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The map label for this gene is ppx [H]

Identifier: 91784525

GI number: 91784525

Start: 3510809

End: 3512338

Strand: Reverse

Name: ppx [H]

Synonym: Bxe_A1274

Alternate gene names: 91784525

Gene position: 3512338-3510809 (Counterclockwise)

Preceding gene: 91784527

Following gene: 91784522

Centisome position: 71.74

GC content: 64.64

Gene sequence:

>1530_bases
ATGGAGTCCGCTTACTCGATGGTCACTACGCCACAACTCCTCGCTGCCGTCGATCTCGGCTCGAACAGCTTCCGGCTGAT
CGTCGGCCGGGTCGAGGAAACCGACGCGGGCAGCCAGATTTATCAGGTCGACGCGTTGCGCGAACCGGTCCGTCTTGCCG
CCGGCCTGTCGCGCGACAAGATGCTCGACCGCGCTTCGCAGGTGCGCGGCTGGGACGCCCTCAAGCGCTTTGGCGAGCGT
CTGCGCGACTTTCATCCCGATCACGTCCGCGCGGTCGCCACCAATACGCTGCGCATCGCCAAGAACGCCGGCGAATTTCT
CGGCGAGGCGCAAGCCGCGCTCGGCTTCCCGATCGAAGTGATCGCCGGGCGCGAAGAAGCGCGCCTGATCTACGCAGGCG
CCGCACACTCCGTGCCCGCGAGTCCCGGCAAACGCCTCGTGGTCGATATCGGCGGCGGCTCGACGGAATTCATCATCGGC
TCGCACTACACGCCGATCAAGATGGAGAGTCTGTATATCGGTTGCGTGAGCCATAGCCGTGCATTTTTCCCGGCCGGCAA
TGTCGACGAATACACCATGCGCCAGGCCGAGCTCGCCGCCGGGCGCGAAATCCAGATCATTTCCGCCGAGTACAAGAAAA
CCGGCTGGGAGCAGGCGATCGGCTCGTCGGGCACGGCGCGCGCGCTCGCTGAACTGGTCGAGGCGAACGGCTTCAACGAC
GCGGGCGTCACGCACGGCATTTCGCGCGGCGGCCTCGAACGGCTCAAGCGCGCGCTGATCAAGGCGGAGAACGTCAATCG
GCTGAAGCTCGTCGCGCTGAAGGGCGATCGCATTCCGGTGCTGGCCGGCGGCCTGTCGATCATGATTGCGGTGTTCGACG
AACTGGGCGTCGAATACGTCGACACCACGGACGGCGCGTTGCGTCTGGGCGTGCTGTACGACCTGCTGGGCCGCTCGCAA
CACGAAGACATGCGCACGGTGACGGTGGAGGGCTTCATGCGCCGCTACGGCGTGGATCGCGCGCAGGCGGGGCGTATCGG
CGAACTCGCGGTGCGCTTTTACGACCAGTTCGAGGAACCCGACGAAGAACGCCGGGCGGAGAACCGCATGTTTCTCGGTT
GGGCGGCGGCGCTGCACGAAATCGGTCTGTCCATCTCGCACAGCGCGTATCACAAGCATTCGGCCTACATTGCCAGCAAC
GCGGATATGCCAGGCTTTTCGCGCACCGACCAGGCGCGGCTCGCCGCGCTCGTGCTCGGCCACGCGGGCAAACTCGGCAA
GCTCTCGCAAACGCGCGAAGTGGAGTGGCCGCTGCTGTTCTGTCTACGACTCGCGGCGCTGCTGTGCCGTCGGCGTGCGG
ATGTCGGCTTGCCGGGCATTTCGGTGGCGCAGGTCAACAATGGTTATGAGGCGCGTTTGCCGAACGAGTGGGTGAGCAAC
AATCCGCTCACCGACTACAGCCTGATTCAGGAAGCCGCGGAGTGGGAGAAGGTCGGCATTCCGTATCGTGTGGTTTATAC
GGACGATTGA

Upstream 100 bases:

>100_bases
TAGAATGGCGTCTTTGAACAGCGCGGCCGGCCAGAAGGCGCCCAAGGCGTCGAATGGACATCCGGCTCCCAACGCATCCA
CCGCCGCCGCGCTTGCGCGC

Downstream 100 bases:

>100_bases
AGCGGGTTGAAGCCGGTTGAAGCCTTCTGCGAGGCGCATGAATGAAAAAGCCCGGCATGCACACGCCGGGCTTTTTTTGC
GGCCGTTTTTTCGCAGCCAT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MESAYSMVTTPQLLAAVDLGSNSFRLIVGRVEETDAGSQIYQVDALREPVRLAAGLSRDKMLDRASQVRGWDALKRFGER
LRDFHPDHVRAVATNTLRIAKNAGEFLGEAQAALGFPIEVIAGREEARLIYAGAAHSVPASPGKRLVVDIGGGSTEFIIG
SHYTPIKMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAGREIQIISAEYKKTGWEQAIGSSGTARALAELVEANGFND
AGVTHGISRGGLERLKRALIKAENVNRLKLVALKGDRIPVLAGGLSIMIAVFDELGVEYVDTTDGALRLGVLYDLLGRSQ
HEDMRTVTVEGFMRRYGVDRAQAGRIGELAVRFYDQFEEPDEERRAENRMFLGWAAALHEIGLSISHSAYHKHSAYIASN
ADMPGFSRTDQARLAALVLGHAGKLGKLSQTREVEWPLLFCLRLAALLCRRRADVGLPGISVAQVNNGYEARLPNEWVSN
NPLTDYSLIQEAAEWEKVGIPYRVVYTDD

Sequences:

>Translated_509_residues
MESAYSMVTTPQLLAAVDLGSNSFRLIVGRVEETDAGSQIYQVDALREPVRLAAGLSRDKMLDRASQVRGWDALKRFGER
LRDFHPDHVRAVATNTLRIAKNAGEFLGEAQAALGFPIEVIAGREEARLIYAGAAHSVPASPGKRLVVDIGGGSTEFIIG
SHYTPIKMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAGREIQIISAEYKKTGWEQAIGSSGTARALAELVEANGFND
AGVTHGISRGGLERLKRALIKAENVNRLKLVALKGDRIPVLAGGLSIMIAVFDELGVEYVDTTDGALRLGVLYDLLGRSQ
HEDMRTVTVEGFMRRYGVDRAQAGRIGELAVRFYDQFEEPDEERRAENRMFLGWAAALHEIGLSISHSAYHKHSAYIASN
ADMPGFSRTDQARLAALVLGHAGKLGKLSQTREVEWPLLFCLRLAALLCRRRADVGLPGISVAQVNNGYEARLPNEWVSN
NPLTDYSLIQEAAEWEKVGIPYRVVYTDD
>Mature_509_residues
MESAYSMVTTPQLLAAVDLGSNSFRLIVGRVEETDAGSQIYQVDALREPVRLAAGLSRDKMLDRASQVRGWDALKRFGER
LRDFHPDHVRAVATNTLRIAKNAGEFLGEAQAALGFPIEVIAGREEARLIYAGAAHSVPASPGKRLVVDIGGGSTEFIIG
SHYTPIKMESLYIGCVSHSRAFFPAGNVDEYTMRQAELAAGREIQIISAEYKKTGWEQAIGSSGTARALAELVEANGFND
AGVTHGISRGGLERLKRALIKAENVNRLKLVALKGDRIPVLAGGLSIMIAVFDELGVEYVDTTDGALRLGVLYDLLGRSQ
HEDMRTVTVEGFMRRYGVDRAQAGRIGELAVRFYDQFEEPDEERRAENRMFLGWAAALHEIGLSISHSAYHKHSAYIASN
ADMPGFSRTDQARLAALVLGHAGKLGKLSQTREVEWPLLFCLRLAALLCRRRADVGLPGISVAQVNNGYEARLPNEWVSN
NPLTDYSLIQEAAEWEKVGIPYRVVYTDD

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=498, Percent_Identity=38.7550200803213, Blast_Score=335, Evalue=5e-93,
Organism=Escherichia coli, GI48994966, Length=496, Percent_Identity=36.2903225806452, Blast_Score=300, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55828; Mature: 55828

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESAYSMVTTPQLLAAVDLGSNSFRLIVGRVEETDAGSQIYQVDALREPVRLAAGLSRDK
CCCCCCHHCCHHHHEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCHHH
MLDRASQVRGWDALKRFGERLRDFHPDHVRAVATNTLRIAKNAGEFLGEAQAALGFPIEV
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCEEE
IAGREEARLIYAGAAHSVPASPGKRLVVDIGGGSTEFIIGSHYTPIKMESLYIGCVSHSR
ECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEEEECCCC
AFFPAGNVDEYTMRQAELAAGREIQIISAEYKKTGWEQAIGSSGTARALAELVEANGFND
EECCCCCCCHHHHHHHHHCCCCEEEEEECHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCC
AGVTHGISRGGLERLKRALIKAENVNRLKLVALKGDRIPVLAGGLSIMIAVFDELGVEYV
CCHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEECHHHHHHHHHHHHCCEEE
DTTDGALRLGVLYDLLGRSQHEDMRTVTVEGFMRRYGVDRAQAGRIGELAVRFYDQFEEP
ECCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCC
DEERRAENRMFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLG
CHHHHHHCCEEHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHH
HAGKLGKLSQTREVEWPLLFCLRLAALLCRRRADVGLPGISVAQVNNGYEARLPNEWVSN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCC
NPLTDYSLIQEAAEWEKVGIPYRVVYTDD
CCCCHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MESAYSMVTTPQLLAAVDLGSNSFRLIVGRVEETDAGSQIYQVDALREPVRLAAGLSRDK
CCCCCCHHCCHHHHEEEECCCCCEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCCHHH
MLDRASQVRGWDALKRFGERLRDFHPDHVRAVATNTLRIAKNAGEFLGEAQAALGFPIEV
HHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHEEHHHHHHHHHHHHHHCCCCEEE
IAGREEARLIYAGAAHSVPASPGKRLVVDIGGGSTEFIIGSHYTPIKMESLYIGCVSHSR
ECCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEEEEEEECCCC
AFFPAGNVDEYTMRQAELAAGREIQIISAEYKKTGWEQAIGSSGTARALAELVEANGFND
EECCCCCCCHHHHHHHHHCCCCEEEEEECHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCC
AGVTHGISRGGLERLKRALIKAENVNRLKLVALKGDRIPVLAGGLSIMIAVFDELGVEYV
CCHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEECHHHHHHHHHHHHCCEEE
DTTDGALRLGVLYDLLGRSQHEDMRTVTVEGFMRRYGVDRAQAGRIGELAVRFYDQFEEP
ECCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCC
DEERRAENRMFLGWAAALHEIGLSISHSAYHKHSAYIASNADMPGFSRTDQARLAALVLG
CHHHHHHCCEEHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHH
HAGKLGKLSQTREVEWPLLFCLRLAALLCRRRADVGLPGISVAQVNNGYEARLPNEWVSN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCC
NPLTDYSLIQEAAEWEKVGIPYRVVYTDD
CCCCHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]