGAAGGCATCTCGCACGAAGCC
TGTTCGCTCGCGGGCGTGCTGAAGCTGAACAAGCTGATTGCGTTCTACGACGACAACGGCATCTCGATCGACGGCGAAGT
GGTGCACTGGTTCCACGACGACACGCCCAAGCGCTTCGAGGCGTACGGCTGGAACGTGATCCCGAACGTGGTCGGCCACG
ACGTCGAAGCAGTGGACGCGGCCATCAAGCAGGCGAAGCAATCCGACAAACCCACGCTGATCTGCTGCAAGACGGTGATC
GGCGAAGGCTCGCCGAACAAGGCCGGCAGCCACGATTCGCACGGCGCGGCGCTCGGCGACAAGGAAGTCGCGGCCACGCG
CGAAAAGATCGGCTGGAAGTGGGAGCCGTTCGTGATCCCGCAAGAGGTCTATGCAGCTTGGGACGCAACAGAAGCGGGCG
CACGCAACGAATCCGAGTGGGACAAGGCATTCGCCGCGTACGCTGCCAAATATCCGCAGGAAGCCGCTGAATTCAAGCGC
CGCAACGCGAAGCAGTTGCCGGCGGACTGGAAGGAAAAGGCCAAGGCGATCATTGCCGGCGCGAACGAGCGCGCGGAAAC
CGTAGCGACGCGCAAGGCATCGCAACAGGCTATCGAGGCTTTGTCGGCCGTGCTGCCGGAACTGCTCGGCGGCTCCGCCG
ACCTGACCGGCTCGAACCTGACCAACTGGAAGGCCGCCAAACCGGTACGCGTGAACGCCGAAGGCAAGGCTGCCGGCAAC
TACGTCAACTACGGCGTGCGTGAATTCGGCATGAGCGCCGCGATCAACGGCGTTGCGCTGCACGGTGGCTTCAAGGCGTT
CGGCGGCACGTTCCTGACGTTCTCGGACTACAGCCGCAACGCGCTGCGCGTCGCCGCGCTGATGAAAGCGCCGTCGATCT
TCGTGTTCACGCACGACTCGATCGGTCTGGGCGAAGACGGCCCGACCCACCAGTCGATCGAACATGTTGCGAGCCTGCGT
CTGATTCCGCACCTGCAAGTGTGGCGTCCGGCTGATACCGTCGAGACGGCGGTGGCCTGGACCCACGCGGTCGAACATCA
TGGCCCGTCGTGCCTGATCTTCAGCCGTCAGAACCTGCCGTTCTCGGAGCGCACGGACGCGCAGATCGCCAACATCGAGA
AGGGCGGTTACGTGCTGCGCGACTGGAACGACGAGATCGTCGCGCGCAAGATCATCCTGATCGCCACCGGTTCGGAAGTC
GAACTGGCGCTGAACGCGGTCGAGCCGCTGGCGCGCGAAGGTATCGCGGCGCGCGTCGTGTCCATGCCGTCAACCACCGT
GTTCGACAAGCAGGACGCCGAGTACCGTGAACGCGTGCTGCCGCAAGGCGTGCGCCGCGTCGCGATCGAAGCGGGTGTGA
CGGATTTCTGGCGCAAGTACGTGGGTCTGGAAGGCGGCGTGGTCGGCATCGACACGTTCGGCGAATCGGCCCCGGCTGGC
GTGCTGTTCAAGCATTTCGGCTTCACCGTCGAACACGTGGTAGAGACGGCAAAAGCCGCACTCGGCTGA

Upstream 100 bases:

>100_bases
TGAGCTGGCATTCGAGCATCCGGGCCTCAAGCGCACACCGCTTTCTGACTCTGTCTCCGGACTCGACATGACGACCCCGT
CTCCCGCACCCACTTCCTTG

Downstream 100 bases:

>100_bases
TCCTGGACAAGCGTTGCCGTTCGCGTGCGAACGCGCGGCAACGCGGTCAGTCAGACGAACCTGGACGTATTTTTTTAGCC
ATCAGGAGATAGACCATGAC

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MANAIRALSMDAVQKANSGHPGMPMGMAEIGVALWSRHLRHNPKNPQWADRDRFVLSNGHGSMLLYSLLHLTGYDLPIEE
LKNFRQMHSKTPGHPEYGITPGVETTTGPLGQGLANAVGMALAESLLATEFNKPDATIVDHHTYVFVGDGCLMEGISHEA
CSLAGVLKLNKLIAFYDDNGISIDGEVVHWFHDDTPKRFEAYGWNVIPNVVGHDVEAVDAAIKQAKQSDKPTLICCKTVI
GEGSPNKAGSHDSHGAALGDKEVAATREKIGWKWEPFVIPQEVYAAWDATEAGARNESEWDKAFAAYAAKYPQEAAEFKR
RNAKQLPADWKEKAKAIIAGANERAETVATRKASQQAIEALSAVLPELLGGSADLTGSNLTNWKAAKPVRVNAEGKAAGN
YVNYGVREFGMSAAINGVALHGGFKAFGGTFLTFSDYSRNALRVAALMKAPSIFVFTHDSIGLGEDGPTHQSIEHVASLR
LIPHLQVWRPADTVETAVAWTHAVEHHGPSCLIFSRQNLPFSERTDAQIANIEKGGYVLRDWNDEIVARKIILIATGSEV
ELALNAVEPLAREGIAARVVSMPSTTVFDKQDAEYRERVLPQGVRRVAIEAGVTDFWRKYVGLEGGVVGIDTFGESAPAG
VLFKHFGFTVEHVVETAKAALG

Sequences:

>Translated_662_residues
MANAIRALSMDAVQKANSGHPGMPMGMAEIGVALWSRHLRHNPKNPQWADRDRFVLSNGHGSMLLYSLLHLTGYDLPIEE
LKNFRQMHSKTPGHPEYGITPGVETTTGPLGQGLANAVGMALAESLLATEFNKPDATIVDHHTYVFVGDGCLMEGISHEA
CSLAGVLKLNKLIAFYDDNGISIDGEVVHWFHDDTPKRFEAYGWNVIPNVVGHDVEAVDAAIKQAKQSDKPTLICCKTVI
GEGSPNKAGSHDSHGAALGDKEVAATREKIGWKWEPFVIPQEVYAAWDATEAGARNESEWDKAFAAYAAKYPQEAAEFKR
RNAKQLPADWKEKAKAIIAGANERAETVATRKASQQAIEALSAVLPELLGGSADLTGSNLTNWKAAKPVRVNAEGKAAGN
YVNYGVREFGMSAAINGVALHGGFKAFGGTFLTFSDYSRNALRVAALMKAPSIFVFTHDSIGLGEDGPTHQSIEHVASLR
LIPHLQVWRPADTVETAVAWTHAVEHHGPSCLIFSRQNLPFSERTDAQIANIEKGGYVLRDWNDEIVARKIILIATGSEV
ELALNAVEPLAREGIAARVVSMPSTTVFDKQDAEYRERVLPQGVRRVAIEAGVTDFWRKYVGLEGGVVGIDTFGESAPAG
VLFKHFGFTVEHVVETAKAALG
>Mature_661_residues
ANAIRALSMDAVQKANSGHPGMPMGMAEIGVALWSRHLRHNPKNPQWADRDRFVLSNGHGSMLLYSLLHLTGYDLPIEEL
KNFRQMHSKTPGHPEYGITPGVETTTGPLGQGLANAVGMALAESLLATEFNKPDATIVDHHTYVFVGDGCLMEGISHEAC
SLAGVLKLNKLIAFYDDNGISIDGEVVHWFHDDTPKRFEAYGWNVIPNVVGHDVEAVDAAIKQAKQSDKPTLICCKTVIG
EGSPNKAGSHDSHGAALGDKEVAATREKIGWKWEPFVIPQEVYAAWDATEAGARNESEWDKAFAAYAAKYPQEAAEFKRR
NAKQLPADWKEKAKAIIAGANERAETVATRKASQQAIEALSAVLPELLGGSADLTGSNLTNWKAAKPVRVNAEGKAAGNY
VNYGVREFGMSAAINGVALHGGFKAFGGTFLTFSDYSRNALRVAALMKAPSIFVFTHDSIGLGEDGPTHQSIEHVASLRL
IPHLQVWRPADTVETAVAWTHAVEHHGPSCLIFSRQNLPFSERTDAQIANIEKGGYVLRDWNDEIVARKIILIATGSEVE
LALNAVEPLAREGIAARVVSMPSTTVFDKQDAEYRERVLPQGVRRVAIEAGVTDFWRKYVGLEGGVVGIDTFGESAPAGV
LFKHFGFTVEHVVETAKAALG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=606, Percent_Identity=27.8877887788779, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI4507521, Length=606, Percent_Identity=27.8877887788779, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI133778974, Length=583, Percent_Identity=27.1012006861063, Blast_Score=141, Evalue=3e-33,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=65.0602409638554, Blast_Score=898, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=665, Percent_Identity=62.5563909774436, Blast_Score=839, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=672, Percent_Identity=25.5952380952381, Blast_Score=155, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=50.748502994012, Blast_Score=614, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=45.9016393442623, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45551847, Length=686, Percent_Identity=27.2594752186589, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45550715, Length=686, Percent_Identity=27.2594752186589, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24666278, Length=680, Percent_Identity=26.1764705882353, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24645119, Length=653, Percent_Identity=26.7993874425727, Blast_Score=155, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71705; Mature: 71574

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAIRALSMDAVQKANSGHPGMPMGMAEIGVALWSRHLRHNPKNPQWADRDRFVLSNGH
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
GSMLLYSLLHLTGYDLPIEELKNFRQMHSKTPGHPEYGITPGVETTTGPLGQGLANAVGM
CHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALAESLLATEFNKPDATIVDHHTYVFVGDGCLMEGISHEACSLAGVLKLNKLIAFYDDNG
HHHHHHHHHCCCCCCCEEEECCEEEEECCCHHHHCCCHHHHHHHHHHHHCCEEEEECCCC
ISIDGEVVHWFHDDTPKRFEAYGWNVIPNVVGHDVEAVDAAIKQAKQSDKPTLICCKTVI
EEECCCEEEEECCCCCHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHH
GEGSPNKAGSHDSHGAALGDKEVAATREKIGWKWEPFVIPQEVYAAWDATEAGARNESEW
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECHHHHHHHHCCHHCCCCCCHHH
DKAFAAYAAKYPQEAAEFKRRNAKQLPADWKEKAKAIIAGANERAETVATRKASQQAIEA
HHHHHHHHHHCHHHHHHHHHCCHHCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHH
LSAVLPELLGGSADLTGSNLTNWKAAKPVRVNAEGKAAGNYVNYGVREFGMSAAINGVAL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHCCHHHHCHHHHCCCEEE
HGGFKAFGGTFLTFSDYSRNALRVAALMKAPSIFVFTHDSIGLGEDGPTHQSIEHVASLR
ECCHHHHCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LIPHLQVWRPADTVETAVAWTHAVEHHGPSCLIFSRQNLPFSERTDAQIANIEKGGYVLR
HCCCCEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHEEECCCCEEEE
DWNDEIVARKIILIATGSEVELALNAVEPLAREGIAARVVSMPSTTVFDKQDAEYRERVL
CCCCCEEEEEEEEEEECCCCEEHHHHHHHHHHCCHHEEEEECCCCEEECCCCHHHHHHHH
PQGVRRVAIEAGVTDFWRKYVGLEGGVVGIDTFGESAPAGVLFKHFGFTVEHVVETAKAA
HHHHHHHHHHHCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHH
LG
CC
>Mature Secondary Structure 
ANAIRALSMDAVQKANSGHPGMPMGMAEIGVALWSRHLRHNPKNPQWADRDRFVLSNGH
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCC
GSMLLYSLLHLTGYDLPIEELKNFRQMHSKTPGHPEYGITPGVETTTGPLGQGLANAVGM
CHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALAESLLATEFNKPDATIVDHHTYVFVGDGCLMEGISHEACSLAGVLKLNKLIAFYDDNG
HHHHHHHHHCCCCCCCEEEECCEEEEECCCHHHHCCCHHHHHHHHHHHHCCEEEEECCCC
ISIDGEVVHWFHDDTPKRFEAYGWNVIPNVVGHDVEAVDAAIKQAKQSDKPTLICCKTVI
EEECCCEEEEECCCCCHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHH
GEGSPNKAGSHDSHGAALGDKEVAATREKIGWKWEPFVIPQEVYAAWDATEAGARNESEW
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECHHHHHHHHCCHHCCCCCCHHH
DKAFAAYAAKYPQEAAEFKRRNAKQLPADWKEKAKAIIAGANERAETVATRKASQQAIEA
HHHHHHHHHHCHHHHHHHHHCCHHCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHH
LSAVLPELLGGSADLTGSNLTNWKAAKPVRVNAEGKAAGNYVNYGVREFGMSAAINGVAL
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHCCHHHHCHHHHCCCEEE
HGGFKAFGGTFLTFSDYSRNALRVAALMKAPSIFVFTHDSIGLGEDGPTHQSIEHVASLR
ECCHHHHCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LIPHLQVWRPADTVETAVAWTHAVEHHGPSCLIFSRQNLPFSERTDAQIANIEKGGYVLR
HCCCCEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHEEECCCCEEEE
DWNDEIVARKIILIATGSEVELALNAVEPLAREGIAARVVSMPSTTVFDKQDAEYRERVL
CCCCCEEEEEEEEEEECCCCEEHHHHHHHHHHCCHHEEEEECCCCEEECCCCHHHHHHHH
PQGVRRVAIEAGVTDFWRKYVGLEGGVVGIDTFGESAPAGVLFKHFGFTVEHVVETAKAA
HHHHHHHHHHHCHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHH
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]