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The map label for this gene is ywrD [H]

Identifier: 91785136

GI number: 91785136

Start: 4170656

End: 4172293

Strand: Reverse

Name: ywrD [H]

Synonym: Bxe_A0644

Alternate gene names: 91785136

Gene position: 4172293-4170656 (Counterclockwise)

Preceding gene: 91785140

Following gene: 91785135

Centisome position: 85.22

GC content: 64.77

Gene sequence:

>1638_bases
ATGACTGGCTTCAACTGGCAAAACCCTTATCCGACGCCGCGTCTGCCTGTGTTCGCGCGCAACATCGTTTCGACTTCGCA
TCCGCTCGCCGCGCAAGCGGGGCTGCGCATGCTGTGGAAAGGCGGCAATGCCGTCGATGCGGCGATCGCGGCCGCCGCCG
CCATCACGGTGGTCGAGCCGGTATCGTGCGGGCTGGGCAGCGACGCCTTCGCGCTGGTGTGGGACGGCAAGAAGCTGCAT
GGCCTGAACGCCTCGGGTGTGTCGCCGGCGGCGTGGAATGTCGACTACTTCAAGCGCAAGTACGGCGAGGAAAACGGTCT
CGCGAAGCAGCCCAAGCGCGGCTGGGACGCGGTAACGGTGCCGGGCGTGATCGCCGGCTGGGAAGCGCTGCATCAGAAAT
TCGGCACGCTGCCGTTCGCTGACCTGATGGAGCCGGCTATCGAGATCGCCGAGCGTGGTCATGCGGTGGCGAGCATCGTC
GCCTACAAGTGGGCGGCGGCCGTGCCGGAACTGAAGGATCTGCCGGGCTTCGCGCAAACCTTCATGCCGCGCGGCCGCGC
GCCGGAAGTGAGTGAACTGGTGCGCTTTCCCGGCCATGCGAAGACGCTGCGCAAGCTCGCCGAGCAAGGCCCGCGCGCGT
ACTACGAAGGTGAAATCGCCGAACGGATCGCCGCATTTTCGCGCGAAGGCGGCGGCGCACTGACCGCCGAGGATCTGCGC
AACTATCGCGCGGATTGGGTCGAGCCGATCGGCAAGGACTATCGCGGCTACACGGTGCACGAGATTCCGCCGAACGGGCA
GGGCATTGCGGCGCTGATCGCGCTGGGCATCCTCGAAAAATTCGATGTCAAGGAACTGGCGGTCGACAACGTCGAGTCGC
AGCACCTGCAGATCGAAGCGATGAAGCTGGCGTTCGCCGACGTCTACCGCTACGTGGCGGATCCGCGTTCGATGGACGTC
ACGCCCGAGCAGATGCTCGACGACGCATACCTCACCTCGCGCGCGAAACTGATCGATCACAAGCGCGCTACGCAGTTCGA
CTTCGGCATGCCGAAGGCCGGCGGCACGATCTACATGTCGGTGGCGGACGAGCGCGGCATGATGGTCAGCTTCATCCAGT
CGAACTACATGGGCTTCGGCTCGGGCATCGTGGTGCCGGATAGCGGCATCGCCATGCAGAACCGTGGCTGCGGCTTCTCG
ATGGACCCGAAGTCGCCGAACGTGGTGGAAGGCGGTAAGCGGCCGTTCCACACGATCATCCCGTCGTTCCTCACGCAGCA
GGTGAATGGGCAGCAGGAAGCGGTGATGAGCTTCGGCGTGATGGGCGGCGACATGCAGCCGCAAGGTCATCTGCAATCCA
TCGTGCGGATGCTCGACTACGGTCAGCAGCCGCAGGCCGCGTGCGACGCGCCGCGCTGGAAGGTCAATCGCGACTTCACG
ATCGACATCGAATCGACACTCGATCCGAAGACCGCCGAGGCCTTGCAGAAGCTCGGCCATACGATCAAATCGGTCGACGA
TCCGTACATGGACTTCGGCTCCGGCCAGTACATCTGGAAGCTCGATCGCAACGAGCCGGAGCGCGGCTATGTGGCGGCGA
GCGACAGCCGCCGCGACGGGCTGGCCGCCGGGTTCTAG

Upstream 100 bases:

>100_bases
ATTCCGCGTTGACTTGTGCTTCACTCCGTCCACCCCATTCGCCCCGTTTCCATTGGTTCCGCGTTCCGCAGGCCGGGCCG
CGCTTTCTAGAGTGTTCGAC

Downstream 100 bases:

>100_bases
AAAAGGCATCCATTGGCGAAGCGGCCGCCCGGTGAGGCGGCGCTTCGCTGTGCACGCACGCGAGGCTTCGTGCATCGCTC
GCGGCGCGATTGATCGACTG

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTGFNWQNPYPTPRLPVFARNIVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGSDAFALVWDGKKLH
GLNASGVSPAAWNVDYFKRKYGEENGLAKQPKRGWDAVTVPGVIAGWEALHQKFGTLPFADLMEPAIEIAERGHAVASIV
AYKWAAAVPELKDLPGFAQTFMPRGRAPEVSELVRFPGHAKTLRKLAEQGPRAYYEGEIAERIAAFSREGGGALTAEDLR
NYRADWVEPIGKDYRGYTVHEIPPNGQGIAALIALGILEKFDVKELAVDNVESQHLQIEAMKLAFADVYRYVADPRSMDV
TPEQMLDDAYLTSRAKLIDHKRATQFDFGMPKAGGTIYMSVADERGMMVSFIQSNYMGFGSGIVVPDSGIAMQNRGCGFS
MDPKSPNVVEGGKRPFHTIIPSFLTQQVNGQQEAVMSFGVMGGDMQPQGHLQSIVRMLDYGQQPQAACDAPRWKVNRDFT
IDIESTLDPKTAEALQKLGHTIKSVDDPYMDFGSGQYIWKLDRNEPERGYVAASDSRRDGLAAGF

Sequences:

>Translated_545_residues
MTGFNWQNPYPTPRLPVFARNIVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGSDAFALVWDGKKLH
GLNASGVSPAAWNVDYFKRKYGEENGLAKQPKRGWDAVTVPGVIAGWEALHQKFGTLPFADLMEPAIEIAERGHAVASIV
AYKWAAAVPELKDLPGFAQTFMPRGRAPEVSELVRFPGHAKTLRKLAEQGPRAYYEGEIAERIAAFSREGGGALTAEDLR
NYRADWVEPIGKDYRGYTVHEIPPNGQGIAALIALGILEKFDVKELAVDNVESQHLQIEAMKLAFADVYRYVADPRSMDV
TPEQMLDDAYLTSRAKLIDHKRATQFDFGMPKAGGTIYMSVADERGMMVSFIQSNYMGFGSGIVVPDSGIAMQNRGCGFS
MDPKSPNVVEGGKRPFHTIIPSFLTQQVNGQQEAVMSFGVMGGDMQPQGHLQSIVRMLDYGQQPQAACDAPRWKVNRDFT
IDIESTLDPKTAEALQKLGHTIKSVDDPYMDFGSGQYIWKLDRNEPERGYVAASDSRRDGLAAGF
>Mature_544_residues
TGFNWQNPYPTPRLPVFARNIVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEPVSCGLGSDAFALVWDGKKLHG
LNASGVSPAAWNVDYFKRKYGEENGLAKQPKRGWDAVTVPGVIAGWEALHQKFGTLPFADLMEPAIEIAERGHAVASIVA
YKWAAAVPELKDLPGFAQTFMPRGRAPEVSELVRFPGHAKTLRKLAEQGPRAYYEGEIAERIAAFSREGGGALTAEDLRN
YRADWVEPIGKDYRGYTVHEIPPNGQGIAALIALGILEKFDVKELAVDNVESQHLQIEAMKLAFADVYRYVADPRSMDVT
PEQMLDDAYLTSRAKLIDHKRATQFDFGMPKAGGTIYMSVADERGMMVSFIQSNYMGFGSGIVVPDSGIAMQNRGCGFSM
DPKSPNVVEGGKRPFHTIIPSFLTQQVNGQQEAVMSFGVMGGDMQPQGHLQSIVRMLDYGQQPQAACDAPRWKVNRDFTI
DIESTLDPKTAEALQKLGHTIKSVDDPYMDFGSGQYIWKLDRNEPERGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=27.9279279279279, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=27.9279279279279, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=27.9279279279279, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=27.9279279279279, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI113429324, Length=554, Percent_Identity=26.7148014440433, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI113429326, Length=566, Percent_Identity=27.0318021201413, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI109148539, Length=518, Percent_Identity=28.5714285714286, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI153266885, Length=554, Percent_Identity=24.3682310469314, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI153266901, Length=555, Percent_Identity=24.3243243243243, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI153266907, Length=552, Percent_Identity=24.0942028985507, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789856, Length=557, Percent_Identity=30.5206463195691, Blast_Score=195, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI212646519, Length=528, Percent_Identity=26.5151515151515, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI72000294, Length=528, Percent_Identity=26.5151515151515, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17542894, Length=562, Percent_Identity=25.6227758007117, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17506189, Length=546, Percent_Identity=23.992673992674, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193208245, Length=509, Percent_Identity=24.75442043222, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193208247, Length=509, Percent_Identity=24.75442043222, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24642670, Length=564, Percent_Identity=27.1276595744681, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24642666, Length=564, Percent_Identity=27.1276595744681, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI161077878, Length=564, Percent_Identity=27.3049645390071, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI45551474, Length=564, Percent_Identity=27.3049645390071, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI161077880, Length=564, Percent_Identity=27.3049645390071, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI18859893, Length=530, Percent_Identity=26.6037735849057, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18859741, Length=489, Percent_Identity=26.1758691206544, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077496, Length=511, Percent_Identity=24.853228962818, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 59562; Mature: 59431

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFNWQNPYPTPRLPVFARNIVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEP
CCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHCHHHEECCCCHHHHHHHHHHHHHHCCH
VSCGLGSDAFALVWDGKKLHGLNASGVSPAAWNVDYFKRKYGEENGLAKQPKRGWDAVTV
HCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEC
PGVIAGWEALHQKFGTLPFADLMEPAIEIAERGHAVASIVAYKWAAAVPELKDLPGFAQT
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCHHHH
FMPRGRAPEVSELVRFPGHAKTLRKLAEQGPRAYYEGEIAERIAAFSREGGGALTAEDLR
HCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCCCCCHHHHH
NYRADWVEPIGKDYRGYTVHEIPPNGQGIAALIALGILEKFDVKELAVDNVESQHLQIEA
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCHHEEHHH
MKLAFADVYRYVADPRSMDVTPEQMLDDAYLTSRAKLIDHKRATQFDFGMPKAGGTIYMS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
VADERGMMVSFIQSNYMGFGSGIVVPDSGIAMQNRGCGFSMDPKSPNVVEGGKRPFHTII
ECCCCCHHHHHHHHCCCCCCCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
PSFLTQQVNGQQEAVMSFGVMGGDMQPQGHLQSIVRMLDYGQQPQAACDAPRWKVNRDFT
HHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCEECCCCEE
IDIESTLDPKTAEALQKLGHTIKSVDDPYMDFGSGQYIWKLDRNEPERGYVAASDSRRDG
EEECCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCEEEECCCCCCC
LAAGF
CCCCC
>Mature Secondary Structure 
TGFNWQNPYPTPRLPVFARNIVSTSHPLAAQAGLRMLWKGGNAVDAAIAAAAAITVVEP
CCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHCHHHEECCCCHHHHHHHHHHHHHHCCH
VSCGLGSDAFALVWDGKKLHGLNASGVSPAAWNVDYFKRKYGEENGLAKQPKRGWDAVTV
HCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEC
PGVIAGWEALHQKFGTLPFADLMEPAIEIAERGHAVASIVAYKWAAAVPELKDLPGFAQT
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCHHHH
FMPRGRAPEVSELVRFPGHAKTLRKLAEQGPRAYYEGEIAERIAAFSREGGGALTAEDLR
HCCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCCCCCHHHHH
NYRADWVEPIGKDYRGYTVHEIPPNGQGIAALIALGILEKFDVKELAVDNVESQHLQIEA
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCHHEEHHH
MKLAFADVYRYVADPRSMDVTPEQMLDDAYLTSRAKLIDHKRATQFDFGMPKAGGTIYMS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
VADERGMMVSFIQSNYMGFGSGIVVPDSGIAMQNRGCGFSMDPKSPNVVEGGKRPFHTII
ECCCCCHHHHHHHHCCCCCCCCEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHH
PSFLTQQVNGQQEAVMSFGVMGGDMQPQGHLQSIVRMLDYGQQPQAACDAPRWKVNRDFT
HHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCEECCCCEE
IDIESTLDPKTAEALQKLGHTIKSVDDPYMDFGSGQYIWKLDRNEPERGYVAASDSRRDG
EEECCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCEEEECCCCCCC
LAAGF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]