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The map label for this gene is tyrS [H]

Identifier: 91785169

GI number: 91785169

Start: 4204466

End: 4205716

Strand: Reverse

Name: tyrS [H]

Synonym: Bxe_A0611

Alternate gene names: 91785169

Gene position: 4205716-4204466 (Counterclockwise)

Preceding gene: 91785171

Following gene: 91785168

Centisome position: 85.9

GC content: 62.19

Gene sequence:

>1251_bases
ATGAGCACCGAGCCCACCAAGCCCAACGCCGCTTCCGCCTTCCCGATCACCGACGAAGTCCGTCACGCGCTCGCCGTCAC
CAAACGCGGGGTCGACGAACTGCTGATCGAAGACGAATTCGCGCAAAAACTCGCGAAGAGCGCGGCGACCGGCAAACCGC
TGCGTATCAAGCTCGGGCTCGATCCGACCGCGCCGGACATCCATATTGGCCACACGGTCGTGCTGAACAAGATGCGCCAG
TTGCAGGACCTCGGCCACACCGTGATTTTCCTGATCGGCGATTTCACCTCGCTGATCGGCGATCCGTCGGGCCGTAACGC
CACGCGCCCGCCGCTCACGCGCGAGCAGATCGAATCGAACGCCAAGACGTATTTCGAACAGGCCGCGCTCGTGCTCGACC
GCGACAAGACCGAAATCCGCTACAACAGCGAATGGTCGATGCCGCTCGGCGCCGACGGCATGATCAAGCTCGCGTCGCGC
TACACGGTGGCGCGGATTCTCGAACGCGAAGATTTCACCAGGCGTTTCCAGAGCGGCGTGCCGATCTCGATCCACGAGTT
CCTGTACCCGTTGATGCAAGGCTACGACTCGGTCGCGCTGAACGCGGACCTCGAACTCGGCGGCACGGACCAGAAGTTCA
ACCTGCTCGTGGGCCGTGAGTTGCAGAAGCAGTACGGCCAGGAACAGCAGTGCATCCTGACCATGCCGCTGCTCGAAGGG
CTGGATGGCGTCGAAAAAATGTCGAAGTCGAAGAACAACTACATCGGTATCAGCGAAAAGCCGACCGACATGTTCGGCAA
GCTGATGAGCATTTCCGACGTGCTGATGTGGCGTTACTTCGAACTGCTGTCGTTCCGTCCGATGGAAGAAATCGCGGGCT
TCAAAAAGGAAACCGAAGCAGGCCGCAATCCGCGCGATTTCAAGGTGATGCTCGGCCAGGAAATCGTCGCGCGCTTCCAC
TCGCAAGCCGACGCCGAACGCGCGCTCGAAGACTTCAACCATCGCGCGAAGGGCGGTGTGCCGGACGATATCCCGGCCGT
GACGCTCGCGGGCGCACCGCTCGCGATCGGCCAGTTGCTCAAGCAGGCCAACCTCGCGCCGTCGACCAGCGAAGCGCTGC
GCAACATCGAGCAGGGCGGCGTGAAGATCGACGGCGCAACCGTGTCCGACAAGGGCCTGAAAGTCGAAGCCGGCGAGTAC
GTCGTGCAGGTCGGCAAGCGCCGTTTTGCACGCGTCACGCTGACGGCCTGA

Upstream 100 bases:

>100_bases
GGAAATCGCGCGTCGGCGGCGCACCTGCGGCTGCGCCGATGGGCGCGGCGGCGCGCATCTATGGGACAATCTCCTTTTTT
TGCGACTTCACGTTTCCAGC

Downstream 100 bases:

>100_bases
TGGGCCCGACGTCGCATCTGGAGTCGAACCGATGATCGCGCTGATTCAACGTGTGCGGCGCGCGGAGGTGCGCGTGGCCG
ACCGCGTAACGGGCGCGATC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MSTEPTKPNAASAFPITDEVRHALAVTKRGVDELLIEDEFAQKLAKSAATGKPLRIKLGLDPTAPDIHIGHTVVLNKMRQ
LQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASR
YTVARILEREDFTRRFQSGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEG
LDGVEKMSKSKNNYIGISEKPTDMFGKLMSISDVLMWRYFELLSFRPMEEIAGFKKETEAGRNPRDFKVMLGQEIVARFH
SQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQANLAPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEY
VVQVGKRRFARVTLTA

Sequences:

>Translated_416_residues
MSTEPTKPNAASAFPITDEVRHALAVTKRGVDELLIEDEFAQKLAKSAATGKPLRIKLGLDPTAPDIHIGHTVVLNKMRQ
LQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASR
YTVARILEREDFTRRFQSGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEG
LDGVEKMSKSKNNYIGISEKPTDMFGKLMSISDVLMWRYFELLSFRPMEEIAGFKKETEAGRNPRDFKVMLGQEIVARFH
SQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQANLAPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEY
VVQVGKRRFARVTLTA
>Mature_415_residues
STEPTKPNAASAFPITDEVRHALAVTKRGVDELLIEDEFAQKLAKSAATGKPLRIKLGLDPTAPDIHIGHTVVLNKMRQL
QDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRY
TVARILEREDFTRRFQSGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGL
DGVEKMSKSKNNYIGISEKPTDMFGKLMSISDVLMWRYFELLSFRPMEEIAGFKKETEAGRNPRDFKVMLGQEIVARFHS
QADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQANLAPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEYV
VQVGKRRFARVTLTA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=402, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1787925, Length=421, Percent_Identity=28.5035629453682, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25145802, Length=209, Percent_Identity=28.7081339712919, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325160, Length=370, Percent_Identity=24.0540540540541, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20130383, Length=450, Percent_Identity=24.6666666666667, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46061; Mature: 45930

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEPTKPNAASAFPITDEVRHALAVTKRGVDELLIEDEFAQKLAKSAATGKPLRIKLGL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DPTAPDIHIGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESN
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTVARILEREDFTRRFQSGV
HHHHHHHHHHHEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEG
CEEHHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHC
LDGVEKMSKSKNNYIGISEKPTDMFGKLMSISDVLMWRYFELLSFRPMEEIAGFKKETEA
CHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHC
GRNPRDFKVMLGQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
KQANLAPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEYVVQVGKRRFARVTLTA
HHCCCCCCHHHHHHHHHHCCEEECCCEECCCCCEEEHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure 
STEPTKPNAASAFPITDEVRHALAVTKRGVDELLIEDEFAQKLAKSAATGKPLRIKLGL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
DPTAPDIHIGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESN
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AKTYFEQAALVLDRDKTEIRYNSEWSMPLGADGMIKLASRYTVARILEREDFTRRFQSGV
HHHHHHHHHHHEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEG
CEEHHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHC
LDGVEKMSKSKNNYIGISEKPTDMFGKLMSISDVLMWRYFELLSFRPMEEIAGFKKETEA
CHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHC
GRNPRDFKVMLGQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
KQANLAPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEYVVQVGKRRFARVTLTA
HHCCCCCCHHHHHHHHHHCCEEECCCEECCCCCEEEHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA